Clinical trials: Infertility Female
Infertility, Fertility
A Trial to Compare the Efficacy and Safety of Ovarian Stimulation With GONAL-f® and Luveris® Starting on Day 1 Versus Day 6 in Women Undergoing Assisted Reproductive Technique
This is a phase IIIb, interventional, multicenter, multinational, randomised, open-label, comparative trial which primary objective is to generate data on the ovarian stimulation profile obtained when Luveris® is started either…
- Conditions
- Infertility, Fertility, Follicle Stimulating Hormone Deficiency
- Trial name
- NCT01497197
- Testing
- GONAL-f®, Luveris®, Recombinant human chorionic gonadotropin (r-hCG)
- Where
- United Arab Emirates
- Volunteers
- 174 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Breast Cancer, Infertility
S0230 Goserelin in Preventing Ovarian Failure in Women Receiving Chemotherapy for Breast Cancer
RATIONALE: Goserelin blocks hormone production in the ovaries. It is not yet known whether ovarian suppression using goserelin will prevent ovarian failure (early menopause) in women receiving chemotherapy for breast cancer.
- Conditions
- Breast Cancer, Infertility, Menopausal Symptoms
- Trial name
- NCT00068601
- Testing
- cyclophosphamide, goserelin acetate
- Where
- 34 sites in Australia, Belgium and 4 more
- Volunteers
- 257 people
- Sponsor
- SWOG Cancer Research Network
Infertility
Phase III Study Comparing Efficacy and Safety of AFOLIA vs Gonal-f® RFF in Women (35 to 42) Undergoing IVF
The purpose of this study is to show that AFOLIA, a recombinant manufactured human follicle stimulating hormone (r-hFSH) has a similar efficacy and safety profile compared to Gonal-f® RFF.
- Trial name
- NCT01687712
- Testing
- AFOLIA, Gonal-f® RFF
- Where
- 22 sites in United States
- Volunteers
- 1,100 people
- Sponsor
- Fertility Biotech AG
Infertility, Female
Study to Compare Efficacy and Safety of Primapur and Gonal-f in Women for Assisted Reproductive Treatment
The purpose of this study is to show equivalence with regard to the number of oocytes retrieved between follitropin alfa (pen-injectors) Primapur® and Gonal-f® in woman undergoing IVF/ICSI
- Trial name
- NCT03088137
- Testing
- Follitropin alfa (Gonal-f), Follitropin alfa (Primapur)
- Where
- 3 sites in Russia
- Volunteers
- 118 people
- Sponsor
- IVFarma LLC
Asherman's Syndrome
Reproductive Outcome Affected by Two Adjunctive Treatments in Patients With Severe Intrauterine Adhesions
The purpose of this study is to compare the outcome of loop intrauterine contraceptive device and heart-shaped intrauterine balloon for the adjunctive treatment of severe intrauterine adhesions in patients with infertility.
- Trial name
- ROABTIPWSIUA (NCT02708277)
- Testing
- loop-shaped intrauterine contraceptive device, intrauterine balloon (Cook Medical)
- Volunteers
- 93 people
- Sponsor
- Yuqing Chen
Infertility
Rekovelle PK Trial in Chinese Women
FE 999049 is a gonadotropin preparation containing recombinant human follicle stimulating hormone (rhFSH) under development by Ferring Pharmaceuticals.
- Trial name
- NCT04150861
- Testing
- Follitropin Delta
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ferring Pharmaceuticals
Infertility, Asherman's Syndrome
Platelet-rich Plasma (PRP) for Endometrial Regeneration and Repair
Patients with intrauterine adhesions (Asherman's Syndrome) and persistent thin endometrial lining in in vitro fertilization (IVF) treatment programs, particularly those resistant to standard therapies, present a significant…
- Trial name
- PRP-E (NCT02825849)
- Testing
- Intrauterine infusion of platelet rich plasma
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Infertility, Infertility, Female
Retrospective Study on the Use, Efficiency, and Safety of the At-home Mosie Kit
This study examines the experience of people who have selected to use the at-home insemination Mosie Kit to understand the user's experience, the perceived safety and the efficiency.
- Conditions
- Infertility, Infertility, Female, Infertility, Male
- Trial name
- NCT04646291
- Testing
- Insemination with the Mosie Baby Kit
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Mosie Baby
Infertility, Female, Deferred Childbearing
Investigational Oocyte Cryopreservation for Medical and Non Medical Indications
This is a prospective study to assess the long term benefits and outcomes of the existing oocyte cryopreservation methods for fertility preservation in women with a potential medical or non medical risk of loss of fertility
- Trial name
- NCT04616417
- Testing
- Investigational Oocyte Cryopreservation
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Polycystic Ovarian Syndrome
Efficacy Study of Raloxifene to Induce Ovulation in Polycystic Ovarian Syndrome
This study examines Raloxifene versus Clomiphene to induce ovulation in women with polycystic ovarian syndrome (PCOS).
- Trial name
- PCOS (NCT01607320)
- Testing
- Raloxifene, Clomiphene
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Bruce Lessey
Endometriosis, Infertility
GnRH-a and Pregnancy Rate in In Vitro Fertilization (IVF) Cycles.
