Clinical trials: Inflammation Chronic
Nervous System Malformations, Arthropathy, Neurogenic
Anakinra to Treat Patients With Neonatal Onset Multisystem Inflammatory Disease
This study will evaluate the safety and effectiveness of anakinra (Kineret) for treating patients with neonatal-onset multisystem inflammatory disease (NOMID), also known as chronic infantile neurological, cutaneous and…
- Conditions
- Nervous System Malformations, Arthropathy, Neurogenic, Urticaria, Papilledema
- Trial name
- NCT00069329
- Testing
- anakinra
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Ulcerative Colitis (UC), Crohn Disease (CD)
Wild Blueberries in Colitis
The goal of this exploratory, prospective, monocentric randomized crossover study is to investigate the influence of a blueberry-rich diet compared to a blueberry-poor diet on the microbiome, the intestinal barrier and the…
- Trial name
- BlueVantage (NCT06698601)
- Testing
- blueberry-rich diet, Control diet
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Universität Duisburg-Essen
Pancreatic Adenocarcinoma, Pancreatic Cysts
Robotic Versus Open Pancreaticoduodenectomy for Pancreatic and Periampullary Tumors
This multicenter randomized trial aims to primarily assess and compare the functional recovery of patients who undergo open versus robotic pancreaticoduodenectomy for benign and malignant lesions of the head of the pancreas.
- Conditions
- Pancreatic Adenocarcinoma, Pancreatic Cysts, Pancreatic Endocrine Tumors, Chronic Pancreatitis
- Trial name
- PORTAL (NCT04400357)
- Testing
- Robotic pancreaticoduodenectomy, Open pancreaticoduodenectomy
- Where
- China
- Volunteers
- 268 people
- Sponsor
- Ruijin Hospital
Congestive Heart Failure Chronic, Atrial Fibrillation (Permanent)
Inflammation, Epigenetics in CHF Patients With AF
the goal of this case-control cross-sectional study is assessing in a cohort of patients with CHF and permanent AF The serum levels of some candidate cytokine variables and their relationship with some selected metabolic…
- Trial name
- NCT07152301
- Where
- Italy
- Volunteers
- 164 people
- Sponsor
- University of Palermo
Chronic Obstructive Pulmonary Disease
Pivotal Study to Assess the Efficacy, Safety and Tolerability of Dupilumab in Patients With Moderate-to-severe COPD With Type 2 Inflammation
Primary Objective: To evaluate the efficacy of dupilumab administered every 2 weeks in patients with moderate-or severe Chronic Obstructive Pulmonary Disease (COPD) as measured by Annualized rate of acute moderate and severe COPD…
- Trial name
- BOREAS (NCT03930732)
- Testing
- Dupilumab SAR231893, Inhaled Corticosteroid, Inhaled Long-Acting Beta Agonist
- Where
- 275 sites in United States, Argentina and 22 more
- Volunteers
- 939 people
- Sponsor
- Sanofi
Cirrhosis, Liver, Sepsis
Volume Resuscitation in Cirrhosis With Sepsis Induced Hypotension
In critically ill patients with liver disease like cirrhosis or ACLF, fluid therapy needs to be instituted after identification of patients who will be fluid responsive and initiate appropriate inotropes early to prevent the…
- Conditions
- Cirrhosis, Liver, Sepsis, Acute on Chronic Liver Failure
- Trial name
- NCT05059795
- Testing
- Albumin + electrolyte solution, POCUS guided fluid resuscitation
- Where
- 2 sites in India
- Volunteers
- 350 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Coronary Artery Diseases
BIOFLOW-III VIP Russia Registry Orsiro Stent System
Clinical evaluation of the Orsiro LESS in subjects requiring coronary revascularization with Drug Eluting Stents (DES). Along with it, an explanatory (hypothesis-finding) problem will be investigated, whether the patient's body…
- Trial name
- NCT02247492
- Where
- 7 sites in Russia
- Volunteers
- 200 people
- Sponsor
- Biotronik Russia
Chronic Infectious Disease, Chronic Skin Disease
Relationships Among Inflammation, Physical and Mental Health in Subjects With Chronic Inflammatory Physical Diseases.
The prevalence of common mental disorders is high in patients with chronic inflammatory physical diseases(e.g., autoimmune or infectious diseases).
- Conditions
- Chronic Infectious Disease, Chronic Skin Disease, Mental Disorders, Psoriasis
- Trial name
- InflaMent (NCT05125458)
- Where
- Italy
- Volunteers
- 93 people
- Sponsor
- University of Campania Luigi Vanvitelli
COPD, Chronic Bronchitis
Regulation of the Release of Inflammatory Mediators From Lung Macrophages.
The aim of this study is to investigate the mechanisms whereby specific white cells called macrophages found in the lung release inflammatory mediators or chemicals together with enzymes that destroy the surrounding lung tissue.
