Clinical trials: Inflammation, Brain
Migraine Headache, Migraine Without Aura
Investigation of Vascular Inflammation in Migraine Using Molecular Nano-imaging and Black Blood Imaging MRI
The investigators aim to investigate inflammation of cranial and meningeal arteries during pharmacologically induced migraine attacks, using ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles and black blood imaging…
- Trial name
- NCT02549898
- Testing
- Feraheme, Cilostazol, USPIO-MRI
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- Danish Headache Center
Migraine
Mechanistic Studies of Psilocybin in Headache Disorders
In previous clinical trial work, the investigators observed lasting reductions in headache burden after limited dosing of psilocybin. This purpose of this study is to examine potential sources for this observed effect.
- Trial name
- NCT06464367
- Testing
- Psilocybin
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Yale University
Progressive Multifocal Leukoencephalopathy
Pembrolizumab in Progressive Multifocal Leukoencephalopathy (PML) in Immunocompromised Patients Without HIV Infection
This study aims to assess the efficacy and safety of pembrolizumab in immunocompromised patients with progressive multifocal leukoencephalopathy (PML).
- Trial name
- PENALTY (NCT06276504)
- Testing
- Pembrolizumab, 25 mg/ml solution for intravenous (IV) injection
- Where
- 3 sites in France
- Volunteers
- 33 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Methamphetamine-dependence
Pilot Study of the Effect of Ibudilast on Neuroinflammation in Methamphetamine Users
Addiction to methamphetamine is a serious health problem in the United States. Right now, there are no medications that a doctor can give someone to help them stop using methamphetamine.
- Trial name
- Ibudilast (NCT03341078)
- Testing
- Ibudilast
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Rabies
Rabies Immunization Concomitant With JEV in Children
Background. The World Health Organization recommends pre-exposure vaccination (PreP) to protect children living in canine rabies endemic countries.
- Trial name
- NCT00703521
- Testing
- Rabies vaccine
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Frailty Syndrome, Dementia
The Impact of Transcutaneous Vagal Nerve Stimulation on Frailty Syndrome in Older Adults
This clinical study, conducted at the Techirghiol Balneary and Rehabilitation Sanatorium, aims to evaluate the effectiveness of transcutaneous auricular vagus nerve stimulation (taVNS) in improving clinical and biological…
- Trial name
- NCT07416708
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation, Physiotherapy
- Where
- Romania
- Volunteers
- 80 people
- Sponsor
- Balnear and Rehabilitation Sanatorium Techirghiol
Diabetes, Chronic Kidney Diseases
Benchtop NMR Spectroscopy for Assessment of Clinical Human Pathologies (BRANCH-P STUDY)
This research programme seeks to combine the resources of NHS primary care, with the leading spectroscopic work in low-magnetic fields of the Wilson Group (Nottingham Trent University) to demonstrate the potential for benchtop…
- Conditions
- Diabetes, Chronic Kidney Diseases, Cancer, Bowel Disease
- Trial name
- BRANCH-P (NCT05473325)
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Willows Health
Endometriosis, Endometriosis and Dysmenorrhea
Brain and Blood Vessel Health Following Endometriosis Treatment in People With Endometriosis
This research study wants to understand how medications used to treatment symptoms of endometriosis impact brain health in patients with endometriosis.
- Conditions
- Endometriosis, Endometriosis and Dysmenorrhea, Endometriosis (Diagnosis)
- Trial name
- BLOOM (NCT07799246)
- Testing
- Investigate how norethindrone acetate, a commonly used medication used to treat symptoms of endometriosis, impact biomarkers of brain health, Investigate how Orlissa, a commonly used medication used to treat symptoms of endometriosis, impact biomarkers of brain health, Investigate how Oriahnn, a commonly used medication used to treat symptoms of endometriosis, impact biomarkers of brain health
- Volunteers
- 45 people
- Sponsor
- Colorado State University
Venezuelan Equine Encephalitis, Venezuelan Equine Encephalitis Virus Infection
A Phase 1 Study Evaluating the Safety, Tolerability, and Immunogenicity of V4020 Vaccine in Healthy Volunteers
The purpose of the study is to evaluate the safety and immunogenicity of a novel Venezuelan Equine Encephalitis virus (VEEV) vaccine (V4020) for the first time in humans compared to placebo when administered by subcutaneous or…
- Trial name
- VEEV (NCT07088822)
- Testing
- V4020
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Medigen, Inc.
