Clinical trials: Inflammatory
Non-steroidal Anti-inflammatory Drug Adverse Reaction
Research for Prevention and Treatment of NSAIDs Related Gastrointestinal Side Effects
We aim to evaluate the protective effects of eradication of HP and continue using Geranylgeranylacetone (GGA) on NSAIDs related gastroenterological lesions.
- Trial name
- NCT01547559
- Testing
- part1:teprenone, part1:EAC-T, part1:EA-EMC-T
- Where
- 2 sites in China
- Volunteers
- 369 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Pain
Comparison of Pain Sensation During Single Use of Two Topical Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
Different case reports are showing that depending on the drug used for eye drops, it might provoke a painful sensation. Actually two leading NSAIDs are used in ophthalmology.
- Trial name
- NCT00869219
- Testing
- Nevanac, Acular LS
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Santa Casa de Misericordia de Santos
Massage, Inflammatory Response
Comparison of Different Forms of Recovery on the Functionality After Physical Exercise
Delayed onset muscle soreness (DOMS) and decrease of musculoskeletal function are due to high intensity training and / or sports activities. These occur due to micro lesions of muscle tissue resulting in nociceptor sensitization.
- Conditions
- Massage, Inflammatory Response, Muscle, Skeletal, Cryotherapy Effect
- Trial name
- NCT04201977
- Testing
- Foam Roller Recovery, Active recovery, Immersion in cold water
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Santa Maria
Parkinson's Disease
Defining a PD-specific Breath Fingerprint of Underlying Inflammatory and Neurodegenerative Processes
The purpose of this study is to determine the potential for a Parkinson's Disease (PD) -specific breath signature as a non-invasive screening tool for identifying PD patients with inflammation, tracking the progression of…
- Trial name
- NCT02749214
- Testing
- Blood Sample Collection, Breath Sample Collection
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Emory University
Chorioamnionitis, Chorioamnionitis Affecting Fetus or Newborn
Amniotic Fluid & the Preterm Gut
Background: Necrotizing enterocolitis (NEC) and sepsis in preterm infants have been linked to intestinal immaturity and preclinical gut microbiota alterations.
- Conditions
- Chorioamnionitis, Chorioamnionitis Affecting Fetus or Newborn, Necrotizing Enterocolitis of Newborn, Neonatal Sepsis, Early-Onset
- Trial name
- AMFIBIE (NCT07152106)
- Where
- 2 sites in Netherlands
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Maxima Medical Center
Sepsis, Septic Shock
We Collected Blood Samples From Septic Shock Patients and Measured ELABELA, Creatinine, and NGAL Levels. Survival After 7 Days Was Recorded and Analyzed to Evaluate the Potential of Serum ELABELA as an Early Diagnostic Marker for Sepsis-associated Acute Kidney Injury.
The investigators selected patients diagnosed with sepsis who were admitted to the Intensive Care Unit (ICU) of Huai'an First People's Hospital between June 2022 and December 2023, as well as healthy individuals with normal…
- Conditions
- Sepsis, Septic Shock, Acute Kidney Injury
- Trial name
- ELABELA（ELA） (NCT06001294)
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Xiangcheng Zhang
Primary Sclerosing Cholangitis, Inflammatory Bowel Disease
Telomere Length and Other Parameters of Telomere Dysfunction in PSC and Colitis
PSC is a chronic cholestatic disorder. The investigators intend to study some telomere parameters and telomere length in order to predict a premalignant state.
- Trial name
- NCT02247622
- Where
- Israel
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Sepsis
Effects of BCG on Immune Response
In the present study, we want to investigate whether BCG-vaccination enhances the innate immune response in humans in vivo during (single) human endotoxemia.
- Trial name
- NCT02085590
- Testing
- BCG vaccine, Lipopolysaccharide (LPS) E. Coli 1 ng/kg intravenously
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
IBD, Covid19
Covid-19 Vaccine Responses in Patients With Inflammatory Bowel Diseases
The 2019-coronavirus disease (COVID-19), caused by SARS-CoV-2, was identified as the source of pneumonia cases in Wuhan city in China. It rapidly spread worldwide and was declared by WHO as a pandemic.