The investigators attempted to establish a rationale for the Gonadotropin Releasing Hormone-agonist (GnRH-a) administration, post-laparoscopically, in women with mild endometriosis (until stage II, according to AFS) who underwent…
- Trial name
- NCT01269125
- Testing
- Leuprolide, IVF
- Where
- Greece
- Volunteers
- 180 people
- Sponsor
- University of Ioannina
Infertility
Progesterone Serum Levels in Subfertile Female Patients Undergoing in Vitro Fertilisation (IVF)
This study is aimed to demonstrate that highly purified Menotrophin produces significant lower progesterone serum levels during the follicular phase in comparison to Follitropin alpha in the treatment of subfertile females…
- Trial name
- PREDICT (NCT01225835)
- Testing
- Menotrophin, Follitrophin alpha, Cetrorelix
- Where
- 8 sites in Germany
- Volunteers
- 124 people
- Sponsor
- Ferring Pharmaceuticals
Infertility
CONSORT Randomized Controlled Trial in Assisted Reproductive Technology
The overall objective of this trial is to compare the ovarian response in assisted reproductive technology (ART) subjects administered GONAL f® according to the 'Consistency in recombinant follicle stimulating hormone [r-FSH]…
- Trial name
- NCT00829244
- Testing
- GONAL f® prefilled pen
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Female Infertility
A Study Comparing the Efficacy, Safety and Tolerability of Oral Dydrogesterone 30 mg Daily Versus Crinone 8% Intravaginal Progesterone Gel 90 mg Daily for Luteal Support in In-Vitro Fertilization (LOTUS II)
The purpose of this randomized, two-arm and open label study is to demonstrate that the treatment of a daily dose of 3x10mg dydrogesterone orally is as effective and safe as the daily dose Crinone 8% intravaginal progesterone gel…
- Trial name
- LOTUS II (NCT02491437)
- Testing
- Dydrogesterone 30 mg, intravaginal progesterone gel 90 mg
- Where
- 40 sites in Australia, Belgium and 8 more
- Volunteers
- 1,034 people
- Sponsor
- Abbott
Infertility, Female, Pain, Postoperative
Assessing Efficacy of Intravenous Acetaminophen for Perioperative Pain Control for Oocyte Retrieval
In this research study we want to learn more about how effective certain medications are at reducing pain after oocyte (egg) retrieval surgery and how effective they are at reducing the time between the retrieval and discharge…
- Trial name
- NCT03073980
- Testing
- IV Acetaminophen, PO Acetaminophen
- Where
- United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Infertility
Evidence-based Stimulation Trial With Human rFSH in Europe and Rest of World 2
This trial investigates the immunogenicity of FE 999049 in repeated cycles.
- Trial name
- ESTHER-2 (NCT01956123)
- Testing
- Follitropin Delta (FE 999049), Follitropin Alfa (GONAL-F)
- Where
- 13 sites in Belgium, Brazil and 9 more
- Volunteers
- 513 people
- Sponsor
- Ferring Pharmaceuticals
Preterm Labor, Preterm Birth
Use of Placental Alpha Microglobulin-1(PAMG-1) to Diagnose Premature Rupture of Membranes in Pregnant Women
The study is to evaluate the accuracy of a test device called "PAMG-1" to see if a pregnant women has ruptured membranes in comparison to standardly used testing methods.
- Trial name
- PAMG-1 (NCT03715530)
- Testing
- PAMG-1 immunoassay
- Where
- United States
- Volunteers
- 162 people
- Sponsor
- Mark Santillan
Anovulation
Sildenafil Vaginal Gel Co-treatment With Clomiphene Citrate in Infertile Women With Thin Endometrium
This is a prospective self controlled clinical trial. Women with clomiphene Citrate failure, and thin endometrium were recruited (N = 42).
- Trial name
- NCT02710981
- Testing
- clomiphene citrate, Sildenafil vaginal gel
- Volunteers
- 42 people
- Sponsor
- Assiut University
Infertility, Female
A Randomised Trial Comparing the Ovarian Response of a Starting Dose of Either 10 μg or 15 μg Follitropin Delta (FE 999049) to a Starting Dose of Either 150 IU or 225 IU Follitropin Alfa (GONAL-F) in Conventional Regimens in China
This is a phase 3b clinical trial with follitropin delta (FE 999049) and Gonal-F. The trial is a randomised, controlled, assessor-blind, parallel groups, multicentre trial comparing the ovarian response of a starting dose of…
- Trial name
- COCO (NCT06173869)
- Testing
- FE 999049, GONAL-F
- Where
- 11 sites in China
- Volunteers
- 301 people
- Sponsor
- Ferring Pharmaceuticals
Polycystic Ovary Syndrome, Infertility
Ovulation Induction in Women With Clomiphene Citrate Resistant PCOS
Polycystic ovary syndrome (PCOS) affects 5-10% of women in childbearing age. Hyperinsulinemia contributes to chronic anovulation commonly encountered in women with PCOS. The first choice therapy is clomiphene citrate (CC).
- Trial name
- NCT01909141
- Testing
- induction of ovulation using letrozole-pioglitazone-metformin, induction of ovulation using clomiphene citrate-pioglitazone-metformin, transvaginal ultrasound
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Cairo University