Clinical trials: Infertility, completed
Polycystic Ovary Syndrome
Clomiphene Citrate (CC) Co-treatment With HP Urinary FSH vs HP Urinary FSH in CC-resistant PCOS
To test whether adding small doses of HP urinary FSH to standard regimen of clomiphene citrate in clomiphene resistant PCOS well yield better results in terms of better ovulation rate,lower follicle number, less consumption of HP…
- Trial name
- NCT01212263
- Testing
- Step-up HP u FSH, Clomiphine citrate plus low dose uFSH
- Where
- Egypt
- Volunteers
- 174 people
- Sponsor
- Mansoura Integrated Fertility Center
Infertility, Female
Physical Activity and Fertility Care Study
Randomized control trial to determine if performing the US Health and Human Services recommended amount of weekly physical activity during ovarian stimulation will differentially affect mental health or clinical outcomes of…
- Trial name
- PACE (NCT04002414)
- Testing
- Sufficient physical activity, Insufficient physical activity
- Where
- United States
- Volunteers
- 215 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Infertility
Role of Myo-inositol and D-chiro-inositol on Oocyte Quality
Controlled ovarian hyperstimulation with gonadotropins is an integral part of the various stimulation protocols for patients undergoing in-vitro fertilization (IVF) and other Assisted Reproductive Technologies (ART) such as…
- Trial name
- NCT01338844
- Testing
- Myo-inositol, D-chito-Inositol
- Where
- 3 sites in Italy
- Sponsor
- AGUNCO Obstetrics and Gynecology Centre
Infertility
Comparison of MENOPUR Liquid and Powder in Women Undergoing Assisted Reproductive Technology (ART)
Development of multiple follicles and pregnancy in ovulatory women undergoing controlled ovarian stimulation as part of an assisted reproductive technology (ART) cycle.
- Trial name
- CLARA (NCT04163458)
- Testing
- MENOPUR solution for injection in pre-filled pen, 1200 IU/1.92 mL, MENOPUR powder and solvent for solution for injection, 75 IU
- Where
- 20 sites in United States
- Volunteers
- 405 people
- Sponsor
- Ferring Pharmaceuticals
Infertility
Follicular Activation in Poor Responders
This study aims to assess whether activation of primordial follicles through ovarian cortex fragmentation may increase the number of antral follicles present in the ovary of patients with diminished ovarian reserve.
- Trial name
- FAPPOR (NCT02354963)
- Testing
- In vitro fragmentation of the ovarian tissue
- Where
- Spain
- Volunteers
- 34 people
- Sponsor
- César Díaz García
Unexplained Infertility
Dual FSH/HCG Trigger in Letrozole Stimulated Intrauterine Insemination Cycles in Women With Unexplained Infertility
The objective of this study was to evaluate the outcome of follicle stimulating hormone (FSH) co-administration with human chorionic gonadotrophins trigger for women with unexplained infertility (UEI) and assigned for letrozole…
- Trial name
- NCT02739516
- Testing
- Human chorionic gonadotropin, FSH co-trigger, Letrozole
- Volunteers
- 108 people
- Sponsor
- Benha University
Infertility
Subcutaneous Progesterone Versus Vaginal Progesterone Gel for Luteal Phase Support
It is well known that implantation of the developing blastocyst occurs during the luteal phase of the menstrual cycle when the endometrium is under the direct influence of Progesterone (P).Several prospective randomized…
- Trial name
- NCT02316626
- Testing
- Subcutaneous progesterone, Vaginal progesterone
- Where
- Italy
- Volunteers
- 246 people
- Sponsor
- Roberta Venturella
Infertility
Mild Versus Conventional Ovarian Stimulation for Poor Responders Undergoing In Vitro Fertilisation
The investigators will examine the balance between IVF success in terms of outcome parameters, using a mild ovarian stimulation protocol, opposing it to the conventional stimulation regimens in poor responders undergoing IVF.
- Trial name
- NCT01319708
- Testing
- mild ovarian stimulation, conventional ovarian stimulation
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- National and Kapodistrian University of Athens
Infertility, Female
Corifollitropin Alfa Combined With Menotropin Versus Follitropin and Lutropin Alfa in Expected Suboptimal Responders
In an opened randomized study of women undergoing in vitro fertilization with expected suboptimal response to controlled ovarian stimulation (Poseidon Group 2b) investigators will examine clinical efficacy and safety of two…
- Trial name
- TEMPER (NCT03177538)
- Testing
- Corifollitropin alfa and menotropin, Follitropin alfa and lutropin alfa
- Where
- Russia
- Volunteers
- 32 people
- Sponsor
- D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Infertility, Male
Reproductive Outcome After Sperm Selection for Intracytoplasmic Sperm Injection (ICSI) Using Zona Pellucida Proteins
The aim of this study is to analyze the effect of a sperm selection method by adhesion to partners' zona pellucida proteins on the assisted reproduction treatment (ART) outcome parameters.
