Clinical trials: Inflammation
Hypoxia, Altitude
The Impact of Physical Training Under Normobaric Hypoxia on Oxidative Stress Level, Inflammatory State, Intestinal Damage, and Mitochondrial Metabolism in Young Males
Cognitive assessment of the influence of a 4-week proprietary training program under normobaric hypoxia conditions on the levels of inflammatory markers, disturbances in prooxidant-antioxidant balance, degree of intestinal…
- Trial name
- NCT06204731
- Testing
- Exercise and environmental conditions
- Where
- Poland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University School of Physical Education, Krakow, Poland
Sepsis
The Effect of rTEM in the Prognosis and Severity of Sepsis Induced ARDS
To observe the changes of plasma rTEM levels in patients with sepsis, sepsis induced ARDS, and to explore its clinical significance.
- Trial name
- NCT06063707
- Testing
- Taking peripheral blood
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Southeast University, China
Stress, Psychological, Inflammation
Bringing the Practice of Mindfulness Into Nature - Preventing Mental Fatigue in Healthcare Professionals.
The purpose of the study is to determine whether a five day mindfulness retreat in nature can increase measures of attention and self-compassion, and reduce stress among bachelor students at Danish Universities and University…
- Conditions
- Stress, Psychological, Inflammation, Stress, Physiological
- Trial name
- NCT02867657
- Testing
- Mindfulness
- Where
- 2 sites in Denmark
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- VIA University College
Psychological Stress, Depression - Major Depressive Disorder
The Effect of Mindfulness in Inflammation Markers (MLR, NLR, PLR), Stress, Anxiety, and Depression Rate Among Survivors of Tidal Flooding in Sayung Demak
Tidal flood disasters in coastal areas cause chronic psychological stress due to economic, social, and residential disruption. Psychological stress is closely linked to systemic inflammatory responses-marked by elevated…
- Conditions
- Psychological Stress, Depression - Major Depressive Disorder, Anxiety, Post-traumatic Stress Symptoms
- Trial name
- NCT07796919
- Testing
- Mindfulness Body Scan
- Where
- Indonesia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Natalia Dewi Wardani, MD
Type 2 Diabetes, Obesity
Examination of the Anti-inflammatory and Insulin Sensitizing Properties of Doxycycline in Humans
Obesity is a heightened state of inflammation in which production of cytokines and matrix metalloproteinases (MMPs) result in loss of function of insulin receptors and insulin resistance.
- Trial name
- DOXY (NCT01375491)
- Testing
- Doxycycline
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Eye Manifestations
Ocular Surface Changes in Patients With Cystic Fibrosis
Cystic fibrosis(CF) is an inherited disease affecting children, adolescents and young adults with dysfunction of secretory glands.It is caused by mutations in the protein-coding gene which function as the cystic fibrosis…
- Trial name
- NCT00345280
- Testing
- impression cytology, obtain the tear fluid
- Where
- Poland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Bialystok
Dysbiosis, Endotoxemia
Gut-level Antiinflammatory Activities of Green Tea in Metabolic Syndrome
This study evaluates dietary green tea extract to improve gut health and inflammation in persons with metabolic syndrome and healthy adults.
- Conditions
- Dysbiosis, Endotoxemia, Metabolic Syndrome, Inflammation
- Trial name
- NCT03973996
- Testing
- Green Tea Extract
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Skeletal Muscle Damage, Exercise-induced Aseptic Inflammation
NAC Supplementation and Soccer Specific Performance
In this investigation the investigators utilized NAC supplementation to boost GSH availability during an one-week-microcycle consisting of three soccer games, in order to test the hypotheses that: i) antioxidant supplementation…
- Conditions
- Skeletal Muscle Damage, Exercise-induced Aseptic Inflammation, Skeletal Muscle Performance, Antioxidant Status
- Trial name
- NCT04523675
- Testing
- N-acetylcysteine
- Where
- Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Thessaly
Skin Photoaging, Inflammation and Skin Pathogenic Bacteria
The Effect of Pomegranate on Aging and Inflammation of the Skin
The purpose of this study is to determine the efficacy of pomegranate extract and pomegranate juice on skin inflammation and aging.
- Trial name
- PomSkin (NCT02258776)
- Testing
- Pomegranate Extract, Pomegranate Juice
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Arthritis, Rheumatoid, Inflammatory Response
Postprandial Inflammation in Rheumatoid Arthritis
Patients with RA will be studied to see whether meals of different content will affect inflammation and metabolic variables in the postprandial state.
- Conditions
- Arthritis, Rheumatoid, Inflammatory Response, Dietary Exposure, Diet, Healthy
- Trial name
- PIRA (NCT04247009)
- Testing
- Meal based on red meat, fish products or vegan products, Meal based on red meat
- Where
- Sweden
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Diet, Healthy
The Effects of Dietary Fibres on Metabolic Health and the Gut Microbiome
The study involves intake of dietary supplements, which are commonly found in the UK diet (not pharmacological agents) to test their effects on inflammation in the body and gut microbiome composition.
- Conditions
- Diet, Healthy, Systemic Inflammatory Response
- Trial name
- NCT06580132
- Testing
- Pectin, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Elizabeth Simpson
Inflammation
Effects of Adding Chickpeas to the American Diet on Fecal Microbiota Composition and Markers of Inflammation
This prospective study will assess the effects of adding legumes, especially chick peas, to the diet of healthy adults on the commensal bacteria from feces of human subjects and resulting self-reported GI symptoms as well as…
- Trial name
- NCT02375347
- Testing
- Chickpea Enhanced Diet (Short term)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Florida
Neonatal SEPSIS
Pre-delivery Administration of Azithromycin to Prevent Neonatal Sepsis & Death
Though maternal and neonatal health are high priority areas for international development, maternal and neonatal mortality remain unacceptably high.
- Trial name
- PregnAnZI-2 (NCT03199547)
- Testing
- Azithromycin
- Where
- 2 sites in Burkina Faso, The Gambia
- Volunteers
- 11,985 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Cystic Fibrosis
Blood Flow and Vascular Function in Cystic Fibrosis
Cystic fibrosis (CF) has many health consequences. A reduction in the ability to perform exercise in patients with CF is related to greater death rates, steeper decline in lung function, and more frequent lung infections.
- Trial name
- CF-FLOW (NCT02057458)
- Testing
- Sildenafil (Acute-1 hour), Sildenafil (Subchronic-4 weeks)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Augusta University
Positron-Emission Tomography, Alzheimer's Disease
Evaluation of ZK 6032924 in Probable Alzheimer's Disease Patients Versus Healthy Volunteers and the Radiation Dosimetry of ZK 6032924 in Healthy Volunteers
PET (positron emission tomography) imaging with BAY85-8101 (ZK 6032924) in patients with Alzheimer's Disease compared to healthy volunteers.
- Trial name
- NCT01035164
- Testing
- F-18 FEDAA1106 (BAY85-8101)
- Where
- 3 sites in Netherlands, Sweden
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Bayer
Bronchiolitis Obliterans
Lung Function, LCI, Bronchial Inflammation and Epigenetics of Patients With BO
Bronchiolitis obliterans is a chronic disease in which a persistent inflammatory process leads to obliteration of the small airways.
- Trial name
- FRABO-03 (NCT02627833)
- Testing
- observation
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Muscle Composition, Sarcopenia
Effects of Increased, Egg-Based Protein Intake on Muscle Composition,
This study is designed to assess the effect of a diet-controlled nutrition program utilizing an egg-based higher protein diet on muscle composition and size, and indices of metabolic health and markers of systemic inflammation in…
- Conditions
- Muscle Composition, Sarcopenia, Hypertrophy, Inflammation
- Trial name
- S25 (NCT01396915)
- Testing
- Dietary Protein Intake
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Purdue University
Blood Pressure, Lung Function
The Use of Air Cleaners to Mitigate Cardiopulmonary Health Impact of Indoor Exposure to Particles and Phthalates
This study aims to evaluate whether a short-term intervention strategy using air cleaner reduces indoor exposure to airborne particles (particulate matter with an aerodynamic diameter ≤2.5μm, PM2.5) and phthalates and improves…
- Conditions
- Blood Pressure, Lung Function, Inflammation, Oxidative Stress
- Trial name
- NCT03500614
- Testing
- Air cleaner use method 1, Air cleaner use method 2
- Where
- China
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Peking University
Dry Eye Syndrome, Sjogren's Syndrome
Dry Eye Syndrome, Healthy Control, Sjögren's Syndrome and Other Inflammation Disease in Taiwan Biobank
The comprehensive analysis of health records, TCM constitution, biomarker, and whole-genome sequencing among dry eye syndrome, healthy control, Sjögren's syndrome and other inflammation disease in Taiwan: an integrated analysis…
- Conditions
- Dry Eye Syndrome, Sjogren's Syndrome, Healthy Control, Inflammation
- Trial name
- NCT03938207
- Testing
- Whole-genome genotyping, Whole-genome sequencing, TCM pattern
- Where
- Taiwan
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Inguinal Hernia
Inflammatory Response: General vs Spinal Anesthesia
Objective: This study aimed to compare the effects of general and spinal anesthesia on the inflammatory response by measuring intercellular adhesion molecule-1 (ICAM-1), P-selectin (SELP), and thrombomodulin (TM) levels in…
- Trial name
- NCT07567534
- Testing
- inflammatory response during inguinal hernia repair.
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sezen Kumaş Solak