Clinical trials: Inflammation in Cardiac Surgery
Male Infertility, Heart Valve Disease
Warfarin Effects on Male Fertility After Cardiac Surgery
Young male patients undergoing cardiac surgery may require oral anticoagulation with warfarin either lifelong, such as after mechanical valve replacement, or for a limited postoperative period, for example following valve repair…
- Trial name
- NCT07330869
- Testing
- Semen analysis, sperm DNA fragmentation and hormonal evaluation
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Città di Lecce Hospital, GVM Care & Research
Surgery-Complications
Crystalloid Fluids and Cardiac Surgery
All cardiac patients admitted to the intensive care unit after surgery received crystalloid fluids as standard care procedure. 3 crystalloid fluids can be used during their stay: Normal Saline, PlasmaLyte or Ringer's Lactate.
- Trial name
- NCT05834257
- Testing
- Normal Saline for fluid resuscitation, PlasmaLyte for fluid resuscitation, Ringer's Lacatate for fluid resusciation
- Where
- Canada
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Circulatory Shock, Sepsis
Shock and Acute Conditions OutcOmes Platform
In-hospital mortality of patients admitted in the intensive care unit (ICU) for circulatory shock remains high (between 20 and 40%).
- Conditions
- Circulatory Shock, Sepsis, Cardiogenic Shock, Major Trauma
- Trial name
- ShockCO-OP (NCT06376318)
- Testing
- Inotrope, Mechanical circulatory support, anti-bodies
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- Saint-Louis Hospital, Paris, France
Acute Kidney Injury Due to Circulatory Failure (Disorder)
The Effects of Oxiris on Systemic Inflammation and Endothelial dysFunction
CS-AKI occurring in 20% to 70% of cases depending of the type of cardiac surgery. The systemic inflammatory response is often observed and associated with increased risk of AKI.
- Trial name
- EOSIEF (NCT04257006)
- Testing
- oXiris membrane
- Where
- Russia
- Volunteers
- 50 people
- Sponsor
- St. Petersburg State Pavlov Medical University
Inflammation in Cardiac Surgery
Hydrocortisone Plus Fludrocortisone in High-risk Patients Undergoing for Cardiac Surgery
Cardiac surgery is a high-risk surgery and is associated with a rate of postoperative adverse outcomes. Like many others major surgery, cardiac surgery procedures induce a proinflammatory phase usually counterbalanced with an…
- Trial name
- VASOCORT (NCT07037043)
- Testing
- hydrocortisone plus fludrocortisone
- Where
- France
- Volunteers
- 196 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Aortic Stenosis, TAVI(Transcatheter Aortic Valve Implantation)
Demographic and Interpopulation Variations in Evaluation and Results of TAVI
The aim of the project is to evaluate demographic, clinical, and laboratory variations in patients with aortic stenosis treated with TAVI in different countries.
- Conditions
- Aortic Stenosis, TAVI(Transcatheter Aortic Valve Implantation), Computed Tomography, Inflammatory Response During Cardiac Surgery
- Trial name
- DIVER-TAVI (NCT07258706)
- Testing
- laboratory biomarker analysis, Computed tomography of aortic root and aorta
- Where
- 5 sites in Italy, Poland and 3 more
- Volunteers
- 800 people
- Sponsor
- Poznan University of Medical Sciences
Inflammation
Efficacy and Safety of Bovine Intestinal Alkaline Phosphatase (bIAP) During Heart Surgery
This multi-centre prospective, randomised, double-blind, placebo-controlled study is designed to evaluate the efficacy and safety of bovine intestinal alkaline phosphatase (bIAP) in reducing the pro-inflammatory post-surgical…
- Trial name
- APPIRED-II (NCT01144611)
- Testing
- bIAP bolus and 8h infusion
- Where
- Netherlands
- Volunteers
- 53 people
- Sponsor
- Alloksys Life Sciences B.V.
Infective Endocarditis (IE)
European Research Group on Outcomes of Surgical Treatment of Infective Endocarditis
The European Research Group on Outcomes of Surgical Treatment of Infective Endocarditis (ERGOSTE) is a nascent large surgical registry that would encompass most relevant aspects of IE in Europe in the contemporary era.
- Trial name
- ERGOSTE (NCT07108803)
- Where
- Italy
- Volunteers
- 2,500 people
- Sponsor
- Azienda Sanitaria Universitaria Giuliano Isontina (ASU GI)
Systemic Inflammatory Response Syndrome
Evaluation of Corticosteroid in Systemic Inflammatory Response Syndrome
Cardiac surgery and cardiopulmonary bypass (CPB) initiate a whole-body systemic inflammatory response (SIRS) characterized by the activation of leukocytes, monocytes, and the complement cascade.
- Trial name
- NCT03876041
- Testing
- solumedrol, Dexamethasone phosphate
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Atrial Fibrillation
Vitamin C and Atrial Fibrillation After Cardiac Surgery
The purpose of this study is to determine if vitamin C decreases the chance of developing atrial fibrillation, a type of arrhythmia or irregular heartbeat, following cardiac surgery.
