Clinical trials: Inflammatory
Inflammation, Sleep Deprivation
Circadian Rhythm Disruption Effects on Smoke Inhalation
Particulate matter exposure during smoke inhalation provokes inflammatory immune responses in people exposed to burning biomass including fire fighters and civilians.
- Conditions
- Inflammation, Sleep Deprivation, Circadian Rhythm Sleep Disorder, Shift Work Type, Smoke Inhalation
- Trial name
- NCT04955431
- Testing
- Sleep Restriction, Normal Sleep
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Montana
Critical Illness
Lactoferrin Use in ICU Patients
Introduction: Lactoferrin has several uses due to its effects. It has anti-inflammatory, antioxidant, immunomodulatory, antibacterial, antifungal, and antiviral effects. Its safety is proven by food and drug administration.
- Trial name
- RCT (NCT05936528)
- Testing
- Lactoferrin, Antioxidant therapies, Dexamethasone
- Where
- Egypt
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Mansoura University Hospital
Crohn Disease, Ovary Disease
Ovarian Reserve in Crohn's Disease
Crohn's disease reduces fertility by inducing inflammation both directly and in the fallopian tubes and ovaries and indirectly through surgical interventions and tubal adhesions associated with disease treatment.
- Conditions
- Crohn Disease, Ovary Disease, Anti-Mullerian Hormone Deficiency
- Trial name
- NCT03897400
- Testing
- AMH levels in young women with crohn's disease will be considered.
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Atopic Dermatitis
Exploratory Study of the Cutaneous Penetration of Biodegradable Polymeric Microparticles in Atopic Dermatitis
This proof of concept study aims to assess in patients suffering from atopic dermatitis if polymeric microparticles reach the pilosebaceous follicles of inflamed skin.
- Trial name
- MicroIskin (NCT02369432)
- Testing
- Biodegradable and biocompatible polymeric microparticles containing a fluorochrome applied to the skin followed by a skin biopsy
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Sepsis
Immune Activation, Hypoxia and Vasoreaction in Sepsis of Pulmonary Versus Abdominal Origin
Sepsis remains a common entity in critical care patients with remarkable mortality. Pulmonary and abdominal infections (with subsequent sepsis) are the most common in the ICU.
- Trial name
- NCT01530932
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universitätsmedizin Mannheim
Inflammatory Bowel Disease, Crohn's Disease
ENhanced Recovery in CHildren Undergoing Surgery
The institution of perioperative Enhanced Recovery Protocols (ERPs) has been found to decrease hospital length of stay, in-hospital costs, and complications among adult surgical populations but data in pediatric populations are…
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- ENRICH-US (NCT04060303)
- Testing
- Perioperative surgical care
- Where
- United States
- Volunteers
- 597 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Inflammatory Bowel Diseases
The Inflammatory Bowel Disease Mediterranean Diet (IBDMED) Microbiome-targeting Nutritional Education Program
The rising incidence of Crohn's disease (CD) and ulcerative colitis (UC), especially in the newly industrialized nations of Asia, highlights the possible role of environmental triggers such as diet and the gut microbiome in the…
- Trial name
- IBDMED (NCT05536544)
- Testing
- IBDMED, Control
- Where
- 2 sites in India, Israel
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Pain, Hematuria
Diclofenac Suppository to Control Pain During Flexible Cystoscopy
Flexible cystoscopy has diagnostic as well as therapeutic role in many patients presenting in urology clinic with lower urinary tract symptoms (frequency, nocturia etc) and hematuria (blood in urine).
- Conditions
- Pain, Hematuria, Lower Urinary Tract Symptoms
- Trial name
- DUF (NCT01812928)
- Testing
- Diclofenac
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Eczema, Psoriasis
Non-invasive Photoacoustic Imaging of Skin Inflammatory Disorders With Machine Learning-assisted Scoring
Inflammatory skin disorders are usually assessed by disease scoring system such as Scoring AD (SCORAD)/Eczema Area and Severity Index (EASI) and Psoriasis Area and Severity Index (PASI) for atopic eczema and psoriasis…
- Trial name
- NCT04809571
- Testing
- Photoacoustic imaging and Confocal Raman spectroscopy measurement
- Where
- Singapore
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Institute of Bioengineering and Bioimaging (IBB)
Diseases, Metabolic, Insulin Sensitivity
Comparing Soybean Oil-Based (Intralipid) With an Olive Oil-Based (ClinOleic) Lipid Emulsion on Healthy Volunteers
Many patients in the hospital who are malnourished or not eating received intravenous feeding or total parenteral nutrition (TPN). Despite improving nutrition, TPN may increase the risk of infections and hospital complications.
