Clinical trials: Inflammation Indices
Septic Shock and Use of Vasopressin
Effect of Adding Vasopressin on Cardiac Output, Blood Pressure, Diuresis, and Tissue Perfusion Indices in Patients With Septic Shock
In patients with septic shock, vasopressin is increasingly used in combination with norepinephrine, but its timing of initiation remains heterogeneous and its clinical hemodynamic effects are still insufficiently characterized.
- Trial name
- VASO-PHENO (NCT07697144)
- Where
- 8 sites in France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Crush Syndrome, Rhabdomyolysis
Inflammation Indıces and Mortality in Adult Crush Syndrome
This single-center, retrospective observational cohort study evaluated the prognostic value of complete blood count-derived inflammatory indices - the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR)…
- Conditions
- Crush Syndrome, Rhabdomyolysis, Systemic Inflammatory Response, Critical Illness
- Trial name
- NCT07433127
- Where
- Turkey (Türkiye)
- Volunteers
- 325 people
- Sponsor
- Ataturk University
Pregnancy, Headache After Spinal Puncture
Prediction of Postdural Puncture Headache
The primary objective of this study is to evaluate the effectiveness of inflammation index (pan-immune inflammation value, systemic immune inflammation index, and systemic inflammatory response index) values, calculated from…
- Trial name
- NCT07706751
- Where
- Turkey (Türkiye)
- Volunteers
- 260 people
- Sponsor
- Amasya University
Multiple Myeloma
CBC-Based Inflammatory Indices in Newly Diagnosed Multiple Myeloma
Multiple myeloma is a type of blood cancer characterized by the abnormal growth of plasma cells in the bone marrow. Increasing evidence indicates that interactions between myeloma cells and the host immune-inflammatory response…
- Trial name
- NCT07823959
- Volunteers
- 60 people
- Sponsor
- Assiut University
Sepsis
Serial Platelet Count and Indices for Predicting In-Hospital Mortality in Sepsis
This observational study aims to determine if tracking changes in blood platelets over time can help predict the clinical outcomes of adult patients hospitalized with sepsis.
- Trial name
- NCT07832903
- Testing
- Serial Complete Blood Counts (CBC)
- Volunteers
- 120 people
- Sponsor
- Assiut University
Systemic Inflammation Markers, Birth Weight
Combined Systemic Inflammatory Indices and Birth Weight
The study aimed to explore the complex relationship between various systemic inflammatory indices and birth weight
- Conditions
- Systemic Inflammation Markers, Birth Weight, Combined Systemic Inflammatory Indices
- Trial name
- NCT06325735
- Testing
- None intervention
- Where
- Italy
- Volunteers
- 199 people, healthy volunteers welcome
- Sponsor
- University of Campania Luigi Vanvitelli
Inflammatory Response, Perioperative Hypothermia
Effects of Intraoperative Warming Methods on Hematologic Inflammatory Indices in Laparoscopic Cholecystectomy
Perioperative hypothermia is a frequent and preventable complication that may cause adverse outcomes such as increased blood loss, impaired coagulation, and delayed recovery.
- Conditions
- Inflammatory Response, Perioperative Hypothermia, Laparoscopic Cholecystectomy, Surgical Stress Response
- Trial name
- WARM-CHOL (NCT07232251)
- Testing
- Standard Active Warming Blanket, Intravenous Warmer Group, External Warmer Group
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Ataturk University
Platelet Indices, Mortality
Platelet Indices in Prediction of Mortality in Critically Ill Septic Patients
Platelets (PLT), a major and essential constituent of blood, plays an important role in physiological and pathological processes such as coagulation, thrombosis, inflammation and maintenance of vascular endothelial cells the…
- Conditions
- Platelet Indices, Mortality, Sepsis
- Trial name
- NCT04335955
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Amany Faheem
Neuropathic Pain, Neuropathic Pain Diagnostic Questionnaire (DN4) ≥ 4
Hematological Indices and Sympathetic Block Response in Neuropathic Pain
This prospective observational study aims to evaluate the relationship between hematological inflammatory indices and clinical treatment response in patients with neuropathic pain undergoing sympathetic nerve block procedures as…
- Trial name
- HINSPAIN (NCT07596823)
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Ankara City Hospital Bilkent
Inflammation
Impact of JuicePlus+ on the Health Status of an Overweight Stressed Population
The purpose of this study is to determine if a dried fruit and vegetable supplement (Juice Plus+) can alter the gut microbiome and improve gut permeability and inflammatory levels in an obese, stressed population.
- Trial name
- NCT02512107
- Testing
- Juice Plus+
- Where
- United States
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University of Memphis
Gastric Cancer
Prognostic Values of Inflammation-based Indices in Gastric Cancer
This study aims to evaluate the prognostic values of preoperative inflammation-based indices in patients undergoing potentially curative resection of gastric cancer.