- Trial name
- NCT05161247
- Testing
- Zona pellucida sperm selection, Conventional sperm selection, Intracytoplasmic Sperm Injection (ICSI)
- Where
- Bulgaria
- Volunteers
- 368 people
- Sponsor
- Nadezhda Women's Health Hospital
Infertility
GNRH Agonist Trigger and Modified Luteal Phase Adding a Bolus of GnRHa at the Time of Implantation: a RCT
Purpose:The aim of this project is to prospectively determine whether a single dose of GnRH-agonist administered at the time of implantation increases or not the reproductive outcome in patients undergoing in vitro fertilization…
- Trial name
- NCT03039049
- Testing
- Triptorelin 0.1 mg
- Where
- 2 sites in Algeria
- Volunteers
- 328 people
- Sponsor
- Centre Hospitalier Universitaire Ibn Rochd
Fertility Disorders
Effects of Lifestyle Changes on Semen Quality in Healthy Young Men Living in Highly Polluted Areas (FAST)
We planned a randomized controlled trial (RCT) with the main aim to evaluate the effects of lifestyle changes on semen quality in healthy young men living in polluted areas in Italy.
- Trial name
- FAST (NCT04012385)
- Testing
- lifestyle counseling
- Where
- 4 sites in Italy
- Volunteers
- 363 people, healthy volunteers welcome
- Sponsor
- Azienda Sanitaria Locale Salerno
Diabetes, Diabetes Mellitus, Type 1
Comparison of NovoFine® Needles (4 mm vs. 6 mm)
This trial is conducted in Europe. The aim of this investigation is to explore the safety of a 4 mm needle compared to a 6 mm needle when injected in children and lean adults with diabetes.
- Conditions
- Diabetes, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Delivery Systems
- Trial name
- NCT00343343
- Testing
- NovoFine® needle 6 mm, NovoFine® needle 4 mm
- Where
- 2 sites in Denmark
- Volunteers
- 62 people
- Sponsor
- Novo Nordisk A/S
Infertility, Female
Can Antioxidants Affect Pregnancy Rate in Patients With Expected Low Number of Egg Retrieval in IVF Cycles?
The aim of the study is to evaluate the effect of antioxidants on IVF outcome in infertile patients undergoing IVF who are expected to produce low number of eggs compared to a control group.
- Trial name
- NCT03085030
- Testing
- Antioxidant Formula
- Where
- Egypt
- Volunteers
- 593 people
- Sponsor
- Cairo University
Sterility
Assessment of the Therapeutic Utility of r-FSH in Association With hMG-HP
To assess the effectiveness of a protocol of ovarian hyperstimulation combining urinary gonadotrophins + recombinant gonadotrophins, to achieve clinical pregnancy in females undergoing IVF.
- Trial name
- NCT01330771
- Testing
- hMG-HP/r-FSH
- Where
- Spain
- Volunteers
- 51 people
- Sponsor
- Ferring Pharmaceuticals
Surgical Site Infection
Incisional Negative Pressure Wound Therapy in Patients Undergoing Spine Surgery
Introduction: Posterior post-operative spine wounds involving surgery at multiple levels are known to have higher rates of wound complications relative to other areas of the body.
- Trial name
- NCT03820219
- Testing
- Prevena™ system, Standard sterile wound dressing
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Nova Scotia Health Authority
Infertility
Involuntary Childlessness and Stress Management
Many couples experience involuntary childlessness and seek treatment at fertility clinics. Going through treatment procedures can be very challenging, time consuming and emotionally demanding.
- Trial name
- NCT01187095
- Testing
- Expressive writing, Active ctrl
- Where
- Denmark
- Volunteers
- 298 people
- Sponsor
- University of Aarhus
Polycystic Ovary Syndrome, Infertility
Letrozole vs Clomiphene Citrate for Induction of Ovulation in Women With Polycystic Ovarian Syndrome
It was randomised controlled study to compare the efficacy of clomiphene and letrozole in polycystic ovarian syndrome(PCOS) women with infertility.The aim was to select more appropriate treatment for ovulation induction in PCOS…
- Trial name
- NCT05702957
- Testing
- letrozole 2.5mg-7.5mg, Clomiphene Citrate 50mg-150mg
- Where
- Pakistan
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Services Institute of Medical Sciences, Pakistan
Endometriosis
Anti-TNFα Therapy for Improving Pregnancy Rates in Endometriosis Patients With Failed ICSI
This prospective study targets infertile women with endometriosis (EM) who have experienced a previously failed Intracytoplasmic Sperm Injection (ICSI) trial.
- Trial name
- NCT07509411
- Testing
- TNF-α Inhibitor, Frozen Blastocyst Transfer (FBT)
- Where
- Egypt
- Volunteers
- 145 people
- Sponsor
- Benha University
Infertility Female, Recurrent Miscarriage
Study on the Association Between SXCI and RM and the Possible Genetic Mechanism
To determine whether there is higher incidence of skewed X chromosome inactivation(SXCI) in the recurrent miscarriage(RM) population compared with normal population, and verify the existing hypothesis of the possible genetic…
- Trial name
- NCT02504281
- Where
- China
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute