Clinical trials: Inflamatory Bowel Disease
Inflamatory Bowel Disease, Crohn Disease (CD)
Safety and Efficiency of the Universal CNK-UT009 in Difficult-to-treat Inflammatory Bowel Disease Patients
Inflammatory bowel disease patients who failed from at least two types of biologics or suffered refractory after at least twice surgery are defiened as difficult-to-treat IBD.
- Conditions
- Inflamatory Bowel Disease, Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- NCT07416383
- Testing
- injection of CNK-UT009
- Volunteers
- 40 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Inflammatory Bowel Diseases, Colitis, Ulcerative
Chronic Care Model on Symptom Status, Stress and Quality of Life in Individuals With Inflammatory Bowel Disease
This study aims to evaluate the effects of nurse counseling provided based on the Chronic Care Model on symptom status, stress, and quality of life in individuals diagnosed with Inflammatory Bowel Disease (IBD).
- Conditions
- Inflammatory Bowel Diseases, Colitis, Ulcerative, Crohn Disease
- Trial name
- NCT06757231
- Testing
- Nurse Counseling Based on the Chronic Care Model (CCM)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
Crohn's Disease, Intestinal Fibrosis
68Ga-FAPI-46 PET/CT for Assessing Small Bowel Fibrostenosis in Crohn's Disease
This study is a prospective, case-control study evaluating whether the PET radiotracer 68Ga-FAPI-46 can detect fibrostenosing Crohn's disease in the small bowel.
- Conditions
- Crohn's Disease, Intestinal Fibrosis, Inflamatory Bowel Disease, Intestinal Strictures Related to Crohn´s Disease
- Trial name
- FAPI-PETCD (NCT07273188)
- Testing
- Ga68-FAPI-46
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Mayo Clinic
IBD
Impact of IBD Activity on Frailty in Patients Over 60 Years
The goal of this observational, multicenter, descriptive, prospective, and longitudinal study is to evaluate the impact of IBD activity on frailty in a prospective and longitudinal cohort of patients with IBD, and also to assess…
- Trial name
- FRAGIL (NCT06844318)
- Where
- 34 sites in Spain
- Volunteers
- 153 people
- Sponsor
- Grupo Espanol de Trabajo en Enfermedad de Crohn y Colitis Ulcerosa
Inflammatory Bowel Diseases
Subclinical Cardiac Involvement in Patients With Inflamatory Bowel Disease
Aim of the study is to determine the prevelance of subclinical cardiac involvement in patients with inflamatory bowel disease.
- Trial name
- NCT04330105
- Testing
- ECG, HolterECG ,Echocardiography
- Volunteers
- 200 people
- Sponsor
- Hossam Eldin Mohammed Essam Abdelhafez
IBD and Renal Involement, Chronic Kidney Disease
Renal Dysfunction in Patients With Inflammatory Bowel Disease and the General Population (NEPHRO-IBD)
The NEPHRO-IBD study is a multicenter prospective observational study designed to evaluate the prevalence of renal dysfunction and renal complications in adult patients with inflammatory bowel disease (IBD) compared with…
- Conditions
- IBD and Renal Involement, Chronic Kidney Disease, Inflamatory Bowel Disease (Crohn's and Ulcerative Colitis)
- Trial name
- NEPHRO-IBD (NCT07593352)
- Testing
- Prospective assessment of the prevalence of kidney disease and/or renal complications in patients with IBD/the general population based on routine laboratory test and abdominal ultrasound.
- Where
- Poland
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- Państwowy Instytut Medyczny Ministerstwa Spraw Wewnętrznych i Administracji
Inflamatory Bowel Disease
Fecal Microbiome Signature of Multi-Strain Probiotics Supplementation in Children and Adolescents With Inflammatory Bowel Disease
In this study the intestinal microbiome and metabolic profiles of patients with inflammatory bowel disease will be determined upon probiotic intervention.
- Trial name
- MicroSig (NCT07533890)
- Testing
- Probiotic Formula, Observation
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Inflammatory Bowel Disease
Early Biomarkers in Circulating α 4β7 + T Cells to Predict Response to Vedolizumab in Inflamatory Bowel Disease Patients.
Background: Infiltration of GI by T lymphocytes is a pathogenic mechanism both in ulcerative colitis (UC) and in Crohn's disease (CD).
- Trial name
- NCT02712866
- Testing
- Vedolizumab
- Where
- Spain
- Volunteers
- 24 people
- Sponsor
- Parc de Salut Mar
Inflamatory Bowel Disease
A Study of Curcumin (Soloways ™) in Patients With Inflammatory Bowel Disease Homozygous for the IL-10 Variant
This pilot, genotype-stratified clinical trial aims to evaluate the safety and preliminary efficacy of liposomal curcumin in patients with inflammatory bowel disease (IBD) who are homozygous for a specific "unfavorable" IL-10…
- Trial name
- NCT06867939
- Testing
- liposomal curcumin
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- S.LAB (SOLOWAYS)
Inflamatory Bowel Disease
Construction and Validation of a Predictive Model for the Efficacy of Different Biologics in Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a group of chronic progressive gastrointestinal diseases that can recur throughout life and for which there is no cure.
