Clinical trials: Inflammation Function
Type2 Diabetes, Major Depressive Disorder
Vortioxetine Monotherapy for Major Depressive Disorder in Type 2 Diabetes
This study will enroll participants who have been diagnosed with type 2 diabetes and are experiencing symptoms of depression. This study will look at an anti-depressant medication called vortioxetine (Trintellix).
- Trial name
- NCT03580967
- Testing
- Vortioxetine
- Where
- United States
- Sponsor
- Todd Doyle
Obesity, Diabetes Mellitus, Type 2
Bariatric Surgery and Male Reproductive Function
Obesity is a global public health problem. According to literature reports, as of 2016, China's obese population has reached more than 90 million and type 2 diabetes mellitus has reached more than 100 million, which has brought a…
- Conditions
- Obesity, Diabetes Mellitus, Type 2, Bariatric Surgery Candidate, Roux en Y Gastric Bypass
- Trial name
- NCT04237311
- Testing
- Sleeve gastrectomy, Roux-en-Y gastric bypass
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The Third Xiangya Hospital of Central South University
Aging, Malnutrition
Optimisation of Nutrition and Medication for Acutely Admitted Older Medical Patients
Malnutrition and inappropriate medication prescribing are highly prevalent among acutely admitted older medical patients leading to re-admissions, frailty, poor physical, performance compromised quality of life and mortality.
- Conditions
- Aging, Malnutrition, Drug Prescribing
- Trial name
- OptiNAM (NCT03741283)
- Testing
- Optimisation of nutrition and medication
- Where
- Denmark
- Volunteers
- 193 people
- Sponsor
- Hvidovre University Hospital
Multiple Sclerosis, Relapsing-Remitting
Photobiomodulation Therapy in Persons With Multiple Sclerosis
This study will test whether photobiomodulation therapy improves muscle endurance and decreases inflammation in persons with relapsing-remitting multiple sclerosis. We will also investigate mechanisms for any improvements.
- Trial name
- NCT03691766
- Testing
- Photobiomodulation Therapy
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Marquette University
Metabolic Syndrome
Effect of Brown Rice on the Risk Factors for Metabolic Syndrome
The purpose of the study is to determine the effect of consumption of brown rice on the risk factors of metabolic syndrome (MetS) as compared to consumption of white rice.
- Trial name
- NCT02321553
- Testing
- Brown rice, White rice
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Tufts University
Carnosine
Carnosine Supplementation and Cardiovascular Function
Carnosine is a dipeptide synthesized in the body from β-alanine and L-histidine. It was originally discovered in skeletal muscle where it is present in larger amounts than in other tissues, but it is also found in high…
- Trial name
- NCT05723939
- Testing
- Carnosine supplementation, Controls
- Where
- Croatia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female
Wild Blueberries for Gut, Brain, and Cardiometabolic Health in Prediabetes
The goal of this clinical trial is to determine the effectiveness of using a freeze-dried wild blueberry powder on cardiometabolic health, cognitive function, and gut microbiota composition in adult women with prediabetes.
- Conditions
- Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Female, Adult, Endothelial Function (Reactive Hyperemia)
- Trial name
- NCT06735651
- Testing
- Wild Blueberry
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Georgia State University
Asthma; Eosinophilic
Evaluating the Effect of Benralizumab in Severe, Poorly-controlled Eosinophilic Asthma Using Inhaled Hyperpolarized 129-Xenon MRI
The purpose of this study is to evaluate the effect of a drug called benralizumab in individuals with severe, poorly controlled asthma with eosinophilic airway inflammation.
- Trial name
- AERFLO (NCT03733535)
- Testing
- Benralizumab, 129 Xenon
- Where
- Canada
- Volunteers
- 29 people
- Sponsor
- Dr. Grace Parraga
Irritable Bowel Syndrome
Irritable Bowel Syndrome Evaluation and Treatment in Primary Care
Overview of Methods: This is a double blind, randomized controlled trial with a non-balanced randomization and a cross-over to active treatment for placebo treated individuals who do not respond to the placebo treatment.
- Trial name
- NCT01641341
- Testing
- Bifidobacterium infantis, Pancrelipase, Nitazoxanide
- Where
- 9 sites in United States
- Volunteers
- 61 people
- Sponsor
- American Academy of Family Physicians
Muscle Damage, Muscle Soreness
The Effects of Whey Protein Supplements on Markers of Exercise-induced Muscle Damage in Resistance-trained Individuals
Intense exercise can bring about various side effects to one's body. Less range of motion, increased pain sensitivity, increased muscle swelling, and decreased muscle strength can occur immediately after exercise.
- Trial name
- WheyProtein (NCT05100459)
- Testing
- Pasture-raised whey protein, Conventional whey protein
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Indiana University
Cancer, Inflammation
Implementing Good Nutrition to Improve, Transform, and Enhance (IGNITE) Firefighters' Health
Investigators hope to learn about potential dietary intervention strategies (specifically a whole-food, plant-based diet) that may help lower cancer markers in firefighters.
