Clinical trials: Inflammation Knees
Inflammation, Osteo Arthritis Knee
Inflammation Impact on Pain in Knee Osteoarthritis
The aim of this study is to use gold particles as a model compound to modulate specifically and selectively the function of macrophages and mast cells and investigate how this modulates pain and pain sensitization in the…
- Trial name
- NCT03389906
- Testing
- Gold
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Sten Rasmussen, MD, PhD
Total Knee Arthroplasty Revision, Inflammatory Markers
Fiber Smoothie Supplement
This study aims to assess the feasibility of a 2-week dietary whole-food smoothie intervention and compare outcomes between two groups: patients that integrated a daily whole food plant-based smoothie into their diet for two…
- Conditions
- Total Knee Arthroplasty Revision, Inflammatory Markers, Gut Microbiota
- Trial name
- NCT06896240
- Testing
- Assigned Interventions
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Hospital for Special Surgery, New York
Knee Osteoarthritis
Dietary Supplementation With Blueberry in OA
Osteoarthritis is a painful long term joint condition that is associated with poor quality of life. There are no treatments to prevent it. Inflammation is one cause of osteoarthritis. This inflammation is complex.
- Trial name
- NCT05784545
- Testing
- Blueberry powder supplement, Maltodextrin supplementation
- Where
- United Kingdom
- Volunteers
- 58 people
- Sponsor
- University of Exeter
Pain Reduction, Physical Function Improvement
Methorexate and Knee Osteoarthritis
Osteoarthritis (OA) is considered a complex, multifactorial disease leading to considerable pain and functional disability amongst older adults in particular.Synovial inflammation and proliferation has emerged as a key component…
- Trial name
- NCT04326894
- Testing
- 25 mg/week oral methotrexate tablets
- Where
- Egypt
- Volunteers
- 128 people
- Sponsor
- University of Alexandria
Osteoarthritis
Meniscal Tear and Osteoarthritis Risk (MenTOR)
Adults with degenerative meniscal tear receiving arthroscopic surgical management or knee drainage (arthrocentesis) +/- intra-articular steroid injection will be recruited to this non-interventional cohort study.
- Trial name
- MenTOR (NCT02684864)
- Testing
- Non-interventional
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- University of Oxford
Osteo Arthritis Knee, Pain, Chronic
Study of the Effects of Photobiomodulation in Patients With Osteoarthritis
PhotoBioModulation (PBM) is a mature science with therapeutic efficacy in humans and animals, and with excellent results in different medical specialties without side effects.
- Conditions
- Osteo Arthritis Knee, Pain, Chronic, Inflammation
- Trial name
- NCT03924128
- Testing
- Photobiomodulation
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Inflammation, Knee Pain Chronic
Effects of UC-II, Glucosamine and Curcumin Supplementation on Knee Pain and Inflammation.
This research evaluated the effects of UCII, glucosamine and curcumin supplementation on knee pain and inflammation.
- Trial name
- NCT06581094
- Testing
- UCII, glucosamine and curcumin
- Where
- Taiwan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Knee Osteoarthritis, Arthritis
Inflammatory Response Conventional Total Knee Replacement Versus Mako Total Knee Replacement
Total knee Arthroplasty (TKA) is a highly effective treatment for knee osteoarthritis. Mid- to long-term follow-up studies have shown good clinical outcomes following TKA; despite these results, there is a high incidence of…
- Conditions
- Knee Osteoarthritis, Arthritis, Surgery
- Trial name
- NCT04192006
- Testing
- Total Knee Arthroplasty
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University College, London
Knee Injuries
Acute Pain and Inflammation After Surgery
The purpose of this study is 1. to observe acute pain after surgery and measure the natural course of inflammatory mediators 2. study pain relieving effects and local anti-inflammatory effects of systemically administered…
- Trial name
- Knemikro01 (NCT00774540)
- Testing
- 1 Ketorolac intraarticular
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Total Knee Arthroplasty, Inflammation
Gut Microbiome in Orthopaedics
Patients having knee replacement surgery regularly experience joint pain and compromised bone quality leading to implant loosening and periprosthetic fractures.
