Clinical trials: Inflammation in Cardiac Surgery
Atrial Fibrillation, Postoperative, Postoperative Complications
Transcutaneous Autonomic Modulation in Thoracic Surgery
In this study, the investigators aim to determine whether non-invasive autonomic modulation decreases inflammation and complications after thoracic surgery.
- Conditions
- Atrial Fibrillation, Postoperative, Postoperative Complications, Inflammation
- Trial name
- TON-POINTS (NCT02783157)
- Testing
- Transcutaneous Low-Level Vagal Nerve Stimulation (LLVNS)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Duke University
Postoperative Cognitive Dysfunction
Palmitoylethanolamide/Luteolin Supplementation in Older Adults Undergoing Cardiac Surgery
Postoperative Cognitive Dysfunction (POCD) is a common complication after surgery, particularly among older adults. It is characterized by cognitive impairment, reduced functional independence, and decreased quality of life.
- Trial name
- NCT07681063
- Testing
- co-ultramicronized Palmitoylethanolamide + Luteolin (700 mg + 70 mg in 10 ml), Standard of Care
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione IRCCS San Gerardo dei Tintori
Nosocomial Infection
Glutamine to Improve Outcomes in Cardiac Surgery
Patients undergoing heart surgery with a heart-lung machine (termed cardiopulmonary bypass) are at an increased risk of having abnormal "inflammation" in their body after surgery.
- Trial name
- GLADIATOR (NCT01704430)
- Testing
- Glutamine, Maltodextrin
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- University of Alberta
Coronary Artery Bypass Grafting, Heart Valve Surgery
VItamin D Metabolism in SEnescent Cardiac Surgery Patients
Advanced age is associated with an increase in postoperative morbidity and mortality in cardiac surgery patients. In detail, compared with younger patients those aged 75 years and older have significantly higher rates of…
- Trial name
- VISE (NCT01378221)
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Congenital Heart Disease, Disorder of Fetus or Newborn
Corticosteroid Therapy in Neonates Undergoing Cardiopulmonary Bypass
Although cardiopulmonary bypass (heart-lung machine) is a necessary component of heart surgery, it is not without consequences. Cardiopulmonary bypass initiates a potent inflammatory response secondary to the body's recognition…
- Trial name
- NCT01579513
- Testing
- Methylprednisolone
- Where
- 2 sites in United States
- Volunteers
- 190 people
- Sponsor
- Medical University of South Carolina
Ischemia/Reperfusion Injury After Neonatal Cardiac Surgery, Inflammatory Reaction After Neonatal Cardiac Surgery
Efficacy of Nitric Oxide Administration in Attenuating Ischemia/Reperfusion Injury During Neonatal Cardiopulmonary Bypass
Around 7500 neonates born yearly in the United States have complex congenital heart disease that require surgical repair in the first few days of life.
- Trial name
- NCT02151877
- Testing
- Inhaled Nitric Oxide
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Wake Forest University Health Sciences
Respiratory Failure, Respiratory Arrest
Postoperative Respiratory Abnormalities
The study aims to determine how historical cases of respiratory abnormalities are documented by clinicians in the electronic health records (EHR) of Memorial Hermann Healthcare System (MHHS) inpatient facilities.
- Conditions
- Respiratory Failure, Respiratory Arrest, Respiratory Distress Syndrome, Acute Respiratory Failure
- Trial name
- AI-ARF (NCT04079829)
- Testing
- Observational retrospective cohort to describe data validity; and Data reliability; and Completeness of the data
- Where
- United States
- Volunteers
- 50,000 people, healthy volunteers welcome
- Sponsor
- Efficacy Care R&D Ltd
Coronary Artery Disease
The Peri-OPerative COlchicine to Reduce Negative Events (POPCORN) Trial
Heart disease remains the leading cause of death in Veterans. Inflammation in the arteries of the heart may increase the risk of cardiac death.
- Trial name
- POPCORN (NCT05618353)
- Testing
- Colchicine
- Where
- 9 sites in United States
- Volunteers
- 700 people
- Sponsor
- VA Office of Research and Development
Cardiac Surgical Procedures, Cardiopulmonary Bypass
Artificial Intelligence for Ulinastatin Responder Outcome & Risk Assessment in CPB
This is a multicenter, retrospective, real-world observational study aimed at developing and validating an artificial intelligence-based tool for identifying ulinastatin treatment responders and risk stratification in cardiac…
- Conditions
- Cardiac Surgical Procedures, Cardiopulmonary Bypass, Systemic Inflammatory Response Syndrome, Multiple Organ Dysfunction Syndrome
- Trial name
- AURORA (NCT07583290)
- Testing
- ulinastatin
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Anzhen Hospital
Renal Failure Acute, Multiple Organ Failure
Evaluation of the Effectiveness of Extracorporeal Methods for Removing Mediators of Systemic Inflammation
The purpose of this study is to assess the effectiveness and the safety of extracorporeal methods for removing mediators of systemic inflammation in patients with multiple organ dysfunction syndrome after heart and aorta surgery.
