Clinical trials: Inflamed Gums
Halitosis
A Clinical Study to Examine the Effects of an Experimental Toothpaste Compared to a Regular Fluoride Toothpaste on Breath Odor in a Population With Gingivitis
The purpose of this study is to investigate the efficacy of an experimental dentifrice, containing 0.454 percent (%) stannous fluoride and 0.3% zinc chloride, to reduce oral malodor, compared to a marketed regular fluoride…
- Trial name
- NCT05524948
- Testing
- Experimental Dentifrice, Reference Dentifrice
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- HALEON
Gingivitis
Stingless Bee Honey Mouth Rinse on Gingivitis
The currently used chemical mouth rinse, chlorhexidine, was prescribed widely among dental practitioners for its ability to kill bacteria.
- Trial name
- NCT07461155
- Testing
- mouth rinse, scaling, oral hygiene education and instruction
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ministry of Higher Education, Malaysia
Gingivitis
Effects of Aloe Vera Toothpaste on Periodontal Parameters
This study aimed to assess the effects of Aloe Vera toothpaste on dental plaque and gingivitis. The single-blind cross-over clinical trial was conducted on 20 dental students (10 males and 10 females with a mean age of 24.5±4…
- Trial name
- NCT02235532
- Testing
- Foramen Herbal Aloe toothpaste, fluoride toothpaste
- Where
- Iran
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Islamic Azad University, Sanandaj
Periodontal Diseases
Periodontal Status and Endothelial Dysfunction in Patients With Polycystic Ovary Syndrome
Emerging research indicates a link between polycystic ovary syndrome (PCOS) and periodontal diseases, revealing the intricate relationship between oral health and systemic conditions.
- Trial name
- NCT06184412
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana
Periodontitis, Gingivitis
GCF Bax and Bcl-xl Levels in Periodontitis
Intrinsic apoptosis pathway plays a critical role in the host immune defense and inflammation and its dysregulation is involved in various chronic diseases. Bcl-2 protein family primarly mediates this mitochondrial pathway.
- Conditions
- Periodontitis, Gingivitis, Periodontal Health
- Trial name
- NCT06443372
- Testing
- Clinical periodontal measurements, GCF sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Gingivitis, Mucositis
Clinical, Immunological and Microbiological Evaluation of Experimental Gingivitis and Peri-implant Mucositis
The objective of this study is to evaluate, through clinical, microbiological and immunological tests, the changes during the experimental gingivitis and mucositis model, between teeth and implants, and between patients with a…
- Trial name
- NCT03713567
- Testing
- Experimentally induced plaque
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Gingivitis
Clinical Effects of Bacillus Containing Oral Hygiene Products on Gingivitis: a Randomized Controlled Trial
Aim: Evaluating the clinical effects of a Bacillus subtilis, Bacillus megaterium and Bacillus pumulus containing toothpaste, mouthwash and toothbrush cleaner versus a placebo in patients with generalized gingivitis.
- Trial name
- NCT02597192
- Testing
- probiotic oral hygiene products with Bacillus (PIP, Chrisal), oral hygiene products without Bacillus
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Gingivitis, Dental Plaque
The Effect of Mouthrinses Containing Bamboo Salt, Magnolia Bark and Centella Asiatica on Reducing Plaque and Gingivitis
This study aims to evaluate the effect of novel mouthrinse formulations containing bamboo salt, magnolia bark and centella asiatica extracts on gingivitis and dental plaque.
- Trial name
- NCT03047798
- Testing
- Mouthrinse
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Seoul National University
Dental Plaque, Gingivitis
Plaque Reduction Sesame-based Oil
The goal of this clinical trials to learn about potential additives in reducing dental plaque. The main questions it aims to answer is: is there a difference in the plaque reducing effect of oil pulling with sesame-based oil…
- Conditions
- Dental Plaque, Gingivitis, Oral Microbial Colonization
- Trial name
- NCT06841380
- Testing
- sesame-based oil, distilled water
- Where
- Austria
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Christine Zürcher
Gingivitis, Oral Disease
Metagenome Resilience in Experimental Gingivitis
This study aims to identify new biomarkers that indicate the resilience of individuals to developing oral disease. An 'experimental gingivitis' model will be employed in which subjects will refrain from oral hygiene in one…
- Trial name
- NCT05389124
- Testing
- Partial abstinence from oral hygiene
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Newcastle University
Dental Plaque
A Four-Week Study to Measure the Effectiveness of an Experimental Mouthwash Used After Teeth Cleaning
This study will test the idea that using an experimental mouth rinse after each time you brush your teeth will result in a healthier mouth than using the regular mouth rinse.
