Clinical trials: Inflammation Chronic
Coronary Artery Disease, Systemic Inflammatory Response
CCTA Coronary Hemodynamics, Systemic Inflammation and Vulnerable Plaques (COHESIVE)
Although there are numerous studies that have demonstrated the impact of systemic inflammation on coronary plaque vulnerability, there are few literature data regarding the influence of coronary plaque localization within the…
- Conditions
- Coronary Artery Disease, Systemic Inflammatory Response, Chronic Coronary Syndrome, Atherosclerosis
- Trial name
- COHESIVE (NCT05488249)
- Testing
- Cardiac imaging tests, Venous blood sample collection
- Where
- Romania
- Volunteers
- 100 people
- Sponsor
- Cardio Med Medical Center
Post-COVID-19 Syndrome, Long COVID
ImPROving Quality of LIFe in the Long COVID Patient
The purpose of this study is to investigate the efficacy of orally administered nirmatrelvir/ritonavir compared with placebo/ritonavir to improve quality of life in non-hospitalized adult participants suffering from post-acute…
- Conditions
- Post-COVID-19 Syndrome, Long COVID, Long Covid19, COVID-19
- Trial name
- PROLIFIC (NCT05823896)
- Testing
- Nirmatrelvir/ritonavir
- Where
- Sweden
- Volunteers
- 219 people
- Sponsor
- Karolinska Institutet
End Stage Renal Disease on Dialysis
Dietary Therapy in Dialysis Patients
Patients with end-stage kidney disease have hyperphosphatemia and accumulated uremic toxin level due to decreased urine excretion ability.
- Trial name
- NCT04505462
- Testing
- Therapeutic diet
- Where
- Taiwan
- Volunteers
- 32 people
- Sponsor
- Far Eastern Memorial Hospital
Pulmonary Hypertension, Primary, 4
Serum Bio-markers in Pulmonary Hypertension
Chronic thromboembolic pulmonary hypertension (CTEPH) is caused by scarred blood clots in the blood vessels supplying the lungs. This in turn leads to failure of the right side of the heart.
- Trial name
- NCT04472533
- Where
- United Kingdom
- Volunteers
- 377 people, healthy volunteers welcome
- Sponsor
- Papworth Hospital NHS Foundation Trust
Breast Pain, Mastalgia
Hormones, Outcomes, and Pain Pathways in Exercise Study
The goal of the proposed project is to evaluate a mechanical intervention (sports bras designed specifically for full busted women) to alleviate neck, shoulder, arm, and back pain in full-busted women and investigate the…
- Conditions
- Breast Pain, Mastalgia, Back Pain, Back Pain, Low
- Trial name
- HOPE (NCT07579182)
- Testing
- Interventional Sports bra
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Houston
Healthy
Impact of Purple Wheat Consumption on Markers of Inflammation and Oxidative Stress in Adults.
The main purpose of this study is to determine the effect of consumption of purple wheat anthocyanin-rich products for eight weeks by human participants with an elevated level of chronic inflammation, on oxidative stress and…
- Trial name
- NCT02840357
- Testing
- Purple Wheat Convenience Bars, Control Wheat Convenience Bars
- Where
- Canada
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Guelph
ESRD
Influence of the PEPA Membrane on the Undernutrition Syndrome Inflammation in Chronic Hemodialysis
NutriPEPA2 is a randomized, single-blind, prospective, multicenter trial, in two parallel arms to confirm that the adsorbent PEPA membrane may decrease mortality related to inflammation and malnutrition encountered in HD or…
- Trial name
- NutriPEPA2 (NCT04185571)
- Testing
- PEPA
- Where
- 12 sites in France, Monaco
- Volunteers
- 106 people
- Sponsor
- Theradial
Chronic Kidney Disease (Stage 3-4)
Effects of Maqui Supplementation on Gut Microbiota, Inflammation, and Oxidative Stress in Patients With Chronic Kidney Disease
Chronic kidney disease (CKD) is a highly prevalent condition in Chile and worldwide and is associated with a substantial burden of morbidity, particularly cardiovascular morbidity.
- Trial name
- maquibiota (NCT07776925)
- Testing
- maqui supplementation, PLA
- Where
- Chile
- Volunteers
- 30 people
- Sponsor
- Universidad Mayor
Pain, Acute, Pain, Chronic
Evaluation of the Effect of a Food Supplement Based on Hydrolyzed Collagen on Joint Function.
This clinical study evaluates the effect of taking a hydrolyzed collagen-based supplement on pain, function and quality of life in a moderately physically active population.
- Conditions
- Pain, Acute, Pain, Chronic, Knee Osteoarthritis, Knee Injuries
- Trial name
- COLART (NCT05917925)
- Testing
- COLLAGEN (COL)
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Francisco Javier Martínez Noguera
Type 1 Diabetes, Cardiovascular Diseases
Repurposing Colchicine for Reduction of Residual Inflammatory Risk in Type 1 Diabetes
The aim of this clinical trial is to evaluate if colchicine in addition to standard of care improves markers of inflammation and cardiovascular disease in persons with type 1 diabetes.
