Clinical trials: Inflammatory
Inflammatory Bowel Diseases, Crohn Disease
Shared Decision Making in Paediatric Inflammatory Bowel Disease
The goal of this mixed-methods prospective cohort study is to assess the impact of shared decision-making (SDM) on newly diagnosed pediatric inflammatory bowel disease (IBD) patients and their families.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, IBD
- Trial name
- SDM-IBD (NCT05689892)
- Testing
- Decision Coach Sessions
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre
Healthy
Effect of Brazilian Fruits Peel on Metabolic Regulation and Appetite in Healthy Subjects
The purpose of the study was to investigate how Brazilian fruits peel affect acute/postprandial glucose and insulin responses, inflammatory markers, appetite control peptides, antioxidative capacity, as well as subjective…
- Trial name
- BRASIL-MET (NCT02245906)
- Testing
- Control drink, Brazilian fruit peel flour, Negative control drink
- Where
- Sweden
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Lund University
Hereditary Angioedema (HAE)
Open-label, Single-arm Study to Assess the Pharmacokinetics, Safety, and Tolerability of a Single Subcutaneous Dose of Icatibant in Healthy Japanese Volunteers
This is a single-dose study to evaluate the pharmacokinetics, safety, and tolerability of icatibant administered to adult Japanese subjects.
- Trial name
- NCT02045264
- Testing
- Icatibant (30 mg)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Shire
Inflammatory Bowel Disease, Iron Deficiency Anemia
EffiCacy and sAfEty of Low doSe orAl iRon for Anaemia in IBD
Iron deficiency anaemia (IDA) is common in inflammatory bowel disease (IBD). However, although iron is commonly prescribed, the amount of elemental iron needed to achieve clinical efficacy, and the optimal method of…
- Trial name
- CAESAR (NCT06321887)
- Testing
- Ferrous fumarate syrup 2.5ml/70mg (22.5mg elemental iron), Ferrous fumarate syrup 2.5ml/70mg(45mg elemental iron), Ferrous fumarate syrup 2.5ml/70mg (90mg elemental iron)
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
COVID-19-Associated Encephalitis, Multisystem Inflammatory Syndrome in Children
Investigation of Prognostic Biomarkers, Host Factors and Viral Factors for COVID-19 in Children
Background and objective From this April, there was a COVID-19 outbreak in Taiwan. The first fatal case of pediatric COVID-19 encephalitis was reported on April 19, 2022 and fatal fulminant cerebral edema in other 4 children with…
- Trial name
- NCT05576714
- Testing
- delineate its prognostic biomarker, host genetic factors, immunopathogenesis and viral pathogenesis
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Healthy, Postprandial
Acute Effects of Wine Consumption on Healthy Volunteers
The purpose of this study is to investigate whether red and white wine consumption has acute effects on postprandial biochemical markers related to platelet aggregation, inflammation and oxidative stress compared to water or…
- Trial name
- winepost (NCT01627912)
- Testing
- Robola, Cabernet Sauvignon wines
- Where
- Greece
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Severe Asthma
3TR Asthma Biologics Cohort (ABC) Study
The 3TR-ABC study is a multicentre observational prospective cohort study platform that follows patients with severe asthma from the start of biological therapy and three years onwards.
- Trial name
- 3TR-ABC (NCT06126692)
- Where
- 2 sites in Denmark, Netherlands
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Periapical Periodontitis
Effect of Corticosteroid Injection in Symptomatic Pulpitis Cases
This randomized clinical trial compared standard single-visit root canal treatment with adjunctive submucosal betamethasone and gentamicin in 100 patients with symptomatic irreversible pulpitis, assessing postoperative pain and…
- Trial name
- (SCIP) (NCT07704398)
- Testing
- Corticosteroid, Standard endodontic treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Trigger Finger
Effect of Therapeutic Ultrasound Versus Anti-inflammatory Drugs in the Treatment of Trigger Finger
to determine the effect of US on pain intensity in TF patients 2) to determine the effect of US on number of daily finger triggering in TF patients.
