Clinical trials: Inflammatory
Sepsis
Dysfunctions of Human Muscle Stem Cells in Sepsis
Severe critical illness is often complicated by Intensive Care Unit - Acquired Weakness (ICU-AW), which is associated with increased in and post-ICU mortality, with delayed weaning from mechanical ventilation and with long-term…
- Trial name
- DISCUSS (NCT02789995)
- Testing
- Human biological samples
- Where
- 7 sites in France
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur
Acne
577-nm Diode Laser in the Treatment of Non -Inflammatory Acne
The aim of this study is to evaluate the clinical efficacy and safety of the 577 nm diode laser in the treatment of non -inflammatory acne.
- Trial name
- NCT06909344
- Testing
- 577 nm Diode laser
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Decay, Dental, Missing Teeth
Relationship Between Oral Findings and Salivary Factors in Sars-Cov-2 Patients
Two hundred individuals will be formed according to the study and control groups: Group-1: coronavirus 2 (Covid-19) (+) patients (n=100) and Group-2: Healthy individuals (in which the volunteers will be included due to group-1)…
- Conditions
- Decay, Dental, Missing Teeth, COVID-19, Cytokine Storm
- Trial name
- NCT05476848
- Testing
- ELISA test for Cytokines
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Ege University
Chronic Obstructive Pulmonary Disease
Endotoxin and Inflammatory Markers in Healthy Non-Smokers and Current Smokers Including Patients With Chronic Obstructive Pulmonary Disease (COPD)
The primary aim of this study is to investigate the effects of inhaled lipopolysaccharide endotoxin (LPS) on bronchial and alveolar exhaled nitric oxide (NO) and NO metabolites and other inflammatory markers and mediators in…
- Trial name
- NCT00159289
- Testing
- Inhalation of LPS
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Imperial College London
Neonatal Sepsis, Necrotizing Enterocolitis
Bovine Lactoferrin and Neonatal Survival in Low Birth Weight Babies.
Pakistan has the third highest number of neonatal deaths worldwide. During the last two decades (1990-2013), neonatal mortality rate in the country has declined by only 1.0% per year.
- Trial name
- NCT03431558
- Testing
- bLF (Bovine lactoferrin)
- Where
- Pakistan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Inflammatory Disease
A First-in-Human Study of Single and Multiple Doses of Amilo-5MER in Healthy Subjects
This is a three-part, single Centre, double-blind, randomized, placebo-controlled first-in-human study of single ascending doses (SADs, Part 1) and multiple doses (Part 2) of amilo-5MER in healthy young adult male subjects and a…
- Trial name
- NCT05857215
- Testing
- amilo-5MER
- Where
- United Kingdom
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Galmed Pharmaceuticals Ltd
CIDP - Chronic Inflammatory Demyelinating Polyneuropathy, Guillain-Barré Syndrome (GBS)
Multispectral Optoacoustic Imaging for the Detection of Inflammation and Damage of Peripheral Nerves in Guillain-Barré Syndrome and Chronic Inflammatory Demyelinating Polyneuropathy
The aim of this study is to assess disease activity in patients with Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) and Guillain-Barré Syndrome (GBS) using multispectral optoacoustic tomography (MSOT).
- Trial name
- MIND (NCT07121985)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Erlangen-Nürnberg Medical School
Myalgic Encephalomyelitis, Chronic Fatigue Syndrome
Analysis of Post-exertional Malaise Using a Two-day CPET in People With ME/CFS
This study aims to collect and identify key outcome measures or disease parameters in ME/CFS that are altered during elevated symptoms relative to baseline by gathering information before and after symptom provocation using a…
- Trial name
- NCT04026425
- Testing
- Two-day cardiopulmonary exercise test
- Where
- 3 sites in United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Ithaca College
IBD, Crohn Disease
Volatile Organic Compounds (VOCs) in Active Inflammatory Bowel Disease
Inflammatory Bowel Disease (IBD) are chronic diseases of the gut comprising Crohn's Disease (CD) and Ulcerative Colitis (UC). The symptoms of IBD consist of diarrhea, abdominal discomfort, weight loss, fatigue and rectal…
- Conditions
- IBD, Crohn Disease, Ulcerative Colitis
- Trial name
- VOC (NCT04827368)
- Testing
- Breath Test
- Where
- United States
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Ulcerative Colitis
Thermography in Surveillance of Ulcerative Colitis
Ulcerative colitis represents a chronic condition occurring in relapsing and remitting fashion with uncertain outcome and requires lifelong treatment with considerable side effects.
