Clinical trials: Inflamed Gums
Root Resorption, Orthodontic Appliance Complication
Proteomics and Orthodontic Root Resorption
The majority of previous studies for early detection of Orthodontically Induced Inflammatory Root Resorption (OIIRR) were conducted to assess individual biomarkers which are representative of single biological pathway.
- Conditions
- Root Resorption, Orthodontic Appliance Complication, Orthodontic Pathological Resorption of External Root, Gingival Diseases
- Trial name
- NCT04291443
- Testing
- Heavy Force (225g), Light Force (25g)
- Where
- Iraq
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Baghdad
Gingivitis
A Bleeding-Model Clinical Study
The objective of the study is to evaluate the gingivitis control benefit of an established stannous fluoride containing toothpaste relative to a negative control dentifrice.
- Trial name
- NCT05916508
- Testing
- 0.454% stannous fluoride, 0.76% sodium monofluorophosphate, 0.454% stannous fluoride AM and 0.76% sodium monofluorophosphate PM
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Gingivitis, Pregnancy
Oral Hygiene and Maternity Outcomes Multicenter Study (OHMOM)
This study will track changes in oral health in pregnant women. Subjects will be assigned to either regular oral care or advanced oral care and be given oral care products to use until they deliver.
- Trial name
- OHMOM (NCT01549587)
- Testing
- 0.243% sodium fluoride, toothbrush, dental floss
- Where
- 2 sites in United States
- Volunteers
- 746 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Gingivitis, Dental Plaque
Clear Aligner Cleaning: Brushing, Chlorhexidine, and BlueM Effects on Oral Microbial Ecology and Periodontal Indices
This randomized crossover study will assess how three aligner-cleaning methods affect early supragingival oral microbial ecology and periodontal health in adults using clear aligners.
- Trial name
- NCT07307716
- Testing
- Mechanical toothbrushing (fluoride toothpaste), Chlorhexidine mouthwash (0.2%), Oxygen-based cleanser
- Where
- Saudi Arabia
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
Gingivitis, Plaque
A Study of Experimental Mouthwashes
The purpose of this study is to evaluate the safety and efficacy of experimental mouthwash formulations compared to a hydroalcohol control mouthwash and a positive control mouthwash for the reduction of gingivitis and plaque when…
- Trial name
- NCT05121909
- Testing
- Colgate (R) Cavity Protection Toothpaste, Colgate (R) Cello Toothbrush, Prototype 1 Mouthwash
- Where
- Canada
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Consumer Inc. (J&JCI)
Gingivitis
A Phase 3 Clinical Study Investigating the Gingivitis Efficacy of a Test Dentifrice Containing Stannous Fluoride
The purpose of this study is to evaluate and compare the gingival health of a test dentifrice (0.454% weight by weight [w/w] stannous fluoride) to a negative control dentifrice by comparing modified gingival index, bleeding index…
- Trial name
- NCT04123665
- Testing
- Stannous fluoride, Sodium monofluorophosphate
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Epilepsy, Gingivitis
Air Polishing Effect on Biological, Clinical and Patient-reported Experience Among Epileptic and Non-epileptic Children
In epileptic and non Epileptic children, the full dentition of each patient was split into four quadrants, starting from the upper right quadrant (1) and moving clockwise until the lower right quadrant (4).
- Trial name
- NCT06144034
- Testing
- Air polishing with erythritol powder, Conventional treatment
- Where
- 2 sites in Jordan
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- King Abdullah University Hospital
Plaque Induced Gingivitis
Comparative Efficacy of Oil Pulling and Chlorhexidine on Plaque Induced Gingivitis
This randomized clinical trial aims to compare the efficacy of chlorhexidine and coconut oil in plaque-induced gingivitis patients.
- Trial name
- chx oilpulling (NCT07769112)
- Testing
- Chlorhexidine mouthwash (0.12%), coconut oil pulling
- Where
- Pakistan
- Volunteers
- 80 people
- Sponsor
- Liaquat College of Medicine and Dentistry
Gingivitis
Effectiveness of Propolis Mouthwash on Gingivitis
Mouthrinses have been in used for centuries as breath fresheners, medicaments, and antiseptics. Recently, propolis has caught the eyes of dentists worldwide and researches are being carried out to infuse the usage of propolis in…
- Trial name
- NCT04032548
- Testing
- Propolis mouthwash, Chlorhexidine mouthwash
- Where
- Malaysia
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Mahsa University
Sickle Cell Anemia in Children
Gum Arabic as Anti-oxidant, Anti-inflammatory and Fetal Hemoglobin Inducing Agent in Sickle Cell Anemia Patients
To study the efficacy of Gum Arabic as an anti-oxidant, anti-inflammatory and Fetal Hemoglobin-inducing agent among Sickle Cell Disease children. Half of participants will receive Gum Arabic and the other half will receive placebo
- Trial name
- GA&SCA (NCT04191213)
- Testing
- Acacia Senegal extract, Pectin
- Where
- Sudan
- Volunteers
- 100 people
- Sponsor
- Al-Neelain University
Gingivitis
Effect of Probiotics on Oral Homeostasis During Oral Hygiene Discontinuation
The present study is a double-blinded randomized clinical trial with a duration of 28 days.
