Clinical trials: Inflammaging
Mild Cognitive Impairment (MCI), Cognition
LpD3.5 Intervention Study in Older Adults- LISA-I Trial
This randomized placebo-controlled clinical study, called the LpD3.5 Intervention Study in Older Adults (LISA), aims to evaluate whether a heat-inactivated postbiotic of human origin (LpD3.5) can serve as a non-pharmacological…
- Conditions
- Mild Cognitive Impairment (MCI), Cognition, Brain Aging, Microbiome Dysbiosis
- Trial name
- Postbiotics (NCT07794956)
- Testing
- LpD3.5
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Inflammation Biomarkers, Cardiometabolic Health Indicators
Resveratrol Effects on Inflammatory Biomarkers and Cardiometabolic Parameters.
This study aims to evaluate the effect of the supplementation of grape pomace bars enriched in resveratrol on inflammatory biomarkers and cardiometabolic parameters in community-dwelling adults
- Conditions
- Inflammation Biomarkers, Cardiometabolic Health Indicators, Antioxidant Status, Inflammation, Antioxidant Capabilities
- Trial name
- RESINCA (NCT07395921)
- Testing
- RES 120, RES 250, RES 500
- Where
- Chile
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Center for Research and Innovation Viña Concha y Toro
Heart Failure, Aging
DNA Methylation Trajectories in Aging
The goal of this observational study is to profile changes in DNA methylation of circulating CD4+ T and CD8+ T cells from healthy young to aged with diagnosis of HFpEF, a particular phenotype of HF which is highly prevalent in…
- Trial name
- EPI-GERAS (NCT06582992)
- Testing
- RRBS
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Campania Luigi Vanvitelli
Frail Elderly Syndrome, Malnutrition Elderly
Effect of a Combined Exercise and Anti-Inflammatory Nutritional Intervention in Frail Older Adults
The goal of this clinical trial is to evaluate whether a combined intervention of therapeutic exercise and anti-inflammatory nutritional supplementation improves physical performance and reduces systemic inflammation in frail…
- Trial name
- AliFrail (NCT07182292)
- Testing
- Anti-Inflammatory Supplement, Conventional Nutritional Supplement
- Volunteers
- 158 people
- Sponsor
- Fundacion Miguel Servet
Melanoma
Adding Anakinra and Tocilizumab to Nivolumab and Ipilimumab for the Treatment of Melanoma Patients 50 Years of Age or Older
This phase I trial studies the side effects of adding anakinra and tocilizumab to standard treatment with nivolumab and ipilimumab and to see how well it works in treating melanoma patients who are 50 years of age or older.
- Trial name
- NCT07838974
- Testing
- Anakinra, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Southern California
Aged, Healthy
Low Grade Inflammation, Gut Microbiota and Barrier Function in Elderly Humans
Cardiovascular diseases (CVD) are the main cause of death in the European Union. A large part of the aging process, including immunosenescence, is explained by an imbalance between inflammatory and anti-inflammatory networks…
- Trial name
- NCT01218165
- Testing
- Probiotic drink, Control Group
- Where
- Germany
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Inflammaging, Sarcopenia
Inflammaging and Muscle Protein Metabolism
The development of a low-grade, chronic, systemic inflammation observed in the elderly (inflammaing) has been associated with increased risk for skeletal muscle wasting, strength loss and functional impairments.
- Trial name
- NCT03308747
- Testing
- Instantized Whey Protein Isolate
- Where
- Greece
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Periodontal Diseases, Old Age
Effect of Low-Level Laser on Crevicular Interleukin-1β Concentration in Patients With Periodontal Disease: A Relation to Periodontal Inflammaging
This study is done to compare between young age and old age patients with periodontitis (inflammaging) and the effect of diode laser as adjunctive to scaling and debridement
- Trial name
- NCT06677385
- Testing
- diode laser as adjunctive to conventional scaling and debridement, conventional scaling and debridement
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Immunity Disorders, Aging
The Impact of a Polyphenol-Rich Supplement on Epigenetic and Cellular Markers of Immune Age
This is a prospective, interventional, single-arm, open-label pilot study of 50 patients to evaluate the effect of a polyphenol-rich nutritional supplement on epigenetic and cellular markers of immune age.
- Conditions
- Immunity Disorders, Aging, Inflammation
- Trial name
- NCT05234203
- Testing
- HTB Rejuvenate
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Big Bold Health, PBC
Aging
Ecosystem Nourishment for Gut Restoration After Fecal Transplantation
The purpose of this study is to test whether young-donor fecal microbiome transplantation (FMT) and a fermented, plant-rich high-fiber, microbiome rejuvenating diet (MRD) reduce inflammatory and biological aging markers.