- Trial name
- Thermo (NCT02149043)
- Testing
- Thermography, Colonoscopy
- Where
- Croatia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University Hospital Dubrava
Sepsis, Infection
Biomarkers in Infection
The purpose of this investigation is to evaluate how early biomarkers of infection and inflammation perform in identifying patients at risk for poor outcome in sepsis and septic shock.
- Conditions
- Sepsis, Infection, Inflammation
- Trial name
- NCT02545478
- Where
- 2 sites in United States
- Volunteers
- 4,200 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Inflammatory Bowel Diseases
Can we Rely on HLA to Predict Resistance to Biological Therapy in IBD Patients
The investigators propose an observational study including patients with inflammatory bowel disease under biological therapy with anti-TNF, anti-integrin α₄β₇ or anti-interleukin 12-23 (Ustekinumab), followed by an external…
- Trial name
- NCT05040854
- Testing
- HLA-DQA1*05 and DRB1
- Where
- Portugal
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Centro Hospitalar Tondela-Viseu
Muscle Synthesis
Protein Blends (Soy, Whey and Casein) for Muscle Synthesis
Soy protein is a high quality, plant-based protein that is comparable to milk, meat and eggs. Soy protein has a digestion rate (intermediate) compared to whey (fast) and casein (slow).
- Trial name
- NCT01358305
- Testing
- Protein Blend
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- DuPont Nutrition and Health
Iron Deficiency (Without Anemia)
Effect of Ferrous iROn and cUrcumin sTatus on Inflammatory and Neurotrophic markErs
INTRODUCTION: Iron is a vital nutrient for many physiological processes including DNA production, oxygen transport and neuronal processes.
- Trial name
- Fe-ROUTINE (NCT04465851)
- Testing
- Ferrous Sulphate 65 mg, Curcumin, Ferrous Sulphate 18mg
- Where
- United Kingdom
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- University of Westminster
Asthma, Allergic Asthma
Towards Targeting the ORigin of the Inflammatory Cascade in Allergic Asthma
Allergic asthma is a complex and heterogeneous disease caused by excessive responses to inhaled allergens. Current medication, including corticosteroids and bronchodilators, does not act on the origin of inflammation but rather…
- Trial name
- ORIENT (NCT04264377)
- Testing
- Bronchoscopy
- Where
- Netherlands
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Systemic Lupus Erythematosus, Lupus Nephritis
Systemic Immune Inflammatory Index in Systemic Lupus Erythematosus
This study aims to investigate the association between the systemic immune-inflammation index and disease activity, as well as lupus nephritis in patients with systemic lupus erythematosus
- Trial name
- NCT06796569
- Testing
- systemic immune inflammatory index
- Where
- Egypt
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Sohag University
Crohn Disease
Biologics and Partial Enteral Nutrition Study
Crohn's disease (CD) is a chronic, incurable condition associated with inflammation in the gut lining. It causes diarrhoea, severe abdominal pain, poor nutrition and adversely affects the quality of life of sufferers.
- Trial name
- BIOPIC (NCT04859088)
- Testing
- Partial Enteral Nutrition
- Where
- 4 sites in United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- NHS Greater Glasgow and Clyde
Acne Vulgaris
Anti-inflammatory Effects of Topical Erythromycin and Clindamycin in Acne Patients
The combined bacteriostatic and immunomodulatory effects of erythromycin and clindamycin will be explored. Treatment effects will be extensively characterized by conventional methods including lesion counts, global assessment…
- Trial name
- NCT03883269
- Testing
- Erythromycin 4% topical gel formulation, Clindamycin 1% topical lotion formulation, 70% topical ethanol solution
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Centre for Human Drug Research, Netherlands
Low Back Pain
Effects of Spinal Manipulative Treatment on Inflammatory Markers in Low Back Pain Patients
It is expected that mechanical low back pain (LBP) is associated with inflammatory changes localized to the affected tissues. Could such changes be detected in cells involved in the inflammatory process in an in vitro model? The…
- Trial name
- NCT01766141
- Testing
- Spinal manipulation
- Where
- Canada
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Canadian Memorial Chiropractic College
Alzheimer Disease, Dementia
Delaying Alzheimer Disease Symptoms With Anti-Inflammatory Drugs
The purpose of this study is to determine whether the anti-inflammatory drug celecoxib can delay the onset of Alzheimer Disease (AD) in people with Age Associated Memory Impairment (AAMI).
- Trial name
- NCT00065169
- Testing
- Celecoxib
- Where
- United States
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
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