Clinical trials: Inflammatory
Sepsis
Melatonin in Healthy Volunteers
Antioxidant therapy targeted at mitochondria has the potential to reduce inflammation, mitochondrial damage and organ dysfunction in sepsis.
- Trial name
- DAMSEL1 (NCT01724424)
- Testing
- Melatonin
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Sepsis, Intensive Care (ICU)
Investigation of the Relationship Between MD, MLR and NLR With APRs in Sepsis in the ICU
The aim of this study is to investigate, in patients admitted to the intensive care unit either for reasons other than sepsis who subsequently develop sepsis or with a primary diagnosis of sepsis, whether monocyte distribution…
- Conditions
- Sepsis, Intensive Care (ICU), Acute Phase Biomarkers
- Trial name
- NCT07537179
- Testing
- Monocyte Distribution
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Oguz Gundogdu
Healthy, Colorectal Adenoma
IMPACT OF SEDENTARY BEHAVIOR IN THE HOMEOSTASIS OF THE DIGESTIVE ECOSYSTEM
This study seeks to determine the relationship between sedentary behavior, gut transit, gut microbiota and polyps development. Will be conducted an evaluation which includes assessments of physical activity behaviors (through…
- Trial name
- NCT07398820
- Testing
- Initial assessment
- Where
- Chile
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Clínica Universidad de los Andes
Inflammatory Bowel Diseases, Quality of Life
Effect of Probiotic Administration on Patients With Inflammatory Bowel Disease
The study is a single-center, randomized, single-blinded, controlled trial conducted at ZHUMC's endoscopy unit. It aims to assess the short-term effects of probiotic administration on disease course, quality of life, and…
- Conditions
- Inflammatory Bowel Diseases, Quality of Life, Food Intolerance, Flare Up
- Trial name
- NCT06392061
- Testing
- Trilac
- Where
- Lebanon
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lebanese University
Post Concussive Symptoms
Chasing Biomarkers in Post-concussion Syndrome
The goal of this study was to investigate the biomarkers, neurofilament light chain, inflammatory markers, calcitonin-gene-related peptide, and metabolites from the kynurenine pathway in patients with severe post-concussive…
- Trial name
- NCT05812742
- Testing
- Early intervention programme, Enhanced usual care
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Covid19, Myopathy
Safety and Efficacy of Inactivated SARS-CoV-2 Vaccine in Immune-related Myopathy (Myasthenia Gravis and Inflammatory Myopathy) Patients ：a Prospective Observational Study
This study is a prospective observational study. We aim to investigate the safety and efficacy of inactivated SARS-CoV-2 vaccine between immune-related myopathy (myasthenia gravis and inflammatory myopathy) patients and health…
- Trial name
- NCT04941079
- Testing
- no intervention
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Dry Eye Syndrome
Point of Care Testing of Inflammatory Markers in Tears
To evaluate the use of a point of care device to measure markers of inflammation in various eye conditions. In particular, matrix metalloproteinase-9 (MMP-9) will be measured. MMP-9 is an enzyme that plays a role in inflammation.
- Trial name
- NCT02315079
- Testing
- Eye inflammation, Without eye inflammation
- Where
- United States
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- University of Florida
RA, SLE
Vaccination in Inflammatory Rheumatic Disease (VACCIMIL). The Impact of Antirheumatic Treatment on Antibody Response
The overall objective of this project is to study the influence of modern anti-inflammatory treatments in established inflammatory rheumatic diseases (IRD) on immune response elicited by pneumococcal vaccination using 13-valent…
- Conditions
- RA, SLE, Vasculitis, Scleroderma
- Trial name
- Vaccimil (NCT02240888)
- Testing
- 0,5 mg Prevenar i.m., 0,5 mg seasonal influenza vaccine i.m.
- Where
- Sweden
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Region Skane
Sepsis, Pneumonia
Genetic Variation and Immune Responses After Injury
Our overall hypothesis is that genetic variations in innate immunity genes predispose patients to varying responses after injury by altering the systemic and local inflammatory responses.
- Conditions
- Sepsis, Pneumonia, Trauma, Burn
- Trial name
- NCT00294697
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- National Institute of General Medical Sciences (NIGMS)
Vital Pulp Therapy
Diagnostic Biomarkers to Correlate Molecular Changes and Inflammatory Cascade in the Dental Pulp.
This study aimed to evaluate the molecular changes that occur within the pulp tissue during inflammation and its correlation with vital pulp therapy with its different treatment modalities (Direct pulp capping, Partial Pulpotomy…
- Trial name
- NCT05464797
- Testing
- Pulp therapy, Cytokines level in pulpal blood.
