Clinical trials: Inflammation Knees
Knee Osteoarthritis
taVNS in Veterans With Knee OA (AVAHCS)
The objectives of this study are to identify an optimal transcutaneous auricular vagus nerve stimulation (taVNS) dosing regimen for pain relief and anti-inflammatory effects in Veterans with knee osteoarthritis (OA), compared to…
- Trial name
- taVNS (NCT07804199)
- Testing
- Methylprednisolone acetate, taVNS
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- VA Office of Research and Development
Osteoarthritis, Knee
Follow on Extension of XT-150-1-0201
XT-150 safety and efficacy in severe osteoarthritic pain.
- Trial name
- NCT03769662
- Testing
- XT-150
- Where
- Australia
- Volunteers
- 16 people
- Sponsor
- Xalud Therapeutics, Inc.
Osteoarthritis, Injury
Predicting Osteoarthritis Risk Following Knee Injury.
This observational study seeks to identify and validate novel soluble biomarkers (within blood, synovial fluid, urine) which contribute to the prognostic assessment of an individual with an acute knee injury, a group of…
- Trial name
- KICK (NCT02667756)
- Testing
- Non-interventional
- Where
- United Kingdom
- Volunteers
- 150 people
- Sponsor
- University of Oxford
Osteoarthritis, Knee, Knee Pain Chronic
Impact of Dexamethasone Route on Pain and Inflammation in iPACK With ACB for Knee Arthroplasty
"The Effect of Dexamethasone Administration Route on Pain and Inflammatory Response in iPACK With ACB for Total Knee Arthroplasty" - written in plain language according to ClinicalTrials.gov standards: The goal of this clinical…
- Conditions
- Osteoarthritis, Knee, Knee Pain Chronic, Arthropathy of Knee
- Trial name
- NCT07180953
- Testing
- NaCl 0.9%, Dexamethasone 4mg
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Poznan University of Medical Sciences
Osteoarthritis
Safety & Effectiveness of Autologous Regenerative Cell Therapy on Pain & Inflammation of Osteoarthritis of the Knee
This is a prospective open-label clinical study of 50 patients to determine safety and treatment potential of autologous cell therapy for pain and inflammation associated with Osteoarthritis of the knee.
- Trial name
- NCT02844751
- Testing
- [StroMed + platelet rich plasma (PRP)], [PRP] platelet rich plasma
- Where
- United States
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- VivaTech International, Inc.
Synovitis, Osteoarthritis
Effect of Chondroitin Sulphate on Synovial Inflammation in Patients With Osteoarthritis of the Knee
The purpose of this study is to determine the effect of a chondroitin sulphate conventional treatment on the degree of severity of synovitis, as measured by magnetic resonance in patients with knee OA with clinical synovitis.
- Conditions
- Synovitis, Osteoarthritis, Joint Diseases, Muskuloskeletal Diseases
- Trial name
- NCT00604539
- Testing
- Chondroitin sulphate (Condrosan)
- Where
- 4 sites in Canada
- Volunteers
- 70 people
- Sponsor
- Bioiberica
Knee Osteoarthritis
Exercise Therapy for Osteoarthritis Pain: How Does it Work?
International guidelines recommend exercise as the first choice treatment for knee osteoarthritis (KOA). Muscle strengthening training (MST) and behavioural graded activity (BGA) show comparable effects on KOA pain, but the…
- Trial name
- KOA-PAIN (NCT04362618)
- Testing
- Muscle Strengthening Training, Behavioral graded activity
- Where
- Belgium
- Volunteers
- 90 people
- Sponsor
- Vrije Universiteit Brussel
Arthroplasty Complications, Inflammatory Response
Effects of Navigation Versus Conventional Total Knee Arthroplasty on the Levels of Inflammation Markers
Total knee arthroplasty (TKA) is a well-established modality for the treatment of advanced knee osteoarthritis with high satisfaction rate.
- Trial name
- NCT03163888
- Testing
- Navigation TKR
- Volunteers
- 200 people
- Sponsor
- Chang Gung Memorial Hospital
Osteoarthritis of Knee, Edema
Microcurrent Stimulation Reduces Post-Operative Swelling and Healing Time Following Knee Replacement Surgery
The purpose of this study is to determine if patients undergoing a total knee arthroplasty (TKA) experience a clinically significant reduction in healing time when treated post operatively with a specific form of micro and…
- Conditions
- Osteoarthritis of Knee, Edema, Wounds and Injuries
- Trial name
- NCT02623660
- Testing
- ODIN1, Standard Care, Diagnostic Device Testing
- Where
- 2 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Bioelectric Research Corporation
Knee Arthritis Osteoarthritis, Platelet Rich Plasma Injection
Comparison of Platelet-rich Plasma and Activated Cytokine-rich Serum Injection Treatments in Patients With Knee Osteoarthritis. (KOA PRP ACS)
The effects of single dose injection of platelet rich plasma or conditioned serum in the knee joint in patients with knee osteoarthritis will be compared
- Conditions
- Knee Arthritis Osteoarthritis, Platelet Rich Plasma Injection, Conditioned Serum
- Trial name
- KOA PRP ACS (NCT07473232)
- Testing
- Autologous Platelet-Rich Plasma (PRP), Conditioned serum (CS)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Pamukkale University
Inflammation, Postoperative Delirium
Propofol and Dexmedetomidine on Inflammation
Dexmedetomidine, was reported to prevent postoperative delirium in elderly patients following its use in intensive care units. Possible mechanisms included improved quality of sleep and an inhibitory effect on inflammation.
- Conditions
- Inflammation, Postoperative Delirium, Anesthesia
- Trial name
- NCT03600727
- Testing
- Propofol, Dexmedetomidine
- Volunteers
- 200 people
- Sponsor
- The First Affiliated Hospital of Anhui Medical University
Pain, Acute, Pain, Chronic
Evaluation of the Effect of a Food Supplement Based on Hydrolyzed Collagen on Joint Function.
This clinical study evaluates the effect of taking a hydrolyzed collagen-based supplement on pain, function and quality of life in a moderately physically active population.
- Conditions
- Pain, Acute, Pain, Chronic, Knee Osteoarthritis, Knee Injuries
- Trial name
- COLART (NCT05917925)
- Testing
- COLLAGEN (COL)
- Where
- Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Francisco Javier Martínez Noguera
Postoperative Pain, Inflammation
Steroids in Total Knee Arthroplasty
The purpose of this study is to evaluate if the use of two small doses of intravenous (IV) steroids around the time of knee replacement surgery decrease a patient's pain or use of pain medication.
- Conditions
- Postoperative Pain, Inflammation, Osteoarthritis
- Trial name
- NCT02219581
- Testing
- Dexamethasone 10 mg, Dexamethasone 20 mg, Standard multimodal pain management regimen
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Thomas L Bradbury
Osteoarthritis, Knee Infection
Articulating Versus Static Antibiotic Loaded Spacers for the Treatment of Prosthetic Knee Infection
Infection remains a difficult-to-treat complication of total knee arthroplasty. The gold standard treatment is two-stage removal of the prosthesis with later replacement of permanent implants.
- Conditions
- Osteoarthritis, Knee Infection, Prosthetic Joint Infection, Complications; Arthroplasty, Infection or Inflammation
- Trial name
- NCT01373112
- Testing
- Static Spacer, Articulating Spacer
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Rush University Medical Center
Rheumatoid Arthritis
Draining PLN and Synovial Inflammation in RA Knee Joints Pre and Post Anti-TNF or B Cell Depletion Therapy
The purpose of this study is to examine the effect of anti-TNF therapy on rheumatoid arthritis using magnetic resonance imaging (MRI) and ultrasound imaging.
- Trial name
- NCT01083563
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- University of Rochester
Inflammation, Magnesium Deficiency
Systemic Inflammatory Response: Thiamine and Magnesium Status (Sir TaM Study)
We wish to determine to what extent magnesium, thiamine and transketolase activity are affected by the Systemic Inflammatory Response (SIR).
- Conditions
- Inflammation, Magnesium Deficiency, Iron-deficiency, Thiamine Deficiency
- Trial name
- SirTaM (NCT03554668)
- Testing
- Blood draw
- Where
- United Kingdom
- Volunteers
- 47 people
- Sponsor
- Glasgow Royal Infirmary
Knee Osteoarthritis
Effectiveness and Safety of Sphaeralcea Angustifolia Standardized Extract as a Topical Treatment of Knee Osteoarthritis
Knee Osteoarthritis is one of the most frequent rheumatic disorders in the population and, in many cases, it causes disability due to pain, stiffness and deformation.
- Trial name
- NCT04511195
- Testing
- Standardized extract of Sphaeralcea angustifolia, Diclofenac Sodium Gel
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Osteoarthritis, Knee, Inflammation Knees
How TKA Implants Affect Muscle Quality and Activity During Daily Living and Immunological Response
This study compares two total knee replacement implants to asses muscle function and quality, and the immune response to the implants.
- Trial name
- NCT04105179
- Testing
- Zimmer NexGen LPS-Flex, Smith & Nephew Journey II
- Where
- Canada
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute