Clinical trials: Infertility/Sterility
Infertility
Novel Approach for Embryo Transfer Medium by Adding Cytokine to Hyaluronan Enriched Embryo Transfer Medium (Embryo Glue)
It was proven that the Cytokine granulocyte-Macrophage clony stimulating factor had been found naturally in reproductive tract so our target is to test its effect if added to embryo transfer medium.
- Trial name
- NCT02422134
- Testing
- Cytokine group
- Where
- 2 sites in Egypt
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Ibn Sina Hospital
Female Infertility
The Embryologist's Impact on Blastocyst Vitrification and Thawing
The goal of this monocentric retrospective observational study is to analyse, for the first time in literature, the role of the embryologist who freezes and thaws the embryos.
- Trial name
- NCT06220227
- Testing
- vitrification and thawing procedures
- Where
- Italy
- Volunteers
- 6,800 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Infertility
Study on Influence of Leutinizing Hormone (LH) on Oocyte Maturity
1. Leutinizing hormone (LH) has been demonstrated to exert variable physiological actions during menstrual cycle at appropriate plasma levels' 2.
- Trial name
- LH/M2-Oocyte (NCT01595334)
- Testing
- Cetrorelix, Luprolide Acetate
- Where
- 3 sites in India
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Southern Cross Fertility Centre
Female Infertility
Highly Purified Menotropin (HP-hMG) Versus Recombinant FSH (rFSH) Plus Recombinant LH (rLH) in Intrauterine Insemination Cycles in Women ≥35 Years: a Prospective Randomized Trial.
This study evaluates the effects of different therapies in ovulation induction in Intrauterine Insemination Cycles.
- Trial name
- NCT01604044
- Testing
- Meropur 150 a day, Gonal-f 150 plus Luveris 150
- Where
- Italy
- Volunteers
- 579 people, healthy volunteers welcome
- Sponsor
- Catholic University of the Sacred Heart
Infertility
Role of Heparin in Poor Responders Undergoing In Vitro Fertilisation
The addition of heparin increases pregnancy outcome parameters in poor responders undergoing In Vitro Fertilisation (IVF)
- Trial name
- NCT01315093
- Testing
- Heparin, Low-Molecular-Weight, no heparin
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Sperm DNA Fragmentation, Embryo Quality
Sperm Selection by Microfluidic Separation Improves Embryo Quality
This is a randomized controlled trial of couples with a history of poor embryo quality undergoing a repeat in vitro fertilization (IVF) cycle for unexplained infertility.
- Conditions
- Sperm DNA Fragmentation, Embryo Quality, Fertility Disorders, Infertility
- Trial name
- SPERM (NCT03085433)
- Testing
- Microfluidic Sperm Sorting, in vitro fertilization
- Where
- United States
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Infertility
Vaginal Culture Using INVOcell Compared to Traditional IVF Incubation
The purpose of this study is to evaluate intravaginal culture using the medical device INVOcell to generate day 5 blastocysts in comparison to traditional IVF.
- Trial name
- NCT02363426
- Testing
- INVOcell Culture Device, IVF Incubation
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Invaron Pharmaceuticals Inc.
Infertility
Correlation Between Serum Anti-Müllerian Hormone & Müllerian Ducts Anomalies in Infertility
Anti-Müllerian hormone (AMH), also known as Müllerian inhibiting substance, is a dimeric glycoprotein that belongs to the transforming growth factor-beta family.
- Trial name
- NCT02436538
- Testing
- Anti Mullerian hormone level; Mullerian duct anomaly type
- Where
- Egypt
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Ahmed M.Kamel
Infertility, Female
Cabergoline Before or After Oocyte Collection for Follicular Resolution
Randomized trial comparing the efficacy of two different times of administration of cabergoline in patients undergoing controlled ovarian stimulation and oocyte collection.
- Trial name
- NCT04096027
- Testing
- Cabergoline Pill
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fertility Center of Las Vegas
Mood
Differential Effects of Clomiphene Citrate in Women Undergoing Superovulation
Clomiphene citrate is commonly used for ovulation induction in women with anovulation, correction of luteal phase deficiency or for superovulation as empiric therapy for unexplained infertility.
