Clinical trials: Inflammation Function
Diabetes Mellitus, Type 2
Examining the Effect of Exogenous Ketone Supplementation on Glucose Control in Type 2 Diabetes
Ketone bodies are a fuel source and signaling molecule that are produced by the body during prolonged fasting or if an individuals consistently eats a low-carbohydrate "keto" diet.
- Trial name
- NCT05155410
- Testing
- Exogenous Ketone Monoester
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Inflammation
Effect of Probiotic Supplementation on Immune Function in Healthy Infants
The purpose of this study is to understand how a probiotic might change the immune response of healthy infants.
- Trial name
- ProBoost (NCT01542320)
- Testing
- Lactobacillus reuteri DSM 17938
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Emory University
Septic Shock
Life After Pediatric Sepsis Evaluation
Sepsis represents the leading cause of childhood mortality worldwide. However, as distinct from adult medicine, there exists a large knowledge gap regarding long term health related quality of life (HRQL) and functional status…
- Trial name
- LAPSE (NCT01415180)
- Where
- 11 sites in United States
- Volunteers
- 389 people
- Sponsor
- Seattle Children's Hospital
Peripheral Arterial Disease
Circulating Anti-Beta2-glycoprotein Antibodies and Endothelial Dysfunction
Circulating anti-beta2-glycoprotein antibodies have been associated with coronary artery disease and peripheral arterial disease.
- Trial name
- NCT01822990
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Getafe
Peripheral Arterial Disease, Walking, Difficulty
Passive Stretching in Peripheral Arterial Disease Patients
Peripheral artery disease (PAD) leads to higher mortality rates and strains healthcare systems due to increased costs. It causes leg pain during walking due to reduced blood flow.
- Conditions
- Peripheral Arterial Disease, Walking, Difficulty, Inflammation
- Trial name
- NCT06420752
- Testing
- Calf Plantar flexion, Dietary nitrate
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of Wisconsin, La Crosse
Inflammation, Psychosocial Functioning
Mindfulness Meditation Neuroimaging Study for Undergraduates
This study is designed to test the effectiveness of mindfulness meditation intervention classes on psychosocial health outcomes.
- Conditions
- Inflammation, Psychosocial Functioning, Depression, Anxiety
- Trial name
- NCT05304052
- Testing
- Mindfulness Meditation classes
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Type 2 Diabetes
Diet With or Without Metarecod® in Obese Subjects With Type 2 Diabetes
Obesity is considered the largest chronic non-communicable disease (globesity) worldwide with a growing trend in the near future.
- Trial name
- MONDO (NCT06813170)
- Testing
- Metarecod, Diet
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Metabolic Syndrome
Pea Protein and Postprandial Response (PEA)
The main objective is to investigate the postprandial effect of arginine-rich protein (i.e. pea-protein) on metabolic control, inflammation and endothelial function after a high-fat meal in subjects with characteristics of the…
- Trial name
- PEA (NCT01215370)
- Testing
- High-fat shake with Pea protein, High-fat shake with Pea protein hydrolysate, High-fat shake - Control
- Where
- Netherlands
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Mild Cognitive Impairment (MCI), Cognition
LpD3.5 Intervention Study in Older Adults- LISA-I Trial
This randomized placebo-controlled clinical study, called the LpD3.5 Intervention Study in Older Adults (LISA), aims to evaluate whether a heat-inactivated postbiotic of human origin (LpD3.5) can serve as a non-pharmacological…
- Conditions
- Mild Cognitive Impairment (MCI), Cognition, Brain Aging, Microbiome Dysbiosis
- Trial name
- Postbiotics (NCT07794956)
- Testing
- LpD3.5
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Pain
Investigation of Kritech Efficacy on Subjects Having Functional Discomfort Associated to Joints and Muscles Disorders
Joints and muscles disorders are common symptoms in the population. They are characterized by swelling, pain, functional impairment and morning stiffness.
- Trial name
- Easykrill (NCT02318875)
- Testing
- Kritech administration
- Where
- France
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Vivatech
Peripheral Arterial Disease
The Effects of Omega-3 Fatty Acids on Peripheral Arterial Disease II
Investigators hypothesize that high-dose n-3 polyunsaturated fatty acids (PUFA) oral supplementation will improve systemic inflammation, vascular function, and symptomatic status of patients with PAD.
