Clinical trials: Inflammatory
Healthy
Tolerability, Safety and Pharmacokinetic Study Of Methosulide in Healthy Adult Subjects
The purpose of this study is to determine the safety and tolerability, and to evaluate the pharmacokinetic characteristics and food effect of Methosulide after oral administration in healthy adult subjects.
- Trial name
- NCT02374684
- Testing
- Methosulide
- Where
- China
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Hubei Biological Medicine Industrial Technology Institute Co., Ltd.
Obesity, Skeletal Muscle
Anti-Inflammatory Milk Matrix
Obesity is pro-inflammatory, impairs metabolism, and physically limiting. Specifically, muscle in obese persons does not synthesize proteins normally. This further increases metabolic and physical dysfunction.
- Conditions
- Obesity, Skeletal Muscle, Inflammation
- Trial name
- AIMM (NCT04216004)
- Testing
- Controlled-Feeding Intervention, Non-dairy beverage, Full-fat milk
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Colorectal Cancer (CRC), Colorectal Cancer and Pre-cancer Polyps
Examination of the Large Intestine With Camera Capsule in Patients With Blood Stream Infection With Gut-associated Bacteria
The goal of this observational study is to diagnose colorectal cancer or precancerous tumors in participants over the age of 18 hospitalized with blood stream infection with anaerobic gut-associated bacteria.
- Conditions
- Colorectal Cancer (CRC), Colorectal Cancer and Pre-cancer Polyps, Blood Stream Infection, Anaerobic Infection
- Trial name
- AB-care (NCT06919068)
- Testing
- Colon capsule endoscopy
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
PCOS
Endocrine, Metabolic and Inflammatory Characteristics of Offspring of Mothers With PCOS Hyperandrogenism
This study is a cross-sectional study to explore the endocrine metabolism and inflammatory characteristics of the offspring of mothers with PCOS hyperandrogenism, in order to provide a theoretical basis for finding the cause of…
- Trial name
- NCT06371313
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Guangdong Women and Children Hospital
Abdominal Obesity
Effect of Replacing HFCS With Sucromalt in Subjects With Raised Waist Circumference
Weight gain is linked to a high consumption of soft-drinks and other beverages sweetened with high fructose corn syrup. Being overweight increases risk for diabetes and heart disease.
- Trial name
- NCT00374218
- Testing
- High Fructose Corn Syrup, Sucromalt
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Polycystic Ovary Syndrome, Metabolic Syndrome
Study of the Effect of a Nutritional Supplement on Microbiota, Metabolic Control, Inflammatory Profile, and Quality of Life in Patients With Polycystic Ovary Syndrome.
Polycystic Ovary Syndrome (PCOS) is a complex endocrine-metabolic disorder characterized by elevated androgen levels due to ovarian overproduction.
- Trial name
- NCT06551285
- Testing
- Ovapro (Lifepro)
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Celia Bañuls
Dermatitis, Healthy
Induction of Suction Blisters in Patients With Urticaria, Blistering Diseases, Inflammatory Dermatoses and Neoplastic Disorders, and in Normal Volunteers
The use of a suction blister apparatus has facilitated study of the immunologic capacity of human epidermal cells. We have been able to prepare purified populations of these cells after blister formation.
- Conditions
- Dermatitis, Healthy, Neoplasm, Urticaria
- Trial name
- NCT00001150
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Neonatal Sepsis
Clinical Impact of an Antibiotic Stewardship Program in a Neonatal Intensive Care Unit
Antimicrobial resistance is one of the biggest and most urgent threat to global health. Initiating antimicrobial stewardship programs is one of the main efforts to control antimicrobial resistance.
- Trial name
- NCT04039152
- Testing
- locally adapted neonatal sepsis treatment protocol
- Where
- Egypt
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Assiut University
Crohn Disease
The Intensive Post Exclusive Enteral Nutrition Study
Crohn's disease (CD) is a chronic inflammatory condition with phases where the disease is active and other, where there are no symptoms.
- Trial name
- iPENS (NCT04225689)
- Testing
- CD-TREAT diet
- Where
- 5 sites in United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Inflammatory Disease
Inhaled Nanosilver Study
Background: Nanosilver is tiny silver particles. Many products contain nanosilver, like antimicrobial cleaning supplies and antimicrobial fabrics. Some products also contain nanosilver in a solution that people inhale.
