Clinical trials: Inflammatory
Systemic Lupus Erythematosus, Arthritic Psoriasis
A Study to Evaluate BMS-986165 Tablet Formulation Relative to BMS-986165 Capsule Formulation and the Effect of a High-Fat/ High-Calorie Meal and Increased Gastric pH on the BMS-986165 Tablet Formulation
The purpose of this study is to evaluate BMS-986165 tablet formulation versus BMS-986165 capsule formulation. This study will also evaluate the effect of a high-fat/ high-calorie meal and increased gastric pH on the BMS-986165…
- Conditions
- Systemic Lupus Erythematosus, Arthritic Psoriasis, Psoriasis, Inflammatory Bowel Diseases
- Trial name
- NCT03254784
- Testing
- BMS-986165 Capsule, BMS-986165 Tablet
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Obesity, Overweight
Promoting Gastrointestinal Health and Reducing Subclinical Inflammation in Obese Individuals
This study evaluates the impact of increased intake of fruits and vegetables and whole grains on markers of inflammation and gut microbial composition.
- Trial name
- NCT02602496
- Testing
- Fruits and Vegetables, Whole Grain, Control
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Crohn's Disease, Inflammatory Bowel Disease
A Comparison of Ultrasound Guided Transversus Abdominis Plane Nerve Block Techniques
Postoperative pain can pose significant challenges in the postoperative recovery of patients undergoing major colorectal surgery. Traditionally, opioids have played an important role in treating postoperative pain.
- Conditions
- Crohn's Disease, Inflammatory Bowel Disease, Postoperative Pain
- Trial name
- NCT02538679
- Testing
- US TAP Bupivacaine/Epinephrine, Lap TAP Bupivacaine/Epinephrine
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Inflammation
To Demonstrate the Relative Bioavailability of Diclofenac Sodium 50 mg Enteric-Coated Tablets Under Non-Fasting Conditions
To demonstrate the relative bioavailability of Diclofenac Sodium 50 mg enteric-coated tablets under non-fasting conditions.
- Trial name
- NCT00914160
- Testing
- Diclofenac Sodium 50 mg Tablets Under Fasting Conditions (Geneva Pharmaceuticals, Inc), Diclofenac Sodium 50 mg Tablets Under Fed Conditions (Geneva Pharmaceuticals, Inc), Voltaren 50 mg Tablets Under Fed Conditions (Geigy Pharmaceuticals)
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Sandoz
Chronic Obstructive Pulmonary Disease
Endotoxin and Inflammatory Markers in Healthy Non-Smokers and Current Smokers Including Patients With Chronic Obstructive Pulmonary Disease (COPD)
The primary aim of this study is to investigate the effects of inhaled lipopolysaccharide endotoxin (LPS) on bronchial and alveolar exhaled nitric oxide (NO) and NO metabolites and other inflammatory markers and mediators in…
- Trial name
- NCT00159289
- Testing
- Inhalation of LPS
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Imperial College London
Acute Inflammatory Response to Non-antigenic Stimulus
Phase 1a Study in Healthy Smokers to Investigate the Effect With MMI-0100 on Airway Inflammation in Induced Sputum After Challenge With Inhaled Lipopolysaccharide
A Phase 1a, randomized, placebo controlled, two-way crossover study is to determine the effect of inhaled MMI-0100 compared to placebo following LPS challenge on inflammatory markers.
- Trial name
- LPS (NCT02515396)
- Testing
- MMI-0100
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Moerae Matrix, Inc.
Preterm Birth
Study of Cervix and Inflammation in Preterm Birth Prediction
Preterm birth rate is 7.2% in Quebec, it's risen worldwide in the past decade and it's the leading cause of perinatal mortality and morbidity. Preterm birth is a major public health problem.
- Trial name
- COLIBRI (NCT01007513)
- Testing
- Transvaginal ultrasound, Vaginal secretion sampling
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Colorectal Cancer
Changes in Stem Cells of the Colon in Response to Increased Risk of Colorectal Cancer
Colorectal cancer is a common disease worldwide. Increasing evidence is demonstrating that colorectal cancers arise from 'cancer stem cells.' Stem cells in the colon reside at the bottom of thousands of microscopic crypts…
- Trial name
- NCT01075893
- Where
- 2 sites in United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Newcastle University
Inflammatory Bowel Diseases
Serum NGAL as a Predictor of Clinical and Endoscopic Activity of Inflammatory Bowel Disease
Ulcerative colitis (UC) and Crohns disease (CD) represent the two major forms of inflammatory bowel disease (IBD), characterized by epithelial cell damage and prominent mucosal infiltration by inflammatory cells including…
- Trial name
- NCT05151458
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assiut University
Ulcerative Colitis
A Study of LIV001 in Healthy Subjects and Those with Mild-to-Moderate Active Ulcerative Colitis (UC)
This study is only for the first in human phase 1a study designed to investigate the safety and tolerability of LIV001 in healthy participants.
