Clinical trials: Infiltration
Low Back Pain, Anxiety
Efficacy on Anxiety of the Digital Music Application Versus Equimolar Mixture of Oxygen and Nitrous Oxide in Patients Receiving CT-guided Lumbar Infiltration
Since the Covid-19 crisis, patients appear more stressed, with increasing fear of exams and the hospital environment, in particular for CT scan teams, which require injections.
- Trial name
- MKI-TDM (NCT06928740)
- Testing
- Music Care® device, EMONO
- Where
- France
- Volunteers
- 128 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Tumor Skin, Metastatic Melanoma
Safety and Efficacy of OBX-115 in Advanced Solid Tumors
This is a study to investigate the safety and efficacy of an investigational OBX-115 regimen in adult participants with advanced solid tumors.
- Conditions
- Tumor Skin, Metastatic Melanoma, Melanoma, Lung Cancer
- Trial name
- Agni-01 (NCT06060613)
- Testing
- OBX-115
- Where
- 10 sites in United States, Australia
- Volunteers
- 254 people
- Sponsor
- Obsidian Therapeutics, Inc.
Pneumonia, Radiographic Lung Infiltrates
Use Of Procalcitonin Level For Guidance of The Treatment of Suspected Community Acquired Pneumonia
The purpose of the study is to learn if a blood test is helpful to the doctors in deciding whether you need antibiotic therapy for possible pneumonia.
- Trial name
- NCT00914550
- Testing
- Procalcitonin level, caregiver informed
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Winthrop University Hospital
Serratus Anterior Plane Block, Transversus Thoracis Plane Block
Serratus Anterior Plane Block Combined With Transversus Thoracic Muscle Plane Block Versus Conventional Local Anesthetic Infiltration for SICD Implantation: A Randomized Controlled Trial
This is a prospective randomized study. The aim is to investigate the efficacy of a combined SAPB with TTPB for perioperative pain control compared to the standard local anesthetic infiltration technique in adult patients…
- Conditions
- Serratus Anterior Plane Block, Transversus Thoracis Plane Block, Subcutaneous ICD
- Trial name
- NCT05092490
- Testing
- Combined serratus anterior plane block and transversus thoracis plane block, Standard local infiltration technique
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- New York Presbyterian Brooklyn Methodist Hospital
Posterior Knee Infiltration
Posterior Capsular Injection With Femoral Nerve Block for Total Knee Arthroplasty
To assess pain control after total knee replacement surgery using two different nerve block techniques. The 2 methods are: 1. Continuous femoral nerve block with ultrasound guided posterior capsular injection 2.
- Trial name
- NCT02701296
- Testing
- Ropivacaine with Epinephrine, Ropivacaine
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Trinity Health Of New England
Nephrostomy; Complications, Upper Urinary Tract Dilatation and Obstruction
Quadratus Lumborum Block for Percutaneous Nephrostomy
Percutaneous nephrostomy (PCN) is one of the interventions in the radiology department in which pain control is necessary. Quadratus Lumborum (QL) block will be tried to limit the use of systemic analgesics and its accompanying…
- Conditions
- Nephrostomy; Complications, Upper Urinary Tract Dilatation and Obstruction, Regional Anesthesia Morbidity, Adverse Anesthesia Outcome
- Trial name
- QLB (NCT02121951)
- Testing
- Local Anesthetic infiltration, Quadratus Lumborum block, MAC
- Where
- Egypt
- Sponsor
- National Cancer Institute, Egypt
Inguinal Hernia Unilateral, Postoperative Pain Management
Transversalis Fascia Plane Block Versus Surgical Wound Infiltration for Postoperative Analgesia in Open Inguinal Hernia Repair
The purpose of this clinical trial is to evaluate whether two different analgesic techniques - ultrasound-guided Transversalis Fascia Plane Block (TFPB) and surgical wound infiltration - can improve postoperative pain control in…
- Conditions
- Inguinal Hernia Unilateral, Postoperative Pain Management, Regional Anaesthesia, Transversalis Fascia Plane Block
- Trial name
- TFPB-WIN (NCT07238829)
- Testing
- Ultrasound-Guided Transversalis Fascia Plane Block (TFPB), Surgical Wound Infiltration
- Volunteers
- 104 people
- Sponsor
- Ondokuz Mayıs University
Anesthetic Effectiveness
Testing the Anesthetic Effectiveness of Three Different Dental Local Anesthetics Injected Next to a Lower First Molar
Infiltration (injecting next to the tooth) injections are common in dentistry and a number of studies have shown that articaine anesthetic, when injected next to the tooth as a supplemental injection, works very well following a…
- Trial name
- NCT01567839
- Testing
- Mandibular buccal Infiltration injection
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Pain, Postoperative
Intrathecal Morphine and Local Infiltration Analgesia in Total Knee Arthroplasty
Double-blinded randomized control study investigating intrathecal morphine as an additive to spinal anesthesia in patients undergoing elective total knee arthroplasty.
- Trial name
- NCT03434951
- Testing
- Bupivacaine Hydrochloride, Spinal, Morphine hydrochloride, Spinal
- Where
- Finland
- Volunteers
- 120 people
- Sponsor
- South Carelia Central Hospital
Correlate Tracer Uptake to TCell Tumor Infiltration & CkIT Benefit
A Study Using [18F]F AraG PET to Evaluate Response to Checkpoint Inhibitor Therapy(CkIT) in Patients With Solid Tumors
In this study, patients with advanced solid tumors will undergo [18F]F AraG PET/CT imaging to assess for changes in tracer uptake following treatment with CkIT.
- Trial name
- NCT04260256
- Testing
- [18F]F-AraG
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- CellSight Technologies, Inc.
Tonsillectomy, Ropivacaine
Analgesic Efficacy of Peritonsillar Ropivacaine Infiltration After Tonsillectomy in Children
Tonsillectomy is one of the most frequently performed surgical procedures in children and is commonly associated with significant postoperative pain.
- Conditions
- Tonsillectomy, Ropivacaine, Analgesia, Local Anesthesia
- Trial name
- NCT07825922
- Testing
- Peritonsillar infiltration with ropivacaine, Peritonsillar infiltration with normal saline, Normal Saline
- Where
- Tunisia
- Volunteers
- 60 people
- Sponsor
- University Hospital, Mahdia
Infiltrating Bladder Urothelial Carcinoma
NEoadjuvant Dose-dense MVAC In cOmbination With Durvalumab and Tremelimumab in Muscle-invasive Urothelial Carcinoma
This is an open label, phase I/II clinical trial to evaluate the efficacy and safety of 2 cycles of durvalumab without (Arm A) or with (Arm B) tremelimumab in association with ddMVAC as neoadjuvant therapy in patients with MIUC.
- Trial name
- NEMIO (NCT03549715)
- Testing
- Durvalumab, Tremelimumab, MVAC Protocol
- Where
- 15 sites in France
- Volunteers
- 121 people
- Sponsor
- Association Pour La Recherche des Thérapeutiques Innovantes en Cancérologie
Muscle Planes, Muscle Volumes, Fat Infiltration in Cervical MRI
Comparison of Cervical Extensor Muscle Thickness, Fat Infiltration, and Cervical Alignment in Patients With Ankylosing Spondylitis With a Healthy Population: a Retrospective Controlled Study
In the literature, we found only one study evaluating the thickness of the cervical paraspinal muscles (multifidus, semispinalis cervicis, semispinalis capitis, splenius capitis, and trapezius) in patients with AS.
- Trial name
- NCT07148167
- Testing
- Magnetic resonance imaging
- Where
- Turkey (Türkiye)
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Postcesarean Analgesia
Transversus Abdominis Plane Block Versus Wound Infiltration for Postcesarean Analgesia
The study will compare the analgesic efficacy of transversus abdominis plane block and wound infiltration in parturients undergoing cesarean delivery under spinal anesthesia.
- Trial name
- NCT02691572
- Testing
- Spinal anesthesia, Intrathecal bupivacaine, Intrathecal fentanyl
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Ulcerative Colitis
Association Between Effectiveness of Mirikizumab and UC Patients With High Neutrophilic Infiltration in Epithelium of the Colonic Mucosa
The goal of this study is to confirm that Mirikizumab therapy may provide clinical, endoscopic, and histopathologic improvements in patients with moderate to severe UC refractory to maintenance therapy when high neutrophilic…
- Trial name
- NCT06626165
- Testing
- Mirikizumab, Vedolizumab
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Showa Inan General Hospital
Dental Anxiety
Pain Perception of Dental Local Anesthesia Using "DentalVibe Comfort System" in a Group of Egyptian Children
The aim of this study is to compare pain during maxillary infiltration local anesthesia injection with the aid of DentalVibe comfort system in comparison to maxillary infiltration injection alone in pediatric dental patients.
- Trial name
- NCT03033628
- Testing
- injection using DentalVibe comfort system, traditional dental injection
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Cairo University
Pain, Postoperative, Postoperative Nausea and Vomiting
Local Infiltration Analgesia With Ropivacaine Versus Placebo in Vaginal Hysterectomy: a Randomized, Double-Blind Study
The purpose of this study is to compare systematic local infiltration with Ropivacaine 0.5 % vs. Placebo in patients undergoing vaginal hysterectomy.
- Trial name
- NCT00768456
- Testing
- Ropivacaine 0.5 %, Isotonic NaCl
- Where
- Denmark
- Volunteers
- 48 people
- Sponsor
- Hvidovre University Hospital
Total Knee Arthroplasty
Comparison of Analgesic Efficiency Between IPACK Block and Surgical Infiltration After Total Knee Arthroplasty
The purpose of this retrospective study is to compare the analgesic efficiency of IPACK block (Interspace between the Popliteal Artery and the Capsule of the posterior Knee) with surgical infiltration after total knee…
- Trial name
- IPACK (NCT03704831)
- Testing
- Injection of local anesthetics during total knee arthroplasty by a locoregional anesthesia named IPACK block, Injection of local anesthetics during total knee arthroplasty by surgical infiltration
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Endometriosis
Treatment by HIFU With Focal One® of Posterior Deep Infiltrating Endometriosis Lesions With Intestinal Involvement.
Deep invasive endometriosis (DIE) includes lesions of the rectosigmoid. Theses lesions are associated with painful symptoms that can alter quality of life.
- Trial name
- NCT03613298
- Testing
- HIFU (Focal One®)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- EDAP TMS S.A.
Metastatic Melanoma, Unresectable Melanoma
Study to Investigate Lifileucel Regimen Plus Pembrolizumab Compared With Pembrolizumab Alone in Participants With Untreated Advanced Melanoma.
This is a Phase 3, multicenter, open-label, randomized, parallel group, treatment study to assess the efficacy and safety of lifileucel in combination with pembrolizumab compared with pembrolizumab alone in participants with…
- Conditions
- Metastatic Melanoma, Unresectable Melanoma, Melanoma
- Trial name
- NCT05727904
- Testing
- Lifileucel plus Pembrolizumab, Pembrolizumab with Optional Crossover Period
- Where
- 82 sites in United States, Australia and 14 more
- Volunteers
- 670 people
- Sponsor
- Iovance Biotherapeutics, Inc.