Clinical trials: Inflammation
Periodontal Disease
Artificial Intelligence for Diagnosing Periodontitis and Monitoring Gingival Inflammation
Background and Objective: Periodontitis and gingivitis are highly prevalent oral diseases that require accurate diagnostic classification and continuous gingival health monitoring.
- Trial name
- NCT07629934
- Testing
- AI-driven Periodontal Diagnostic and Monitoring Algorithms
- Where
- China
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Cholestasis of Pregnancy
Association of Intrahepatic Cholestasis of Pregnancy and Chronic Placental Inflammation
This observational prospective study will help to determine if an immune process similar to allograft rejection is responsible for the occurrence of an intrahepatic cholestasis of pregnancy (ICP).
- Trial name
- INTREPIDE (NCT05197387)
- Where
- 11 sites in France
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Inflammation, Inflammatory Response
Inflammatory Response to OMT
Investigators will evaluate inflammation before and after an osteopathic manipulative treatment (OMT) in healthy adults, 18-59 years of age. Investigators will look at proteins in the blood called "cytokines".
- Trial name
- NCT06820684
- Testing
- Osteopathic Manipulative Treatment (OMT)
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Pacific Northwest University of Health Sciences
Hayfever
Lactobacillus Acidophilus L92 on Markers of Allergic Inflammation by Nasal Provocation With Grass Pollen
This is a placebo controlled double-blind single center study initiated and sponsored by CALPIS, Inc., Japan, and CALPIS U.S.A., Inc., Torrance, CA.
- Trial name
- NCT00554736
- Testing
- Lactobacillus acidophilus L-92
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Davis
Obesity, Hyperglycemia
The Effect of a Bifidobacterium and Polydextrose on Body Fat Mass
Obesity is a major problem worldwide, and it is related to abnormalities in glucose and lipid metabolism. The purpose of this study is to investigate the effect of a dietary supplement containing probiotic (Bifidobacterium…
- Conditions
- Obesity, Hyperglycemia, Insulin Resistance
- Trial name
- MetSProb (NCT01978691)
- Testing
- Bifidobacterium animalis ssp. lactis 420, Polydextrose
- Where
- 4 sites in Finland
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Danisco
Sepsis
Lactate Metabolism After an Endotoxin Challenge in Healthy Humans
Sepsis is characterized by hyperlactatemia, the severity of which is proportionate with sepsis severity. The pathophysiological mechanisms (increased lactate production vs decreased lactate utilization; tissues involved in…
- Trial name
- NCT01647997
- Testing
- bacterial endotoxin challenge
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Oxidative Stress, Inflammation
Influence of a Short Term Supplementation With Ubiquinol on Diverse Aspects Related to the Physical Activity
The General Aim of this study is to verify if a short term supplementation can modulate diverse aspects related to the physical regular high intensity activity.
- Conditions
- Oxidative Stress, Inflammation, Muscle Injury
- Trial name
- NCT01940627
- Testing
- Ubiquinol, Control
- Where
- Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Generation of Reactive Oxygen Species, Intestinal Inflammation
Assessment of Complementary Feeding of Canadian Infants
With the recent recommendation from Health Canada to extend exclusive breast-feeding to 6 months of age there has arisen concern about what is the best solid food to introduce at that time.
- Trial name
- Infant Feeding (NCT01790542)
- Testing
- Iron fortified cereal, Iron fortified cereal with fruit, Meat
- Where
- Canada
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Obesity, Metabolic Disease
mTORC1 and Autophagy in Human Brown Adipocytes
The long term goal is to identify the potential therapeutic targets for the treatment of obesity and its associated disorders by studying the driving factors of activation of brown adipose tissue (BAT) in human adults.
- Trial name
- mTORHBFC (NCT04206124)
- Testing
- Brown Fat Harvest During Anterior Neck Surgery
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Neuroinflammation, Autism Spectrum Disorder
Imaging - Clinical Evaluation of Altered Nervous System Drainage
The current study aims to evaluate the aspects of perfusion, fluid diffusivity in the interstitium and the T1 and T2 signal of the PVS and WMH.
