Clinical trials: Infertility/Sterility
Infertility
Cumulative Live Birth Rates After Cleavage-stage Versus Blastocyst-stage Embryo Transfer
The aim of this RCT is to compare differences in the efficacy and safety between cleavage-stage embryo transfer and blastocyst-stage embryo transfer in IVF/ICSI treatment cycle, taking into account of subsequent vitrified embryo…
- Trial name
- CLBR-CBSET (NCT03152643)
- Testing
- blastocyst-stage embryo transfer, cleavage-stage embryo transfer
- Where
- 11 sites in China
- Volunteers
- 992 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Healthy
Pergoveris FD and Liquid China BE Study
The main purpose of this study is to assess the bioequivalence (BE) of the fixed combination of follitropin alfa and lutropin alfa in Pergoveris freeze-dried (FD) (Test 1) or in Pergoveris Liquid (Test 2) versus the…
- Trial name
- NCT04899193
- Testing
- Pergoveris FD, Pergoveris Liquid, Gonal-f
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Ovarian Cancer, Borderline Ovarian Tumors
Treg, Th17 Cells, NKT in Epithelial Ovarian Tumor
The aim of the study was to estimate the percentage and of Treg, Th17 and NKT in peripheral blood and the tissue of the epithelial ovarian tumor and relationship with blood serum level of HE4, CA125, as well as algorithm ROMA.
- Conditions
- Ovarian Cancer, Borderline Ovarian Tumors, Benign Ovarian Tumor, Unexplained Infertility
- Trial name
- NCT03779399
- Testing
- Assessment of percentage of Treg, Th17, NKT and serum level of HE4, CA125 and ROMA.
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Lublin
Infertility
Implementing IVM for Fertility Treatment in Clinical Practice
The ovarian reserve consists of a finite pool of follicles that gradually declines throughout a woman's reproductive life. During conventional IVF, exogenous gonadotropins are administered for 10-14 days to support the growth and…
- Trial name
- IVM-DK 2-0 (NCT07894952)
- Testing
- In vitro maturation
- Where
- Denmark
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Hvidovre
Infertility
Maternal Serum Cytokine Levels and Angiogenic Factor Levels in IVF vs Spontaneously Conceived Pregnancies
The objective of the study is to compare maternal levels of cytokines and angiogenic factors in IVF vs spontaneously conceived singleton pregnancies. The null hypothesis is that there will be no significant difference.
- Trial name
- NCT00837278
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- MemorialCare
Infertility, Female, Deferred Childbearing
Investigational Oocyte Cryopreservation for Medical and Non Medical Indications
This is a prospective study to assess the long term benefits and outcomes of the existing oocyte cryopreservation methods for fertility preservation in women with a potential medical or non medical risk of loss of fertility
- Trial name
- NCT04616417
- Testing
- Investigational Oocyte Cryopreservation
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Infertility, Pregnancy
The Effect of Pre-washing the Insemination Catheter on Pregnancy Outcome
The investigators hypothesize that washing the insemination catheter prior to performing the IUI (intrauterine insemination) will improve the pregnancy outcome in IUI cycles when compared to controls (without pre-washing the…
- Trial name
- NCT02445092
- Testing
- washing the insemination catheter with sperm washing media
- Where
- Canada
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Ovarian Stimulation
Luteinizing Hormone (LH) Supplementation in Gonadotropin-releasing Hormone (GnRH) Antagonist Cycles
To analyse the impact on cycle outcome of LH supplementation in ovarian stimulation controlled with a GnRH antagonist in two ages groups: patients upto 35 years old, and patients aged between 36 and 39 years old.
- Trial name
- NCT01037699
- Testing
- rFSH: Follicle Stimulating Hormone, rFSH: Follicle Stimulating Hormone and rLH: Luteinizing Hormone (Recombinant Luteotrophin alfa)
- Where
- Spain
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Ovarian Failure, Ovarian Insufficiency
Ovarian Tissue Allo-transplantation
Premature ovarian failure, also known as primary ovarian insufficiency (POI), or premature menopause, affects 1-2% of women under 40.
- Conditions
- Ovarian Failure, Ovarian Insufficiency, Menopause Ovarian Failure, Menopause, Premature
- Trial name
- NCT06673004
- Testing
- Ovarian tissue allo-transplantation
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Asthenozoospermia
Effect of Fermented Ginseng (GINST) on Sperm Motility
This randomized, double-blind, placebo-controlled study aimed to evaluate the effect of ginseng(GINST) supplementation for 12 weeks on sperm motility.
