Clinical trials: Infertility
APHRODITE Group
Gonadotropin Therapy in Idiopathic Hypogonadal Non-Obstructive
The goal of this clinical trial is to determine whether short-term gonadotropin therapy (hCG + FSH) can increase sperm availability for ICSI in men with idiopathic non-obstructive azoospermia (NOA) and hypogonadism.
- Trial name
- GTIHNO (NCT07540611)
- Testing
- No intervention, hCG + FSH therapy
- Where
- 8 sites in India
- Volunteers
- 860 people, healthy volunteers welcome
- Sponsor
- Indira IVF Hospital Pvt Ltd
Endometriosis, Infertility
Harnessing the Disease Signatures From Endometrium and Menstrual Blood to Identify Avenues for the Treatment of Chronic Conditions Such as Endometriosis and Related Pathologies: This is an Observational Study Aimed at Shedding Light on Women's Health
Many women's health conditions have limited treatments available and poor outcomes, in part due to the lack of understanding of disease processes and lack of data available.
- Conditions
- Endometriosis, Infertility, Endometrial Cancer, Adenomyosis, Endometriosis
- Trial name
- CYCLE_ENDO (NCT06990971)
- Testing
- No Intervention: Observational Cohort
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cycle Therapeutics Ltd
Infertility
Clinical Pregnancies After Cryopreservation of Donor Oocytes With an Open or Closed Device
This randomized pilot study will assess if there is a difference in clinical pregnancies using donor oocytes cryopreserved in either a closed or a semi-closed vitrification device.
- Trial name
- NCT02940106
- Testing
- Cryotop device, CBSvit device
- Where
- Belgium
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Infertility, IVF
Sex Selection of Human Spermatozoa
This study aims to demonstrate a reliable method of selecting gender specific sperm. X-bearing spermatozoa and Y-bearing spermatozoa will be identified from the density gradient layers.
- Trial name
- NCT05500573
- Testing
- Sperm Sorting
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Uterine Abnormality
Comparison of Ultrasound and Hysterosalpingography in Evaluation of Uterine Abnormality in Patients With Infertility
The leading issue that every couple is experiencing in present era is infertility and it has become the major problem worldwide. Many hormonal disorders, weight, diet, and uterine abnormalities contributes in infertility.
- Trial name
- NCT06763380
- Testing
- Ultrasound, ultrasound then hysterosalpingography
- Where
- Pakistan
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Superior University
Infertility, Female, Perimenopausal Disorder
Autologous Platelet Rich Plasma (PRP) Intra Ovarian Infusion in Perimenopausal Women
Autologous PRP intra ovarian infusion may improve ovarian response and women's hormonal profile and may promote folliculogenesis in perimenopausal women.
- Conditions
- Infertility, Female, Perimenopausal Disorder, Menstrual Cycle Abnormal
- Trial name
- PRP (NCT03951194)
- Testing
- Autologous Platelet Rich Plasma (PRP) intra ovarian infusion
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Genesis Athens Clinic
Infertility
Ovarian Stimulation: Inositol and Melatonin
An efficient protocol of ovarian stimulation is a key part of assisted reproductive technology. In order to obtain the highest oocyte retrieval with no adverse effects, numerous studies have evaluated the efficiency of the…
- Trial name
- NCT01267604
- Testing
- Recombinant FSH (rFSH), rFSH + Inositol + Melatonin
- Where
- 2 sites in Italy
- Volunteers
- healthy volunteers welcome
- Sponsor
- AGUNCO Obstetrics and Gynecology Centre
Female Infertility, NF-κB Ligand
Clinical Relevance of Modifying RANKL Signaling During Folliculogenesis
Female infertility presents a significant societal challenge that will be aggravated in the future due to delayed parenthood. Our translational research suggests that receptor activator of NF-κB ligand (RANKL) is a novel…
- Conditions
- Female Infertility, NF-κB Ligand, RANKL, Osteoporosis
- Trial name
- NCT07546552
- Testing
- Denosumab, PBS
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Peter Humaidan
Catherization, Urinary Tract Infection Bacterial
Betadine vs Sterile Water for Periurethral Preparation
The purpose of this study is to determine whether cleaning of the urethra, or external opening to the bladder, with sterile water (water that has been treated to remove bacteria and living organisms) vs Betadine also known as…
- Trial name
- NCT07044726
- Testing
- Povidone-Iodine, Sterile water
- Where
- 2 sites in United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Infertility
Cavity Evaluation Before Intracytoplasmic Sperm Injection
Uterine cavity evaluation is an integral part of assessment Of women for ICSI
- Trial name
- NCT04257708
- Testing
- ultrasound
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aljazeera Hospital
Infertility, ART
Automation of the In Vitro Fertilization Laboratory
Enrolled patients will undergo an Assisted Reproductive technology (ART) treatment using intracytoplasmic sperm injection (ICSI, the direct injection of a single sperm cell into an oocyte) as the method of insemination.