- Trial name
- NCT01462110
- Testing
- 19416-154-1, W002194-0221P
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Periodontal Diseases
Evaluation of Galectin-3 Levels in GCF And Saliva of Patients With Different Periodontal Diseases
The aim of this study is to assess the levels of galectin-3 in the GCF and saliva in patient with gingivitis and patient with stage III periodontitis.
- Trial name
- NCT05281796
- Testing
- GCF obtaining, saliva obtaining
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cairo University
Periodontitis, Gingivitis and Periodontal Diseases
Salivary Free Amino Acid Profiles in Periodontitis: Associations With Clinical Parameters and Dynamic Responses to Non Surgical Therapy
# Brief Summary (Word count: 198) This combined observational and interventional study investigates salivary amino acid profiles and their connections to periodontal conditions, as well as how these substances change after…
- Conditions
- Periodontitis, Gingivitis and Periodontal Diseases, Periodontal Debridement, Periodontal Attachment Loss
- Trial name
- FAA-CP-SRP (NCT07669233)
- Testing
- Non-surgical periodontal therapy
- Where
- China
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Zhang, Yuwei
Gingivitis
Effectiveness of Brush DJ App in Improving Oral Hygiene Compliance of Fixed Orthodontic Patients
In this day and age, smartphones are occupying big portions of our lives. Expanding development of mobile applications focusing on delivering behavioral health intervention have intrigued us to know better about their efficacy.
- Trial name
- NCT05853276
- Testing
- Brush DJ app
- Where
- Malaysia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IMU University, Malaysia
Gingivitis, PCOS
Effect of EE/NETA With Scaling on Periodontium and hsCRP in PCOS Women With Gingivitis
As gingivitis is known to add to the systemic inflammatory burden and may consequently contribute to progression of PCOS and vice-versa, So, controlling local and systemic inflammatory burden by scaling g and medical treatment…
- Trial name
- NCT05129878
- Testing
- scaling and OHI, oral Hygiene instructions, Scaling and oral hygiene instruction
- Where
- 2 sites in India
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Caries, Dental, Gingivitis
Dental Health Epidemiology Among Israel Defense Forces (IDF) Recruits
An epidemiological survey for prevalence description of dental morbidity (caries, gingivitis, dental trauma and fluorosis) among Israel Defense Forces (IDF) general recruits.
- Conditions
- Caries, Dental, Gingivitis, Fluorosis, Dental Trauma
- Trial name
- NCT02958891
- Testing
- Data collection
- Where
- Israel
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Periodontal Diseases
Periostin and Non-Surgical Periodontal Treatment
A total of 90 subjects, 30 patients with chronic periodontitis, 30 with gingivitis and 30 periodontally healthy subjects were included. Patients with periodontal disease received non-surgical periodontal treatment.
- Trial name
- NCT04332965
- Testing
- Non-Surgical Periodontal Treatment
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Allogeneic Stem Cell Transplantation
Xylitol BSI Multisite - Reduction of Bloodstream Infections From Oral Organisms in Pediatric Stem Cell Transplant
Bloodstream infections (BSI) caused by bacteria translocating across injured oral mucosa are a significant cause of morbidity and mortality in patients undergoing stem cell transplantation (SCT).
- Trial name
- NCT05579639
- Testing
- Xylitol
- Where
- 3 sites in United States
- Volunteers
- 256 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Gingivitis, Periodontitis
OSE as a Pre-procedural Mouth Rinse: A Clinical and Microbiological Study.
Periodontal disease- Inflammatory, Multifactorial, and Threshold disease. Periodontal disease is a highly prevalent dental disease, an almost 100% prevalence in developing countries.
- Conditions
- Gingivitis, Periodontitis, Aerosol Disease, Gingival Disease
- Trial name
- NCT03839719
- Testing
- Group PI, Group OC, Group CHX
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Government College of Dentistry, Indore
Periodontal Diseases, Inflammatory Response
SCREENING OF EPIGENETIC BIOMARKERS (miRNAs) IN THE GINGIVAL SULCUS
Epigenetics has produced a high impact in biomedical research and is providing new biomarkers for the diagnosis and prognosis of diseases.
- Trial name
- NCT03510702
- Testing
- Levels of epigenetic biomarkers present in the gingival fluid and its possible relationship with bone metabolism.
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Valencia