Clinical trials: Infertility; In Vitro Fertilization; Embryo Development
Infertility, Female, Reproductive Techniques, Assisted
SISTER: Sibling Oocyte Insemination With Frozen Sperm From Third Party Donors: Evaluation of Reproductive Techniques
The goal of this clinical trial is to learn whether two different methods of helping eggs and sperm join-intracytoplasmic sperm injection (ICSI) and conventional in vitro fertilization (IVF)-lead to better embryo development when…
- Conditions
- Infertility, Female, Reproductive Techniques, Assisted, Fertilization in Vitro
- Trial name
- SISTER (NCT07175571)
- Testing
- Intracytoplasmic Sperm Injection (ICSI), Conventional Insemination (IVF)
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
Female Infertility, Embryo Development
Day-4 Embryo Defragmentation: Blastocyst Rate and clInical Outcomes
Background: Embryo fragmentation is one of the main morphological parameters assessed during in vitro culture in assisted reproductive technology (ART).
- Conditions
- Female Infertility, Embryo Development, In Vitro Fertilization
- Trial name
- DEBRIS (NCT07500337)
- Testing
- Mechanical embryo defragmentation at Day 4 (morula stage), Standard embryo culture without intervention
- Where
- Italy
- Volunteers
- 320 people
- Sponsor
- Momo Fertilife
Infertility, Infertility, Male
Laser-Assisted Versus Conventional Intracytoplasmic Sperm Injection
Laser-assisted intracytoplasmic sperm injection (ICSI) has been suggested as a more effective alterative to conventional ICSI when this method of insemination is indicated for patients undergoing in vitro fertilization (IVF).
- Trial name
- NCT00114725
- Testing
- Laser-assisted intracytoplasmic sperm injection
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Shady Grove Fertility Reproductive Science Center
Infertility (IVF Patients)
Study of Abnormally Fertilized Embryos
The goal of this observational study is to determine the diploidy rate of haploid and triploid embryos from in vitro fertilization (IVF) cycles.
- Trial name
- SAFE (NCT06940973)
- Testing
- Parental samples, PGT-A, TE rebiopsies and spent blastocyst media collection
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Igenomix
Primary Ovarian Insufficiency, Female Infertility Due to Diminished Ovarian Reserve
Effect of Testosterone Treatment on Embryo Quality
The purpose of this study is to determine the effect of treatment with trans-dermal testosterone cream compared to placebo on measures of ovarian reserve, oocyte and embryo quality, and pregnancy rates among women with evidence…
- Trial name
- NCT01662466
- Testing
- Testosterone cream (0.5mg per gram), DHEA
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Center for Human Reproduction
Infertility, Pregnancy Outcome, Live Birth
in Vitro Fertilization (IVF) Media Protein and Live Birth Rates
Human conception in vivo occurs in a complex milieu that includes proteins. It has been speculated that the addition of proteins more complex than human serum albumin to culture media may improve IVF outcomes.
- Conditions
- Infertility, Pregnancy Outcome, Live Birth, In Vitro Fertilization
- Trial name
- SSS (NCT00708383)
- Testing
- 10% SSS embryo culture medium protein supplementation, 0.5% HSA embryo culture medium protein supplementation
- Where
- 2 sites in United States
- Volunteers
- 538 people
- Sponsor
- Texas Health Resources
Infertility, Female
Comparison of in Vitro Fertilization Rates of Oocytes and Embryo Development Using Two Techniques of Semen Processing
The investigators propose to assess one method of sperm selection based on the characteristics of spermatozoa recently introduced: Sperm Selection Assay, which used a gradient of concentration of progesterone to act as…
- Trial name
- NCT03186170
- Testing
- SSA sperm selection
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Infertility (IVF Patients)
Correlation of the Genetic Constitution of the Spent Blastocyst Media
The main objective of this study is to improve niPGT-A (non-invasive Preimplantation Genetic Testing for Aneuploidies) to avoid the need of a biopsy to perform the genetic analysis of the embryo and to help in understanding the…
- Trial name
- CONNECTED (NCT06780605)
- Testing
- niPGT-A, Multifocal TE biopsies and ICM biopsy
- Where
- 2 sites in Cyprus
- Volunteers
- 230 people
- Sponsor
- Igenomix
IVF, Infertility
Improvement of Fertilization Rate and Embryo Quality by Treating Calcium Ionophore in IVF Patients: a Sibling Oocyte Control Study
GM508 CultActive is a bicarbonate buffered reagent and ready-to-use designed to investigate oocytes of patients with failed fertilization after previous Intracytoplasmatic Sperm Injection cycles.
- Conditions
- IVF, Infertility, Artificial Oocyte Activation
- Trial name
- GM508 in IVF (NCT05722067)
- Testing
- calcium ionophore
- Where
- Taiwan
- Volunteers
- 68 people
- Sponsor
- Chang Gung Memorial Hospital
Infertility, Reproduction
Molecular Markers of Human Sperm Function
Objectives: Male factor infertility is poorly understood and our ability to evaluate the male contribution to a couple's infertility is very limited.