- Trial name
- NCT03183999
- Testing
- fermented ginseng (GINST)
- Where
- 3 sites in South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jae Hoon Lee
Infertility, Female
Effects of Physical Activity and Fitness, Cardiovascular- and Psychosocial Health on Medically Assisted Reproduction
This prospective observational study aims to investigate the association between physical activity and clinical pregnancy rates in women undergoing medically assisted reproduction.
- Trial name
- REPRO-FIT (NCT07321665)
- Testing
- Health, fitness and lifestyle assessment
- Where
- Switzerland
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Infertility, Female
Biological Effects of Treatment With Resveratrol in ART Patients
To evaluate the effects of a new nutraceutical formulation containing resveratrol (trademark GENANTE) on gamete quality in order to improve the reproductive process during ART.
- Trial name
- NCT04386499
- Testing
- Resveratrol, Folic acid
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Of Perugia
Infertility Low Over Reserve, IVF
BPA Levels Relationship With IVF/ICSI Outcomes in Low Ovarian Reserve
The relationship between BPA elevation in urine, blood, and follicle fluid and embryo quality, IVF/ICSI outcomes.
- Conditions
- Infertility Low Over Reserve, IVF, Infertility, Female
- Trial name
- NCT04654598
- Testing
- BPA levels
- Where
- Turkey (Türkiye)
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Nefise Nazlı YENIGUL
Weight Loss
Infertile Polycystic Ovary Syndrome (PCOS) Women With Obesity and Lifestyle Changes
Infertile PCOS women with obesity were included into lifestyle change weight loss program prior to inclusion to IVF procedures. They attended group as well as individual workouts and they were advised on healthy eating.
- Trial name
- NCT04989244
- Testing
- Weight loss program
- Where
- Slovenia
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Cancer, Hematologic Diseases
Autologous Transplantation of Human Cryopreserved Testis Tissue
For pre-pubertal boys undergoing gonadotoxic therapies, freezing immature testicular tissue (ITT) containing spermatogonial stem cells (SSCs) is currently the only option to potentially preserve future fertility.
- Conditions
- Cancer, Hematologic Diseases, Infertility, Male, Azoospermia, Nonobstructive
- Trial name
- ReSTORE (NCT07364409)
- Testing
- Autologous Transplantation of Testis Tissue
- Where
- Denmark
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Herlev and Gentofte Hospital
Uterine Fibroids, Infertility
a Study to Evaluate Adhesion Risk in Fertility Patients' Status Post Laparoscopic Myomectomy.
Premenopausal Women ages 18-42 will undergo a laparoscopic myomectomy. Prior to the myomectomy, adhesions will be assessed using a modified AFS scoring technique.
- Trial name
- VLocmyo (NCT01971060)
- Testing
- surgery utilizing V-Loc suture
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- The Advanced Gynecologic Surgery Institute
Primary Infertility Unspecified, Infertility
Routine Hysteroscopy in IVF/ICSI Cycles in Patients With Primary Unexplained Infertility
The aim of the present study is to evaluate the impact of hysteroscopy prior to starting the IVF (in vitro fertilisation) cycle on treatment outcome in women with unexplained primary infertility.
- Conditions
- Primary Infertility Unspecified, Infertility, Ovarian Hyperstimulation, Pregnancy
- Trial name
- NCT02416596
- Testing
- Hysteroscopy, Hysteroscope
- Volunteers
- 680 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Infertility
Circadian Variation in Serum-progesterone Levels Following Controlled Ovarian Hyperstimulation.
The aim of the study is to investigate the circadian variation in serum-progesterone in women undergoing controlled ovarian stimulation.
- Trial name
- NCT02673034
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Regionshospitalet Viborg, Skive
Infertility, Failed in Vitro Fertilisation
An Intervention on Psychosocial Health in Women With Unsuccessful IVF Experience
The goal of this interventional study is to learn if web-based support program can improve the psychosocial health status in women with unsuccessful IVF experience.
- Trial name
- NCT06426472
- Testing
- Web-based support program
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Infertility
Elonva in Combination With Hp-FSH Versus Elonva With Low Dose hCG
The study compares in a randomized controlled way two stimulation methods. One of these stimulation methods implements a new insight in ovarian follicular growth.
- Trial name
- NCT03208972
- Testing
- low dose hCG, hp-FSH, Corifollitropin Alfa
- Where
- Belgium
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- AZ Jan Palfijn Gent
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