Clinical trials: Infertility
Cystic Fibrosis, Congenital Bilateral Absence of Vas Deferens
Establishment of a Primary Epididymal Cell Model From Epididymal Samples to Study CFTR Gene Regulation
The aim of this observational study is to better understand the role and involvement of the regulatory elements of the CFTR gene, with the aim of better describing the 3D organisation of chromatin at the CFTR locus in epididymal…
- Conditions
- Cystic Fibrosis, Congenital Bilateral Absence of Vas Deferens, Sterility, Male
- Trial name
- CFTR-EP (NCT06045702)
- Testing
- Epididymal sample
- Where
- France
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Reproductive Issues, Fertility Issues
Towards Optimal Fertility, Fathering and Fatherhood studY
This case-control study involving fertile and subfertile couples aims to identify male factors related to pregnancy likelihood, create a fertility index measure combining male and female factors to predict pregnancy likelihood…
- Trial name
- TOFFFY (NCT06293235)
- Testing
- Lifestyle and metabolic indicators
- Where
- Singapore
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- KK Women's and Children's Hospital
Fertility
An Ethno-bridging Study of Pergoveris in Healthy Premenopausal Participants of Japanese or Caucasian Origin
The purpose of this study is to assess the Pharmacokinetic (PK) of Recombinant human follicle-stimulating hormone (follitropin alfa) (r-hFSH) and Recombinant human luteinizing hormone (lutropin alfa) (r-hLH) following a single…
- Trial name
- NCT07269327
- Testing
- Desogestrel and ethinylestradiol fixed dose combination, Follitropin alfa/lutropin alfa
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Infertility, Female
Association Between Serum Thyroid-stimulating Hormone (TSH) and Intracytoplasmic Sperm Injection (ICSI) Outcome in Women Undergoing ICSI
TSH has been suggested to be involved in reproductive challenges such as ovulatory issues, infertility, miscarriage, and maternal complications for many years.
- Trial name
- NCT07449260
- Testing
- Basal TSH level
- Where
- Egypt
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Cairo University
Infertility in Women Undergoing Assisted Reproductive Treatment, Infertility
Gamified Healthy Lifestyle Training in Women Undergoing Assisted Reproductive Treatment
Objective: A prospective randomized controlled trial with a pretest-posttest design was planned to evaluate the effects of a gamified healthy lifestyle behaviors training intervention using the D6 model, to be administered to…
- Conditions
- Infertility in Women Undergoing Assisted Reproductive Treatment, Infertility, Assisted Reproductive Technology, Health Lifestyle Behaviors
- Trial name
- NCT07460661
- Testing
- Gamified Healthy Lifestyle Education+Digital Healthy Lifestyle Education Booklet, Digital Healthy Lifestyle Education Booklet
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Marmara University
Infertility Treatment, Pregnancy Rates
Effect Clomiphene vs Clomiphene Along With Pioglitazone on Ovarian Stimulation Rate
Women who meet the study requirements will be enrolled and randomly assigned by a computer system to receive either pioglitazone 30 mg daily or a placebo starting from the second day of their menstrual period for the same…
- Trial name
- NCT07462065
- Testing
- Clomiphene Citrate., Pioglitazone (PIO) + Clomiphene citrate
- Where
- Pakistan
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- PAEC General Hospital, Islamabad
Reproductive Disorder
Recall by Genotype: Neuropeptide Stimulation
The objective of this protocol is to assess response to kisspeptin and gonadotropin-releasing hormone (GnRH) stimulation testing as well as the baseline patterns of luteinizing hormone (LH) secretion in individuals who carry…
- Trial name
- NCT05901467
- Testing
- kisspeptin 112-121, GnRH
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Stephanie B. Seminara, MD
Obesity, Infertility
Reprometabolic Syndrome Mediates Subfertility in Obesity
Obesity plays an adverse role at every stage of conception and pregnancy and mounting evidence implicates relative hypogonadotropic hypogonadism, and reduced menstrual cycle hormone secretion as likely contributors to the…
- Conditions
- Obesity, Infertility, Hypogonadotropic Hypogonadotropism, Hyperinsulinemia
- Trial name
- NCT02653092
- Testing
- Insulin, Intralipid, Dextrose
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypogonadism
A Study to Assess the Bioequivalence of Follitropin Alfa Solution in Pen and Follitropin Alfa Powder in Vial in Healthy Downregulated Male Participants
The purpose of this study is to assess the bioequivalence of Test and Reference in healthy downregulated male participants. This is a 2-sequence, 2-period study using the following treatment sequences across Study Periods 1 and…
- Trial name
- NCT07097259
- Testing
- Test: Follitropin alfa, Reference: Follitropin alfa, Zoladex
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- EMD Serono Research & Development Institute, Inc.
Infertility, Female
Study on the Pharmacokinetics and Safety of QL1012D and Gonal-F® in Healthy Female Volunteers
The goal of this Interventional study is to Compare the Pharmacokinetics and Safety of Recombinant Human Follicle Stimulating Hormone Injection (QL1012D) and Gonal-F® in Healthy Female Volunteers.