- Trial name
- NCT05268757
- Testing
- Oral hygiene discontinuation
- Where
- Denmark
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Gingivitis
To Investigate the Gingivitis Efficacy of a Stannous Fluoride Dentifrice in a Chinese Population
This single-centre, examiner-blind, randomized, stratified, two-treatment, parallel group clinical study will evaluate the efficacy of a 0.454% w/w stannous fluoride dentifrice compared to a reference dentifrice to control…
- Trial name
- NCT02937636
- Testing
- Stannous fluoride, Sodium monofluorophosphate
- Where
- China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Gingivitis, Plaque Induced Gingivitis
The Effect of Enzyme-containing Mouth Spray on Oral Health Status and S.Mutans Levels in Paediatric Patients
An interventional study was done on evaluating the Effect of Enzyme-containing Mouth Spray on Oral Health Status and S.Mutans levels in Paediatric Patients attending Hospital Universiti Sains Malaysia ( HUSM ) , Kelantan.
- Trial name
- NCT05576610
- Testing
- Standard preventive advice+ enzymatic mouth sprays ( Oral7 mouth spray)
- Where
- Malaysia
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Hospital Universiti Sains Malaysia
Dental Plaque and Gingivitis
The Comparative Effects of Using 0.12% Chlorhexidine and Silver Nanoparticles Mouthwashes in Medical Students
This double-blind, randomized intervention study aims to evaluate and compare the efficacy of 0.12% Chlorhexidine (CHX) mouthwash and Nano Silver (AgNPs) mouthwash.
- Trial name
- mouthwash (NCT06963788)
- Testing
- Chlorhexidine 0,12%, 0,9% Chloride Sodium, Silver nanoparticles mouthwash
- Where
- Vietnam
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Can Tho University of Medicine and Pharmacy
Gingival Inflammation, Plaque
The Effectiveness of Brushing and Flossing Sequence on Control of Plaque and Gingival Inflammation
This study evaluates the effectiveness of brushing and flossing sequence in the control of dental plaque and gingival inflammation.
- Conditions
- Gingival Inflammation, Plaque, Gingival Bleeding, Plaque Control
- Trial name
- RCT (NCT03989427)
- Testing
- Brushing first and Flossing later (BF), Flossing first and Brushing later (FB)
- Where
- Malaysia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Melaka Manipal Medical College
Neurogenic Inflammation, Periimplant Diseases
Neurogenic Inflammation in Peri-implant and Periodontal Diseases
Regulatory effects of some neuropeptides substance-P (SP), neurokinin-A (NKA), calcitonin gene-linked peptide (CGRP) and neuropeptide-Y (NPY) )on inflammatory responses in periodontal disease has been described; however, the…
- Conditions
- Neurogenic Inflammation, Periimplant Diseases, Periodontal Diseases, Gingival Crevicular Fluid
- Trial name
- NCT03663140
- Testing
- gingival crevicular fluid (GCF) and peri-implant sulcular fluid(PISF) collection
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Gingivitis
Evaluation of the Effect of the Mouthwash on Delicate Gums
The goal of this study is to learn if a mouthwash works to alleviate gingivitis in adults. It will also learn about the safety of the product.
- Trial name
- NCT07551908
- Testing
- Mouthwash for delicate gums
- Where
- Spain
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Lacer S.A.
Dental Caries, Gingivitis
Interdental Microbiota Among Adolescents
Adolescence remains a period during which tooth decay is still very active. There are few epidemiological studies in adolescents, and the majority of them were young people aged 15 and under.
- Trial name
- MIARC (NCT03700840)
- Testing
- Interdental brushes
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Université Montpellier
Gingivitis
Dietary Diversities: Exploring the Influence of Keto Diet and Intermittent Fasting on Oral Health and Salivary Inflammatory Biomarkers
This study aims to investigate the impact of short term, two distinct dietary interventions, namely the Keto diet and Intermittent Fasting on oral health by measuring the severity of: Periodontal diseases (Gingivitis).
- Trial name
- NCT06597708
- Testing
- keto diet, intermittent fasting with calorie restriction
- Where
- Iraq
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Al-Mustansiriyah University
Gingivitis
A Person-centered, Theory-based, Intervention - Method Development Through the Integration of Digital Technology.
Studies have shown that Swedish adolescents have poor oral hygiene and with high prevalence of gingivitis. Therefore, more effective preventive programs in dental care are needed.
- Trial name
- NCT07306117
- Testing
- Person-centered, theory-based, intervention
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Vastra Gotaland Region