Clinical trials: Inflammation
Aging
Effects of Glycoxidative Stress on Human Aging
Advanced glycation products or AGEs are a heterogeneous group of molecules formed by exposure of tissue constituents to high levels of reducing sugars, e.g. glucose.
- Trial name
- NCT00579774
- Testing
- Low AGE Diet, Regular Diet
- Where
- United States
- Volunteers
- 438 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Acute Appendicitis, Abscess
Water And Saline Head-to-head In The Blinded Evaluation Study Trial
Patients who are diagnosed with acute appendicitis consented and then randomized into two arms of the trial. In one arm, patients receive irrigation of the abdomen during surgery with normal saline, or salt water.
- Trial name
- WASHITBEST (NCT02714023)
- Testing
- Normal Saline, Sterile Water
- Where
- United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Inflammatory Status, P-cresol
HFR Cartridge and Inflammation
A major limitation of standard hemodialysis is that it does not clear the plasma from interleukin-6 (IL-6) and p-cresol, two uremic toxins responsible for the high cardiovascular risk in end stage renal disease (ESRD).
- Trial name
- HFR (NCT01865773)
- Testing
- HFR dialysis
- Where
- Italy
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Federico II University
Inflammation, Frailty
Improving Physical Function in Older Adults Using an Anti-inflammation Drug: The RIGHT Study
The goal of this clinical trial is to learn about the effects of inflammation-lowering therapy on mobility and disability in older adults.
- Trial name
- RIGHT (NCT05727384)
- Testing
- Clazakizumab
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Anne B. Newman
Healthy
Effect of MOF on Exercise Blood Pressure
The purpose of this study is to establish an effect of monomeric and oligomeric flavanols supplementation on exercise blood pressure and vascular function in healthy volunteers.
- Trial name
- NCT04907097
- Testing
- Monomeric and oligomeric flavanols
- Where
- Netherlands
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Endotoxemia, Sepsis
Anti-inflammatory Effects of GTS-21 After LPS
Rationale: The vagus nerve exerts an anti-inflammatory effect in in vitro and animal experiments. This 'vagal anti-inflammatory pathway' is mediated by the nicotinergic α7nACh receptor that can be selectively stimulated by…
- Conditions
- Endotoxemia, Sepsis, Vagal Activity
- Trial name
- NCT00783068
- Testing
- GTS-21, [3-(2,4-dimethoxybenzylidene)-anabaseine dihydrochloride], Lipopolysaccharide E. Coli 113:H 10:K negative
- Where
- Netherlands
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Healthy Participants
SP16 SERPIN-like Peptide Administration in Healthy Individuals
This study is a randomized, double-blind, placebo-controlled Phase 1 Clinical Trial of 24 healthy individuals to test the safety, tolerability and pharmacokinetics of a single subcutaneous administration of Serpin Peptide 16…
- Trial name
- NCT03651089
- Testing
- SP16
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Serpin Pharma, LLC
Healthy
Normative State and Variation in Growth, Hematology, Hydration, Oxidation, Infection, Inflammation, Guatemalan Children
This study will provide the researchers with an opportunity for the investigation of the biomarkers and different human biology component variable interactions in children; information that can generate new correlations between…
- Trial name
- NCT02203890
- Where
- Guatemala
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- María José Soto
Post-stroke Cognitive Impairment, Neuroinflammation
The Influence of [18F]PMPBB3 and [18F]THK5351 PET Distribution Patterns on Post-stroke Cognitive Impairment
Background and objects： Neuroinflammation is an active process detectable in the earliest stages of the neurodegeneration pathway.
- Trial name
- NCT04318626
- Testing
- PMPBB3, THK5351
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Age-Related Macular Degeneration
The Role of Inflammation in AMD and Related Disorders
This prospective, non-therapeutic study will compare the relative utility of multiple ocular imaging modalities in the detection of the cellular immune response in patients with AMD and related disorders.
- Trial name
- NCT02588378
- Testing
- multi-modal cSLO imaging
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Inflammation
Metabolic and Immune System Responses to a Mixed Meal
Overweight and obesity are major problems and their complications such as cardiovascular disease and type 2 diabetes mellitus pose great burdens on healthcare systems.
- Trial name
- NCT02416843
- Testing
- Consumption of a mixed meal
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Bath
Periodontal Diseases, Inflammation
Kynurenine Pathway in Parkinson's Disease
Parkinson's disease is a slowly progressing disease that affects the motor and non-motor functions of an individual. Periodontitis is an inflammatory chronic disease resulting in the destruction of tooth supporting structures.
- Trial name
- NCT07272564
- Testing
- Saliva and serum sampling, Saliva, serum and GCF sampling
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medipol University
Obstructive Sleep Apnea
Obstructive Sleep Apnea in World Trade Center Responders
The goal of the study is to examine the possible underlying causes of sleep apnea (a disorder in which there are problems with breathing during sleep) in World Trade Center Responders.
- Trial name
- NCT01753999
- Testing
- Standard CPAP, CPAP - Flex
- Where
- 3 sites in United States
- Volunteers
- 317 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Acute Intermittent Porphyria
Dental Health, Diet, Inflammation and Biomarkers in Patients With Acute Intermittent Porphyria(AIP)
Acute intermittent porphyria (AIP) is an autosomal dominant inherited disease, which is relatively prevalent in northern Norway with a total of around 90 patients. This provides us with a special opportunity to study AIP.
- Trial name
- NCT01617642
- Where
- Norway
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nordlandssykehuset HF
Metabolic Syndrome X
Soy Protein Intake and the Metabolic Syndrome
Soy protein has a high biological value, and contains several potential health-related nutritional factors, i.e. its amino acids pattern, biological active peptides and non-protein compounds such as isoflavones.
- Trial name
- SOY (NCT01694056)
- Testing
- Soy protein diet, Control diet
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Periodontal Inflammation
The Periodontal Status and Failure Rates With Different Retainer Bonding Techniques Using One-step Adhesive
The aim of this study was to evaluate fixed retainers, bonded with either direct or indirect techniques using one- or two-step adhesives, in terms of periodontal status and failure rates.
- Trial name
- NCT05458583
- Testing
- Baseline periodontal measurements (T0), Periodontal measurements (T1), Periodontal measurements (T2)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Overweight, Obesity
Can We Achieve 'high-quality' Weight Loss Through Supplementation and Exercise? the TRIM MUSCLE Study
The purpose of this study is to determine whether the combination of two dietary supplements: MUSCLE 5, which contains protein, creatine and vitamin D and TRIM 7, which contains beet extract, caffeine, coenzyme Q10, alpha lipoic…
- Trial name
- NCT05384431
- Testing
- Muscle5 and TRIM7, Mixed exercise
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Exerkine Corporation
Non-alcoholic Fatty Liver Disease, Metabolic Syndrome
Role of Immune System in Obesity-related Inflammation and Cardiometabolic Risk
The purpose of this study is to learn more about how the body stores fat in and around organs (for example in the liver) and why this affects some people's health more than others.
- Conditions
- Non-alcoholic Fatty Liver Disease, Metabolic Syndrome, Metabolically Abnormal Obesity, Metabolically Normal Obesity
- Trial name
- NCT01104220
- Testing
- Weight loss
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Peri-implantitis
Surface Decontamination in Treatment of Peri-Implantitis
Peri-implantitis represents a major biological complication of implant dentistry with reported prevalence of up to 47% of implants.
- Trial name
- NCT03114956
- Testing
- Gauze, Titanium brush, Air powder abrasion
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Southern California
Obesity, Diabetes Mellitus
Inflammation, Diabetes, Ethnicity and Obesity Cohort
Obesity affects over one third of US adults (>72 million, with BMI ≥30 kg/m2), and the proportion of US adults with BMI ≥40 kg/m2 has doubled in the last 20 years.
- Conditions
- Obesity, Diabetes Mellitus, Pre Diabetes
- Trial name
- IDEO (NCT03022682)
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
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