Chronic Low Back Pain (CLBP)
Brain and Gene Expression Responses to Exercise in Chronic Back Pain
This study is registered retrospectively for transparency. This mechanistic randomized controlled trial examined whether a 14-week supervised physical exercise training program reduces chronic low back pain (CLBP) by modulating…
- Trial name
- CLBPE (NCT07480460)
- Testing
- Supervised physical exercise training
- Where
- Canada
- Volunteers
- 57 people
- Sponsor
- McGill University
Epilepsy, Focal Cortical Dysplasia
Use of a Tonometer to Identify Epileptogenic Lesions During Pediatric Epilepsy Surgery
Refractory epilepsy, meaning epilepsy that no longer responds to medication, is a common neurosurgical indication in children. In such cases, surgery is the treatment of choice.
- Conditions
- Epilepsy, Focal Cortical Dysplasia, Tuberous Sclerosis, Hemimegalencephaly
- Trial name
- NCT04344626
- Testing
- Intra-operative brain tonometry
- Where
- 2 sites in United States, Canada
- Sponsor
- University of California, Los Angeles
NMO Spectrum Disorder, NMDA-R Encephalitis
Sensitivity and Specificity of TSA-CBA for Autoantibodies Against Neural Antigen Determination
Determination of autoantibodies against fragments derived from neurons, glia, and myelin sheath is instrumental in aiding diagnosis, differential diagnosis, as well as determining disease status of neuromyelitis optica spectrum…
- Conditions
- NMO Spectrum Disorder, NMDA-R Encephalitis, Diagnostic Self Evaluation, Immune System Diseases
- Trial name
- STAND (NCT05414890)
- Testing
- CBA-TSA
- Where
- China
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Beijing Tiantan Hospital
Encephalitis, Meningitis
Optimal Encephalitis/Meningitis Roadmap Via Precise Diagnosis and Treatment
Encephalitis and meningitis are serious central nervous system diseases. There is currently a lack of comprehensive and accurate diagnosis and treatment pathways.
- Conditions
- Encephalitis, Meningitis, Meningoencephalitis, Next-Generation Sequencing
- Trial name
- NCT04946682
- Testing
- Types of etiological diagnostic methods
- Where
- 7 sites in China
- Volunteers
- 484 people
- Sponsor
- Wen-hong Zhang
Parkinson Disease
GLP1R in Parkinson's Disease
The purpose of the study is to test the neuroprotective and anti-inflammatory properties of semaglutide in idiopathic Parkinson's disease (PD)
- Trial name
- GIPD (NCT03659682)
- Testing
- Semaglutide
- Volunteers
- 120 people
- Sponsor
- Oslo University Hospital
Pain, Inflammatory
An Imaging Study to Investigate the Distribution of GW842166X in the Brain.
GW842166X is being developed for the treatment and management of inflammatory pain. GW842166X is a CB2 receptor agonist and the mechanism is not fully understood, although it is thought that for the anti-inflammatory action the…
- Trial name
- NCT00511524
- Testing
- GW842166X, [carbonyl-^11C]GW842166
- Where
- Sweden
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Acute Ischemic Stroke, Cerebral Infarction
Safely Quenching Complement in Stroke Survivors
This study will include adults (ages 18-80) who have had a stroke caused by a large blood clot blocking blood flow in the brain.
- Trial name
- SUCCESS (NCT07495722)
- Testing
- Pegcetacoplan Injection [Empaveli]
- Volunteers
- 20 people
- Sponsor
- Columbia University
Major Depression
Brain Inflammation in Major Depressive Disorder Background
Background: Studies have shown that inflammation plays an important role in depression. Brain inflammation may contribute to depression, and may make it more difficult to treat some kinds of depression with current therapies.
- Trial name
- NCT01851356
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Acute Ischemic Stroke
The Efficacy of Remote Ischemic Conditioning on Stroke-induced Immunodeficiency
to detect the effects of RIC on stroke-induced immunodeficiency and inflammation response in acute ischemic stroke patients
- Trial name
- RIC-SIID (NCT04069546)
- Testing
- remote ischemic conditioning
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Capital Medical University
Toxoplasmosis, Cerebral, HIV Infections
A Randomized Prospective Study of Pyrimethamine Therapy for Prevention of Toxoplasmic Encephalitis in HIV-Infected Individuals With Serologic Evidence of Latent Toxoplasma Gondii Infection
To evaluate pyrimethamine as a prophylactic agent against toxoplasmic encephalitis in individuals who are coinfected with HIV and latent Toxoplasma gondii.
- Trial name
- NCT00000666
- Testing
- Pyrimethamine
- Where
- 16 sites in United States
- Volunteers
- 600 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Alzheimer's Disease
Imaging Inflammation in Alzheimer's Disease
This study is being done to learn about inflammation and amyloid in Alzheimer's disease. A type of brain scan called a PET scan is used measure 1) inflammation and 2) abnormal accumulation of a the amount of a certain protein…
- Trial name
- NCT02831283
- Testing
- 11C-PBR28, 18F-Florbetaben, Lumbar puncture (optional)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Patrick Lao