Clinical trials: Infertility/Sterility
Infertility
Evidence-based Stimulation Trial With Human rFSH in Europe and Rest of World 1
This trial investigates the effects of FE 999049 compared to GONAL-F.
- Trial name
- ESTHER-1 (NCT01956110)
- Testing
- Follitropin Delta (FE 999049), Follitropin Alfa (GONAL-F)
- Where
- 13 sites in Belgium, Brazil and 9 more
- Volunteers
- 1,329 people
- Sponsor
- Ferring Pharmaceuticals
Female Infertility
Effects of Intrauterine Flushing With Human Chorionic Gonadotropin on ICSI Outcome
a number of infertile women who were prepared for ICSI and immediately post ova pick up intrauterine flushing with human chorionic gonadotropin was done to study the effect of this drug on ICSI outcome and ultrasound parameter.
- Trial name
- NCT06684951
- Testing
- hCG
- Where
- Iraq
- Volunteers
- 90 people
- Sponsor
- Omayma Ismail Khalaf
Infertility
Safety and Efficacy of Pre-defined, Fixed Dose of Gonal-f Pen Based on Subject Baseline Characteristics in Subjects Undergoing in Vitro Fertilization (IVF)
Clinical validation of the assisted reproductive technology (ART) treatment guidelines, which determine the optimal dose of recombinant human follicle stimulating hormone (r-hFSH) based on subject baseline…
- Trial name
- CONSORT (NCT00249834)
- Testing
- Gonal-f, Recombinant human chorionic gonadotrophin (r-hCG)
- Where
- France
- Volunteers
- 166 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility, Female
Improving Reproductive Fitness Through Pretreatment With Lifestyle Modification in Obese Women With Unexplained Infertility
A two-arm, multicenter, prospective, randomized clinical trial of a lifestyle modification program with tracked increased physical activity and weight loss (intensive) compared to recommendations to tracking of increased physical…
- Trial name
- FIT-PLESE (NCT02432209)
- Testing
- Caloric Restriction, Orlistat, Moderate physical activity
- Where
- 10 sites in United States
- Volunteers
- 379 people
- Sponsor
- Yale University
Polycystic Ovarian Syndrome, Infertility
Menopur® Versus Follistim® in Polycystic Ovarian Syndrome (PCOS)
This multicenter, randomized, open-label exploratory study will be performed in approximately 200 polycystic ovary syndrome (PCOS) but otherwise healthy females undergoing in vitro fertilization (IVF).
- Trial name
- NCT00805935
- Testing
- Menotropin, Progesterone vaginal insert, Follitropin beta
- Where
- 6 sites in United States
- Volunteers
- 110 people
- Sponsor
- Ferring Pharmaceuticals
Anovulation
Sildenafil Vaginal Gel Co-treatment With Clomiphene Citrate in Infertile Women With Thin Endometrium
This is a prospective self controlled clinical trial. Women with clomiphene Citrate failure, and thin endometrium were recruited (N = 42).
- Trial name
- NCT02710981
- Testing
- clomiphene citrate, Sildenafil vaginal gel
- Volunteers
- 42 people
- Sponsor
- Assiut University
Endometriosis
BGS649 Monotherapy in Moderate to Severe Endometriosis Patients
This study will assess the safety and tolerability of BGS649 in women with moderate to severe endometriosis.
- Trial name
- NCT01190475
- Testing
- Active treatment with a high dose of BGS649, Active treatment with a low dose of BGS649
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Mereo BioPharma
Pressure Ulcer, Spinal Cord Injuries
Pressure Ulcer Healing With Microcyn
The purpose of this study is to test how well Microcyn™ works on Stage 3 and Stage 4 pressure ulcers compared to sterile saline among persons with spinal cord injury.
- Trial name
- NCT02001558
- Testing
- Microcyn, Sterile saline
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Alabama at Birmingham
Anovulation
Comparison of Anastrozole Verses Clomiphene Citrate in Stimulating Follicular Growth and Ovulation in Infertile Women With Ovulatory Dysfunction
The purpose of this study is to investigate and compare the safety and efficacy of various doses of the aromatase inhibitor (anastrozole) versus clomiphene citrate in stimulating follicular growth and ovulation in infertile women…
- Trial name
- NCT00213148
- Testing
- Anastrozole 1 mg, Anastrozole 5 mg, Anastrozole 10 mg
- Where
- United States
- Volunteers
- 271 people
- Sponsor
- EMD Serono
Infertility
Progesterone Serum Levels in Subfertile Female Patients Undergoing in Vitro Fertilisation (IVF)
This study is aimed to demonstrate that highly purified Menotrophin produces significant lower progesterone serum levels during the follicular phase in comparison to Follitropin alpha in the treatment of subfertile females…
- Trial name
- PREDICT (NCT01225835)
- Testing
- Menotrophin, Follitrophin alpha, Cetrorelix
- Where
- 8 sites in Germany
- Volunteers
- 124 people
- Sponsor
- Ferring Pharmaceuticals
Infertility
The Effect of a Higher Dose of Dehydroepiandrosterone (DHEA) Supplementation in Poor Responders
The supplementation of Dehydroepiandrosterone (DHEA) has been used in some centers for patients with previous poor ovarian reserve and response in an attempt to improve pregnancy outcomes.