- Trial name
- NCT05975047
- Testing
- LIV001
- Where
- Australia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Liveome Inc.
Inflammatory Bowel Disease
A Randomized, Double-Blind, Dose-Escalation, Placebo-Controlled Phase I Clinical Trial Investigating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single and Multiple Oral Doses of HRS-7085 Tablets in Healthy Subjects, With Assessment of Food Effects
This is a multicenter, randomized, double-blind, placebo-parallel-controlled, Phase I clinical trial investigating the safety, tolerability, pharmacokinetics, and pharmacodynamics of single and multiple oral doses of HRS-7085…
- Trial name
- NCT06175949
- Testing
- HRS-7085 Tablets, HRS-7085 simulant
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Shandong Suncadia Medicine Co., Ltd.
Acute Post-operative Pain
Ibuprofen Use on Post-operative Pain Following Cholecystectomy
In this study, the investigators compared the effects of IV forms of ibuprofen and acetaminophen on pain perception and opioid consumption following laparoscopic cholecystectomy.
- Trial name
- NCT06478758
- Testing
- Ibuprofen 400 mg, Acetaminophen 100 MG/ML
- Where
- Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Giresun University
Fibrinogen Abnormality, Telomere Length, Mean Leukocyte
Pediatric ACEs Screening and Resiliency Study
Stressful and traumatic experiences in childhood (Adverse Childhood Events, or ACEs) have been associated with poor health outcomes that extend into adulthood.
- Conditions
- Fibrinogen Abnormality, Telomere Length, Mean Leukocyte, Atopic, Acute Infection
- Trial name
- PEARLS (NCT04182906)
- Testing
- Care Coordination, Resiliency Clinic, Usual Care
- Where
- United States
- Volunteers
- 555 people, healthy volunteers welcome
- Sponsor
- UCSF Benioff Children's Hospital Oakland
Posttraumatic Stress Disorder (PTSD)
Inflammatory Challenge and Fear
The goal of this study is to learn if short-term changes in the immune system alter how we process information and experience fear.
- Trial name
- LIFE (NCT06630884)
- Testing
- Typhoid VI Polysaccharide Vaccine Injectable Solution
- Where
- United States
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Sport
Effects of Decohexaenoic Acid Supplementation on Markers of Inflammatory Muscle Damage
Randomized, placebo-controlled, double-blind, placebo-controlled clinical trial consisting of 15 triathletes in which it is intended to observe less inflammatory damage at the muscular level after performing eccentric exercises.
- Trial name
- (EDA) (NCT04125199)
- Testing
- supplement consumption
- Where
- Spain
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Inflammatory Bowel Disease
Cytokine Production of Colonic Tissue From IBD Patients
Chronic intestinal inflammation characterizes inflammatory bowel diseases (IBD), which consist mainly of Crohn's disease and ulcerative colitis.
- Trial name
- NCT02828748
- Testing
- no intervention in patients treatment, only biopsy taken
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Perceived Discrimination, RNA
Social Experiences and Demographic Factors in the Regulation of Immune Cells
Immune-mediated inflammatory diseases are a health burden for approximately seven percent of the population of Western nations. Preliminary data suggest variations in ethnic identity and/or geography influence discrimination…
- Conditions
- Perceived Discrimination, RNA, Inflammatory Response
- Trial name
- NCT06519487
- Testing
- Cyberball
- Where
- 2 sites in United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Morgan State University
Healthy
The Absorption and Metabolism of Seaweed Polyphenols in Humans
Brown seaweeds are a rich source of phlorotannins, a characteristic class of polyphenols which are unique to seaweeds of this type and can comprise 5 to 15 % of the dried weight.
- Trial name
- SWAFAX (NCT02496806)
- Testing
- Seaweed extract
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Reading
Healthy
Gastroprotective Agent Utilization and Compliance in Elderly Patients Taking Non-steroidal Anti-inflammatory Drug (NSAID) in France
The purpose of this study is to assess in general population NSAID and gastroprotective agent utilization and compliance in elderly people.
- Trial name
- NCT01211652
- Where
- 3,510 sites in France
- Volunteers
- 8,186 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Inflammatory Bowel Disease
Characterization of Phenotype and Genotype of Early Onset Enteropathies
This study has been set up in order to characterize phenotypes and genotypes of patients with early onset enteropathies. In that goal, Investigators will collect biological samples (mainly blood) of patients suffering from early…
- Trial name
- IMMUNOBIOTA (NCT02614911)
- Testing
- Biological sampling
- Where
- 12 sites in France
- Volunteers
- 1,445 people, healthy volunteers welcome
- Sponsor
- Imagine Institute
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