Clinical trials: Inflammation
Obesity, Skeletal Muscle
Anti-Inflammatory Milk Matrix
Obesity is pro-inflammatory, impairs metabolism, and physically limiting. Specifically, muscle in obese persons does not synthesize proteins normally. This further increases metabolic and physical dysfunction.
- Conditions
- Obesity, Skeletal Muscle, Inflammation
- Trial name
- AIMM (NCT04216004)
- Testing
- Controlled-Feeding Intervention, Non-dairy beverage, Full-fat milk
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Sepsis
New Strategy to Predict Early Sepsis
This is an observational prospective multicentre study on patients attending the emergency department and suspected to have sepsis.
- Trial name
- NCT04118179
- Testing
- Blood sample collection
- Where
- 5 sites in United States, Australia and 3 more
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Mood Disturbance
Effect of Saffron Extract Supplementation on Emotional Well-being Alterations
This study aims to test whether a saffron extract represents a good candidate to improve emotional well-being in subjects with subclinical symptoms of depression, fatigue, stress or anxiety.
- Trial name
- SAFFROMFOOD (NCT05690126)
- Testing
- Saffron extract, Maltodextrin
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
Inflammatory Response, Inflammation
Fat Quality and Postprandial Inflammation
This aim of this randomized controlled postprandial study is to compare the effects of four different far sources (butter, coconut, corn oil and flax seed oil) on postprandial inflammation and metabolic response.
- Trial name
- PI:fat (NCT05674708)
- Testing
- Fat intake
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Göteborg University
E.Coli Infections, Bloodstream Infection
A Study Investigating the Safety, Recovery, and Pharmacodynamics of Multiple Oral Administrations of SNIPR001 in Healthy Subjects
This is a Phase 1, randomized, double-blind, placebo-controlled, multiple dose, dose escalation study in healthy participants, investigating the safety, tolerability, recovery, and PD of multiple oral administrations of SNIPR001.
- Trial name
- NCT05277350
- Testing
- SNIPR001
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- SNIPR Biome Aps.
Healthy
Normative State and Variation in Growth, Hematology, Hydration, Oxidation, Infection, Inflammation, Guatemalan Children
This study will provide the researchers with an opportunity for the investigation of the biomarkers and different human biology component variable interactions in children; information that can generate new correlations between…
- Trial name
- NCT02203890
- Where
- Guatemala
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- María José Soto
Severe Sepsis, Organ Failure
Comparative Study of the Protein C Pathway in Septic and Non Septic Patients With Organ Failure
This is a comparative study performed in 3 groups of patients/subjects: 30 severe sepsis patients, 30 non-septic patients with organ failure, 30 healthy subjects.
- Trial name
- NCT00361725
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Breast Cancer, Fatigue
The Role of Circadian Rhythms in Cancer-Related Symptoms
Emerging evidence indicates that circadian rhythms may be disrupted following cancer and its treatment, and that circadian rhythm disruption may be an underlying pathophysiological mechanism of cancer- and cancer…
- Conditions
- Breast Cancer, Fatigue, Cognitive Impairment, Sleep
- Trial name
- CHRONO (NCT04401189)
- Where
- Denmark
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Aarhus University Hospital
Lipid Disorder, Systemic Inflammatory Response
Evaluation of the Consumption of Lupins in Brine on Metabolic Markers in Healthy Individuals
The aim of the project was the evaluation of the effects of the consumption of different amounts of lupins in brine on lipid, glucose, inflammatory, oxidative stress, gut microbiota profile and (epi)genetic markers in healthy…
- Trial name
- SUPERLUPINO (NCT06595082)
- Testing
- 4-week lupins in brine consumption, 4-week lupins in brine consumption and dietary suggestion
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Teramo
Sepsis, Autophagy
Regulatory Network and Diagnostic Value of Key Autophagy-related Genes in Sepsis
Autophagy plays an important role in the occurrence and development of sepsis. This study aims to explore and verify the key autophagy-related genes in sepsis, then construct their regulatory networks and evaluate their potential…
- Trial name
- NCT05524376
- Testing
- no intervention
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Anxiety
Does Treating Anxiety Symptoms With ACT Improve Vascular Inflammation and Function?