- Trial name
- DHEA (NCT02357472)
- Testing
- dehydroepiandrosterone
- Where
- China
- Volunteers
- 60 people
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Chemical Injuries, Unspecified Complication of Corneal Transplant
Use of Cross-linked Donor Corneas as Carriers for the Boston Keratoprosthesis
The purpose of the pilot study is to test the efficacy and safety of riboflavin/Ultraviolet A (UVA) cross-linked human donor corneas as carriers for the Boston Keratoprosthesis (Boston KPro) in patients with higher risk for…
- Conditions
- Chemical Injuries, Unspecified Complication of Corneal Transplant, Autoimmune Diseases, Ocular Cicatricial Pemphigoid
- Trial name
- NCT01582880
- Testing
- Riboflavin
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Joseph B. Ciolino, MD
Infertility
Comparison Of The Embryoscope Time-Lapse System With Standard Embryo Culture
"Embryoscopes," allow for embryo culture to be performed in an automated incubation system under time lapse photography. Manufacturers of these systems (and investigators who have used these systems) claim that the availability…
- Trial name
- NCT02246309
- Testing
- Embryoscope Time Lapse System, Standard Embryo Culture
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Infertility
A Korean Post-Marketing Surveillance Study On Pergoveris® (Follitropin Alfa + Lutropin Alfa)
This prospective study collected safety information from more than 600 participants treated with Pergoveris®. During the Post-Marketing Surveillance (PMS) period, data about the participant's background, participant's medical…
- Trial name
- NCT01416987
- Testing
- Pergoveris®
- Where
- 2 sites in South Korea
- Volunteers
- 600 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility
Comparison of Crinone 8% Intravaginal Gel and IM Progesterone Supplementation for In Vitro Fertilization (IVF)
The goal of this research study is to compare the pregnancy rates for two different types of progesterone supplementation after in-vitro fertilization (IVF).
- Trial name
- NCT00656201
- Testing
- Crinone 8% Vaginal Gel, Intramuscular Progesterone
- Where
- United States
- Volunteers
- 468 people
- Sponsor
- Brigham and Women's Hospital
Infertility
Endometrial Injury for Assisted Reproduction
The objective of this study is to evaluate the effect of endometrial injury performed prior ovulation induction for assisted reproductive techniques main outcomes.
- Trial name
- NCT01132144
- Testing
- Endometrial injury, Control group
- Where
- Brazil
- Volunteers
- 158 people
- Sponsor
- University of Sao Paulo
In Vitro Fertilization
EXpression PRofile Endometrium Samples Study
This is a Phase IV, pilot, open-label, national, multi-centric study planned to determine the gene expression profiles and histologic changes of the endometrial tissue before and after stimulation with Gonal-f®.
- Trial name
- EXPRESS (NCT01210144)
- Testing
- Gonal -f® [r-hFSH], Ovitrelle® [r-hCG alfa], Gonadotropin-releasing hormone (GnRH) Agonist
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Infertility, Endometriosis
Pre-IVF Treatment With a GnRH Antagonist in Women With Endometriosis
A Phase 3 clinical trial of oral GnRH antagonist pre-treatment for women with endometriosis who are undergoing IVF, with a primary outcome of live birth rate.
- Trial name
- PREGnant (NCT04173169)
- Testing
- Elagolix 200 MG
- Where
- 5 sites in United States
- Volunteers
- 103 people
- Sponsor
- Yale University
Infertility
Efficacy Study of Granulocyte-macrophage Colony Stimulating Factor (GM-CSF) for Use in Human IVF
This study is to assess whether addition of 2 ng/ml GM-CSF into a specific culture medium will increase the chance of a pregnancy after in vitro fertilisation.
- Trial name
- GM-CSF (NCT00565747)
- Testing
- Test culture, Control culture
- Where
- 14 sites in Denmark, Sweden
- Volunteers
- 1,332 people
- Sponsor
- Origio A/S
Progesterone Supplementation in Women Undergoing ART
Clinical Safety Study of the Progesterone Vaginal Ring in Women Undergoing Assisted Reproductive Technology Procedures
The purpose of the study is to assess the safety of Progesterone Vaginal Ring (PVR) in women undergoing fresh embryo transfer (ART).
- Trial name
- SARA (NCT03565211)
- Testing
- Progesterone vaginal ring
- Where
- 15 sites in United States
- Volunteers
- 352 people
- Sponsor
- Ferring Pharmaceuticals