Clinical trials: Inflammation
Hypertension, Hyperlipidemias
Clinical Trials of Two Helichrysum Infusions in Adults
The study evaluates the effects of Helichrysum italicum and Helichrysum Arenarium on different components of the metabolic syndrome.
- Conditions
- Hypertension, Hyperlipidemias, Inflammation, Hyperglycemia
- Trial name
- SMILJ (NCT04866628)
- Testing
- Helichrysum italicum infusion, Helichrysum arenarium
- Where
- Slovenia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Primorska
Overweight
ENDOCUR - Modulation of Endotoxaemia Via Curcumin Intake in Healthy Overweight Adults
Chronic diseases such as diabetes, cardiovascular diseases and cancer are a major burden on the Scottish population. Obesity and inflammation have strong links to these diseases.
- Trial name
- ENDOCUR (NCT03329781)
- Testing
- BCM-95
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
The Focus of the Study is to Monitor MRI Signal Changes and Inflammatory Biomarkers With Use of Aspirin in Patients With Unruptured Cerebral Aneurysm
Aspirin Attenuates Inflammation in Human Cerebral Aneurysms
Hypothesis: aspirin attenuates inflammation in cerebral aneurysms and hence reduces the incidence of rupture. This effect can be monitored using the signal generated by macrophages (inflammatory biomarker) in ferumoxytol-enhanced…
- Trial name
- NCT01710072
- Testing
- aspirin
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Venous Thrombosis, Venous Insufficiency
Evaluating the Relationship Between Blood Clotting Disorders, Inflammation, and Obesity in Individuals With Venous Disorders and Post-Thrombotic Syndrome
Venous thrombosis is the development of a blood clot in a vein. Post-thrombotic syndrome (PTS) is a painful condition that can develop following a venous thrombosis in one of the deep veins of the leg.
- Trial name
- NCT00395265
- Where
- United States
- Volunteers
- 2,211 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Cutaneous Inflammation
Skin Barrier Dysfunction and the Role of Skin Barrier Restoration
The objective of this exploratory study is to gain an understanding of cutaneous and systemic inflammation and how restoration of the skin barrier through the use of moisturizer may restore the skin barrier function and reduce…
- Trial name
- NCT03728569
- Testing
- Vanicream Moisturizing Skin Cream, Vanicream Cleansing Soap
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Elite Athlete, Healthy
Longitudinal Follow-up of High School Athletes
In this study the investigators will study the lung function and airway inflammation in elite athletes starting at the elite sport school (age: 12-13 year) and the change in lung function parameters and airway inflammation after…
- Trial name
- NCT02432183
- Where
- Belgium
- Volunteers
- 134 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Neonatal Sepsis, Neonatal Infection
Infection, Sepsis and Meningitis in Surinamese Neonates
Suriname is a small developing country in South America with a population of half a million people. Early neonatal death in Suriname is high with 16 per 1000 live births.
- Conditions
- Neonatal Sepsis, Neonatal Infection, Neonatal Meningitis
- Trial name
- InSepSur (NCT02486783)
- Where
- Suriname
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Academic Hospital Paramaribo
Cardiovascular Diseases, Vasodilation
Effects of n-3 Polyunsaturated Fatty Acids and Antioxidants on Postprandial Hyperlipidemia and Vascular Function in Men
Diet has long been used as a way to provide enough nutrients to an individual in order to meet metabolic requirements. However, recent scientific advancements have suggested that beyond meeting nutrition needs, diet may also be…
- Trial name
- NCT00296595
- Testing
- Nutrition
- Where
- Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Laval University
Endotoxemia, Sepsis
Determining the Fingerprint of Endotoxin Tolerance
An explorative, prospective study in 100 healthy volunteers who will be challenged with endotoxin twice to identify SNPs and transcripts that are associated with the degree of endotoxin tolerance
- Conditions
- Endotoxemia, Sepsis, Systemic Inflammation, Immunosuppresion
- Trial name
- 100LPS (NCT06801873)
- Testing
- Endotoxin (E. coli O:113, Reference Endotoxin)
- Where
- Netherlands
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Leukocytosis, Triglycerides
Acute High Fat Bulletproof Coffee vs Black Coffee on Metabolism, Inflammation and Cognitive Function in Healthy Adults
This study will determine whether acute ingestion of a high fat "Bulletproof Coffee" will lead to changes in plasma triglycerides, immune cell function, as well as cognitive function when compared to a black coffee.