- Conditions
- Cancer, Inflammation, Microbiome, Immune Function
- Trial name
- NCT06567561
- Testing
- Whole Foods Plant-Based Diet, Usual Firehouse Diet
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Stanford University
Healthy
Spices, Inflammation and Vascular Response in Humans
The objectives of this study are: 1. To characterize the time course of herbs/spice action on endothelial function as measured by FMD over 24 h using a challenge meal paradigm. 2.
- Trial name
- SPC (NCT03926442)
- Testing
- Italian Herb meal, Cinnamon Meal, Pumpkin Spice meal
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Major Depressive Disorder, Depression
Anti-INFLammatory to Address Mood and Endothelial Dysfunction (INFLAMED)
The objective of this clinical trial is to evaluate whether an anti-inflammatory medication, pentoxifylline, reduces depressive symptoms and improves artery function.
- Conditions
- Major Depressive Disorder, Depression, Depressive Symptoms, Cardiovascular Disease (CVD)
- Trial name
- INFLAMED (NCT01625845)
- Testing
- Pentoxifylline, Standard Treatment
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Indiana University
Somatoform Disorders, Fibromyalgia
Immune Patterns in Pain Patients DSM-IV
The purpose of this study is to define subgroups of patients with somatoform disorders due to DSM-IV by immunological, psychological and genetic characterization.
- Conditions
- Somatoform Disorders, Fibromyalgia, Myofascial Pain Syndrome, Diffuse, Depression
- Trial name
- IPPPDIV (NCT01106339)
- Where
- Germany
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Septic Shock, Hyperlactatemia
Peripheral Perfusion Versus Lactate Targeted Fluid Resuscitation in Septic Shock
Persistent hyperlactatemia has been traditionally considered as representing tissue hypoxia, and lactate normalization is recommended as a resuscitation target by the Surviving Sepsis Campaign (SSC).
- Conditions
- Septic Shock, Hyperlactatemia, Peripheral Perfusion
- Trial name
- NCT03762005
- Testing
- CRT guided resuscitation, Lactate guided resuscitation
- Where
- Chile
- Volunteers
- 46 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Critical Illness, Intensive Care Unit Delirium
The Gut Microbiome - Source of Sepsis and Novel Target in Intensive Care Units?
Here, the investigators propose to study host responses to reduced microbiome complexity driven by treatment with broad spectrum antibiotics in patients with severe infections or sepsis.
- Conditions
- Critical Illness, Intensive Care Unit Delirium, Neurocognitive Deficit, Microbiome,immune Function, Critically Ill
- Trial name
- MS-ICU (NCT06749483)
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Jena University Hospital
Endometriosis, Endometriosis and Dysmenorrhea
Brain and Blood Vessel Health Following Endometriosis Treatment in People With Endometriosis
This research study wants to understand how medications used to treatment symptoms of endometriosis impact brain health in patients with endometriosis.
- Conditions
- Endometriosis, Endometriosis and Dysmenorrhea, Endometriosis (Diagnosis)
- Trial name
- BLOOM (NCT07799246)
- Testing
- Investigate how norethindrone acetate, a commonly used medication used to treat symptoms of endometriosis, impact biomarkers of brain health, Investigate how Orlissa, a commonly used medication used to treat symptoms of endometriosis, impact biomarkers of brain health, Investigate how Oriahnn, a commonly used medication used to treat symptoms of endometriosis, impact biomarkers of brain health
- Volunteers
- 45 people
- Sponsor
- Colorado State University
Sepsis, Septic Shock
Administration of Human Protein C Concentrates in Patients With Sepsis and Septic Shock.
The purpose of this study is to investigate the effects on systemic hemodynamics, microcirculation and organ function of human Protein C concentrate in patients with sepsis and septic shock.
- Trial name
- NCT01411670
- Testing
- Human protein C concentrate, Activated protein C
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Roma La Sapienza
Metabolic Syndrome
Mediterranean Diet and the Metabolic Syndrome
The metabolic syndrome has been identified as a target for dietary therapies to reduce risk of cardiovascular disease; however, the role of diet in the etiology of the metabolic syndrome is poorly understood.
- Trial name
- NCT00640783
- Testing
- Mediterranean diet, Control
- Where
- Italy
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Cognitive Change, Mood
Cognitive, Mood, Anti-Inflammatory and Metabolic Effects of Chronic Oyster Mushroom Intervention in Older Adults
The Pleurotus oyster species is a common edible mushroom rich in phytochemicals such as proteins, phenolic compounds, dietary fibre and is also particularly rich in ergothioneine, a bioactive known for its neurocognitive…
- Conditions
- Cognitive Change, Mood, Metabolism, Inflammatory Response
- Trial name
- OYSCOG (NCT06846827)
- Testing
- Oyster mushroom, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Reading