Clinical trials: Inflammation, Brain
Post-Acute Sequelae of SARS-CoV-2 Infection, Long COVID
Observational Study of Intranasal IVIG in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Patients Undergoing Medical Tourism
This observational study is being conducted by Healing Hope International to collect real-world data on an emerging treatment approach for Long COVID in patients with immunodeficiency.
- Conditions
- Post-Acute Sequelae of SARS-CoV-2 Infection, Long COVID, Long COVID Fatigue, Long COVID Syndrome
- Trial name
- IVIG-LC (NCT06992401)
- Volunteers
- 50 people
- Sponsor
- Tamara C Tamas
Tick-borne Encephalitis (TBE)
TBE Seropersistence up to 10 Years After First Booster in Adults
The purpose of this study is to evaluate TBE antibody persistence from 7 to 10 years after the first booster TBE vaccination with FSME-IMMUN 0.5ml.
- Trial name
- NCT01582698
- Testing
- FSME-IMMUN 0.5 ml
- Where
- 2 sites in Poland
- Volunteers
- 243 people, healthy volunteers welcome
- Sponsor
- Pfizer
Cognitive Impairment, Functional Magnetic Resonance Imaging
Functional Magnetic Resonance Imaging (fMRI) of Brain in ICU Survivors With Cognitive Impairment
Long-term cognitive dysfunction greatly influences patient's quality of life after critical illness. However,its neurophysiological basis remains unknown.This is a 3 year fMRI study conducted at the Jiangyin people's Hospital.
- Conditions
- Cognitive Impairment, Functional Magnetic Resonance Imaging, Septic Shock, Inflammation
- Trial name
- NCT03946839
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Jian-jun Yang
Meningitis, Encephalitis
The Effectiveness and Safety of Human Lumbar Puncture Assist Device (LPat)
The purpose of this study is to proof and investigate the effectiveness and safety of the invented device named "Human Lumbar Puncture Assist Device (LPat)" as an assist tool to be utilized to improve the success rate of…
- Conditions
- Meningitis, Encephalitis, Guillain-Barré, Subarachnoid Hemorrhage
- Trial name
- LPat (NCT03710278)
- Testing
- LPat Device
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Spartanburg Regional Healthcare System
Cerebrovascular Accident, Cerebral Stroke
The Role of HMGB-1 in Chronic Stroke
The purpose of this study is to measure the presence of HMGB-1 and other proteins in the blood across five time points after stroke, and to determine if their presence correlates with rate of stroke recovery.
- Conditions
- Cerebrovascular Accident, Cerebral Stroke, Stroke, Acute
- Trial name
- NCT01705353
- Where
- 2 sites in United States
- Volunteers
- 39 people
- Sponsor
- Northwell Health
Atherosclerosis, Atherosclerotic Plaque
Indocyanine Green Fluorescence Uptake in Human Carotid Artery Plaque
This will be a pilot study of 9 patients undergoing standard-of-care clinically indicated carotid endarterectomy. The nine patients will receive an injection of Indocyanine green (ICG) at a dose of 0.25 mg/kg (maximum 25 mg) as…
- Conditions
- Atherosclerosis, Atherosclerotic Plaque, Carotid Stenosis
- Trial name
- BRIGHT-CEA (NCT01873716)
- Testing
- Indocyanine green
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Massachusetts General Hospital
Japanese Encephalitis
Diagnostics and Surveillance of Acute Meningo-encephalitis Among Children in Cambodia With a Focus on Japanese Encephalitis Virus
The primary objective of this study is to quantify the clinical burden of Japanese Encephalitis (JE) and the asymptomatic circulation of JEV among Cambodian children, through two pediatric cohorts: non-febrile children at…
- Trial name
- DEMELE-JEV (NCT06674837)
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- ANRS, Emerging Infectious Diseases
Migraine Headache
Repeat Dosing of Psilocybin in Migraine Headache
In seeking to understand the capacity for psilocybin to reduce migraine headache burden, this study will investigate single and repeated dosing of psilocybin up to two doses.
- Trial name
- NCT04218539
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Yale University
Brain Disease
Inflammatory and Infectious Diseases of the Nervous System
Background: Inflammation is how the body reacts to infection or injury. Infections or inflammation in the brain and nerves can be serious. There aren t always good tests to detect this.
