Clinical trials: Inflammation Function
Liver Diseases, Liver Cirrhosis
Sepsis, Endothelial Function, and Lipids in Critically Ill Patients With Liver Failure (the SELLIFA Study)
The purpose of the study is to determine the role of new biomarkers in the diagnosis of sepsis in critically-ill patients with liver failure and to correlate the prognosis of these patients with parameters of endothelial function…
- Conditions
- Liver Diseases, Liver Cirrhosis, Sepsis, Critical Illness
- Trial name
- SELLIFA (NCT00488917)
- Where
- Belgium
- Volunteers
- 167 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Cystic Fibrosis
Blood Flow and Vascular Function in Cystic Fibrosis
Cystic fibrosis (CF) has many health consequences. A reduction in the ability to perform exercise in patients with CF is related to greater death rates, steeper decline in lung function, and more frequent lung infections.
- Trial name
- CF-FLOW (NCT02057458)
- Testing
- Sildenafil (Acute-1 hour), Sildenafil (Subchronic-4 weeks)
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Augusta University
Bronchiectasis, Inflammation
Bronchiectasis and Long Term Azithromycin Treatment
1. SUMMARY Rationale: Patients with bronchiectasis often experience lower respiratory tract infections with progression of symptoms and decline in quality of life.
- Trial name
- BAT (NCT00415350)
- Testing
- Azithromycin
- Where
- 16 sites in Netherlands
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- W.G.Boersma
Ischemic Preconditioning, Coenzyme Q Deficiency
Effect of CoQ10 on the Endocrine Function of Skeletal Muscle
Recent studies have also shown that repeated episodes of ischemia, followed by reperfusion (IPC), can contribute to the development of adaptive changes not only in the area of the heart muscle, but also in the structure of the…
- Conditions
- Ischemic Preconditioning, Coenzyme Q Deficiency, Exercise Training
- Trial name
- NCT05412888
- Testing
- CoQ10 supplementation, Ischemic preconditioning training, IPC training combined with CoQ10 supplementation
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Sepsis, Septic Shock
Administration of Human Protein C Concentrates in Patients With Sepsis and Septic Shock.
The purpose of this study is to investigate the effects on systemic hemodynamics, microcirculation and organ function of human Protein C concentrate in patients with sepsis and septic shock.
- Trial name
- NCT01411670
- Testing
- Human protein C concentrate, Activated protein C
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Roma La Sapienza
Liver Enzymes, Inflammatory Markers
Moderate Intensity Intermittent Walking in Postmenopausal Women
The goal of this clinical trial is to investigate the impact of a walking training intervention program on liver enzymes and selected inflammatory markers in postmenopausal women with obesity.
- Trial name
- NCT06809270
- Testing
- Walking training intervention
- Where
- Tunisia
- Volunteers
- 36 people
- Sponsor
- Wissal Abassi
Immune System Processes, Inflammatory Activation and Modulation
The Compassion and Attention Longitudinal Meditation Study
The increasingly widespread use of meditation for stress-related emotional and medical conditions highlights the urgent need to rigorously evaluate mechanisms through which the benefits of practice might be conferred.
- Conditions
- Immune System Processes, Inflammatory Activation and Modulation, ANS Function
- Trial name
- CALM (NCT01251341)
- Testing
- Cognitive-Based Compassion Training, Mindful Attention Training, Adult Health Education Curriculum
- Where
- United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Hiv
The Effect on Lipid Profile of Switching to Delstrigo in HIV Positive Patients
This is an open label, randomised, two-arm switch study over 48 weeks in which virally suppressed participants on a stable combined ART regimen will be randomised (1:1) to an immediate switch to 3TC/TDF/DOR (immediate switch arm…
- Trial name
- META-D (NCT05289986)
- Testing
- DELSTRIGO 100Mg-300Mg-300Mg Tablet
- Where
- 2 sites in United Kingdom
- Volunteers
- 19 people
- Sponsor
- Chelsea and Westminster NHS Foundation Trust
Sepsis, Septic Shock
Immune Function Monitoring and Immunotherapy in Sepsis
At present, the clinical studies of various anti-inflammatory drugs and immune-enhancing drugs show that immunotherapy will bring new hope for the treatment of sepsis.
- Trial name
- IMITS (NCT04903405)
- Testing
- No intervention
- Volunteers
- 5,000 people
- Sponsor
- Sun Yat-sen University
Periodontitis, Olfactory Dysfunction
Olfactory Function and Oral Malodor in Periodontitis Before and After Periodontal Therapy
This prospective cohort study investigated the relationship between oral malodor and olfactory function in adults with generalized periodontitis.