- Trial name
- NCT05075421
- Testing
- Gastrectomy
- Where
- Turkey (Türkiye)
- Volunteers
- 350 people
- Sponsor
- Gulhane Training and Research Hospital
Knee Osteoarthritis, Osteoarthritis
Blood Cell Ratios as Predictors of Response to Platelet-Rich Plasma in Knee Osteoarthritis
Intra-articular platelet-rich plasma (PRP) injection is a widely used treatment for knee osteoarthritis, but patients respond to it very differently and there is currently no simple, inexpensive way to predict who will benefit.
- Trial name
- PRP-NLR (NCT07617233)
- Where
- Cyprus
- Volunteers
- 120 people
- Sponsor
- Utku Gürhan
Internal Jugular Vein, Inferior Vena Cava
Internal Jugular Vein and Inferior Vena Cava Collapsibility Indices as a Guidance of Fluid Responsiveness in Septic Shock Cancer Patients
This study aimed to compare between internal jugular vein and inferior vena cava collapsibility indices as a guidance of fluid responsiveness in septic shock cancer patients.
- Conditions
- Internal Jugular Vein, Inferior Vena Cava, Collapsibility Indices, Fluid Responsiveness
- Trial name
- NCT07879287
- Testing
- Ultrasonographic assessment of internal jugular vein (IJV) collapsibility, Ultrasonographic assessment of inferior vena cava (IVC) collapsibility
- Where
- Egypt
- Volunteers
- 106 people
- Sponsor
- Cairo University
Heart Failure With Reduced Ejection Fraction (HFrEF), Chronic Heart Failure
Vericiguat and Reverse Remodeling Indices in Heart Failure
The goal of this clinical trial is to investigate how vericiguat benefits adults with stable heart failure with reduced ejection fraction (HFrEF) who are already receiving guideline-directed medical therapy.
- Trial name
- VERI-PATH (NCT07405944)
- Testing
- Vericiguat, Guideline Directed Medical Therapy for Heart Failure (GDMT)
- Where
- 4 sites in Slovenia
- Volunteers
- 70 people
- Sponsor
- University Medical Centre Ljubljana
HIV Infections, HIV Seronegativity
A Study of Male Rectal Samples in Preparation for Future Rectal Microbicide Trials
Microbicides are drugs that destroy microbes such as viruses and bacteria. Rectal microbicides may be able to prevent transmission of HIV during anal intercourse.
- Trial name
- NCT00075062
- Testing
- Flexible Sigmoidoscopy, Rectal Biopsy
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Chronic Total Occlusions of Coronary Arteries, Stress Echocardiography (SE)
Predicting Functional Recovery After Coronary Chronic Total Occlusion Revascularization
Chronic total occlusion (CTO) is defined as complete coronary occlusion with TIMI flow grade 0 persisting for more than three months, identified in 15-25% of patients undergoing coronary angiography.¹,² CTO is associated with…
- Conditions
- Chronic Total Occlusions of Coronary Arteries, Stress Echocardiography (SE), Inflammation Biomarkers
- Trial name
- StressECHOCTO (NCT07879573)
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acute Kidney Injury Due to Sepsis
Hemodynamic Resuscitation Guided by Non-Invasive Mean Systemic Filling Pressure to Prevent Acute Kidney Injury in Septic Shock
The goal of this clinical trial is to evaluate the efficacy of a hemodynamic resuscitation protocol guided by the Venous Return Gradient (Pmsf - CVP), measured via the non-invasive arm cuff technique, in reducing the incidence of…
- Trial name
- NCT07481097
- Testing
- Hemodynamic measurements during reduction in Norepinephrine and fluid boli.
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Sepsis, Septic Shock
Non-invasive Hemodynamic Optimization of Sepsis in Internal Medicine: a Randomized Study Comparing Therapy Guided by Non-invasive Hemodynamic Indices Versus Standard of Care.
Background and Rationale Sepsis affects 20 to 30 million people globally each year, with an estimated 48.9 million cases in 2017. Despite medical advances, it still carries a high risk of death.
- Trial name
- NCT07863323
- Testing
- non-invasive hemodynamic assessment, Treatment per SSC Guidelines
- Where
- 2 sites in Italy
- Volunteers
- 430 people
- Sponsor
- Regione del Veneto - AULSS n. 7 Pedemontana
Abdominal Sepsis, Critically Ill
Blood Indices of Systemic Inflammation in Critically Ill Patients With Abdominal Sepsis
This study aims to clarify the role of blood indices of systemic inflammation in ICU-admitted patients with abdominal sepsis to assess their diagnostic significance as well as their prognostic value.
- Trial name
- NCT06095830
- Testing
- Complete blood count
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Assiut University
Sepsis, Septicemia
Observational Study of Sepsis and Pneumonia to Develop Diagnostic Tests
We propose to develop novel diagnostic tests for severe sepsis and community acquired pneumonia (CAP). This program, entitled Community Acquired Pneumonia \& Sepsis Outcome Diagnostics (CAPSOD), is a multidisciplinary…
- Conditions
- Sepsis, Septicemia, Sepsis Syndrome, Shock, Septic
- Trial name
- NCT00258869
- Where
- 3 sites in United States
- Volunteers
- 1,200 people
- Sponsor
- National Center for Genome Resources