- Trial name
- OMEGA-PAD II (NCT01979874)
- Testing
- Pro-Omega
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of California, San Francisco
Metabolic Syndrome, Predisposition to Cardiovascular Disease
Analysis of the Postprandial Effects of a Vegetable Protein Mixture Rich in Arginine, Cysteine and Leucine on Endothelial Dysfunction and Inflammation at Low Noise in Elderly People With Cardiometabolic Risk
By 2050, the expanding world population will consume two-thirds more animal protein than it consumes today. The increase in chronic diseases associated with the generalization of these consumption patterns tend to understand the…
- Trial name
- P-PROBS CM (NCT04923555)
- Testing
- Vegetable proteins (VP) rich in leucine, cystein, arginine, Animal proteins (AP), No protein (T)
- Where
- France
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Metabolic Syndrome
Trial of Supplementation With Aged Garlic Extract to Improve Endothelial Function in Patients With Metabolic Syndrome
Many studies have addressed the relationship between metabolic syndrome and cardiovascular disease. Risk factors include abdominal obesity, insulin resistance, abnormal lipid profile and hypertension.
- Trial name
- Kymes (NCT01168700)
- Testing
- aged garlic extract
- Where
- Colombia
- Volunteers
- 46 people
- Sponsor
- Universidad de Santander
Ischemic Heart Disease, Myocardial Infarction
Polyamine Treatment in Elderly Patients With Coronary Artery Disease
The present study is testing spermidine treatment in elderly patients with coronary artery disease. The study is a randomized, double-blind, placebo-controlled, two-armed, parallel-group, single centre, clinical study.
- Conditions
- Ischemic Heart Disease, Myocardial Infarction, Cardiovascular Diseases, Hypertensive Heart Disease
- Trial name
- PolyCAD (NCT06186102)
- Testing
- Spermidine
- Where
- Denmark
- Volunteers
- 187 people
- Sponsor
- University of Aarhus
Sepsis, Septic Shock
The Effect of Fluid Resuscitation With 0.9% Sodium Chloride Versus Balanced Crystalloid Solution on Renal Function of Sepsis Patients
The high chloride content of 0.9%sodium chloride (0.9%NaCl) leads to adverse pathophysiological effects in both animals and healthy human volunteers.
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- NCT03277677
- Testing
- Normal saline, Ringer's Acetate
- Where
- Thailand
- Volunteers
- 116 people
- Sponsor
- Chulalongkorn University
End Stage Kidney Disease (ESKD), Hemodialysis
Randomized Cross-Over Comparison of Medium Cut-Off and High-Flux Hemodialysis Membranes
Patients receiving maintenance hemodialysis are at increased risk of cardiovascular disease, chronic inflammation, endothelial dysfunction, and impaired quality of life.
- Conditions
- End Stage Kidney Disease (ESKD), Hemodialysis, Cardiovascular Diseases (CVD), Inflammation
- Trial name
- MCO-HD (NCT07679763)
- Testing
- Medium Cut-Off Hemodialysis Membrane, High-Flux Hemodialysis Membrane
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gazi University
Cardiovascular Diseases, Aging
Cardio-vascular Protective Effects of Wolfberry in Middle-aged and Older Adults
This purpose of this study is to assess the impact of consuming wolfberry on cardiovascular risk in Singapore's middle-aged and older adults.
- Trial name
- NCT03535844
- Testing
- Wolfberry, Healthy diet
- Where
- 2 sites in Singapore
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Exercise Therapy, Pain
Physical Exercise and Its Impact on Signs of Inflammation in Fibromyalgia
The study aims to compare low-intensive and high-intensive physical exercise and its impact on physical function, pain and signs of inflammation.
- Trial name
- NCT00643006
- Testing
- Physical exercise, Active comparator: low intensive exercise
- Where
- 3 sites in Sweden
- Volunteers
- 67 people
- Sponsor
- Göteborg University
Sleep Deprivation
Effects of Sleep Loss on Endothelial Function and Cytokine Levels in Internal Medicine Residents
Work requirements for medical trainees result in substantial sleep loss. Sleep loss has been associated with increased levels of certain inflammatory hormones that could have negative impact on blood vessel function.
- Trial name
- NCT00272233
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Yale University
Hypercholesterolemia, Postmenopause
Vascular and Metabolic Effects of Hormone Therapy Combined With L-Arginine in Postmenopausal Women
Estrogen therapy has been associated with reduced risk of coronary heart disease events in observational studies of postmenopausal women.
- Trial name
- NCT00001752
- Testing
- L-arginine, Estrogen
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)