- Trial name
- NCT01580683
- Testing
- Ascorbic Acid
- Where
- United States
- Sponsor
- Regional Hospital of Scranton
Valvular Cardiac Surgery
A Trial to Evaluate the Effect of Rosuvastatin on Inflammation in Patients Undergoing Isolated Cardiac Valve Surgery
High-dose statin therapy around the time of surgery, decreases inflammation in patients undergoing cardiac valve surgery, and thereby improves clinical outcomes.
- Trial name
- NCT01425398
- Testing
- Rosuvastatin
- Where
- Canada
- Volunteers
- 170 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Insufficiency; Cardiac, Complicating Surgery, Systemic Inflammatory Response Syndrome
Myeloid-Derived Supressor Cells in Cardiac Surgery Patients
Pro- and anti-inflammatory response during the formation of the critical state develops at the same time. Because of its balanced or unbalanced systemic inflammation can be either aborted or able to lead to multiple organ…
- Trial name
- MyDeCCS (NCT02902939)
- Testing
- minimal extracorporeal circulation (MEC), The cytokines modulations
- Where
- Russia
- Volunteers
- 100 people
- Sponsor
- Research Institute for Complex Problems of Cardiovascular Diseases, Russia
Cardiac Surgery, Cardiopulmonary Bypass
Change in Platelet Lipid Metabolism and Procoagulant Phenotype Induced by Cardiopulmonary Bypass. Impact on Postoperative Inflammatory Response and Bleeding Complications During Cardiac Surgery.
The PLACARD research project aims to investigate the impact of CPB-induced platelet modifications during cardiac surgery on the post-operative inflammatory response and bleeding complications.
- Conditions
- Cardiac Surgery, Cardiopulmonary Bypass, Platelet Activation
- Trial name
- PLACARD (NCT07630987)
- Testing
- Arterial blood sample
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Université Catholique de Louvain
Sepsis, Cancer, Heart Attack, Heart Failure, Abdominal Surgery, Trauma, Diabetes, Lung Disease, Gynaecology, Fertility, Cardiac Surgery,
Medical Record Study on Adverse Events Requiring a Higher Level of Care in Flemish Hospitals
An adverse event (AE) is defined as unintended injury or complication, which results in disability, death or prolongation of hospital stay, and is caused by healthcare management (including omissions) rather than the patient's…
- Trial name
- NCT02044718
- Where
- Belgium
- Volunteers
- 878 people
- Sponsor
- Hasselt University
Oxidative Stress, Inflammatory Stress
Melatonin Treatment and Inflammation, Oxidative Stress and Autonomic Function in Connection With Surgery
The purpose of this study is to determine whether treatment with melatonin can reduce cell damage and inflammation in connection with laparoscopic gall bladder surgery.
- Conditions
- Oxidative Stress, Inflammatory Stress, Myocardial Ischaemia
- Trial name
- NCT00311259
- Testing
- Melatonin (drug), Laktose
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Post Cardiac Surgery Systemic Inflammatory Response
Single Dose Administration of Alpha-1 Anti-Trypsin for the Amelioration of Organ Injury in Patients Undergoing Cardiac Surgery
Protocol Summary STUDY DESIGN A pilot, prospective, double blind, randomized, placebo controlled study. STUDY POPULATION Patients assigned to elective CABG with cardiopulmonary bypass (CPB) at the Department of Cardiothoracic…
- Trial name
- NCT02191839
- Testing
- Alpha 1-Antitrypsin
- Volunteers
- 20 people
- Sponsor
- Soroka University Medical Center
Selenium Level
Effect of Heart-lung-machine on Selenium Status of Cardiac Surgical Patients Undergoing Coronary Bypass Surgery
Since selenium has demonstrated significant characteristics for a series of biochemical processes, for antioxidant activity and immune stimulation, this observational study should represent the effect of heart-lung-machine on…
- Trial name
- SEOPCAB (NCT01409057)
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- RWTH Aachen University
Congenital Heart Disease
Washed Versus Standard Blood Cell Transfusions in Pediatric Open Heart Surgery
Background: Children having open heart surgery to repair congenital heart defects demonstrate a large inflammatory response to the heart-lung machine and to surgery itself.
- Trial name
- NCT00693498
- Testing
- Standard leukoreduced irradiated blood cell transfusion, Washed leukoreduced irradiated blood cell transfusions
- Volunteers
- 162 people
- Sponsor
- University of Rochester
Systemic Inflammatory Response Syndrome
INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery
The aim of the study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of inflammatory response related complications in patients undergoing heart surgery with use of cardiopulmonary…
- Trial name
- INFLACOR (NCT01020409)
- Testing
- cardiac surgery with CPB use
- Where
- Poland
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Inflammation Gum, Cardiac Surgery
Impact of Teeth Extraction on Inflammation Marker's Levels in Patients Who Undergoing Cardiac Surgery
The aim of this study is to examine effects of dental treatments, surgical (extractions) and non-surgical procedures (non-surgical periodontal therapy), on serum levels for PCR, WBCs and PCT in patients needing a dental…
- Trial name
- NCT04626011
- Testing
- Tooth extractions
- Where
- Italy
- Volunteers
- 38 people
- Sponsor
- University of Trieste