Clinical trials: Inflammatory Activation and Modulation
Septic Shock
Modulation of Vasoreactivity in Septic Shock: Impact of Recombinant Protein C
The purpose is to demonstrate that vasoreactivity of patients with septic shock evaluated with dose-response curve is diminished in septic shock and ameliorated by activated protein C (APC).
- Trial name
- PCA (NCT02885168)
- Testing
- Recombinant Activated Protein C, Near-infrared spectroscopy (NIRS), Phenylephrine
- Volunteers
- 30 people
- Sponsor
- Central Hospital, Nancy, France
Platelet Aggregation and Inflammation
Cardioprotective Properties of Natural Anti-Platelet Activating Factor Extract From Winery By-products in Healthy Women
The purpose of this study is to investigate the anti-platelet and anti-inflammatory properties of a winery by-products extract as well as to detect extract compounds and their metabolites in biological fluids.
- Trial name
- NAPE (NCT04436263)
- Testing
- Supplement
- Where
- Greece
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Immune System Processes, Inflammatory Activation and Modulation
The Compassion and Attention Longitudinal Meditation Study
The increasingly widespread use of meditation for stress-related emotional and medical conditions highlights the urgent need to rigorously evaluate mechanisms through which the benefits of practice might be conferred.
- Conditions
- Immune System Processes, Inflammatory Activation and Modulation, ANS Function
- Trial name
- CALM (NCT01251341)
- Testing
- Cognitive-Based Compassion Training, Mindful Attention Training, Adult Health Education Curriculum
- Where
- United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Type 2 Diabetes, Cardiovascular Diseases
Genetic-Dependent Cardiovascular Response to PPAR-Alpha Agonist Fenofibrate
Fenofibrate, a peroxisome proliferator-activated receptor-alpha (PPAR-a) agonist known to improve diabetic dyslipidemia, has been proposed as a drug to prevent cardiovascular disease (CVD) in type 2 diabetes (T2D).
- Conditions
- Type 2 Diabetes, Cardiovascular Diseases, Pharmacogenomic Drug Interaction
- Trial name
- MAGNETIC (NCT05542147)
- Testing
- Fenofibrate 145 mg
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Mario Luca Morieri
Dengue, Dengue With Warning Signs
Anakinra in Dengue With Hyperinflammation ( AnaDen )
This study aims to evaluate the effect of anakinra in dengue patients with hyperinflammation as compared to placebo Primary Objective: To evaluate the efficacy of Anakinra in moderate-severe dengue patients with…
- Conditions
- Dengue, Dengue With Warning Signs, Severe Dengue, Anakinra
- Trial name
- NCT05611710
- Testing
- Anakinra
- Where
- Vietnam
- Volunteers
- 160 people
- Sponsor
- Oxford University Clinical Research Unit, Vietnam
Immune System Processes, Inflammatory Activation and Modulation
The Sounds of Compassion: Testing How Specific Elements of Meditation Change Daily Life
Important health benefits of meditation may be conferred as much by what people actually do and say in their daily lives as by how they self-perceive the effect of training on their behavior and emotions.
- Conditions
- Immune System Processes, Inflammatory Activation and Modulation, ANS Function
- Trial name
- NCT01643369
- Testing
- Cognitive-Based Compassion Training, Adult Health Education Curriculum, Mindful Attention Training
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Arizona