- Trial name
- ENGRAFT (NCT07826793)
- Testing
- Fecal Microbiota Transplant Capsules, Microbiome Rejuvenating Diet
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Stanford University
Healthy Elderly People
Potential Benefits of Dietary Advices Alone or Associated to Nutraceutical Food Supplements Argan Oil, VSL#3 Probiotic Blend, 5203-L Fruit Extract Terpene
Ageing of the population is a major event in the world. Gerontological/geriatric literature unanimously indicate that physical exercise and diet are at present the two available fundamental approaches to contrast/prevent most of…
- Trial name
- RISTOMED (NCT01069445)
- Testing
- VSL#3® probiotic blend, AISA-5203-L fruit extracted terpene, Argan oil
- Where
- France
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Menopause, Gut Microbiome
AGEWISE: Unravelling the Gut-Hormone Axis in Women's Ageing
AGEWISE is an observational study that aims to understand how changes in gut microbiome are related to hormonal changes during women's ageing, particularly across the different stages of menopause.
- Conditions
- Menopause, Gut Microbiome, Hormonal Changes, Chronic Low-Grade Inflammation
- Trial name
- NCT07614542
- Where
- Portugal
- Volunteers
- 300 people
- Sponsor
- Gulbenkian Institute for Molecular Medicine
Healthy Aging, Inflammaging
The Effects of Quercefit® and Ubiqsome™ in Mitigating Inflammation and Promoting Metabolic Health
The goal of this clinical trial is to learn if Quercefit® or Ubiqsome™ can improve markers of healthy aging, blood sugar control, and heart health in older adults. It will also learn about the safety of these supplements.
- Conditions
- Healthy Aging, Inflammaging, Metabolic Health, Quercetin
- Trial name
- NCT07760506
- Testing
- Quercetin (dietary supplement), Coenzyme Q10, Rice Flour
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Applied Science & Performance Institute
Inflammation, Malnutrition
Effects of Camelina Sativa Oil in Free-living Older Adults
The present study aims at evaluating the anti-inflammatory effects of a novel food in older adult volunteers. Briefly, this randomized, double-blind and placebo-controlled study is performed on 91 apparently healthy older adults…
- Conditions
- Inflammation, Malnutrition, Hyperglycemia, Dyslipidemias
- Trial name
- NCT04965948
- Testing
- Novel food snack
- Where
- Italy
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Pavia
Allogeneic HCT Survivors
Improving Self-Efficacy, Resolving Inflammaging Allo HSCT Survivors in Personal Training
This protocol is a pilot study of a personalized and supervised 10-week strength training program to improve self-efficacy and resolve biomarkers of inflammaging in a cohort of allogeneic hematopoietic transplant (HCT) long-term…
- Trial name
- NCT03609203
- Testing
- 10 Weeks of Strength Trailing, Group Nutrition Discussion: week 1, week 5 and week 10
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Masonic Cancer Center, University of Minnesota
Influenza, Herpes Zoster
Age Differences in Influenza and Herpes Zoster Vaccine Responses (INFLUENZA-SHINGRIX)
Vaccines are used to prevent infectious diseases worldwide. Unfortunately, many vaccines, like the flu vaccine, are less effective in older adults.
- Trial name
- NCT05082688
- Testing
- Herpes zoster vaccination (Shingrix, GSK), Influenza Vaccine (Fluarix Tetra Northern Hemisphere 2021 or 2022, GSK)
- Where
- Netherlands
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Aging, Immunology
Peri-operative Inflammaging in the Elderly After Surgery
The population older than 80 years will significantly increase in the near future. Older patients' cognitive and physical status is known to deteriorate after surgery, leading to a high 30-day mortality due to post-operative…
- Conditions
- Aging, Immunology, Postoperative Complications, Surgery
- Trial name
- POPIMAGE (NCT05368896)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- University of Bonn
Sarcopenia, Diabetes Mellitus
Glucose Metabolism, Muscle Mass/Function and Inflammation in the Elderly
A thorough characterization of glucose metabolism and "inflammaging" in elderly subjects will help determine to what extent each of these factors affects muscle mass/function and contributes to age-related muscle wasting.
- Trial name
- NCT02426073
- Where
- 2 sites in Italy
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Periodontal Disease
Effect of Low-Level Laser Therapy on Salivary Toll Like Receptor- 4 Concentration of Periodontitis Patients: a Relation to Periodontal Inflammaging
Effect of Low-Level Laser Therapy on Salivary Toll Like Receptor- 4 Concentration of Periodontitis Patients: A Relation to Periodontal Inflammaging
- Trial name
- NCT06677736
- Testing
- conventional scaling and debridement, Diode laser as adjunctive to conventional scaling and debridement
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Rawda Saleh Saad Alashmawy
Periodontitis, Periodontitis Stage I
Relationship Between NLRP3 Inflammasome Activation and Stages of Periodontitis: An Association With Inflammaging
This study aims to investigate the relationship between NLRP3 inflammasome activation and different stages of periodontitis, with a focus on its association with inflammaging.
- Conditions
- Periodontitis, Periodontitis Stage I, Periodontitis Stage II, Periodontitis Stage III
- Trial name
- NCT07590089
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology