Clinical trials: Infertility,Male
Cryptozoospermia
Varicocelectomy for Cryptozoospermic Men.
Patient Information leaflet on varicoceles surgery
- Trial name
- NCT07759713
- Testing
- Varicoceles ligation
- Where
- Egypt
- Volunteers
- 69 people
- Sponsor
- Sohag University
Male Infertility
Metabolic Syndrome and Male Infertility
Multidisciplinary, multicentric, cross-sectional study on men in infertile couples who conduct their sperm test through their diagnosis of infertility
- Trial name
- Metasperme (NCT01974947)
- Testing
- Blood sample, sperm sample and clinical examens
- Where
- France
- Volunteers
- 170 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Oligoasthenozoospermia, Male Infertility
Impact of tdrd9 Gene Mutations in the Therapeutic Response to L-carnitine in Oligoasthenozoospermic Men
Infertility remains a significant global burden. Estimates suggest that 10-15% of couples worldwide experience infertility, with male infertility being the underlying cause in 20-50% of cases.
- Trial name
- NCT07402759
- Testing
- L-carnitine
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- South Valley University
Endometriosis
A Long-Term Study to Evaluate the Safety of Asoprisnil in the Treatment of Women With Endometriosis From Study M01-398
The objective of this study is to determine the long-term safety of asoprisnil 5 mg for 12 months in women with endometriosis from study M01-398.
- Trial name
- NCT00160420
- Testing
- Asoprisnil
- Volunteers
- 73 people
- Sponsor
- Abbott
Male Infertility, Varicoceles
Canadian Varicocelectomy Initiative (CVI): Effects on Male Fertility and Testicular Function of Varicocelectomy
A varicocele is the presence of dilated testicular veins in the scrotum. Although it is generally agreed that a varicocele is the most common identifiable pathology in infertile men (detected in up to 40% of men in some series of…
- Trial name
- CVI (NCT00961558)
- Testing
- Varicocelectomy
- Where
- 4 sites in Canada
- Volunteers
- 300 people
- Sponsor
- Mount Sinai Hospital, Canada
Cancer
Sperm Banking Among Adolescents Newly Diagnosed With Cancer: Development of a Profiling and Referral Tool
Despite the known adverse effects of specific cancer treatments on fertility, only 18-26% of at-risk adolescents and young men cryopreserve sperm prior to cancer treatment in the US: These already less than optimal rates of sperm…
- Trial name
- NCT01152268
- Where
- 9 sites in United States, Canada
- Volunteers
- 282 people
- Sponsor
- St. Jude Children's Research Hospital
Oligoasthenoteratozoospermia
Severe Male Factor Infertility Management
This study is the first to evaluate the effect of oral supplementation with antioxidants combined with lifestyle modification for severe male factor partner of couples undergoing ICSI.
- Trial name
- OAT (NCT02752555)
- Testing
- Antioxidant (l-cratinine) + modifiable lifestyle factors
- Where
- 3 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Male Infertility Due to Azoospermia
Round Spermatid Injection Protocol
To evaluate embryology outcomes after application of a technique known as round spermatid injection (ROSI) into donor oocytes in a high-volume clinical infertility practice.
- Trial name
- ROSI (NCT04053309)
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Reproductive Medicine Associates of New Jersey
Infertility
Sperms Activation by Direct Electrical Shocks on Testis in Infertile Males
Background : Up to 15 percent of couples are infertile. In up to half of these couples, male infertility plays a role. Male infertility is due to low sperm production, abnormal sperm function or blockages that prevent the…
- Trial name
- NCT04173052
- Testing
- Testis' shocker
- Where
- Iraq
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Assisted Reproductive Technology, Assisted Reproductive Technology Outcomes
Sperm Selection Strategies and Male-Factor Phenotypes in ICSI
This retrospective multicentre observational cohort study evaluates clinical and reproductive outcomes associated with different sperm-selection strategies used during intracytoplasmic sperm injection (ICSI), including…
- Trial name
- ANDRO-ART (NCT07825584)
- Testing
- Conventional ICSI, Hyaluronan-Binding Sperm Selection, ZyMōt
- Where
- 10 sites in Poland
- Volunteers
- 12,561 people
- Sponsor
- Center for Reproductive Medicine Bocian
Acquired Hypogonadotropic Hypogonadism
Rec-LH PD and Safety Profile in Hypogonadotropic Hypogonadism Men
Objectives: The overall clinical question is whether LH supplementation to men in indication for FSH according to the AIFA note 74, or with HH, will improve spermatogenesis and pregnancy rate (spontaneous or after ART) over FSH…
- Trial name
- RHYTHM (NCT04189133)
- Testing
- Lutropin alfa, Human chorionic gonadotropin
- Where
- 5 sites in Italy
- Volunteers
- 32 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Male Infertility
Vitamin D Supplementation and Male Infertility: The CBG-study a Randomized Clinical Trial
Today, it is evident that vitamin D (VD) has more widespread effects than the classical actions related to bone mineralization and calcium homeostasis1.