- Conditions
- Type 1 Diabetes, Cardiovascular Diseases, Chronic Inflammation
- Trial name
- REC1TE (NCT05949281)
- Testing
- Colchicine 0.5 MG Oral Tablet
- Where
- Denmark
- Volunteers
- 102 people
- Sponsor
- Asger Lund, MD
Osteoporosis
1 Year Open-label Extension to CZOL446H2337 Safety and Efficacy Trial of Zoledronic Acid Twice Yearly in Osteoporotic Children Treated With Glucocorticoids
This 1-year open-label extension to CZOL446H2337 is designed to evaluate the safety and efficacy of zoledronic acid twice yearly in osteoporotic children treated with glucocorticoids.
- Trial name
- NCT01197300
- Testing
- Zoledronic acid
- Where
- 10 sites in Australia, Canada and 4 more
- Volunteers
- 25 people
- Sponsor
- Novartis Pharmaceuticals
End-stage Renal Disease, Anemia
Iron Therapy in Patients With End-Stage Renal Disease
This study will compare the clinical outcome of patients with maintenance dialysis room after changing the iron treatment guidelines from original upper limit with ferritin>500ng/ml, or TSAT>20% to Ferritin> 800ng / ml, or TSAT>…
- Conditions
- End-stage Renal Disease, Anemia, Cardiovascular Risk Factor, Inflammation
- Trial name
- NCT04491916
- Testing
- irone sucrose
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
Colorectal Cancer
The Role of Gut Microbiome and Chronic Inflammation in Young-onset Colorectal Cancer
This study aims to investigate the role of gut microbiome pattern and inflammation marker NF-ҡB in young-onset colorectal cancer
- Trial name
- NCT04011969
- Testing
- Score assessment, Blood sampling, Fecal sampling
- Where
- Indonesia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
A Study to Understand the Real-world Awareness and Perceptions of Systemic inFLAMmation and rolE of hsCRP as a Biomarker in Patients With AtheroSclerotic CardioVascular Disease and Chronic Kidney Disease Among Nephrologists
The purpose of this survey is to collect information for scientific research and to better understand the role of systemic inflammation in identification, treatment and management of patients with Atherosclerotic Cardiovascular…
- Conditions
- Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD), Systemic Inflammation
- Trial name
- NCT06322641
- Testing
- No treatment given
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Novo Nordisk A/S
Fibromyalgia
Relationships of Affect and Neuroinflammation With Clinical Pain in Veterans With Fibromyalgia
Fibromyalgia (FM) is a chronic pain condition that disproportionately impacts Veterans. Individuals diagnosed with FM patients experience lower self-esteem and positive affect, as well as greater levels of depression, anxiety…
- Trial name
- RAN (NCT06574165)
- Testing
- Moderate Intensity Continuous Training
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Lymphedema, Seroma
Breaststroke Swimming After Breast Cancer Treatment/Surgery as a Means of Treatment for Seroma, Lymphedema, and Chronic Arm and Chest Pain
Following surgery and treatment for breast cancer, many patients experience swelling of lymph nodes (lymphedema) or accumulation of fluid (seroma) that can cause pain, restrict movement, and reduce quality of life.
- Conditions
- Lymphedema, Seroma, Pain, Postoperative, Pain, Chest
- Trial name
- NCT04080934
- Testing
- Swimming
- Where
- Canada
- Volunteers
- 128 people
- Sponsor
- Ottawa Hospital Research Institute
COPD
Does Extra-fine Hydrofluoroalkane-beclomethasone Dipropionate (HFA-BDP) Suppress Small Airways Inflammation in Chronic Obstructive Pulmonary Disease (COPD)?
Chronic obstructive pulmonary disease or 'COPD' is a chronic disease, which means that it cannot be cured, but that inhalers and tablets can be used to control the symptoms.
- Trial name
- NCT00921921
- Testing
- HFA-BDP
- Where
- United Kingdom
- Volunteers
- 16 people
- Sponsor
- University of Dundee
Chronic Kidney Diseases
Beetroot Extract Supplementation Associated With an Exercise Protocol for Chronic Kidney Disease Patients
Chronic kidney disease (CKD) patients often present systemic inflammation and oxidative stress, resulting in metabolic disorders and high rates of disease-associated cardiovascular death.
- Trial name
- NCT06286748
- Testing
- Beetroot juice
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Universidade Federal Fluminense
PASC Post Acute Sequelae of COVID 19, Long COVID
From Inflammation to Remodelling Towards Personalized Diagnosis in Post-acute Sequelae of COVID-19
Rationale: The diagnosis and pathogenesis of long COVID remains unknown. We have previously shown that [68Ga]FAPI Positron Emission Tomography-Computed Tomography (PET/CT) imaging shows potential for diagnosis and molecular…
- Conditions
- PASC Post Acute Sequelae of COVID 19, Long COVID, Long Covid-19, PASC
- Trial name
- LIBERATE (NCT06911476)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Obesity, Chronic Kidney Disease
FFT, Inflammation, Lipid Metabolism, Blood Pressure and Organ Damage in Patients With Obesity, Chronic Kidney Disease (CKD).
Fructose intake from added sugars has increased dramatically over the last century and has recently been implicated as potential contributor to metabolic syndrome, obesity, hypertension, inflammation and kidney disease.
- Conditions
- Obesity, Chronic Kidney Disease, Metabolic Syndrome
- Trial name
- NCT01332526
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Collegium Medicum w Bydgoszczy