- Conditions
- Periodontitis, Olfactory Dysfunction, Halitosis
- Trial name
- NCT07424300
- Testing
- Scaling and Root Planing (SRP)
- Where
- Turkey (Türkiye)
- Volunteers
- 101 people
- Sponsor
- Batman University
Systemic Inflammation, Aging
Papaya Study ID:20140628
The purpose of this research study is to explore the effects of fermented papaya preparation (FPP) on whole body inflammation, physical function, fatigue, and health-related quality of life.
- Trial name
- NCT02051634
- Testing
- Fermented Papaya Preparation (FPP), Sugar Pill
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Type 1 Diabetes
Artificial Pancreas Technology to Reduce Glycemic Variability and Improve Cardiovascular Health in Type 1 Diabetes
This study will examine the potential cardiovascular effect(s) of artificial pancreas (AP) technology in patients with type 1 diabetes.
- Trial name
- WBH002 (NCT05653518)
- Testing
- Tandem t:slim X2 with Control-IQ Technology, Sensor augmented pump (SAP) therapy
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Inflammatory Changes in Epithelial Lining Fluid Sampled Non-invasively by Nasal Lavage in CF Patients With G551D Receiving Kalydeco
Effects of Kalydeco on Upper Airway and Paranasal Sinus Inflammation Measured by Nasal Lavage and on Symptoms
The aim of the proposed trial in assessment of effects of Kalydeco™ treatment on sinonasal involvement in CF patients with at least one mutation of G551D receiving a new therapy with the CFTR potentiator.
- Trial name
- KPNSI (NCT02311140)
- Testing
- nasal lavage (routine diagnostic procedure in our centre), assessment of symptoms
- Where
- Germany
- Volunteers
- 10 people
- Sponsor
- University of Jena
Hypogonadotropic Hypogonadism, Type 2 Diabetes
Hypogonadism in Young Men With Type 2 Diabetes
Low testosterone production, known clinically as hypogonadism, appears to be common complication of type 2 diabetes, affecting one in three diabetic men.
- Trial name
- NCT01155518
- Testing
- testosterone, clomiphene
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- State University of New York at Buffalo
Tracheostomy Complication, Inflammation
Postoperative Inflammation and Recovery After Tracheostomy
The main purpose of this study is to examine if there are differences in postoperative inflammation following percutaneous dilatation tracheostomy versus surgical tracheostomy in intensive care unit patients.
- Conditions
- Tracheostomy Complication, Inflammation, Post-operative Complications
- Trial name
- NCT02096640
- Testing
- Type of surgical teqnique for tracheostomy
- Where
- Sweden
- Volunteers
- 150 people
- Sponsor
- Sormland County Council, Sweden
Type 2 Diabetes Mellitus, Obesity
The TRIABETES - ARMMS-T2D Study: A Randomized Trial to Compare Surgical and Medical Treatments for Type 2 Diabetes
This research study is being performed to begin to determine the effectiveness of two dominant bariatric surgery procedures versus an intensive lifestyle intervention to induce weight loss in patients and promote improvements in…
- Trial name
- TRIABETES (NCT01047735)
- Testing
- Roux-en-Y Gastric Bypass Surgery, Laparoscopic Adjustable Gastric Banding, Lifestyle Weight Loss Intervention
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- University of Pittsburgh
Obesity
Substituting Mushrooms for Meat to Control Body Weight
This is a one-year clinical trial to assess weight-loss, weight-maintenance, and biochemical parameters following a weight-control diet using either standard food guide pyramid alone, or standard food guide pyramid with…
- Trial name
- NCT01177085
- Testing
- Weight-loss and weight-maintenance diets
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Methamphetamine-dependence
Pilot Study of the Effect of Ibudilast on Neuroinflammation in Methamphetamine Users
Addiction to methamphetamine is a serious health problem in the United States. Right now, there are no medications that a doctor can give someone to help them stop using methamphetamine.
- Trial name
- Ibudilast (NCT03341078)
- Testing
- Ibudilast
- Where
- United States
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
T2DM (Type 2 Diabetes Mellitus)
GLP1-RAs Effects on Inflammatory and Endothelial Biomarkers in T2DM
Type II diabetes mellitus (T2DM) is a chronic disease associated with a very high risk of developing cardiovascular (CV) events, especially because of its long-term effects.
- Trial name
- STABLE-GLP1 (NCT07314684)
- Testing
- semaglutide, Standard Treatment (Guideline-Based)
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Federico II University
Overweight or Obesity
Precision Nutrition Strategies for Improving the Quality of Life of Pre-senior and Senior Populations
The number and proportion of people aged 60 years old and over is increasing worldwide. Ageing is characterized by a progressive loss of physiological integrity, leading to impaired function and increased vulnerability to death.
- Trial name
- NCT04786925
- Testing
- Control diet, Nutriprecision diet
- Where
- Spain
- Volunteers
- 126 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra