Clinical trials: Inflammatory
Sepsis, Septic Shock
Esomeprazole to Reduce Organ Failure in Sepsis
Sepsis is a severe disease with a high mortality rate and lack of efficacious therapies. Proton pump inhibitors (PPI) are drugs widely used to inhibit acid secretion by gastric cells and with a high safety profile.
- Trial name
- PPI-SEPSIS (NCT03452865)
- Testing
- Esomeprazole
- Where
- 17 sites in Italy, Kazakhstan and 1 more
- Volunteers
- 300 people
- Sponsor
- Università Vita-Salute San Raffaele
Crohn's Disease
A Study To Monitor Long-Term Treatment With PF-00547659
This study provides open-label drug to eligible patients who have completed a prior study of PF-00547659. The primary endpoint for this study is long-term safety.
- Trial name
- OPERA II (NCT01298492)
- Testing
- PF-00547659
- Where
- 112 sites in United States, Austria and 13 more
- Volunteers
- 268 people
- Sponsor
- Shire
Chronic Kidney Diseases, Chronic Kidney Disease stage3
Effects of Brazil Nut Supplementation in Patients With Chronic Kidney Disease Undergoing Conservative Treatment
The aim of this study is to evaluate the effects of Brazil nut supplementation on inflammation, oxidative stress and intestinal microbiota in patients with chronic kidney disease undergoing conservative treatment.
- Conditions
- Chronic Kidney Diseases, Chronic Kidney Disease stage3, Chronic Kidney Disease Stage 3A, Chronic Kidney Disease Stage 3B
- Trial name
- NCT06394544
- Testing
- Brazil Nut
- Where
- Brazil
- Volunteers
- 50 people
- Sponsor
- Universidade Federal Fluminense
Critical Care, Cancer
Antibiotic De-escalation in Onco-hematology Patients for Sepsis or Septic Shock
De-escalation aims at reducing the use of broad-spectrum antibiotics and therefore the emergence of multidrug-resistant (MDR) pathogens. Observational studies suggested that this strategy seems to be safe.
- Trial name
- DéPOH (NCT03683329)
- Testing
- Antibiotic de-escalation, Standard treatment
- Where
- France
- Volunteers
- 398 people
- Sponsor
- Institut Paoli-Calmettes
Inflammatory Bowel Diseases, Mild Cognitive Impairment
Cognitive Impairment and Affective Mood Disorders in Patients With IBD
The aim is to evaluate the presence of mild cognitive impairment (MCI) in patients with inflammatory bowel disease (IBD). This will be done by cognitive tests.
- Conditions
- Inflammatory Bowel Diseases, Mild Cognitive Impairment, Depression, Anxiety
- Trial name
- COGN-IBD-1 (NCT05760729)
- Testing
- Cognitive testing
- Where
- 3 sites in Romania
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
IBS, IBD
Intestinal Microbiome and Psychological Correlates in Irritable Bowel Syndrome and Inflammatory Bowel Disease
Longitudinal Investigation of intestinal microbiome, fecal inflammation markers, stress and psychological variables in patients with irritable bowel syndrome and inflammatory bowel disease undergoing gut-directed hypnotherapy…
- Trial name
- NCT02536131
- Testing
- Gut-directed hypnotherapy
- Where
- Austria
- Volunteers
- 80 people
- Sponsor
- Medical University of Vienna
IBD (Inflammatory Bowel Disease)
Sequencing in Inflammatory Bowel Diseases (IBD) Therapy: "the Latium Net".
Patients with IBD, both UC and CD, who fulfil the inclusion and exclusion criteria will be included consecutively: Retrospective cohort Patients treated with IBD from January 2015 to June 2024 will be included.
- Trial name
- STRIKE (NCT06603337)
- Where
- Italy
- Volunteers
- 2,700 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Ulcerative Colitis
Human Umbilical-Cord-Derived Mesenchymal Stem Cell Therapy in Active Ulcerative Colitis
Phase I-II Clinical Trial - Safety and efficacy of umbilical-cord-derived mesenchymal stem cell (UC-MSC) in patients with active ulcerative colitis，randomized, single blind, controlled prospective study.
- Trial name
- UCMSC-UC (NCT02442037)
- Testing
- UCMSC group, Control group(Normal saline)
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Affiliated Hospital to Academy of Military Medical Sciences
Inflammation, Perioperative Morbidity
The Effects of Corticosteroids, Glucose Control, and Depth-of-Anesthesia on Perioperative Inflammation and Morbidity From Major Non-cardiac Surgery (Dexamethasone, Light Anesthesia and Tight Glucose Control (DeLiT Trial))
Evidence thus suggests that steroid administration, tight glucose control, and avoidance of deep anesthesia may decrease perioperative morbidity by reducing the inflammatory response to surgery.
- Trial name
- NCT00995501
- Testing
- Dexamethasone Sodium Sulfate, Insulin, anesthesia management
- Where
- United States
- Volunteers
- 381 people
- Sponsor
- d sessler
Cognitive Dysfunction
Changes of Cognitive Function and Orphanin FQ in Diabetic Patients Under General Anesthesia.
