Clinical trials: Inflammation Chronic
Sleep Deprivation
A Change in Diet May Decrease the Negative Consequences of Chronic Sleep Deprivation
The purpose of this study is to determine whether or not a low calorie, low glycemic index diet with omega-3 fatty acid supplements can prevent some of the negative consequences of sleep deprivation.
- Trial name
- NCT00123214
- Testing
- Controlled Dietary Intervention
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- St. Vincent's Medical Center
Copd, Obese
COPD in Obese Patients
The study included 176 patients with COPD. The first group included 88 normal weight patients with COPD: 71 men and 17 women, mean age 62.40 ± 8.83 years.
- Conditions
- Copd, Obese, Obesity, Abdominal
- Trial name
- NCT04105075
- Where
- Russia
- Volunteers
- 176 people
- Sponsor
- Voronezh N.N. Burdenko State Medical Academy
Severe Eosinophilic Asthma
Treatment With Mepolizumab on Patients With Severe Refractory Eosinophilic Asthma
Understanding how Interleukin-5 blockade modulates both immune and metabolic pathways may clarify the multidimensional impact of biologic therapy in severe eosinophilic asthma.
- Trial name
- NCT05063981
- Testing
- Mepolizumab
- Where
- 2 sites in Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Healthy
Fisetin Supplementation for Healthy Aging
There is growing interest among the general population in preventive health interventions that can help mitigate age-related decline, reduce the risk of chronic diseases, and promote healthy aging.
- Trial name
- Fisetin LOW (NCT07195318)
- Testing
- Fisetin
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ove Andersen
Cirrhosis, Liver, Acute-On-Chronic Liver Failure
20% Albumin vs. Balanced Salt Solution as Resuscitation Fluid in Cirrhosis With Sepsis Induced Hypotension
Patients with cirrhosis patients have a high incidence of sepsis which can trigger decompensation and may result in prolonged hospital stay and increased mortality.
- Conditions
- Cirrhosis, Liver, Acute-On-Chronic Liver Failure, Shock, Septic, Shock Hypovolemic
- Trial name
- NCT05441878
- Testing
- 20% albumin, Balanced salt solution
- Where
- India
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Chronic Obstructive Pulmonary Disease, Emphysema
Inhaled Steroid Reduces Systemic Inflammation in COPD
Systemic inflammation is present in chronic obstructive pulmonary disease (COPD), which has been linked to cardiovascular morbidity and mortality.
- Conditions
- Chronic Obstructive Pulmonary Disease, Emphysema, Chronic Bronchitis
- Trial name
- NCT00175565
- Testing
- inhaled fluticasone 500 mcg b.i.d.
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- University of British Columbia
Sclerosis, Multiple, Guillain-Barre Syndrome
Expression Profile of ERK5 and PKM2 Kinases in Neuroinflammatory Diseases.
Demyelinating diseases represent a broad spectrum of disorders and are induced by excessive inflammation most often triggered by an autoimmune mechanism.
- Conditions
- Sclerosis, Multiple, Guillain-Barre Syndrome, Inflammation
- Trial name
- NEUROKINASE (NCT04674163)
- Testing
- Blood sample and Cerebrospinal fluid (CSF) collection.
- Sponsor
- Centre Hospitalier Régional d'Orléans
Dry Eye
Clinical Efficacy of Topical Hydrocortisone 0.335% (Softacort®) in Patients With Chronic Dry Eye Disease and Associated Ocular Surface Inflammation
Dry eye disease (DED) is a highly prevalent ocular condition and induces a significant burden to the affected patients. Regardless of the underlying etiology, DED is associated with increased inflammation of the entire ocular…
- Trial name
- NCT03907865
- Testing
- Softacort
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Vienna
Asthma, Chronic Obstructive Pulmonary Disease
Towards Restoring the Physiological Inhibition of Airway Narrowing in Asthma
Asthma and COPD are characterized by airway narrowing. The most potent, physiological mechanism leading to bronchodilation is taking a deep inspiration.
- Trial name
- NCT00279136
- Where
- Netherlands
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Chronic Obstructive Pulmonary Disease (COPD), Chronic Bronchitis
A Phase II, Randomized, Double-blind, Placebo-controlled Study to Assess MEDI3506 in Participants With COPD and Chronic Bronchitis
This is a research study to determine the efficacy and safety of investigational drug MEDI3506 for the treatment of adult participants with Chronic Obstructive Pulmonary Disease and Chronic Bronchitis.