- Trial name
- NCT02435810
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Japanese Encephalitis
Immunogenicity of a JE-CV as a Booster Dose After a Primary Vaccination With SA14-14-2 Vaccine
The objective of this study is to measured the Geometric mean titer (GMT) of Japanese Encephalitis neutralizing antibody and proportion of seroprotection among the children who received a booster dose of JE-CV after the first…
- Trial name
- NCT02602652
- Testing
- a live attenuated chimeric JE vaccine
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Encephalitis, Tick-borne
FSME IMMUN NEW Follow-up to Study 199 in Children Aged 1 to 6 Years
The purpose of this study is to investigate the safety and immunogenicity of the third vaccination with one of three different concentrations of a TBE vaccine in all subjects who completed two vaccinations in one of the three…
- Trial name
- NCT00161850
- Testing
- Tick-Borne Encephalitis (TBE) Vaccine (Inactivated)
- Where
- 25 sites in Austria, Germany
- Volunteers
- 615 people, healthy volunteers welcome
- Sponsor
- Pfizer
TIA, Stroke
Relation of Carotid Artery Plaque Inflammation, Covert Stroke and White Matter Disease
The investigators hypothesize that inflammation in carotid plaque is predictive of the extent of ischemic lesion burden on the brain and will add to risk stratification for individuals with carotid disease.
- Conditions
- TIA, Stroke, Carotid Artery Stenosis
- Trial name
- NCT01236508
- Testing
- PET/CT imaging with F-18 fluorodeoxyglucose
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Anti-NMDA Receptor Encephalitis
Transcranial Direct Current Stimulation on Cortical Plasticity in Patients With Anti-NMDA Receptor Encephalitis
Patients suffering from anti-NMDA receptor encephalitis show impaired NMDA-receptor dependent neuronal transmission. Furthermore, they often have cognitive deficits of different magnitude.
- Trial name
- NCT01865578
- Testing
- tDCS
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Stroke, Dementia
Predictors for Poststroke Outcomes: Tel Aviv Brain Acute Stroke Cohort Acute Stroke Cohort (TABASCO)
Background: Recent studies have demonstrated that even mild stroke survivors experience residual damage, which persists and in fact increases in subsequent years.
- Conditions
- Stroke, Dementia, Cerebrovascular Disorders, Alzheimer's Disease
- Trial name
- TABASCO (NCT01926691)
- Where
- Israel
- Volunteers
- 575 people
- Sponsor
- Eli Sprecher, MD
Rabies
Rabies Immunization Concomitant With JEV in Children
Background. The World Health Organization recommends pre-exposure vaccination (PreP) to protect children living in canine rabies endemic countries.
- Trial name
- NCT00703521
- Testing
- Rabies vaccine
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Intracerebral Hemorrhage, Sepsis
Machine Learning Predictive Models for Sepsis Risk in ICU Patients With Intracerebral Hemorrhage
Patients with intracerebral hemorrhage (ICH) in the intensive care unit (ICU) are at heightened risk of developing sepsis, significantly increasing mortality and healthcare burden.
- Trial name
- NCT06326385
- Testing
- no intervention
- Where
- China
- Volunteers
- 1,800 people
- Sponsor
- Xiangya Hospital of Central South University
Progressive Multifocal Leukoencephalopathy, PML
Observational Study on Characteristics and Survival Correlates of Progressive Multifocal Leukoencephalopathy (PML) in Italy
The goal of this observational study is to learn about the features of Progressive Multifocal Leukoencephalopathy (PML) at the time of its diagnosis and the factors that may influence the outcome of persons with this disease.
- Trial name
- MI_PML (NCT06594614)
- Where
- Italy
- Volunteers
- 456 people
- Sponsor
- Scientific Institute San Raffaele
Gulf War Syndrome
Assessing Neuroinflammation in GWI Using MRS
The primary aim of this study is to determine if Gulf War Illness (GWI) likely involves neuroinflammation. The investigators hypothesize that GWI involves neuroinflammation.
- Trial name
- NCT04638998
- Testing
- Magnetic Resonance Spectroscopic Imaging, Blood draw
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Migraine Headache, Migraine Without Aura
Investigation of Vascular Inflammation in Migraine Using Molecular Nano-imaging and Black Blood Imaging MRI
The investigators aim to investigate inflammation of cranial and meningeal arteries during pharmacologically induced migraine attacks, using ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles and black blood imaging…
- Trial name
- NCT02549898
- Testing
- Feraheme, Cilostazol, USPIO-MRI
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- Danish Headache Center
Alzheimer's Disease
Health Evaluation in African Americans Using RAS Therapy
The purpose of this study is to determine if telmisartan, an FDA approved blood pressure medication, may also have beneficial effects on Alzheimer's disease prevention in African Americans, who are at high risk for Alzheimer's…
- Trial name
- HEART (NCT02471833)
- Testing
- Telmisartan 20mg, Telmisartan 40mg
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Emory University