- Trial name
- NCT07181525
- Testing
- anti-cytokine antibodies, anti-integrin antibodies
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University First Hospital
Inflamatory Bowel Disease
Clinical Characteristics, Treatment Patterns, and Outcomes of Hospitalized Patients With Refractory Inflammatory Bowel Disease
the investigators conducted a multicenter retrospective cohort study of hospitalized patients with IBD from three tertiary referral centers in China to characterize the clinical features, treatment patterns, and outcomes of…
- Trial name
- NCT07697521
- Testing
- Retrospective medical record review
- Where
- China
- Volunteers
- 1,048 people
- Sponsor
- Shanghai 10th People's Hospital
Cardiac MRI in IBD Patient
Cardiovascular Manifestation of Inflamatory Bowel Disease Patient ( Tissue Doppler Echocardiography and Cardiac MRI )
1. Evaluation of cardiovascular changes using Doppler echocardiography and cardiac MRI in IBD patients 2. To detect the frequency of myocardial injury in IBD patients 3.
- Trial name
- NCT04656015
- Testing
- MRI
- Volunteers
- 100 people
- Sponsor
- Assiut University
Inflamatory Bowel Disease (Crohn's and Ulcerative Colitis)
Inflammatory Bowel Disease (IBD) Research Registry
Patients seen at the Center for Inflammatory Bowel Disease will be asked to provide their written informed consent (authorization) to allow their identifiable medical record information related to their Inflammatory Bowel Disease…
- Trial name
- NCT04243525
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- University of Pittsburgh
Inflamatory Bowel Disease (Crohn's and Ulcerative Colitis)
Real-World Study on the Safety and Effectiveness of IL-23 Inhibitors for Inflammatory Bowel Disease in China
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), has shown greatly improved outcomes with biologic therapies.
- Trial name
- NCT07184138
- Testing
- Interleukin-23 Inhibitors (IL-23i)
- Volunteers
- 178 people
- Sponsor
- Sixth Affiliated Hospital, Sun Yat-sen University
Colon Cancer, Inflamatory Bowel Disease (Crohn's and Ulcerative Colitis)
Effectiveness of Health Education as a Nursing Intervention in Improving Quality of Life and Reducing Symptoms of Anxiety and Depression in Ostomy Patients Following Digestive Surgery: A Quasi-Experimental Study.
The proposed project is a prospective quasi-experimental study to be conducted at the Ostomy Clinic of the University Hospital Complex of Santiago de Compostela.
- Conditions
- Colon Cancer, Inflamatory Bowel Disease (Crohn's and Ulcerative Colitis), Colitis Ulcerative
- Trial name
- NCT07347158
- Testing
- Health Education
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Hospital Clinico Universitario de Santiago
Inflamatory Bowel Disease (Crohn's and Ulcerative Colitis)
Efficacy of Different Biological Treatments in Patients With Inflammatory Bowel Disease After One Year of Treatment in Upper Egypt
To study the efficacy of different biological treatment on patient with inflammatory bowel disease after one year of treatment in upper egypt
- Trial name
- NCT07495644
- Testing
- adalimumab, infliximab, ustekinumab, golimumab, and vedolizumab
- Volunteers
- 95 people
- Sponsor
- Assiut University
Inflamatory Bowel Disease (Crohn's and Ulcerative Colitis), Inflamatory Bowel Disease
Physical Activity and Fitness in Pediatric Inflammatory Bowel Disease
Pediatric inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a chronic condition associated not only with intestinal inflammation but also with reduced physical fitness, fatigue, impaired…
- Trial name
- PAFIT-IBD (NCT07484620)
- Testing
- Physical Activity Intervention
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Universidad Complutense de Madrid
Inflamatory Bowel Disease, Crohn Disease (CD)
Investigating the Effect of the Non-nutritive Sweetener Sucralose in Inflammatory Bowel Disease
This study will focus on the commonly used non-nutritive sweetener (NNS) sucralose (2 sachets/day resulting in daily dose: sucralose 2.5mg/kg) and its role in changing the gut microbiota in humans with Inflammatory Bowel Disease…
- Trial name
- NCT07852273
- Testing
- Sucralose (non-nutritive sweetener)
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Case Western Reserve University
Inflammatory Bowel Disease
An Epidemiological Study of the Incidence of Inflammatory Bowel Disease in Spain
This is a prospective, observational, multicenter, population-based incidence cohort study which will enroll cases of IBD (CD, UC, or indeterminate colitis) diagnosed in adults over 1 year in Spain.
- Trial name
- INCIDENCIA (NCT02686892)
- Where
- 16 sites in Spain
- Volunteers
- 4,000 people
- Sponsor
- Javier P. Gisbert
Inflamatory Bowel Disease, Crohn Disease (CD)
Non-nutritive Sweeteners in Inflammatory Bowel Disease
This study will focus on the commonly used non-nutritive sweetener (NNS) sucralose (2 sachets/day resulting in daily dose: sucralose 2.5mg/kg) and its role in changing the gut microbiota in humans with IBD, compared to healthy…
- Trial name
- NCT07769437
- Testing
- Sucralose (non-nutritive sweetener)
- Where
- 3 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center