- Trial name
- NCT01304927
- Testing
- Cholecalciferol and calcium
- Where
- Denmark
- Volunteers
- 307 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Male Infertility Due to Azoospermia
Seminal Levels of PGK2 and ACRV1 as Predictors of Micro-TESE Results in NOA
Measurement of PGK2 and ACRV1 levels in the semen of infertile males undergoing testicular sperm extraction (TESE). Correlate seminal levels of PGK2 and ACRV1 with sperm retrieval results and histopathology analysis of testicular…
- Trial name
- NCT06307639
- Testing
- Measurement of PGK2 and ACRV1 levels in the semen of infertile males undergoing testicular sperm extraction (TESE).
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Assiut University
Infertility, Infertility, Female
Aftificial Inteligence in Assisted Reproductive Techniques to Assess Oocyte Quality and Embryo Ploidy
The assisted reproduction success rate is affected by several factors including the age of the women, oocyte quality and maturation state, as well as sperm quality.
- Conditions
- Infertility, Infertility, Female, Infertility, Male, Infertility Unexplained
- Trial name
- SMARTAI (NCT06539104)
- Testing
- arteficial inteligence evaluation of oocyte and embryo development
- Where
- 4 sites in Czechia
- Volunteers
- 1,000 people
- Sponsor
- Charles University, Czech Republic
Varicocele, Male Infertility
Intratesticular Artery Resistive Index Changes After Varicocelectomy
This study aims to evaluate how blood flow inside the testicles changes after surgery to correct a varicocele, and whether these changes correlate with improvements in semen quality and testosterone levels.
- Conditions
- Varicocele, Male Infertility, Secondary Hypogonadism
- Trial name
- NCT07517952
- Testing
- Microscopic Sub-inguinal Varicocelectomy
- Volunteers
- 40 people
- Sponsor
- Assiut University
Endometriosis
ENDOMET - Novel Diagnostic Tools and Treatments for Endometriosis
Endometriosis is a chronic disease characterized by the presence of functional endometrial glands and stroma in ectopic locations outside the uterine cavity.
- Trial name
- ENDOMET (NCT01301885)
- Testing
- Laparoscopy/laparotomy
- Where
- 4 sites in Finland
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Obesity-related Male Infertility
Can Fat-Burning Shots Boost Fertility? Comparing Weight-Loss Injections vs. Healthy Habits for Obese Men With Low Sperm Health
Why is this study being done? Obesity can harm men's fertility by lowering sperm quality and hormone levels, making it harder to have children. Weight loss through diet and exercise helps, but it's often hard to stick with.
- Trial name
- NCT07179120
- Testing
- Semaglutide (Rybelsus®), Tirzepatide, Standardized Lifestyle Intervention
- Volunteers
- 180 people
- Sponsor
- First Affiliated Hospital of Wenzhou Medical University
Male Subfertility
The Impact of a Nutritional Supplement (Impryl®) on Male Fertility
Infertility is a worldwide problem and about 10%-15% of all couples will be affected by the inability to have children. In approximately 50% of infertile couples a male factor is involved.
- Trial name
- SUMMER (NCT03337360)
- Testing
- Impryl
- Where
- 21 sites in Netherlands
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Male Infertility
Relationship Between Sperm Head Vacuoles and Sperm DNA Alterations in Infertile Men
In men presenting sperm alterations, the selection of genetically undamaged spermatozoa need to be improved in order to increase the success of assisted reproduction treatments.
- Trial name
- VATES (NCT02006446)
- Testing
- Sperm Samples
- Where
- 2 sites in France
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen
Idiopathic Oligoasthenoteratozoospermia, Male Infertility
Comparative Evaluation of the Efficacy of Letrozole, L-Carnitine, and Their Combination on Sperm Quality, Oxidative Stress, and ART Outcomes in Men With Idiopathic Oligoasthenoteratozoospermia.
This is a randomized clinical trial evaluating the efficacy of Letrozole, L-Carnitine, and their combination on sperm quality, oxidative stress, and ART outcomes in men with idiopathic oligoasthenoteratozoospermia.
- Trial name
- NCT07669402
- Testing
- Letrozole 2.5mg, L-carnitine
- Where
- Iran
- Volunteers
- 90 people
- Sponsor
- Tehran University of Medical Sciences