This study is the first to investigate the relationship between the changes of serum calcium and orphanin fq and the changes of cognitive function in patients with diabetes.To general anesthesia surgery of patients with diabetes…
- Trial name
- NCT04576767
- Testing
- anaesthetic
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Second Hospital of Shanxi Medical University
Septic Shock
Lipopolysaccharide Adsorption At Septic Shock
Sepsis is a global healthcare burden sepsis, it reaches 20-30 million cases annually (WHO data). Numerous studies have shown that extracorporeal hemoperfusion therapies that eliminate endotoxin and\or excess of cytokines improve…
- Trial name
- LASSO (NCT04827407)
- Testing
- Efferon LPS hemoperfusion
- Where
- 4 sites in Russia
- Volunteers
- 58 people
- Sponsor
- Efferon JSC
Inflammation, Surgery
The Effects of Lipinova on Inflammatory and Proresolving Lipid Mediator Profiles After Orthopedic Surgery
The aim of this pilot study is to investigate whether pre-operative supplementation with an over the counter dietary supplement containing a fractionated marine lipid concentrate derived from anchovy and sardine oil, Lipinova®…
- Trial name
- NCT03434236
- Testing
- low dose Lipinova (30 mL daily), high dose Lipinova (60mL)
- Volunteers
- 30 people
- Sponsor
- Brigham and Women's Hospital
COPD
Association of Physical Activity Levels and Inflammatory Markers Following Pulmonary Rehabilitation
COPD is characterised by irreversible airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response.
- Trial name
- PALI-COPD (NCT03455153)
- Testing
- Physical activity monitoring
- Where
- 3 sites in United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Lincoln
Ulcerative Colitis
A Study to Learn More About How Risankizumab Works in Young Participants With Ulcerative Colitis
Ulcerative colitis (UC) is a type of inflammatory bowel disease that causes inflammation and bleeding from the lining of the rectum and colon (large intestine).
- Trial name
- MIGHTY (NCT07071519)
- Testing
- Risankizumab
- Where
- 73 sites in United States, Belgium and 14 more
- Volunteers
- 120 people
- Sponsor
- AbbVie
Calprotectin, Inflammatory Bowel Disease
Value of Fecal Calprotectin
For the main goal - the accuracy of calprotectin for the diagnosis of IBD - calprotectin levels will be compared between patients with and without a diagnosis of IBD and the sensitivity, specificity and accuracy will be…
- Trial name
- NCT00577928
- Where
- United States
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Indiana University
Pelvic Inflammatory Disease, Chronic Pelvic Pain Syndrome
Clinical Trial of Acupoint Application in Improving the Sequelae of Pelvic Inflammatory Disease and Chronic Pelvic Pain
Chronic Pelvic Pain is one of the common gynecological symptoms, characterized by persistent and non periodic pain in the pelvic cavity and surrounding tissues.
- Trial name
- NCT06360965
- Testing
- Improved warm meridians and relieve pain plaster, Traditional warm meridians and relieve pain plaster
- Where
- China
- Volunteers
- 102 people
- Sponsor
- Beijing Hospital of Integrated Traditional Chinese and Western Medicine
Colitis, Ulcerative
Combined Nutritional Therapies for the Treatment of Ulcerative Colitis
Ulcerative colitis (UC) is an entity of complex etiology where environmental, genetic and intestinal microflora-related factors trigger and perpetuate a chronic inflammation of the gastrointestinal tract.
- Trial name
- NCT03444311
- Testing
- A: 1 dosis, B: 2 dosis
- Where
- Spain
- Volunteers
- 12 people
- Sponsor
- AB Biotics, SA
28-day Mortality, Sepsis
Predictive Value of Dynamic Combination of BNP and NGAL for the Prognosis of Patients With Sepsis
Objective: to clarify the predictive value of brain natriuretic peptide (BNP) in combination with neutrophil gelatinase associated lipocalin (NGAL) for the prognosis of patients with sepsis.
- Trial name
- NCT02871544
- Testing
- BNP and NGAL
- Volunteers
- 124 people
- Sponsor
- Southeast University, China
Severe Sepsis, Septic Shock
Microcirculatory Changes During Magnesium Sulphate Infusion in Sepsis
During infections (sepsis) bloodflow in small vessels (microcirculation) becomes disturbed. Restoration of bloodpressure and cardiac performance may not be sufficient to correct these alterations.
- Trial name
- NCT01332734
- Testing
- Magnesium Sulfate
- Where
- Lithuania
- Volunteers
- 14 people
- Sponsor
- Frisius Medisch Centrum
Virus Diseases
Study to Evaluate the Efficacy and Safety of Danirixin Co-administered With Oseltamivir in the Treatment of Adults Hospitalized With Influenza
Danirixin (DNX) is a novel, selective, and reversible antagonist of the C-X-C chemokine receptor (CXCR) 2 and has been shown to decrease neutrophil transmigration and activation to areas of inflammation.
- Trial name
- NCT02927431
- Testing
- Danirixin 15 mg FBE, Danirixin 50 mg FBE, Oseltamivir 75 mg
- Where
- 8 sites in United States, Romania and 2 more
- Volunteers
- 10 people
- Sponsor
- GlaxoSmithKline
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