- Trial name
- TPN1 (NCT02185729)
- Testing
- Intralipid, ClinOleic, Dextrose
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Emory University
Acne
577-nm Diode Laser in the Treatment of Non -Inflammatory Acne
The aim of this study is to evaluate the clinical efficacy and safety of the 577 nm diode laser in the treatment of non -inflammatory acne.
- Trial name
- NCT06909344
- Testing
- 577 nm Diode laser
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Periodontitis, Type 2 Diabetes
Inflammatory Response and Gingival iNOS Levels in Diabetic vs. Non-Diabetic Periodontitis Patients
This study investigates the relationship between Type 2 diabetes mellitus (T2DM), glycemic control, and periodontal disease. Researchers analyzed the levels of inducible nitric oxide synthase (iNOS) and proinflammatory cytokines…
- Conditions
- Periodontitis, Type 2 Diabetes, Glycemic Control
- Trial name
- NCT06803836
- Where
- Turkey (Türkiye)
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Systemic Sclerosis
Effect of Rosuvastatin on Systemic Sclerosis-related Pulmonary Hypertension
Although the aetiology of SSc-PAH remains elusive, vascular dysfunction seems to be the initial event and statins through their vasculoprotective effect might be of value in the treatment armamentarium of PAH related to SSc.
- Trial name
- NCT00984932
- Testing
- Rosuvastatin
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Alexandria
Healthy Adults
Turmeric Anti-Inflammatory and Cell-Damage Trial
This trial will be conducted for the BBC. The aim of the project is to assess if consuming the spice turmeric every other day, in the amount consumed in a curry, can reduce cell damage and inflammation.
- Trial name
- TACT (NCT02815475)
- Testing
- Curcumin, Turmeric powder
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Newcastle University
Inflammatory Response
Beef and Plant Burger Metabolomics Study
The purpose of this study is to determine the effects of meat on inflammatory and metabolite profiles in middle-aged individuals after an acute meal.
- Trial name
- NCT05690061
- Testing
- Grain-Fed Beef Hamburger, Grass-Fed Beef Hamburger, Impossible BurgerTM
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Utah State University
Myocarditis, Takotsubo Cardiomyopathy
Manganese-Enhanced Magnetic Resonance Imaging (MEMRI) in Ischaemic, Inflammatory and Takotsubo Cardiomyopathy (MEMORY)
Manganese is a calcium analogue which actively enters viable cells with intact calcium-handling mechanisms and its uptake is evident by an increase in MRI-detectable T1 relaxivity of tissues.
- Conditions
- Myocarditis, Takotsubo Cardiomyopathy, Reversible Coronary Ischaemia
- Trial name
- MEMORY (NCT04623788)
- Testing
- Cardiac MRI
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Body Mass Index Quantitative Trait Locus 5 Disorder, Tangier Disease
Effect of High Protein Diet on Adiponectin and Inflammation Among Overweight and Obese Children
The investigators aimed to determine the effects of HP diet on adiponectin and inflammatory factors among overweight and obese children.
- Trial name
- NCT01886495
- Testing
- nutrition intervention
- Where
- Iran
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Isfahan University of Medical Sciences
Crohn's Disease
A Prospective, Placebo Controlled, Double-Blind, Cross-over Study on the Effects of a Probiotic Preparation (VSL#3) on Metabolic Profile, Intestinal Permeability, Microbiota, Cytokines and Chemokines Expression and Other Inflammatory Markers in Pediatric Patients With Crohn's Disease
Background VSL#3 has been reported as an effective adjuvant therapy both in inducing and maintaining remission in pediatric patients affected by Ulcerative Colitis.
- Trial name
- NCT01632462
- Testing
- VSL#3
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Federico II University
Rheumatoid Arthritis, Inflammatory Arthritis
Sleep and Exercise in Rheumatoid Arthritis
Regular physical activity is important for people with rheumatoid arthritis (RA). Sleep requirements for adults should be on a 'sleep needs spectrum' of between 7 to 9 hours per day.
- Trial name
- NCT03140995
- Testing
- Walking Programme
- Where
- Ireland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital of Limerick
Abnormality in Synovial Tissue
Examination of Biopsies From Healthy Knee Joints
The purpose of the project is to examine what kind of molecular mechanism which causes inflammatory joint diseases. This examination is carried out by a collection and analysis of synovial tissues for patients without…
- Trial name
- NCT02458170
- Where
- Denmark
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Northern Orthopaedic Division, Denmark
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