- Trial name
- NCT06581068
- Testing
- AURA assisted ART treatment
- Where
- 2 sites in Mexico
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Conceivable Life Sciences
Infertility
Effect of Influenza Vaccination on IVF Outcomes - IVF
In this study the investigators propose a randomized controlled trial to evaluate the effect of influenza vaccination on clinical pregnancy rates among women undergoing in vitro fertilization.
- Trial name
- IVF-FluVac (NCT02947217)
- Testing
- Influenza Vaccine, Sterile Saline
- Where
- United States
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Center for Human Reproduction
Infertility, Female
The Role of ICSI in Non-male Factor Infertility in Advanced Maternal Age
The use of Intracytoplasmic sperm injection (ICSI) has increased in the last decades regardless of the cause of infertility. Despite the increased use there is no clear evidence that ICIS is more effective than conventional in…
- Trial name
- ICSI (NCT03370068)
- Testing
- ICSI, Conventional IVF
- Where
- Israel
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Dr. Tal Miller-Elkan
Gynecological Disorders, Male Infertility
Biobank Aimed to Study Gynecological Pathologies, of Male and Female Infertility and Pregnancy Pathologies
The REPRO-Biobank has been established at San Raffaele Hospital in Milan for the purpose of collecting and preserving human biological samples and associated data.
- Conditions
- Gynecological Disorders, Male Infertility, Female Infertility, Pregnancy
- Trial name
- NCT07265908
- Testing
- Blood sampling
- Where
- Italy
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Fertility Disorders, Fertility Issues
Menstrual Phase Endometrial Scratch in IUI Cycles
Patients undergoing treatment with intrauterine insemination (IUI) will be randomized to receive an endometrial scratch or sham procedure during the menstrual phase of the treatment cycle.
- Trial name
- NCT04641598
- Testing
- Endometrial Scratch
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Infertility, Female
The Effectiveness and Safety of the Prolonged Down-regulation Protocol for Controlled Ovarian Hyperstimulation
Since the first "tube baby", Louise Brown, was born in the United Kingdom in 1978, many infertile couples have been benefitted from in vitro fertilization and embryo transfer (IVF-ET) and intracytoplasmic sperm injection (ICSI).
- Trial name
- NCT03809221
- Testing
- Triptorelin acetate
- Volunteers
- 1,892 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Leiomyoma of Uterus
Vaginoscopy Compared to Traditional Hysteroscopy for Hysteroscopy Morcellation in Outpatient Clinic. A Randomized Trial
This study is a randomized controlled trial take place in a fertility outpatient clinic in an academic hospital. Women between 18 and 52 years old requiring polypectomy or myomectomy by hysteroscopy morcellation for abnormal…
- Trial name
- NCT04373694
- Testing
- vaginoscopy, standard hysteroscopy
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Asthenozoospermia, Mitochondrial Damage
Evaluation of the Effects of Semen Incubation With ANDROSITOL®DGN on Sperm Motility and Mitochondrial Membrane Potential
Mitochondria is the cellular organelle responsible for the production of the energy necessary to fuel sperm motility. It has been demonstrated that mitochondrial efficiency is correlated to the fertilizing capacity of the…
- Trial name
- Androsi-Test (NCT04291495)
- Testing
- ANDROSITOL®TEST
- Where
- Italy
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Catania
Infertility, Male, Depression
Impact of Duloxetine on Male Fertility
The investigators are conducting a placebo-controlled, randomized control trial with duloxetine in healthy, fertile men not previously on any antidepressants.
- Trial name
- NCT03038867
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Kallmann Syndrome, Hypogonadotropic Hypogonadism
Genetics of Reproductive Disorders (Including Kallmann Syndrome) and Cleft Lip and/or Palate
The purpose of this study is to explore the genetic basis of reproductive disorders and cleft lip and/or palate.
- Conditions
- Kallmann Syndrome, Hypogonadotropic Hypogonadism, Hypothalamic Amenorrhea, Polycystic Ovarian Syndrome
- Trial name
- NCT01601171
- Where
- Switzerland
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
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