Clinical trials: Inflammation Function
Septic Shock
Cardiovascular Effects of Norepinephrine
Previous studies of our team reported the improvement of myocardial contractility both on hemodynamic parameters (by transpulmonary thermodilution) and morphological (by transthoracic echocardiography: TTE), during the early…
- Trial name
- NCT05761522
- Testing
- transthoracic echocardiography
- Where
- France
- Volunteers
- 49 people
- Sponsor
- CHU de Reims
Lung Inflammation
The Effects of Heated Tobacco Products Use on Lung Function and Volatile Organic Compounds in Exhaled Air
This is a human randomized controlled cross-over study where we investigate the effects of heated tobacco products (HTP) on lung function and on assessing volatile organic compounds in exhaled air.
- Trial name
- NCT05260827
- Testing
- Heated tobacco product
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Metabolic Diseases, Endocrine System Diseases
Effect of Fish Oil (Omega-3 Fatty Acids) on Arteries
The overall objective of LUCHAR Specific Aims 4.1 and 4.2 is to assess the additional contribution of cardiovascular disease (CVD) risk markers to traditional biomedical risk factors in the prediction of pre-clinical CVD.
- Conditions
- Metabolic Diseases, Endocrine System Diseases, Heart Disease, Vascular Diseases
- Trial name
- NCT00935766
- Testing
- Omega-3
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Denver Health and Hospital Authority
Arterial Hypertension, Atherosclerosis Occlusive Disease
Gut Microbiota in Chronic Noncommunicable Diseases
It is an observational study in patients with chronic noncommunicable diseases (i.e. cardiovascular diseases, diabetes mellitus, non-alcoholic fatty liver disease, chronic obstructive pulmonary disease and asthma ) and control…
- Conditions
- Arterial Hypertension, Atherosclerosis Occlusive Disease, Heart Failure With Preserved Ejection Fraction, Heart Failure With Reduced Ejection Fraction
- Trial name
- NCT04820556
- Where
- 2 sites in Russia
- Volunteers
- 1,084 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Oxidative Stress, Healthy
A Randomized, Double-Blind Study to Assess the Effect of a Postbiotic on Oxidative Stress and Exercise Performance
This is a prospective, randomized, placebo controlled, double-blind study to assess the effects of a postbiotic blend on exercise induced oxidative stress markers and exercise performance in healthy adult.
- Conditions
- Oxidative Stress, Healthy, Exercise-induced Muscle Damage, Exercise-induced Muscle Soreness
- Trial name
- PBE (NCT06795425)
- Testing
- Postbiotic Active Lifestyle Blend
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lindenwood University
Acute Ischemic Stroke
Platelet Function in Patients With Ischemic Stroke Treated With Anti-thrombotic or Thrombolytic
Acute stroke afflicts nearly 700,000 patients in the US and is the number 3 cause of death. Only 2-9% of this large number is treated with t-PA if they arrive within 4.5 hours.
- Trial name
- NCT05415150
- Testing
- Thrombolytic Agent
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Baylor College of Medicine
Long COVID-19, Post-COVID-19 Syndrome
Exercise and Post-COVID/ Long-COVID: Effects of Different Training Modalities on Various Parameters in People Affected by the Sequelae of COVID-19
The current COVID-19 pandemic is the most severe health crisis of the 21st century. This is not only due to the deaths caused by the disease.
- Conditions
- Long COVID-19, Post-COVID-19 Syndrome, COVID-19
- Trial name
- NCT05204511
- Testing
- endurance training, concurrent training
- Where
- Austria
- Volunteers
- 66 people
- Sponsor
- University of Vienna
Asthma
A Mechanistic Study to Evaluate the Efficacy of Montelukast on Airway Function in Asthma
The trial is an investigator-driven research study in subjects with intermittent asthma, the aim of which is to explore the likelihood of a functionally important separate leukotriene E4 (LTE4) receptor in airways and/or…
- Trial name
- E-Type (NCT01841164)
- Testing
- Montelukast, Inhaled leukotriene E4
- Where
- Sweden
- Volunteers
- 14 people
- Sponsor
- Karolinska University Hospital
Diabetes Mellitus, Insulin-Dependent, Hypercholesterolemia
Statins in Children With Type 1 Diabetes and Hypercholesterolemia
Children with type1 diabetes (T1DM) have increased risk for cardiovascular disease (CVD) due to chronic increase in the blood sugars and inflammation.
- Trial name
- NCT01236365
- Testing
- Atorvastatin
- Where
- 5 sites in United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Nemours Children's Clinic
Obesity, Metabolic Syndrome
Investigating the Possible Link Between Habitual Diet, Physical Activity, Sleeping Patterns, Obesity Status and Age With Gut Bacterial Composition, Gut Barrier Function, Metabolic Endotoxemia, Systemic Inflammation and Glycaemic Control.