- Conditions
- Renal Failure Acute, Multiple Organ Failure, Cardiovascular Diseases
- Trial name
- NCT05182723
- Testing
- renal replacement therapy
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Inflammation, Cardiac Surgical Procedures
Inflammatory Responses to Lipid Emulsions in Children Before and After Open Heart Surgery
This study is a blinded, randomized, controlled prospective trial comparing immune response (sepsis, inflammatory response, pulmonary vasoconstriction) in 2 groups of infants less than 3-month old receiving pre and post…
- Trial name
- NCT00336908
- Testing
- a combination of MCT, LCT , and Fish Oil
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of Alberta
Inflammation, Thoracic Surgery
The Importance of Wnt-signaling After Cardiac Surgery
Cardiac surgery saves lives when patients suffer from cardiac disease. Local inflammation is important for tissue repair and wound healing after such an operation.
- Trial name
- NCT04058496
- Testing
- Blood sampling
- Where
- Switzerland
- Volunteers
- 64 people
- Sponsor
- Alain Rudiger
Cardiovascular Disease
Ulinastatin's Anti-inflammatory Reaction in Cardiac Surgery
The purpose of the present study is to determine whether ulinastatin, urinary anti-trypsin inhibitor, attenuates cardiopulmonary bypass (CPB)-activated systemic inflammatory response in cardiac surgery with CPB.
- Trial name
- ulistin (NCT01518569)
- Testing
- ulinastatin
- Where
- South Korea
- Volunteers
- 26 people
- Sponsor
- Konkuk University Medical Center
Inflammation, Systemic Inflammatory Response Syndrome
Inflammatory Response in Aortic Valve Replacement
The study investigates inflammatory and antiinflammatory response in patients with severe aortic valve stenosis needing either surgical treatment (surgical aortic valve replacement) or interventional cardiology treatment…
- Conditions
- Inflammation, Systemic Inflammatory Response Syndrome, Thoracic Surgery, Aortic Valve Stenosis
- Trial name
- NCT02324140
- Testing
- Whole blood analysis
- Where
- Switzerland
- Volunteers
- 101 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Sepsis, Heart Failure
Mean Systemic Filling Pressure Continuous Diuretics Critical Care Patients
Within clinical settings observation of hemodynamic changes (e.g. mean systemic filling pressure, cardiac output) in critically ill patients with a clinical indication for deresuscitation with intravenous diuretic therapy.
- Conditions
- Sepsis, Heart Failure, Heart Diseases, Septic Shock
- Trial name
- NCT03395951
- Testing
- Diuretics
- Where
- Netherlands
- Volunteers
- 18 people
- Sponsor
- Catharina Ziekenhuis Eindhoven
Inflammation, Aortic Valve Stenosis
Is Monocyte/HDL Ratio a Predictor of Mortality in Aortic Valve Surgery
In this study, the investigators aimed to determine whether the preoperative Monocyte/HDL ratio would be a predictor of postoperative mortality and morbidity in patients who underwent aortic valve replacement due to aortic…
- Conditions
- Inflammation, Aortic Valve Stenosis, HDL
- Trial name
- NCT05641584
- Testing
- retrospective data review study
- Where
- Turkey (Türkiye)
- Volunteers
- 1 people
- Sponsor
- Bakirkoy Dr. Sadi Konuk Research and Training Hospital
Infective Endocarditis
Infective Endocarditis in Developing Countries, a Prospective, Observational, Multicentre Study
Introduction. Comprehensive data on infective endocarditis in developing countries are scarce. Objectives: Description of the characteristics (clinical and microbiological) and assessment of the outcomes of infective endocarditis…
- Trial name
- EndoDev (NCT02128139)
- Where
- 6 sites in Fiji, Laos and 3 more
- Volunteers
- 300 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Organ Failure, Multiple, Inflammation
Red Cell Rejuvenation for the Attenuation of Transfusion Associated Organ Injury in Cardiac Surgery
The REDJUVENATE Trial proposes to test the hypothesis that postoperative organ injury and inflammation will be less if patients undergoing cardiac surgery who are at risk of large volume blood transfusion (defined as the…
- Conditions
- Organ Failure, Multiple, Inflammation, Sepsis
- Trial name
- NCT03167788
- Testing
- rejuvesol Solution, Standard Care
- Where
- United Kingdom
- Sponsor
- University of Leicester