- Conditions
- COPD, Chronic Bronchitis, Emphysema
- Trial name
- NCT00147017
- Where
- United Kingdom
- Volunteers
- 17 people
- Sponsor
- Imperial College London
Spinal Cord Injury, Chronic Inflammation
Impact of Passive Heat on Metabolic, Inflammatory and Vascular Health in Persons With Spinal Cord Injury
SCI results in higher incidence of heart disease and diabetes and heart disease is the most common cause of death. Chronic inflammation, deleterious changes in vascular structure and impaired glucose metabolism are risk factors…
- Conditions
- Spinal Cord Injury, Chronic Inflammation, Glucose Metabolism, Endothelial Function
- Trial name
- SCIPHS (NCT04971408)
- Testing
- passive heat stress, Control
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- VA Office of Research and Development
Bloodstream Infection
GARNET™ Filter (GARNET Device) IDE Used in Chronic Hemodialysis Patients With a Bloodstream Infection
To evaluate the feasibility of performing combined hemodialysis with the GARNET device in chronic hemodialysis patients with a blood stream infection (BSI), and measure clinical performance and safety endpoints.
- Trial name
- NCT04658017
- Testing
- GARNET device
- Where
- 6 sites in United States
- Volunteers
- 15 people
- Sponsor
- Boa Biomedical, Inc.
End-stage Renal Disease
Peroxisome Proliferator-Activated Receptor-Gamma Activation in Peritoneal Dialysis Patients
To study whether peroxisome proliferator-activated receptor-gamma activation in peritoneal dialysis patients will reduce inflammation, atherosclerosis, calcification and improve survival of peritoneal dialysis patients
- Trial name
- PPAR (NCT00745225)
- Testing
- Pioglitazone
- Where
- Hong Kong
- Volunteers
- 160 people
- Sponsor
- The University of Hong Kong
Copd
Assessment of Trace Elements, Systemic Inflammation and Electrolytes
COPD is one of the most common causes of health problems worldwide. It is a disease that is associated with several systemic features that affect its morbidity and mortality.
- Trial name
- NCT05718453
- Testing
- Laboratory Tests
- Where
- Egypt
- Volunteers
- 140 people
- Sponsor
- Egymedicalpedia
Pulmonary Disease, Chronic Obstructive
A Pilot Study of the Mechanism of Synergism Between FP and Salmeterol in Preventing COPD Exacerbations
The purpose of this study is to evaluate the blood and airway of subjects with mild to moderate COPD while undergoing standard treatment.
- Trial name
- NCT00116402
- Testing
- fluticasone and salmeterol
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Chicago
End-Stage Renal Disease
High Flux Hemodialysis Thrice Versus Once
To investigate the influence of different dialysis frequencies on the outcome of end-stage renal disease patients undergoing chronic hemodialysis therapy.
- Trial name
- NCT00714662
- Testing
- high flux hemodialyzer (FX-60, FX-80 or FX-100)
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- National Taiwan University Hospital
COPD, OSA
The Effect of Exercise on Systemic Inflammation in Veterans With COPD and OSA
The overlap syndrome (OS), i.e. the association of both Chronic Obstructive Pulmonary Disease (COPD) and Obstructive Sleep Apnea (OSA) in a single Veteran, is prevalent and associated with increased cardiovascular disease (CVD)…
- Conditions
- COPD, OSA, Home Exercise, Inflammation
- Trial name
- NCT03431103
- Testing
- Exercise
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Salem Veterans Affairs Medical Center
Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Chronic Obstructive Pulmonary Disease (COPD)
Red Blood Cell and Platelet Indices for Predicting Outcomes in Acute Exacerbations of COPD
The purpose of this study is to evaluate if standard, easily accessible blood tests can help doctors predict the severity and outcomes of sudden flare-ups in patients with Chronic Obstructive Pulmonary Disease (COPD).
- Conditions
- Acute Exacerbation of Chronic Obstructive Pulmonary Disease, Chronic Obstructive Pulmonary Disease (COPD), AECOPD
- Trial name
- NCT07693127
- Volunteers
- 50 people
- Sponsor
- Assiut University
Periodontal Inflammation
The Effect of Low-Level Laser Therapy as an Adjunct to Non-surgical Therapy in Different Age Groups
the summary is to evaluate The Effect of Low-Level Laser Therapy as an Adjunct to Non-surgical Therapy on Inducible Nitrous Oxide Synthase Salivary Levels in Different Age Groups of Chronic Periodontitis Patients
- Trial name
- NCT06140394
- Testing
- diode laser, non surgical scaling
- Where
- 2 sites in Egypt
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Statin, Airway Disease
Adjunctive Role of Statin Therapy on Airway Inflammation and Clinical Consequences of Chronic Obstructive Pulmonary Disease
This study aimed to evaluate the impact of statin therapy on the clinical consequences, as well as airway inflammation and radiological features, in severe chronic obstructive pulmonary cases.
- Conditions
- Statin, Airway Disease, Chronic Obstructive Pulmonary Disease
- Trial name
- NCT07549932
- Testing
- Statin, placepo intervention
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mohamed Salah El-Sayed
HIV, Coronary Artery Disease
Metformin for HIV Inflammation
This proposal seeks to assess the impact of 24 weeks of metformin on non-calcified plaques and calcified plaques assessed by coronary CT angiography, and on whether these changes can be explained by metformin-induced phenotypic…
- Trial name
- NCT02383563
- Testing
- metformin extended release
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- University of Hawaii