- Trial name
- NCT05467501
- Testing
- Theraputic ultrasound
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Eslam Elsayed Ali Shohda
Congenital Heart Disease, Viremia
Congenital Heart Anomaly Risk in Maternal Enteroviral Infection and Diabetes
Beyond EV-B, there are clinical observations to implicate other viruses in birth defects, including CHD. Since the Rubella epidemic of 1960s', however, viruses have received little attention and certainly no comprehensive study…
- Conditions
- Congenital Heart Disease, Viremia, Virus Diseases, Enterovirus
- Trial name
- CHARMED (NCT04769167)
- Testing
- Stool and Blood Specimen Collection, Follow-up Medical Record Review
- Where
- 2 sites in United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Non-steroidal Anti-inflammatory Poisoning
Effects of a Cyclic NSAID Regimen on Levels of GCF PGE-E2 and IL-1beta
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for inflammation control and pain relief. However, while adjunct use of NSAIDs is avoided for periodontal therapy because of related side effects, cyclic…
- Trial name
- NCT02658799
- Testing
- cataflam (diclofenac potassium)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Baskent University
Crohn's Disease
A Study to Assess the Relative Bioavailability of Four New Formulations of GSK1605786 in Healthy Subjects
This is an open-label, single dose, randomized, five-period, crossover study in healthy volunteers to assess the relative bioavailability of four GSK developed oral formulations of GSK1605786 relative to the capsule formulation…
- Trial name
- NCT01114607
- Testing
- GSK1605786 ChemoCentryx: formulation A, GSK1605786 GSK: formulation B, GSK1605786 GSK direct-fill: formulation C
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Human Nutrition, Omega-3 Fatty Acids, Microalgae, Micronutrients
"Health Promoting Effects of the Microalgae Phaeodactylum Tricornutum"
The aim of the research project is to investigate the uptake of omega-3 fatty acids into the blood plasma through the consumption of the microalgae Phaeodactylum tricornutum (PT) in a human study.
- Trial name
- UniHoh-Algen (NCT04288544)
- Testing
- Microalgae, Omega-3-fatty acid capsule, sea fish
- Where
- 2 sites in Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Hohenheim
Medical Education, Simulation Training
Effectiveness of Simulation Based Training in Implementing One Hour Bundle Sepsis
This study aimed to compare simulation training with conventional training (case-based discussion only) to improve team performance in implementing one-hour sepsis bundle in the intensive care unit
- Conditions
- Medical Education, Simulation Training, Sepsis
- Trial name
- NCT05076721
- Testing
- Simulation training, Case-based discussion training
- Where
- Indonesia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Inflammatory Bowel Diseases, Colitis, Ulcerative
Chronic Care Model on Symptom Status, Stress and Quality of Life in Individuals With Inflammatory Bowel Disease
This study aims to evaluate the effects of nurse counseling provided based on the Chronic Care Model on symptom status, stress, and quality of life in individuals diagnosed with Inflammatory Bowel Disease (IBD).
- Conditions
- Inflammatory Bowel Diseases, Colitis, Ulcerative, Crohn Disease
- Trial name
- NCT06757231
- Testing
- Nurse Counseling Based on the Chronic Care Model (CCM)
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hasan Kalyoncu University
Inflammatory Response, Root Canal Infection
Releasing of Inflammatory Mediators During Retreatment of Root Canals
Nonsurgical root canal retreatment may become essential when the initial endodontic treatment fails because of the persistent intracanal or extracanal infections.The aim of this thesis study is to evaluate the effect of ProTaper…
- Trial name
- NCT05039502
- Testing
- Protaper Universal Retreatment, Reciproc, XP-Endo finisher R
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Non-inflammatory Neuropathic Pain, Healthy Subjects
Cortical Representation of Hyperalgesia Induced by Nerve Growth Factor
Intraepidermal injection of nerve growth factor results in a non-inflammatory hyperalgesia for thermal and mechanical stimuli. This hyperalgesia is similar to the pathological ailments of patients with neuropathic pain.
- Trial name
- LOGIN_NGF (NCT02159170)
- Testing
- NGF injection
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Prof Herta Flor
Viral Infections, Bacterial Infections
Emergency PWAS in Respiratory Infectious Disease
Develop an emergency PanorOmics Wide Association Study (ePWAS) for the early, rapid biological and pathophysiological characterisation of known and novel Infectious Diseases in adult patients presenting to emergency departments…
- Conditions
- Viral Infections, Bacterial Infections, Fungal Infections, Mixed Infection
- Trial name
- NCT05336851
- Testing
- Biomarker blood draw and saliva collection
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Type 2 Diabetes, Dietary Inflammatory Index (DII)
Effect of Dietary Inflammatory Index on Inflammatory Markers and Metabolic Parameters, in Patients With Type 2 Diabetes Mellitus
Nutrition is essential in the treatment and management of Type 2 Diabetes. The importance of adding foods with anti-inflammatory effects to daily diet plans in ensuring glycemic control, preventing the progression of diabetes…
- Conditions
- Type 2 Diabetes, Dietary Inflammatory Index (DII), Inflammation, Medical Nutrition Therapy
- Trial name
- NCT05271695
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Inflammatory Bowel Diseases, Insomnia
Feasibility of Insomnia Tracking and Treatment in IBD
This study is a longitudinal clinical trial designed to characterize sleep patterns in individuals with Inflammatory Bowel Disease (IBD) as well as to assess the feasibility of sleep intervention (Cognitive Behavioral Therapy for…
- Trial name
- FITT (NCT04132024)
- Testing
- Cognitive Behavioral Therapy for Insomnia (CBT-I)
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
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