The goal of this study is to evaluate the effectiveness of a brief, intensive 1-day psychotherapy group intervention (Acceptance and Commitment Therapy, ACT), compared to a 12 week time control group on anxiety symptoms, vascular…
- Trial name
- ACT on Anxiety (NCT02915874)
- Testing
- Acceptance and Commitment Therapy
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Healthy
Effect of MOF on Exercise Blood Pressure
The purpose of this study is to establish an effect of monomeric and oligomeric flavanols supplementation on exercise blood pressure and vascular function in healthy volunteers.
- Trial name
- NCT04907097
- Testing
- Monomeric and oligomeric flavanols
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Cirrhosis, Liver
Longitudinal Monitoring of Inflammation in Cirrhosis
Longitudinal monitoring of inflammation using skin devices may help predict outcomes compared to traditional blood draws
- Trial name
- NCT05538962
- Testing
- Sensor skin
- Where
- United States
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Periodontitis
Role of Macrophage in Inflammation Resolution in Periodontal Patients
There is a growing body of evidence to suggest that the resolution of an inflammatory reaction is an active process. This process requiring signals that turn off early inflammatory stages, as neutrophil infiltration and promote…
- Trial name
- NCT01379950
- Where
- Israel
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Osseointegration Failure of Dental Implant Due to Infection, Osseointegration Failure of Dental Implant Prior to Intentional Prosthetic Loading
Two-Piece Zirconia Dental Implant vs Two-Piece Titanium Dental Implant- Randomized Clinical Control Trial
2 Arms (60 subjects - 30 each arm). Experimental group with two-pice zirconia dental implant and Control group with two-piece titanium dental implant Evaluate Changes in inflammatory and microbiology levels from T0 (baseline) T2…
- Trial name
- NCT03336723
- Testing
- Dental Implant
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Implantology Institute
Renal Failure Chronic Requiring Hemodialysis, Hepatitis C
Prohepcidin, Inflammation and Iron Homeostasis in Hemodialysis Patients With Chronic Hepatitis C
The aim of this study is to address questions regarding the link among hepcidin, hematological iron markers, inflammation and hepatitis C in HD patients.
- Trial name
- NCT01272479
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Immunometabolism, Mitochondrial Function, Bioenergetics
Independent and Combined Effects of Short-term Sulforaphane Supplementation and Exercise on Immunometabolism in Healthy Adults
The study consist of 3 interventional periods which will be completed by each consenting participant in a randomized, crossover fashion. The interventional periods will be separated by a minimum 1 week washout period.
- Conditions
- Immunometabolism, Mitochondrial Function, Bioenergetics, Inflammation
- Trial name
- EXSFN (NCT07668596)
- Testing
- Sulforaphane-rich Broccoli Sprout Extract, High Intensity Interval Treadmill Running
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Hemostasis in Decompensated Liver Cirrhosis, Inflammation in Decompensated Liver Cirrhosis
Hemostasis in Liver Cirrhosis and Hepatocellular Cancer
Evaluating hemostasis in decompensated liver cirrhosis with novel hemostatic assays.
- Trial name
- HELICS (NCT06212635)
- Testing
- T-TAS
- Where
- Sweden
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Region Stockholm
Milk Intolerance
Low-grade Inflammation and Gut Symptoms From A2 and Hydrolyzed A1 Milk
The aim of this study is to reveal how different forms of milk casein, lactose and moderate breakdown of proteins affect the symptoms that may arise from milk and markers of inflammation in volunteers receiving symptoms from…
- Trial name
- NCT05305391
- Testing
- Dietary intervention
- Where
- Finland
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Turku
Asthma, Hypersensitivity
Assessment of Lung Inflammation in Patients With Atopic Asthma Using Positron Emission Tomography
Asthma is a chronic inflammatory disease. We propose to study inflammatory changes in the lungs of subjects with atopic asthma of different severity in vivo using positron emission tomography (PET) with…
- Conditions
- Asthma, Hypersensitivity, Lung Diseases, Wegener's Granulomatosis
- Trial name
- NCT00001759
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
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