In the UK, 25% of the adults are affected by metabolic syndrome (NHS, 2016). Metabolic syndrome is a cluster of different conditions including: hyperglycaemia, insulin resistance hypertriglyceridemia, dyslipidaemia and…
- Conditions
- Obesity, Metabolic Syndrome, Insulin Resistance
- Trial name
- NCT03864107
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Asthma, Nasal Polyps
ATP Project (Asthma afTer Polypectomy)
Inflammation of the nasal and bronchial mucosa characterizing rhinitis and asthma are probably manifestations of the same disease. Multiple functional observations, pathogenic and clinical support that assertion.
- Trial name
- ATP (NCT02427503)
- Testing
- Asthma with NP and require surgery
- Where
- Spain
- Volunteers
- 106 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Endothelial Dysfunction, Insulin Resistance
The Effects of Sedentarism on Vascular Function, Inflammation, and Insulin Resistance
The purpose of this study are twofold: 1. To understand the effects of physical inactivity (sedentarism) on vascular function, insulin resistance and inflammation; 2.
- Conditions
- Endothelial Dysfunction, Insulin Resistance, Metabolic Syndrome, Peripheral Arterial Disease
- Trial name
- Bedrest (NCT01412216)
- Testing
- Fish Oil (Omega-3 Fatty Acids)
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Coronary Artery Disease, Type 2 Diabetes Mellitus (T2DM)
Effects of Fecal Microbiota Transplantation in Patients With Type 2 Diabetes and Coronary Artery Disease (CAD-Microbiome) - A Pilot Study
This pilot study investigates whether fecal microbiota transplantation (FMT) can modify the gut microbiome in patients with type 2 diabetes mellitus and stable coronary artery disease (CAD).
- Trial name
- CAD-Microbiome (NCT07421947)
- Testing
- Fecal Microbiota Transplantation
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Diabetic Peripheral Vascular Disease
Measurement of Endothelial Function With Peripheral Arterial Tonometry in Patients Undergoing Hyperbaric Oxygen Therapy
The purpose of this clinical study is to test whether or not patients treated with HBOT for diabetic foot ulcers will demonstrate measurable changes of the blood vessel function during the course of HBOT treatments. , i.e.
- Trial name
- NCT02221466
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Ole Hyldegaard
Exercise Performance
Role of Lung Function for Exercise Capacity in Well-trained Individuals
The purpose of the project is to investigate exercise performance in humans following prolonged inhalation of beta2-agonists vilanterol + fluticasone furoate or indacaterol + mometasone furoate
- Trial name
- NCT06077019
- Testing
- Vilanterol and Fluticasone Furoate, Indacaterol and Mometasone Furoate
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Morten Hostrup, PhD
Endotoxemia, Diet, Healthy
Cereals and Intestinal Function
The aim of the present study is to determine the effect of dietary fiber on intestinal function in healthy subjects.
- Trial name
- NCT04019457
- Testing
- Dietary intervention
- Where
- Austria
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of Vienna
Triple Negative Breast Cancer (TNBC)
Evaluating Ovarian Toxicity Outcomes Following Immunotherapy in Patients With Triple-Negative Breast Cancer (TNBC)
This study aims to collect information about the effects of chemotherapy combined with immunotherapy (immune checkpoint inhibitors) for early-stage triple-negative breast cancer (TNBC) on ovarian function and fertility.
- Trial name
- FERTILE (NCT07527819)
- Where
- 9 sites in Australia
- Volunteers
- 75 people
- Sponsor
- Peter MacCallum Cancer Centre, Australia
Neoplasms, Heart; Disease, Functional
Exercise to Prevent AnthrCycline-based Cardio-Toxicity Study
As the numbers of cancer survivors grow, the long-term adverse effects of cancer therapy are becoming increasingly apparent. Most prominent are the toxic effects on the heart (cardiotoxicity) which may lead to cardiac dysfunction…
- Conditions
- Neoplasms, Heart; Disease, Functional, Inflammation
- Trial name
- EXACT (NCT02471053)
- Testing
- Moderate Intensity Exercise
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- Nova Scotia Health Authority
Coronary Heart Disease
Niacin/Laropiprant and Endothelial Function
Primary objective: To evaluate the impact of 12 weeks' administration of extended release niacin/laropiprant (ERN/LRPT) compared to placebo added to statin therapy on endothelial dependant dilatation of the arterial wall assessed…
- Trial name
- NCT01126073
- Testing
- Niacin/laropiprant
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Alcohol Use Disorder
Sex Differences in Trauma, Inflammation and Brain Function and the Implications for Treatment Efficacy in Alcohol Use Disorder
The goal of this clinical trial is to identify sex-specific biomarkers that confer greater susceptibility for Alcohol Use Disorder (AUD) and differentiate how treatment response varies by sex in people with Alcohol Use Disorder.
- Trial name
- ABSTAIN (NCT06426303)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Milky Kohno