Clinical trials: Inflammatory
Inflammatory Response After Surgery, Postoperative Recovery
Double-blind Pilot Study on the Effect of Anionic Exposome Enrichment (Biow) on Recovery and Sleep Quality in Postoperative Patients
Airborne nanoparticle exposure is increasingly recognized as a significant contributor to oxidative stress, mitochondrial dysfunction, and low-grade systemic inflammation-factors that impair postoperative recovery.
- Trial name
- EOX (NCT06968000)
- Testing
- EOX Anion-Enriched Hospital Room
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Inflammatory Bowel Diseases, Crohn Disease
Effect of a Probiotic Mixture on the Gut Microbiome and Fatigue in Patients With Quiescent Inflammatory Bowel Disease
The study is proposed as a single-site randomized double-blind placebo-controlled trial requiring 4 study visits, where two of the visits are combined with their appointment for routine clinical care.
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- NCT03266484
- Testing
- Probiotic Mixture
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
IBD (Inflammatory Bowel Disease)
Enhancing Endoscopic Scoring Consistency and Accuracy in IBD: a Video-based Training Approach
Endoscopic scoring systems are vital for the objective assessment of disease activity being used in both clinical trials and daily clinical practice.
- Trial name
- CONCORDIA (NCT06961942)
- Testing
- Training
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Anastomotic Leak, Anti-Inflammatory Agents, Non-Steroidal
Risk of NSAIDs on Anastomotic Leak for Rectal Surgery
Conflicting reports of the association between early postoperative non-steroidal anti-inflammatory drugs (NSAIDs) administration and anastomotic leak (AL) after rectal surgery have continued.
- Trial name
- NCT06155175
- Testing
- NSAIDs
- Where
- China
- Volunteers
- 1,969 people
- Sponsor
- Third Military Medical University
Ulcerative Colitis, Inflammatory Bowel Diseases
A Study to Evaluate Biomarkers in Moderate to Severe Ulcerative Colitis (UC) Patients Treated With Different Targeted Therapies
UC is a chronic, idiopathic form of intestinal inflammatory disease (IBD) that affects the colon, most commonly afflicting adults aged 30-40 years and resulting in disability and lower quality of life (1).
- Trial name
- ImmUniverse (NCT05456893)
- Testing
- Procedure: endoscopic biopsy, Blood sampling, stool sampling
- Where
- France
- Volunteers
- 95 people
- Sponsor
- Central Hospital, Nancy, France
Ulcerative Colitis, Inflammatory Bowel Diseases
Janus Kinase Inhibitors for the Treatment of Acute Severe Ulcerative Colitis
Ulcerative colitis (UC) is an incurable, immune-mediated inflammatory disease of the large bowel that typically requires long term immunosuppressive drugs to induce and maintain remission.
- Trial name
- ATTRACT (NCT06449820)
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Central Hospital, Nancy, France
Erector Spinae Plane Block, Systemic Immune-inflammatory Index
Investigation of the Effect of Erector Spinae Plane Block on Systemic Immuno-Inflammatory Index
Erector spinae plane block (ESPB) is a novel interfascial block technique first described by Forero in 2016. It has been reported to be effective in various clinical indications.
- Conditions
- Erector Spinae Plane Block, Systemic Immune-inflammatory Index, Breast Cancer
- Trial name
- NCT06954324
- Testing
- Erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Namik Kemal University
Inflammatory Bowel Diseases, Crohn Disease
Prevalence and Factors Associated With Sleep Disorders in Inflammatory Bowel Disease
Inflammatory bowel diseases (IBD) including Crohn's disease (CD) and ulcerative colitis (UC), are an inflammatory disease that can affect the entire digestive tract from the mouth to the anus for CD and the entire colon and…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis, Sleep Disorder
- Trial name
- SOMMICI (NCT06439641)
- Testing
- Ulcerative colitis Disease Activity Index
- Where
- France
- Volunteers
- 300 people
- Sponsor
- CHU de Reims
Inflammatory Bowel Diseases, Ulcerative Colitis
Enhancing Ultrasound & Photoacoustic for Recognition of Intestinal Abnormalities
The clinical investigation aims to generate clinical data to support the use of Multispectral Optoacoustic Tomography (MSOT) in clinical practice, its inclusion in diagnostic guidelines and to support its reimbursement…
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- EUPHORIA (NCT04456400)
- Testing
- Multispectral Optoacoustic Tomography (MSOT)
- Where
- 6 sites in Germany, Italy
- Volunteers
- 200 people
- Sponsor
- iThera Medical GmbH
Inflammatory Bowel Diseases, Colitis, Ulcerative
Texture and Color Enhancement Imaging (TXI) for Inflammation Assessment in Patients With Inflammatory Bowel Diseases
In the context of the COLORIZE study, it is being tested whether the endoscopic light mode Texture and Color Enhancement Imaging (TXI) is non-inferior to the standard White Light Endoscopy (WLE) in assessing inflammatory activity…
- Conditions
- Inflammatory Bowel Diseases, Colitis, Ulcerative, Crohn Disease
- Trial name
- COLORIZE (NCT06892990)
- Testing
- TXI mode vs. WLE mode
- Where
- Germany
- Volunteers
- 80 people
- Sponsor
- University of Ulm
Alcohol Use Disorder, Inflammatory Response
An Inflammatory Challenge Using Endotoxin
The study design consists of a randomized, double-blind, placebo-controlled trial of low dose endotoxin. The low dose endotoxin challenge induces a transient systemic inflammatory response with normalization of cytokine levels…
- Conditions
- Alcohol Use Disorder, Inflammatory Response, Craving, Depressed Mood
- Trial name
- NCT04310423
- Testing
- Endotoxin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Inflammatory Bowel Disease
Characterization of Phenotype and Genotype of Early Onset Enteropathies
This study has been set up in order to characterize phenotypes and genotypes of patients with early onset enteropathies. In that goal, Investigators will collect biological samples (mainly blood) of patients suffering from early…
- Trial name
- IMMUNOBIOTA (NCT02614911)
- Testing
- Biological sampling
- Where
- 12 sites in France
- Volunteers
- 1,445 people, healthy volunteers welcome
- Sponsor
- Imagine Institute
Inflammatory Response, COVID-19
Pericardial Histopathology and COVID-19 Seropositivity
This prospective study aims to investigate the association between pericardial histopathologic inflammation grades (acute, chronic, or absent) and COVID-19 seropositivity in adult patients undergoing first-time isolated coronary…
- Conditions
- Inflammatory Response, COVID-19, Pericardial Disease
- Trial name
- NCT06952179
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people
- Sponsor
- Samsun University
Colitis, Ulcerative, Inflammatory Bowel Diseases
A Study to Evaluate the Safety and Efficacy of Ustekinumab Induction and Maintenance Therapy in Participants With Moderately to Severely Active Ulcerative Colitis
The purpose of this study is to evaluate the efficacy and safety of ustekinumab as intravenous (IV: into the vein) infusion in induction study in participants with moderately to severely active Ulcerative Colitis (UC) and as…
- Trial name
- UNIFI (NCT02407236)
- Testing
- Ustekinumab IV, Ustekinumab SC
- Where
- 247 sites in United States, Australia and 21 more
- Volunteers
- 961 people
- Sponsor
- Janssen Research & Development, LLC
Pediatrics, Lobar Pneumonia
Application and Effect Evaluation of Integrated Nursing and Medical Management in Pediatric Lobar Pneumonia
Integrated nursing and medical management significantly improves clinical symptoms and pulmonary function in children with lobar pneumonia, shortens hospitalization duration, reduces complication rates, and enhances caregiver…
- Conditions
- Pediatrics, Lobar Pneumonia, Inflammatory Markers, Satisfaction
- Trial name
- NCT06945991
- Testing
- observation group, control group
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Children's Hospital of Hebei Province
Inflammatory Bowel Disease (IBD)
Impact of Transition Programs on Readiness and Quality of Life in IBD
This study is a randomized controlled trial comparing two transition models for adolescents with inflammatory bowel disease (IBD) moving from pediatric to adult care.
- Trial name
- NCT06946810
- Testing
- Combined visits-based transition, Letter-based transition
- Where
- Italy
- Volunteers
- 41 people
- Sponsor
- University of Padova
Pain, Inflammatory, Pain Management
Reduced-pressure Pneumoperitoneum and Intraperitoneal Saline Washout to Alleviate Pain Following vNOTES Hysterectomy
vNOTES, initially employed for cholecystectomy, appendectomy, and nephrectomy, made its debut in the field of gynecologic surgery in 2012.
- Trial name
- Vnotes (NCT06944015)
- Testing
- normal saline
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Erzincan Military Hospital
Inflammatory Myositis, Idiopathic Inflammatory Myositis
Follow-up of Patients With Inflammatory Myopathies Associated With a Biobank
Myositis are rare diseases for which the development of a cohort associated with a bank of biological samples (biobank) will allow for the conduct of researches to better delineate the underlying pathophysiology and find cures.
- Conditions
- Inflammatory Myositis, Idiopathic Inflammatory Myositis, Drug-induced Inflammatory Myositis
- Trial name
- MASC2 (NCT05454527)
- Where
- 2 sites in France
- Volunteers
- 4,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Inflammatory Bowel Disease (IBD), Metabolic Dysfunction Associated Fatty Liver Disease
An Observational Study of Inflammatory Bowel Disease (IBD) Patients With Non-alcoholic Fatty Liver Disease (NAFLD)
Inflammatory bowel diseases (IBD), including ulcerative colitis and Crohn's disease, are currently of unknown etiology and incurable.
- Trial name
- NCT06939569
- Where
- China
- Volunteers
- 337 people
- Sponsor
- Shanghai East Hospital
Major Depressive Episode, Inflammatory Bowel Diseases
Microglial Activation in Inflammatory Bowel Disease
The purpose of this study is to monitor microglial activation in participants with inflammatory bowel disease (IBD) and investigate the relationship that exists between these patients and their risk of acquiring major depressive…
- Trial name
- NCT03487926
- Testing
- [18F]FEPPA
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health