- Trial name
- NCT01291056
- Testing
- Clomiphene
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Utah
Pregnancy
Motile Sperm Organelle Morphology Examination (MSOME) Influence on Intracytoplasmic Sperm Injection (ICSI) Outcomes in Infertile Couples
A new technique based on the motile sperm organelle morphology examination (MSOME) at a magnification of at least ×6000 has been developed.
- Trial name
- NCT01731639
- Testing
- MSOME
- Where
- Brazil
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Sapientiae Institute
Infertility
Impact of Reproductive Problems on Couples
Reproduction is in fact the most basic instinct of all living things. The fertility of a woman is both a biological fact and a determinant of gender role in society.
- Trial name
- NCT03365830
- Testing
- FertQol, Beck's Depression Inventory, Beck's Anxiety Inventory
- Where
- Turkey (Türkiye)
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Female Infertility
Levels of Anti-Mullerian Hormone (AMH) During Ovarian Stimulation With Gonadotropins
Anti-Mullerian Hormone (AMH) is produced only in small ovarian follicles with quite stable levels during the cycle. There is not yet sufficient data to inform couples undergoing IVF about the effect of ovarian stimulation on the…
- Trial name
- NCT02237781
- Testing
- Gonadotropins
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Athens
Infertility, Infertility, Female
The Outcome of Two Protocols Used to Prepare Endometrium for Frozen Embryo Transfer
This is a RCT to test the outcome of two protocols used for preparation of the endometrium for frozen blastocyst embryo transfer
- Conditions
- Infertility, Infertility, Female, Infertility, Male
- Trial name
- NCT04507022
- Testing
- Estradiol Valerate, Progesterone, Aromatase inhibitor
- Where
- Egypt
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Rahem Fertility Center
Infertility, Female
Clinical Efficacy of Virtual Reality During Office Hysteroscopy and Endometrial Biopsy in Subfertility
This study is a comparison between the current standard practice of performing a diagnostic hysteroscopy and a relatively recently developed technology that is added to the standard diagnostic hysteroscopy.
- Trial name
- HYSVIR (NCT04438759)
- Testing
- Oncomfort, commercially available Virtual Reality headset
- Where
- Belgium
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility, Pregnancy
Lifestyle and Fertility Study on Antioxidant Status, Diet and Early Pregnancy
Researchers believe that certain lifestyle factors can influence a couple's ability to conceive and have a baby. The ISIS Study will look at the health habits of couples who are planning their first pregnancy, and then attempt to…
- Conditions
- Infertility, Pregnancy, Fertility, Nutrition
- Trial name
- NCT00642590
- Where
- 2 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Fertility Disorders, Hypothalamic Dysfunction
Reproductive Hormones During Sustained Administration of Kisspeptin
We want to find out what happens to reproductive hormone levels; Luteinising Hormone (LH), Follicle Stimulating Hormone (FSH), testosterone and oestradiol when kisspeptin is administered to people for a period of 8 days each…
- Trial name
- KisspeptPump (NCT02081924)
- Testing
- Kisspeptin 0.1, Saline, Kisspeptin 0.3
- Where
- United Kingdom
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Infertility, IVF
Quality of Human Embryos in IVF, Culturing in Differentiated Oxygen
The goal of this clinical trial is to evaluate the importance of differential O2 tension to the developing embryos. As a secondary aim, we investigate the levels of reactive oxygen species (ROS) in spent media from the developing…
- Conditions
- Infertility, IVF, Embryo
- Trial name
- NCT05737381
- Testing
- Differential oxygen tension
- Where
- Denmark
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Transgender, Gender Incongruence
The Effect of Tucking on Semen Quality of Adult Trans Women
Because gender-affirming hormone therapy (GAHT) can lead to fertility impairment, current guidelines and treatment recommendations require that patients be informed about the possibility of fertility preservation prior to…
- Conditions
- Transgender, Gender Incongruence, Fertility Issues
- Trial name
- NCT06530992
- Testing
- tucking break
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Medical University Innsbruck
Infertility
Study of Axillary Skin Temperature as a Marker of Ovulation
Infertility is the most common reason women (aged 20-45yrs)see their GP, affecting 1 in 7 couples. Measuring basal body temperature is a technique that has been used since the 1930's to attempt to predict ovulation.
- Trial name
- NCT01360684
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Joanne Outtrim
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