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Neonatal SEPSIS
Safety and Efficacy of Oral Bovine Lactoferrin
Oral lactoferrin versus Placebo will be given to preterm neonates
- Trial name
- Lactoferrin (NCT04094597)
- Testing
- Lactoferrin
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cairo University
Inflammatory Bowel Diseases
Autonomic and Cytokines Profiles of Patients With Ulcerative Proctitis
1. To prove that patients with ulcerative proctitis and proctosigmoiditis have impaired autonomic functions, i.e. increased sympathetic activity and/or reduced vagal tone. 2.
- Trial name
- NCT03259659
- Testing
- ECG recording, inflammatory cytokines, microbiota, ulcerative colitis disease activity index
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Osteoarthritis, Knee
Combination of Curcuminoid With Acupressure for Inflammation and Pain in the Elderly With Osteoarthritis Genu
The goal of this clinical trial is to to investigate the efficacy of acupressure and standardized curcuminoids from turmeric extract to inflammatory markers, endorphin hormones in the blood and quality of life in elderly patient…
- Trial name
- NCT06105840
- Testing
- Acupressure and Standardized Curcuminoid from Turmeric Extract
- Where
- Indonesia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Gadjah Mada University
Ulcerative Colitis
Restoration of the Microbiome Through Superdonor Selection
The AIM of this study is to investigate whether the FMT success rate in active UC patients can be increased by intensive donor pre-screening, anaerobic preparation of the FMT and by repeated FMT.
- Trial name
- RESTORE-UC (NCT03110289)
- Testing
- superdonor FMT, autologous FMT
- Where
- Belgium
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Sepsis, Severe Sepsis
Unsupervised Machine Learning for Clustering of Septic Patients to Determine Optimal Treatment
The focus of this study will be to conduct a prospective, randomized controlled trial (RCT) at Cape Regional Medical Center (CRMC), Oroville Hospital (OH), and UCSF Medical Center (UCSF) in which a fluid treatment-specific…
- Conditions
- Sepsis, Severe Sepsis, Septic Shock
- Trial name
- NCT03752489
- Testing
- Treatment-specific InSight, InSight
- Volunteers
- 51,645 people, healthy volunteers welcome
- Sponsor
- Dascena
Depression, Coronary Artery Disease (CAD)
A Trial of Inflammatory Markers, Depressive Symptoms, and Heart Disease
The purpose of this study is to examine the relationship between depressive symptoms and markers of inflammation, two predictors of heart disease.
- Conditions
- Depression, Coronary Artery Disease (CAD), Acute Coronary Syndrome (ACS)
- Trial name
- CHIME (NCT00208117)
- Testing
- Sertraline (Zoloft), Simvastatin (Zocor)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- New York State Psychiatric Institute
Acute on Chronic Liver Failure
Assessment of Coagulation Profile and Haematopoietic Responses in Patients With Acute-on-chronic Liver Failure During Systemic Inflammatory Response (SIRS) and Sepsis
This study attempts to clarify the pathophysiology of haemostasis and haematopoiesis in relation to the evidence of sepsis in liver disease, and compares the accuracy of various available laboratory tests in assessment of these…
- Trial name
- NCT02307409
- Testing
- Sonoclot/TEG test
- Where
- India
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Institute of Liver and Biliary Sciences, India
Chronic Apical Periodontitis, Pulp Necrosis
Clinical and Inflammatory Outcomes of Regenerative Endodontic Treatment Using Injectable Platelet-Rich Fibrin in Mature Necrotic Teeth With Chronic Apical Periodontitis.
This randomized clinical trial aims to compare regenerative endodontic treatment using injectable platelet-rich fibrin (i-PRF) with conventional root canal treatment in mature necrotic anterior teeth with chronic apical…
- Trial name
- REGEN-iPRF (NCT07913399)
- Testing
- Conventional Root Canal Treatment, Regenerative Endodontic Treatment with i-PRF, Injectable Platelet-Rich Fibrin (i-PRF)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medipol University
Acute Uncomplicated Diverticulitis
Acute Uncomplicated Diverticulitis and Conservative Treatment: Accuracy of Inflammatory Indexes for Failure Prediction: Observational Prospective Cohort Study. (AUDRIP Trial)
This is an observational multicenter study that will analyse the accuracy of inflammatory indexes as neutrophil-lymphocyte ratio and platelet-lymphocyte ratio, to predict the failure of conservative treatment of patients…
- Trial name
- AUDRIP (NCT05833698)
- Testing
- Elevation of NLR
- Where
- Spain
- Volunteers
- 2,160 people, healthy volunteers welcome
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Ulcerative Colitis
Oncostatin M in Ulcerative Colitis Patients
Ulcerative colitis (UC) is a refractory disease characterized by symptoms such as diarrhea, bloody stools, and abdominal pain with repeated relapses and remissions.
- Trial name
- NCT05974332
- Testing
- Oncostatin M
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
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