- Trial name
- I-CLEANED (NCT06432023)
- Testing
- Magnetic resonance imaging
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Healthy Volunteers
Effects of a Dietary Supplement on Lipoprotein Lipids and Inflammatory Markers
The goal of this study is to assess the effects of a dietary supplement on fasting lipoprotein lipids and a marker of inflammation in men and women with levels of low-density lipoprotein cholesterol above desirable levels.
- Trial name
- NCT03118583
- Testing
- 300 mg/day of dietary supplement containing carrageenan
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Midwest Center for Metabolic and Cardiovascular Research
Unconscious, Inflammation
Volume Kinetics for 20% Albumin in Different Clinical Situations
The study aims to determine the degree of plasma volume expansion and the half-life of the plasma volume expansion when 3 mL/kg of hyperoncotic (20%) albumin if infused over 30 minutes in conscious healthy volunteers, in patients…
- Trial name
- Albumin (NCT02556580)
- Testing
- Albumin 20%
- Where
- 2 sites in Sweden
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sodertalje Hospital
Fasting
Effects of Prolonged Fasting on Microbiome and HDL
Participants will undergo one day of habitual eating followed by 36 hours of water only fasting and final day of habitual eating of the exact same diet consumed on the first eating day.
- Trial name
- NCT03487679
- Testing
- Fasting
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Muscular Injury
Turmeric and Exercise-Induced Muscle Damage and Oxinflammation
The purpose of this study is to measure the effect of using a turmeric-based supplement for 2-weeks on muscle damage and soreness that occur in the body after 90-minutes of exercise.
- Trial name
- NCT04765527
- Testing
- Turmeric Strength for Joint
- Where
- United States
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Appalachian State University
Preterm Birth
Study of Cervix and Inflammation in Preterm Birth Prediction
Preterm birth rate is 7.2% in Quebec, it's risen worldwide in the past decade and it's the leading cause of perinatal mortality and morbidity. Preterm birth is a major public health problem.
- Trial name
- COLIBRI (NCT01007513)
- Testing
- Transvaginal ultrasound, Vaginal secretion sampling
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Low Back Pain
Serum Cytokine Levels in Patients with Lumbal Disc Herniation and Effectiveness of Exercise
The aim of the study is to investigate serum cytokine levels and the efficacy of lumbar stabilization exercises in patients with lumbar disc herniation with and without neurological deficits.
- Trial name
- NCT04912388
- Testing
- Lumbal stabilization excercises, Conventional exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Periodontitis, Peri-Implantitis
Periodontitis and Inflammation
Today, to understand pathogenic mechanisms involved in periodontitis and peri-implantitis remains a challenge to identify biomarkers or therapeutic targets to improve prevention and screening, as well as the effectiveness of…
- Trial name
- CB-PARO (NCT04831060)
- Testing
- Periodontal or peri-implantitis treatment, Control treatment
- Where
- 2 sites in France
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Inflammation, Obesity
Systemic and White Adipose Tissue Inflammatory Profile in Lean Versus Obese Individuals
This study will compare the systemic and white adipose tissue inflammatory profile of individuals who are classified as lean and obese.
- Conditions
- Inflammation, Obesity, Inflammatory Response, Cardiovascular Risk Factor
- Trial name
- NCT04078776
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Septic Shock
Alterations of the Renin-angiotensin-aldosterone System in sEptic Shock
Septic shock is a common and life-threatening condition associated with an in-hospital mortality rate exceeding 40%. The symptomatic management of septic shock relies primarily on vasopressor therapy, particularly norepinephrine.
- Trial name
- ARES (NCT07721974)
- Testing
- Collection of fluid samples
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HIV, Cannabis
Effects of Cannabidiol and Tetrahydrocannabinol on Microbiome and Neuroinflammation in HIV
This study has the potential to contribute to a more complete understanding of the independent and combined effects of cannabis use and HIV on the brain and on inflammation.
- Conditions
- HIV, Cannabis, THC, Neuroinflammatory Disease
- Trial name
- CAMI (NCT05514899)
- Testing
- THC, CBD
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
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