- Trial name
- NCT06864793
- Testing
- QL1012D, Gonal-F®
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Qilu Pharmaceutical Co., Ltd.
Infertility
Comparative Study of Two Embryo Culture Systems
The centre for Medically-Assisted Procreation (MAP) of Dijon CHU has two high-technology embryo culture systems, with incubation characteristics that are potentially superior to those provided by classical culture systems.
- Trial name
- INCUBATE (NCT02722252)
- Testing
- Embryoscope, Embryo culture system without incorporated camera
- Where
- France
- Volunteers
- 388 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
Hiv, Contraception
Mobile Phone Messaging to Improve Reproductive Health for Women Living With HIV in Kenya (Mobile WACh Empower)
Use of a mobile health (mHealth) intervention to provide reproductive life counseling to women living with HIV may improve delivery of integrated reproductive health/HIV services and prevent adverse reproductive health outcomes.
- Conditions
- Hiv, Contraception, Fertility Issues
- Trial name
- NCT05285670
- Testing
- Digital counseling plus interactive two-way SMS dialogue
- Where
- 10 sites in Kenya
- Volunteers
- 3,310 people, healthy volunteers welcome
- Sponsor
- University of Washington
Infertility, Female, ENDOMETRIAL RECEPTIVITY
Impact of Different Doses and Routes of Exogenous Progesterone Administration on Endometrial Receptivity Parameters
After so many years conducting artificial endometrial preparation cycles for embryo transfer, there is no clear indication about which is the optimal dose of exogenous progesterone in this scenario to optimize the outcome.
- Trial name
- PROGENDO (NCT04499131)
- Testing
- Progesterone, Artificial Cycle (no intervention)
- Where
- Spain
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA
Resolve Infertility
Acceptance of Uterus Transplantation
Transplantation of an uterus
- Trial name
- NCT03048396
- Testing
- Uterus transplantation
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
OVARIAN STIMULATION, Infertility
Pharmacokinetics of FSH and hCG After a Single Subcutaneous Injection of Gonadotropins-IBSA
The objectives of this study is to evaluate the PK and the dose-proportionality of FSH and HCG following a single dose of Gonadotropins-IBSA, administered subcutaneously.
- Trial name
- NCT06781957
- Testing
- Gonadotropins Subcutaneos
- Where
- Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- IBSA Institut Biochimique SA
Male Infertility Due to Azoospermia
Male Factor Infertility Across India Using Aphrodite Criteria
Study Purpose: The purpose of this study is to conduct an observational cross-sectional analysis of male factor infertility across diverse regions of India utilizing the Aphrodite Criteria.
- Trial name
- APHR (NCT06911840)
- Testing
- No Intervention: Observational Cohort
- Where
- India
- Volunteers
- 1,090 people, healthy volunteers welcome
- Sponsor
- Indira IVF Hospital Pvt Ltd
Uterine Fibroid, Pregnancy Complications
Pregnancy Outcomes Following Myomectomy
The most prevalent genital pathology, uterine fibroids have a detrimental impact on the health of women. Fibroid symptoms are typically more impactful on females and frequently require uterine excision.
- Conditions
- Uterine Fibroid, Pregnancy Complications, Reproductive Issues, Reproductive Sterility
- Trial name
- NCT06474065
- Testing
- Myomectomy
- Where
- Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centro di Ricerca Clinica Salentino
Cancer, Hematologic Diseases
Autologous Transplantation of Human Cryopreserved Testis Tissue
For pre-pubertal boys undergoing gonadotoxic therapies, freezing immature testicular tissue (ITT) containing spermatogonial stem cells (SSCs) is currently the only option to potentially preserve future fertility.
- Conditions
- Cancer, Hematologic Diseases, Infertility, Male, Azoospermia, Nonobstructive
- Trial name
- ReSTORE (NCT07364409)
- Testing
- Autologous Transplantation of Testis Tissue
- Where
- Denmark
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Herlev and Gentofte Hospital
Infertility Female, Hemodynamic Instability
Lidocaine vs Magnesium Sulfate for Hemodynamic Stability During Emergence in Infertility-Related Laparoscopic Surgery"
This study is being conducted to compare two medications, intravenous lidocaine and intravenous magnesium sulfate, and their ability to keep blood pressure and heart rate stable during the period of waking up from general…
- Trial name
- LidoMagGyna (NCT07359560)
- Testing
- Lidocaine (drug), Normal Saline (Intravenous), magnesium sulfate
- Where
- Egypt
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Infertility, Female
Effects of Physical Activity and Fitness, Cardiovascular- and Psychosocial Health on Medically Assisted Reproduction
This prospective observational study aims to investigate the association between physical activity and clinical pregnancy rates in women undergoing medically assisted reproduction.
- Trial name
- REPRO-FIT (NCT07321665)
- Testing
- Health, fitness and lifestyle assessment
- Where
- Switzerland
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland