Clinical trials: Inflammation
Intraocular Inflammation
A Comparison of 0.5% Loteprednol Etabonate Versus 1% Prednisolone Acetate Following Cataract Surgery
Patients are routinely given steroid eye drops following cataract surgery. This study will compare 2 approved drops:Loteprednol Etabonate versus Prednisolone Acetate Eye drops used following cataract surgery.
- Trial name
- NCT01384266
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Associated Eye Care, Minnesota
Malaria
Impact of Antimalarial Treatment on Measures of T Cell Suppression/Regulation in Healthy Adults From Doneguebougou, Mali
Background: Malaria is a disease that affects many people in the country of Mali and other parts of Africa. It is caused by germs that are spread by mosquito bites.
- Trial name
- NCT02659566
- Where
- Mali
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Peridontal Disease, Periodontal Inflammation
Analysis of the Impact of Contemporary Subgingival Debridement Techniques on Immunological Biomarkers in Gingival Crevicular Fluid
AIM: This prospective clinical study aimed to evaluate the efficacy of two distinct non-surgical periodontal therapy modalities in patients diagnosed with Stage 1 and Stage 2 periodontitis.
- Conditions
- Peridontal Disease, Periodontal Inflammation, Periodontitis, Adult
- Trial name
- NCT07243145
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Selcen Ozcan Bulut
Quorum Sensing, Prebiotics
Biological Modulation of Bacterial QSSMs, Innate and Adaptive Immunity by Antibiotics, Probiotics and Prebiotics in Healthy Individuals
It has recently been discovered that bacteria are able to communicate using specialised molecules known as Quorum Sensing Signalling Molecules (QSSMs).
- Conditions
- Quorum Sensing, Prebiotics, Probiotics, Sepsis
- Trial name
- NCT01201577
- Testing
- Bifidobacterium longum BB536, Active hexose correlated compound (AHCC), Bifidobacterium longum BB536 and Active hexose correlated compound (AHCC)
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Trauma, Sepsis
Prediction Study of Complications After Severe Trauma
The purpose of this study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of post-traumatic complications in a multicenter sample of severe trauma patients.
- Conditions
- Trauma, Sepsis, Multiple Organ Dysfunction Syndrome
- Trial name
- PSCAT (NCT01713205)
- Where
- 6 sites in China
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Jiang Jianxin
Inflammation
Role of Adenosine in the Release of VEGF and Cytokines
The purpose of this study is to extend previous observations in animal models regarding the effects of adenosine in the release of cytokines to human subjects. We intend to accomplish this in two study protocols.
- Trial name
- NCT00580905
- Testing
- Adenosine, Sodium Nitroprusside
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Empyema, Pleural, Parapneumonic Effusion
Management of Pleural Space Infections
Currently, there is no high-quality evidence comparing the clinical outcomes and cost effectiveness of surgical drainage combined with antibiotics versus dual-agent intrapleural fibrinolytic therapy (IPFT) catheter drainage of…
- Trial name
- NCT03873766
- Testing
- Intrapleural Medications, Surgery, Pleural Sampling
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Swedish Medical Center
Chronic Obstructive Pulmonary Disease, Endothelial Dysfunction
Endothelial Dysfunction and Chronic Obstructive Pulmonary Disease
The purpose of this study is to investigate the role of endothelial dysfunction in chronic obstructive pulmonary disease.
- Trial name
- NCT02092675
- Where
- Croatia
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Andrea Vukic Dugac
Obstructive Sleep Apnea Syndrome
Inflammatory Markers in Infants With Obstructive Sleep Apnea
Obstructive sleep apnea syndrome (OSAS) is a common disorder in children (2-3%). OSAS in turn, is associated with significant behavioral, learning, and heart problems.
- Trial name
- NCT01058590
- Where
- Israel
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
Neonatal SEPSIS
Safety and Efficacy of Oral Bovine Lactoferrin
Oral lactoferrin versus Placebo will be given to preterm neonates
- Trial name
- Lactoferrin (NCT04094597)
- Testing
- Lactoferrin
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cairo University
Sleep, Stress
The Effects of a Nutrition Supplement on Health Related Quality of Life
The purpose of this study is to evaluate the health related benefits of a superfoods nutrition supplement on health related quality of life.
- Conditions
- Sleep, Stress, Health, Subjective, Inflammation
- Trial name
- NCT04499560
- Testing
- Supplement Drink
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Nutraceuticals Research Institute
Embolism and Thrombosis, Infection
Evaluation of the LumiraDx Point of Care D-Dimer and CRP Tests
A Multicenter Study Conducted to Evaluate the Agreement between Fingerstick Whole Blood, Venous Whole Blood and Plasma Determined on the LumiraDx Point of Care D-Dimer and Point of Care CRP Tests to Results on the Reference…
- Conditions
- Embolism and Thrombosis, Infection, Inflammation
- Trial name
- NOVEL-3 (NCT04375982)
- Testing
- Venepuncture, Fingerstick
- Where
- 4 sites in United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- LumiraDx UK Limited
Obesity, Aging
Obesity, Inflammation and Aging: Effects of Physical Exercise and Omega-3 Fatty Acids.
Dysfunction of adipose tissue in obesity, inflammation and aging: mechanisms and effects of physical exercise and omega-3 fatty acids.
- Conditions
- Obesity, Aging, Inflammation
- Trial name
- OBELEX (NCT03300388)
- Testing
- Omega-3 (DHA-rich dietary supplement), Resistance training
- Where
- Spain
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Gut Microbiomes
Grape Impact on Human Gut Microbiome
This is a bio-specimen analysis and dietary intervention study that will examine whether the daily consumption of California table grape powder significantly modulates the gut microbiome and systemic immune profiles in healthy…
- Trial name
- NCT07797803
- Testing
- Grape Powder
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Microplastics, Nanoplastics
Micro and Nanoplastics in Greenhouse Workers: Biomarkers of Exposure and Effect
MNPLs effects on human health are still preliminary. Workers exposed to plastic residues are exposed constantly to MNPLs. One of these jobs corresponds to greenhouse workers, that could be considered as a population highly…
- Conditions
- Microplastics, Nanoplastics, Genotoxic Damage, Inflammation
- Trial name
- NCT05910489
- Testing
- Biomonitoring of MNPLs in biological samples of greenhouse workers and controls
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Ricard Marcos
SIRS, Sepsis
Evaluation of CDSS in Detection of SIRS and Sepsis in Pediatric Patients
This trial aims to evaluate the accuracy of a Clinical Decision-Support System to support early recognition of SIRS in paediatric intensive care patients.
- Conditions
- SIRS, Sepsis, Pediatric SIRS
- Trial name
- CADDIE2 (NCT03661450)
- Testing
- Clinical Decision-Support System
- Where
- Germany
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Inflammation
An Open-Label Pilot Study of Qualia Senolytic Supplementation for the Attenuation of Systemic Inflammatory Cytokines
This open-label pilot study includes adults aged 45 to 79 residing in the United States. The study will last 7 days. Participants will provide blood samples via an at-home finger-prick kit at baseline and day 7 and complete…
- Trial name
- NCT06953518
- Testing
- Qualia Senolytic
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Qualia Life Sciences
Sepsis
Effect of Renin-Angiotensin System on Platelet in Patient With Sepsis
As a common and serious medical condition , sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection , which is a major and familiar cause of death in intensive care units(ICU).
- Trial name
- ERASPPWS (NCT03952390)
- Testing
- control, sepsis
- Where
- China
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Atherosclerosis, Obesity
Vascular Inflammation Stratified by Body Size Phenotype
Vascular Inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18FDG-PET is a promising novel tool for identifying and quantifying vascular inflammation within atherosclerotic plaque Recently…
- Conditions
- Atherosclerosis, Obesity, Metabolic Syndrome
- Trial name
- NCT01979068
- Where
- South Korea
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Korea University
Crohns Disease, Pregnancy
Pregnant Women With and Without Crohns Disease to Explore the Role of Plastics and Toxins in Intestinal Inflammation
The PLANET Study aims to determine the impact of microplastics on intestinal inflammation and gut microbiome in order to understand the role of this pollutant on the risk of developing inflammatory bowel disease (IBD) as well as…
- Conditions
- Crohns Disease, Pregnancy, Inflammatory Bowel Disease
- Trial name
- PLANET (NCT06001450)
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
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