- Trial name
- NCT02408874
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Systemic Inflammatory Response Syndrome
INFLACOR - Clinical and Genetic Predictors of Inflammation Related Complications After Heart Surgery
The aim of the study is to evaluate a clinically and economically most effective diagnostic algorithm for prediction of inflammatory response related complications in patients undergoing heart surgery with use of cardiopulmonary…
- Trial name
- INFLACOR (NCT01020409)
- Testing
- cardiac surgery with CPB use
- Where
- Poland
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- Medical University of Gdansk
Sepsis, Severe Sepsis
Dynamic Changes of Tim-3 on Monocytes and Soluble Tim-3 in Patients With Sepsis
In this study, the investigators will dynamically detect the expression of an immune regulator- T cell Ig and mucin domain protein 3 (Tim-3) in patient with sepsis.
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT02180009
- Where
- China
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Chinese PLA General Hospital
Lentigo, Solar Lentigo
Evaluation of the Tolerance (Main Objective) and Performance of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Brown Spots (Solar and Senile Lentigines, Post-inflammatory Hyperpigmentation) on the Face
The goal of this clinical trial is to compare the 3 different prototype of cyto-selective cryotherapy devices (name of the devices : CRYONOVE) use in brown spots on the face of subject from different ethnicities.
- Conditions
- Lentigo, Solar Lentigo, Post Inflammatory Hyperpigmentation
- Trial name
- CS5_10B (NCT06305897)
- Testing
- CRYONOVE (EC14_4osc), CRYONOVE (EC+05_1osc), CRYONOVE (EC+05_2osc)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Cryonove Pharma
Crohn's Disease
Wireless Capsule Endoscopy in Small-Bowel Crohn's Disease
The purpose of this study is to determine the best role for capsule endoscopy in diagnosing Crohn's disease.
- Trial name
- NCT00178438
- Testing
- Capsule Endoscopy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Rochester
Overweight, Healthy
Absorption and Metabolic Profiles of a Sugar-based Beverage
Primary objective is to determine absorption profile of a sugar-based beverage on inflammatory mechanism by timing of beverage consumption relative to meal intake.
- Trial name
- SR (NCT02226250)
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Age-related Cataract
Effects of Holy-Comod and Tears Naturale Forte in Patients After Phaco+IOL
The purpose of the study it to compare the effects of Holy-Comod and Tears Naturale Forte on ocular surface and tear inflammatory mediators in patients after Phaco+IOL.
- Trial name
- NCT02817191
- Testing
- Hylo-Comod eye drop, Tears Naturale Forte eye drop
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Ptosis, Eyelid, Conjunctiva Inflamed
The Effect of Upneeq (Oxymetazoline Hydrochloride 0.1%) on Eyelid Position, Eye Redness, and Eye Appearance
The purpose of the research is to see if Upneeq ( oxymetazoline 0.1% ophthalmic solution) has an effect on eyelid position, eye redness, or patient-perceived appearance of the eyes.
- Conditions
- Ptosis, Eyelid, Conjunctiva Inflamed, Eye Manifestations
- Trial name
- NCT04831047
- Testing
- Oxymetazoline hydrochloride 0.1% ophthalmic solution
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- University of Miami
Periodontitis
Boron Levels, Oxidative Stress, and Inflammation in Periodontitis
This cross-sectional observational study aims to evaluate the relationship between boron levels and oxidative stress, antioxidant defense, and inflammatory markers in individuals with periodontitis.
- Trial name
- NCT07775378
- Testing
- Biochemical Assessment of Saliva and Gingival Tissue
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Marmara University
Sepsis
Assessing Immune Dysfunction in Sepsis
Sepsis leads to sustained immune system dysfunction resulting in increased susceptibility to secondary infection while in the hospital or after discharge.
- Trial name
- NCT07154615
- Testing
- Observational Only
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Sepsis, Sepsis and Septic Shock
Role of Transposable Elements in Septic Immune Aging
The goal of this observational study is to learn about how transposable element levels affect the patient outcomes in sepsis. The main questions it aims to answer is: 1.
- Conditions
- Sepsis, Sepsis and Septic Shock, Sepsis With Multiple Organ Dysfunction (MOD), Sepsis With Acute Organ Dysfunction
- Trial name
- SITE (NCT06809868)
- Testing
- RNA and DNA Sequencing
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
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