- Trial name
- FRONTIER-4 (NCT04631016)
- Testing
- Tozorakimab
- Where
- 90 sites in United States, Australia and 13 more
- Volunteers
- 137 people
- Sponsor
- AstraZeneca
Periodontal Disease, Chronic Kidney Disease
The Impact Of Periodontal Disease Treatment On The General Health Status In Chronic Haemodialyzed Patients
Several studies revealed a direct relationship between the severity of periodontal inflammation and CRP (NHANES III, Dumitriu HT et al, 1998).
- Trial name
- PAROHEM (NCT01785355)
- Testing
- Dental treatment
- Where
- Romania
- Volunteers
- 30 people
- Sponsor
- Anemia Working Group Romania
End-stage Renal Disease
Nutrition, Inflammation and Insulin Resistance in End-Stage Renal Disease
By 2030 an estimated 2 million people in the US will need dialysis or transplantation. Insulin resistance and chronic inflammation are common in dialysis patients and have been linked to protein-energy wasting, the most important…
- Trial name
- SummerMRI (NCT04067752)
- Testing
- high dialysate sodium concentration (138 mEq/L), Low dialysate sodium concentration
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- VA Office of Research and Development
End Stage Renal Disease
Vitamin D, Insulin Resistance and Inflammation in ESRD
The broad goal of this study is to understand the mechanisms by which Vitamin D receptor activation leads to changes in insulin signaling in advanced uremia.
- Trial name
- NCT00656032
- Testing
- paricalcitol, cinacalcet
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Vanderbilt University
Metabolic Syndrome
Chronic Inflammation and Exercise Responsiveness
The purpose of this study is to determine how chronic inflammation influences skeletal muscle protein metabolism and metabolic function in humans.
- Trial name
- NCT02732509
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Long COVID-19, Long COVID
Effect of Telerehabilitation Practice in Long COVID-19 Patients
The goal of this clinical trial is to test the efficacy of telerehabilitation practice in Long COVID-19 patients. The main question[s] it aims to answer are whether telerehabilitation practice in Long COVID-19 patients help to…
- Conditions
- Long COVID-19, Long COVID, Post COVID-19 Condition, Post-COVID-19 Syndrome
- Trial name
- NCT05817032
- Testing
- Telerehabilitation, Standard rehabilitation care
- Where
- Indonesia
- Volunteers
- 22 people
- Sponsor
- Universitas Indonesia
Type 2 Diabetes Mellitus
Metformin and Pioglitazone Effects on YKL-40 Concentrations in Type 2 Diabetes Patients
Patients with type 2 diabetes are at an increased risk for developing atherosclerosis, largely due to the underlying insulin resistance and chronic low grade inflammation.
- Trial name
- NCT01963663
- Testing
- Metformin, Pioglitazone
- Where
- Iran
- Volunteers
- 84 people
- Sponsor
- Tehran University of Medical Sciences
COPD, Inflammation
Effect of Statin Therapy on C-reactive Protein Levels in Patients With Chronic Obstructive Lung Disease (COPD)
Hypothesis for this pilot study is that simvastatin will lower the levels of CRP and ET-1 in COPD patients.
- Trial name
- NCT00655993
- Testing
- simvastatin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Loma Linda Health Care System
Inflammation
Inflammatory Responses to Acute and Chronic Opioid Exposure in Humans
We aim to examine the extent to which inflammation is affected by acute and chronic opioid exposure.
- Trial name
- NCT01749826
- Testing
- Morphine Sulfate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Stanford University
Pulmonary Disease, Chronic Obstructive, Immunity, Innate
Innate Immune Response in COPD
The purpose of this study is to determine whether the response of the immune system to bacterial components differs between patients with severe COPD compared to those with less severe COPD.
- Conditions
- Pulmonary Disease, Chronic Obstructive, Immunity, Innate, Inflammation, Bronchitis, Chronic
- Trial name
- NCT02637219
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Puget Sound Health Care System
Chronic Obstructive Airway Disease
Effect of Prolonged Decubitus on Nitric Oxide Concentration in Chronic Obstructive Pulmonary Disease
Bronchial obstruction in Chronic Obstructive Pulmonary Disease (COPD) is caused by inflammation of peripheral airways walls. Neutrophils and other inflammatory mediators Interleukin-6 (IL6), Interleukin-8 (IL8), Interleukin-1…
- Trial name
- NCT01555593
- Testing
- Cardioline Exp'air by Medi-soft - Sorinnes (B)
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University of Milan