- Conditions
- Total Knee Arthroplasty, Inflammation, Gastrointestinal Health
- Trial name
- GUMBO (NCT06371950)
- Testing
- Probiotic Formula Bacillus subtilis
- Where
- Canada
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Knee Arthritis Osteoarthritis, Platelet Rich Plasma Injection
Comparison of Platelet-rich Plasma and Activated Cytokine-rich Serum Injection Treatments in Patients With Knee Osteoarthritis. (KOA PRP ACS)
The effects of single dose injection of platelet rich plasma or conditioned serum in the knee joint in patients with knee osteoarthritis will be compared
- Conditions
- Knee Arthritis Osteoarthritis, Platelet Rich Plasma Injection, Conditioned Serum
- Trial name
- KOA PRP ACS (NCT07473232)
- Testing
- Autologous Platelet-Rich Plasma (PRP), Conditioned serum (CS)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Pamukkale University
Knee Osteoarthritis
Effectiveness and Safety of Sphaeralcea Angustifolia Standardized Extract as a Topical Treatment of Knee Osteoarthritis
Knee Osteoarthritis is one of the most frequent rheumatic disorders in the population and, in many cases, it causes disability due to pain, stiffness and deformation.
- Trial name
- NCT04511195
- Testing
- Standardized extract of Sphaeralcea angustifolia, Diclofenac Sodium Gel
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Postoperative Pain
Arthroplasty Inflammation Prophylaxis With Celecoxib
This double blinded, placebo controlled, study seeks to determine the efficacy of preoperative anti-inflammatory therapy on the reduction of postoperative pain in knee arthroplasty surgery.
- Trial name
- NCT00533247
- Testing
- Celecoxib
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Zanbilowicz, Adam, DPM MS
Knee Osteoarthritis
Inulin Supplementation for Reducing Inflammation and Knee Pain in Older Adults With Osteoarthritis
This study will test whether inulin, a type of dietary fiber, can reduce inflammation in older adults with knee osteoarthritis. Inflammation in the body may contribute to both joint pain and the progression of osteoarthritis.
- Trial name
- OA-INULIN (NCT07189585)
- Testing
- inulin
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Yale University
Osteoarthritis
Osteoarthritis: Weakness From Inflammation
The purpose of this study is to understand the factors that lead to muscle weakness with arthritis and aging.
- Trial name
- NCT00104312
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- National Institute on Aging (NIA)
Obesity (Disorder), Knee Osteoarthritis (Knee OA)
Effects of Resveratrol Supplementation Combined With a Low-Calorie Diet in Postmenopausal Women With Obesity and Knee Osteoarthritis
Obesity is a major modifiable risk factor for knee osteoarthritis and is associated with chronic low-grade inflammation, pain, functional impairment, and cartilage degradation.
- Trial name
- ERSOKO (NCT07634302)
- Testing
- Trans-resveratrol extract from Polygonum Cuspidatum, Low-Calorie Diet
- Where
- Russia
- Volunteers
- 97 people
- Sponsor
- Federal State Budgetary Scientific Institution
Osteoarthritis, Obesity
Multi-parametric Imaging of the Knee in Obese Patients With Knee Osteoarthritis; Weight Loss
This is a substudy to a randomised trial investigating the effect of liraglutide on body weight and pain in overweight or obese patients with knee osteoarthritis (NCT02905864).
- Trial name
- IM-LOSEIT-I (NCT02928471)
- Testing
- Intensive dietary intervention
- Where
- Denmark
- Volunteers
- 200 people
- Sponsor
- Henrik Gudbergsen
Knee Osteoarthritis
Exercise Therapy for Osteoarthritis Pain: How Does it Work?
International guidelines recommend exercise as the first choice treatment for knee osteoarthritis (KOA). Muscle strengthening training (MST) and behavioural graded activity (BGA) show comparable effects on KOA pain, but the…
- Trial name
- KOA-PAIN (NCT04362618)
- Testing
- Muscle Strengthening Training, Behavioral graded activity
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Vrije Universiteit Brussel
Osteoarthritis, Knee
Strawberries and Knee Osteoarthritis (OA)
The proposed study aims to examine the hypothesis that strawberry supplementation will lower serum biomarkers of inflammation and improve knee function in patients with symptomatic osteoarthritis (OA).
- Trial name
- NCT02518347
- Testing
- FDS-Strawberry
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Oklahoma State University
Osteoarthritis, Osteo Arthritis Knee
Colchicine for the Treatment of Osteoarthritis of the Knee
This prospective, double-blinded, placebo-controlled, randomized trial will enroll 120 SKOA subjects at the NYU Center for Musculoskeletal Care.
- Trial name
- CLOAK (NCT03913442)
- Testing
- Colchicine 0.8 mg or 0.6 mg orally once daily
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- NYU Langone Health