- Conditions
- Infertility, Reproduction, Reproductive Techniques, Assisted
- Trial name
- NCT00767611
- Where
- United States
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Infertility, In Vitro Fertilization
Effect of Antioxydant-enriched Media on Blastocyst Euploidy Rates.
One of the most sensible factors in IVF culture conditions is the susceptibility of gametes and embryos to an induced increase in reactive oxidative species (ROS) caused by the artificial environment.
- Trial name
- GX (NCT06261671)
- Testing
- antioxidants-enriched culture medium (Gx)
- Where
- United Arab Emirates
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Infertility
A Study Using Recombinant Human Chorionic Gonadotrophin (rhCG, Ovidrel®) in the Induction of Final Follicle Maturation and Early Luteinization in Chinese Women Undergoing in Vitro Fertilization and Embryo Transfer (IVF/ET)
This was an open, randomized, comparative study using rhCG (Ovidrel) in the induction of final follicle maturation and early luteinization in Chinese female subjects undergoing IVF or ET.
- Trial name
- NCT01081756
- Testing
- r-hCG, Urinary-hCG
- Where
- China
- Volunteers
- 218 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
IVF Outcomes
HELIOS Advanced: Human Oocyte Illumination to Enhance Development
Oocytes need a lot of energy to complete meiosis and fertilize successfully. As women get older, the "power plants" of the cells (called mitochondria) don't work as well.
- Trial name
- HELIOS-A (NCT07425080)
- Testing
- Photobiomodulation
- Where
- United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Columbia University
Infertility, Female
Time-lapse Monitoring of Early Embryo Development After Ovarian Stimulation During Infertility Treatment
The number of children conceived by assisted reproductive technology is increasing in Nordic countries as well as worldwide. An important factor of success in treatment of infertility is a short "time to pregnancy" with impact on…
- Trial name
- NCT01882166
- Testing
- fostimon, puregon
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- St. Olavs Hospital
Infertility
Mechanics of Human Pre Implantation Development
The time-lapse is a closed tri-gas incubator of the latest generation that provides optimal and stable culture conditions for the culture of embryos in In Vitro Fertilization (IVF).
- Trial name
- MECANEMB (NCT06408389)
- Volunteers
- 1,500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Infertility
Using Embryo Organoids to Discover Human-specific Mechanisms of Preimplantation Embryo Development and Early Pregnancy
EMBRYOx study aims to establish and validate the use of trophoblast organoids (embryoids) from trophoblast placental stem cells as a 3D research model in understanding further preimplantation embryo development in vitro.
- Trial name
- EMBRYOx (NCT05231551)
- Testing
- Placental tissues
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Montpellier
Infertility; In Vitro Fertilization; Embryo Development
Day-3 vs Day-5 Assisted Hatching: Impact on Blastocyst Morphology and PGT-A Outcomes
This randomized controlled trial compared assisted hatching (AH) performed on Day 3 versus Day 5 in patients undergoing IVF-ICSI with preimplantation genetic testing for aneuploidy (PGT-A).
- Trial name
- AH-PGTA (NCT07154875)
- Testing
- Laser-Assisted Hatching
- Where
- Vietnam
- Volunteers
- 141 people
- Sponsor
- Hoang Minh Ngan
Fertilization in Vitro, Infertility
The Impact of the Timing of Trigger on IVF Success
The aim of this study is to examine the length of ovarian stimulation with the timing of trigger in an IVF cycle and its potential to impact patient outcomes.
- Conditions
- Fertilization in Vitro, Infertility, Embryonic Development
- Trial name
- NCT02990949
- Testing
- Timing of trigger
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Colorado Center for Reproductive Medicine
Infertility
International Pilot Study for Dual Non-invasive Assesment of Embryo Development
Choosing the best embryo is one of the major challenges for achieving success in in vitro fertilization (IVF). Traditionally, embryo evaluation has been based on morphological quality (how the embryo looks like) and chromosomal…
- Trial name
- PANDORA (NCT06524648)
- Testing
- niPGT-A
- Where
- 8 sites in Austria, Spain and 1 more
- Volunteers
- 200 people
- Sponsor
- Igenomix
Infertility, Pregnancy, Multiple
Correlation Between Oocyte and Embryo Mechanical Properties on Embryo Development and Clinical Pregnancy After In Vitro Fertilization
The purpose of this study is to determine whether oocyte and embryo mechanical properties measured during in vitro fertilization can predict embryo development outcomes and clinical pregnancy.
- Trial name
- EMECH (NCT02530892)
- Testing
- EmbryoHug
- Where
- 3 sites in United States, China and 1 more
- Volunteers
- 119 people, healthy volunteers welcome
- Sponsor
- Stanford University