- Conditions
- Leukocytosis, Triglycerides, Cognitive Function, Inflammatory Response
- Trial name
- NCT04307979
- Testing
- High-fat coffee, Black coffee
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Morbid Obesity
Effects of Morbid Obesity and Bariatric Surgery on Brain Inflammation, and Activation of Central Reward System
Background: The investigators have found that obesity and insulin resistance result in significantly increased brain insulin-stimulated glucose uptake, whereas in every other tissue glucose uptake is lower in the obese compared…
- Trial name
- BARIBRAIN (NCT04343469)
- Testing
- Bariatric Surgery (RYGB or LSG)
- Where
- 2 sites in Finland
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Turku University Hospital
Periodontal Inflammation
The Periodontal Status and Failure Rates With Different Retainer Bonding Techniques Using One-step Adhesive
The aim of this study was to evaluate fixed retainers, bonded with either direct or indirect techniques using one- or two-step adhesives, in terms of periodontal status and failure rates.
- Trial name
- NCT05458583
- Testing
- Baseline periodontal measurements (T0), Periodontal measurements (T1), Periodontal measurements (T2)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Obesity, NAFLD
Effects of Two Different Exercise Programs and Diet in Obese Subjects With NAFLD
The aim of the study is to estimate the effectiveness of two different exercise programs combined with the Mediterranean diet versus diet alone on inflammatory status in subjects aged 18-65 years with obesity (BMI>30) and…
- Trial name
- Obesity_AF (NCT06186869)
- Testing
- Aerobic Exercise and diet intervention, Hiit and diet intervention, Diet
- Where
- Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera Specializzata in Gastroenterologia Saverio de Bellis
Cognitive Impairment, Alzheimer Disease, Early Onset
Juice Plus Supplement Clinical Trial
The study is designed to determine whether encapsulated fruit and vegetable juice concentrates can improve biological indicators of cognitive and multiple dimensions of memory and learning.
- Conditions
- Cognitive Impairment, Alzheimer Disease, Early Onset, Mild Cognitive Impairment
- Trial name
- NCT04656860
- Testing
- Juice Plus+
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Alabama, Tuscaloosa
Obesity, Metabolic Diseases
Fibrosis a New Pathological Actor in Adipose Tissue
Adipose tissue (AT) has specific alterations in obesity in particular increased fibrosis amount compared to lean subjects. Fibrosis amount measured by immunohistochemistry on adipose biopsies appears to to predict weight loss…
- Conditions
- Obesity, Metabolic Diseases, Fibrosis, Body Weight
- Trial name
- fibrota (NCT01655017)
- Testing
- biopsy
- Where
- 2 sites in France
- Volunteers
- 281 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depression / Major Depressive Disorder
Biomarkers and Pharmacogenomics for Precision Depression Therapy
Background: The clinical management of major depressive disorder (MDD) is hampered by the lack of objective biomarkers and high inter-individual variability in drug response, with conventional antidepressants achieving only a 50%…
- Trial name
- NCT07738497
- Testing
- Pharmacogenomic Testing, Antidepressant Agents
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- The Fourth Affiliated Hospital of Zhejiang University School of Medicine
Pregnancy
Effect of Mother's Supplementation Omega-3 in the Dynamics of Fetal Ductus Arteriosus: a Randomized Clinical Trial.
The effect of anti-inflammatory substances on the dynamics of the fetal ductus arteriosus is well documented, but the anti-inflammatory property of polyunsaturated fatty acid omega-3 about changing this dynamic is not…
- Trial name
- NCT02565290
- Testing
- Omega 3, Soy Oil
- Where
- Brazil
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Instituto de Cardiologia do Rio Grande do Sul
Sepsis
Lactate Metabolism After an Endotoxin Challenge in Healthy Humans
Sepsis is characterized by hyperlactatemia, the severity of which is proportionate with sepsis severity. The pathophysiological mechanisms (increased lactate production vs decreased lactate utilization; tissues involved in…
- Trial name
- NCT01647997
- Testing
- bacterial endotoxin challenge
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Immune Response, Upper Respiratory Tract Infection
Walnut and Immunity Study
The main objective of the study is to determine if eating walnuts enhances immune function, in older free-living men and postmenopausal women with overweight.
- Trial name
- walnutimmune (NCT05915390)
- Testing
- walnuts, Habitual diet
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Psoriasis, Aging
Effects of Tildrakizumab on Epigenetic Age
Design: Single-center open-label clinical trial. Objective: Evaluate if tildrakizumab reverses peripheral blood leukocyte DNA methylation (epigenetic aging) observed in chronic psoriasis. Number of subjects: 30.
- Conditions
- Psoriasis, Aging, Epigenetic Disorder, Inflammation; Skin
- Trial name
- NCT05110313
- Testing
- TILDRAKIZUMAB
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Carlos Wambier
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