- Trial name
- NCT05067959
- Testing
- Covid-19 vaccine
- Where
- Israel
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- Rabin Medical Center
Endotoxemia
Effect of Selective iNOS Inhibition During Human Endotoxemia
Sepsis or endotoxemia is manifested by hypotension, resistance to vasopressors, myocardial depression,and altered organ blood flow distribution.
- Trial name
- NCT00184990
- Testing
- Aminoguanidine, endotoxin
- Where
- Netherlands
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Mosquito Bite
Evaluation of Anti-inflammatories in the Reduction of Bite Reactions
The purpose of this study is to evaluate two separate antiinflammatory products for the relief of symptoms through suppression of the immunological and inflammatory response following a mosquito bite.
- Trial name
- NCT01452997
- Testing
- NSAI treatment, Steroid treatment
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Sedentariness
The Effect of Walking on Cardiovascular Risk
The purpose of this study was to investigate the effects of an 8 week program of walking for 45 minutes, twice a week, on fitness, body composition , blood pressure and blood markers of cardiovascular risk.
- Trial name
- NCT00284479
- Testing
- Walking 45 mins 2x p.w.
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Sepsis, Septic Shock
Evaluation of Blood Protein O-GlcNAcylation Levels in Children
Stimulation of O-GlcNAcylation has been shown to be beneficial in several acute pathologies and different animal models, such as haemorrhagic and septic shock, and ischaemia-reperfusion (cerebral and cardiac).
- Conditions
- Sepsis, Septic Shock, Development and Health, Metabolism Changes
- Trial name
- CHANCE (NCT06754696)
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Obesity, Inflammation
Effects of Different Coffee Amounts on Energy Intake, Appetite, Glucose Metabolism and Inflammatory Markers
The purpose of the study is to investigate whether different doses of caffeinated coffee consumption has acute effects on subjective appetite feelings, energy intake and biochemical markers related to appetite, inflammation and…
- Trial name
- NCT01495754
- Testing
- coffee
- Where
- Greece
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Colorectal Cancer Stage IV
Predictive and Prognostic Value of Inflammatory Markers and microRNA in Stage IV Colorectal Cancer
This study investigates the predictive and prognostic values of inflammatory markers and microRNA in stage IV colorectal cancer.
- Trial name
- NCT04149613
- Where
- Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Dementia
Copy Number Variations, Inflammatory Cytokines and the Risk of Dementia
Assess the association of copy number variation (CNV) and inflammatory cytokine with the risk of dementia.
- Trial name
- NCT00878280
- Where
- Taiwan
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Colitis, Ulcerative, Crohn Disease
Phase 4, Vedolizumab-4002 Post-marketing, Disease-Drug-Drug Interaction Study
The purpose of this study is to evaluate in a step-wise approach the disease drug-drug interaction (DDI) potential for vedolizumab to indirectly affect the exposure of cytochrome P-450 (CYP) substrate drugs by modulating…
- Trial name
- NCT02760615
- Testing
- Caffeine, Losartan, Omeprazole
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Takeda
Ulcerative Colitis (UC)
The Association Between Interleukin-7 Receptor Gene Polymorphism and the Risk of Ulcerative Colitis
From January 2020 to December 2024, diagnosed ulcerative colitis(UC) patients and gender- and age-matched normal controls were enrolled from the Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical…
- Trial name
- NCT07398586
- Testing
- Vedolizumab
- Where
- China
- Volunteers
- 898 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Adverse Effect of Oral Contraceptives, Sequela
Contraceptive Pill and Hormonal Vaginal Ring in Women With Polycystic Ovary Syndrome
The main aims of this study are: to investigate and compare the effects of long lasting use (59 weeks) of vaginal and oral contraceptives on androgen secretion, insulin and glucose metabolism, lipid profile, and serum levels of…
- Trial name
- NCT01588873
- Testing
- oc:E-E-desogestrel/vaginal ring:E-E -ethonogestrel
- Where
- Finland
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Oulu
Suicide, Attempted, Suicidal Ideation
Biomarkers as Predictors of Suicidal Risk in Adolescents
Suicide is one of the most devastating events in society at all levels. The primary goal of this study is to predict suicide in adolescents at risk.
- Conditions
- Suicide, Attempted, Suicidal Ideation, Suicidal Intention, Suicide
- Trial name
- NCT03014518
- Testing
- Clinical assessments and blood samples; follow-up for 12 mos, Clinical assessments and blood samples; no 12mo follow-up
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
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