Clinical trials: Inflammatory Bowel Disease, open to volunteers
Inflammatory Bowel Disease (IBD), Crohn Disease
Hyperbaric Oxygen Therapy for Perianal Fistulizing Crohn's Disease Not Responsive or Intolerant to Conventional Care: HYPNOTIC Pilot Study
This study aims to test a new treatment called hyperbaric oxygen therapy (HBOT) for a severe type of inflammatory bowel disease called perianal Crohn's disease (PCD).
- Trial name
- HYPNOTIC (NCT06109961)
- Testing
- Oxygen Gas for Inhalation, Standard of care
- Volunteers
- 54 people
- Sponsor
- University of British Columbia
Inflammatory Bowel Diseases, Crohn Disease
Inflammatory Biomarkers and Disease Activity in Inflammatory Bowel Disease
This study aims to evaluate the diagnostic accuracy and clinical utility of routine blood-derived inflammatory biomarker ratios in assessing disease activity among adult patients with inflammatory bowel disease (IBD), including…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis (UC)
- Trial name
- NCT07788131
- Volunteers
- 120 people
- Sponsor
- Assiut University
Colorectal Cancer, Colorectal Adenoma
Colorectal Omics and ofCS Proteoglycans (COCO) in Screening and a Diagnostic Pathway
Colorectal Cancer (CRC), or bowel cancer, is a serious disease that affects many people globally. The earlier CRC is diagnosed, the better the patient outcomes.
- Conditions
- Colorectal Cancer, Colorectal Adenoma, Inflammatory Bowel Disease (IBD)
- Trial name
- COCO-S (NCT07237984)
- Testing
- Blood sampling, Stool samplong
- Where
- 2 sites in Denmark
- Volunteers
- 2,000 people
- Sponsor
- Nordsjaellands Hospital
Healthy Volunteers, Inflammatory Bowel Disease (IBD)
Fermented Vegan Optimized Diet in Health and Colitis
The diet is assumed to contribute to many of our present non-communicable diseases. Vegetarian products are instead considered to be health promoting, However, it is not verified that the modern vegetarian and vegan products are…
- Trial name
- FAVORIT (NCT06696222)
- Testing
- Vegetarian yogurt, Vegetarian meat alternative, Ordinary meat diet
- Where
- 2 sites in Sweden
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Region Skane
Crohn's Disease, Inflammatory Bowel Diseases
Testing the Role of Anti-fungal Therapy in Improving the Response to Therapies for Crohn's Disease
The goal of this clinical trial is to learn about the effects of fluconazole in patients who plan to start or are currently undergoing standard of care treatment and plan to dose-escalate an IL-23 therapy for their Crohn's…
- Trial name
- FUN-CD (NCT06274554)
- Testing
- Fluconazole, IL-23 Therapy
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Weill Medical College of Cornell University
Inflammatory Bowel Disease (IBD), Colonoscopy
Visualization of the Colon Through Use of the Magnetic Flexible Endoscope (MFE) in Participants With Inflammatory Bowel Disease (IBD)
In this study, the investigators will test the ability of the Magnetic Flexible Endoscope (MFE) to travel through the colon of people with Inflammatory Bowel Disease (IBD).
- Trial name
- NCT06989424
- Testing
- Magnetic Flexible Endoscope (MFE)
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Vanderbilt University Medical Center
Inflammatory Bowel Disease (IBD)
Benefit of Moderate Intensity Exercise in Patients With Clinical Quiescent Inflammatory Bowel Disease
The goal of this Randomised controlled trial is to investigate the effect of exercise on changes in quality of life in in patients with clinical quiescent Inflammatory bowel Disease.
- Trial name
- IBDEXERCISE (NCT07775794)
- Testing
- Exercise
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Mahidol University
Inflammatory Bowel Diseases, Crohn Disease
Utility of Random Biopsies in Patients With Inflammatory Bowel Disease
The proposed study is a multicenter parallel group clinical trial that will include 821 evaluable patients per group who will be randomly assigned to either high definition white light colonoscopy (HDWLC) with targeted biopsies…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- URBI (NCT06560021)
- Testing
- Biopsy strategy
- Where
- 21 sites in United States
- Volunteers
- 1,642 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Inflammatory Bowel Disease (IBD)
Phase I Study of QLS1510 Tablets in Healthy Participants
This is a Randomized, Double-Blind, Placebo-Controlled, Single and Multiple Ascending Dose Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of QLS1510 in Healthy participants
- Trial name
- NCT07760077
- Testing
- QLS1510 Tablets
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Shanghai Qilu Pharmaceutical Research and Development Center LTD
Inflammatory Bowel Disease
A Multicenter National Prospective Study of Pregnancy and Neonatal Outcomes in Women With Inflammatory Bowel Disease
A Multicenter National Prospective Study of Pregnancy and Neonatal Outcomes in Women with Inflammatory Bowel Disease study is being conducted at the University of California San Francisco and 30 other sites around the United…
- Trial name
- NCT00904878
- Where
- 2 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- University of California, San Francisco
Inflammatory Bowel Diseases, Crohn Disease
PIBD-SETQuality: the Inception Cohort and Safety Registry
The purpose of this study is to analyse effectiveness and safety signals of current treatment strategies in routine practice for patients with pediatric-onset inflammatory bowel disease (PIBD) and to correlate this to their…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- PIBD-SETQ (NCT03571373)
- Testing
- No intervention
- Where
- 2 sites in Netherlands, United Kingdom
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Inflammatory Bowel Diseases (IBD), Remission of IBD
VIBRANT-IBD: Brain Effects of Non-Invasive Vagus Nerve Stimulation in IBD Remission
The VIBRANT-IBD study is a pilot, prospective, single-arm feasibility study investigating the effects of non-invasive vagus nerve stimulation (nVNS) in adults with inflammatory bowel disease (IBD) in clinical remission.
- Conditions
- Inflammatory Bowel Diseases (IBD), Remission of IBD, In Adults, Inflammatory Bowel Disease (Crohn's Disease; Ulcerative Colitis)
- Trial name
- VIBRANT-IBD (NCT07636304)
- Testing
- Non-invasive vagus nerve stimulation (nVNS)
- Where
- Poland
- Volunteers
- 15 people
- Sponsor
- University of Gdansk
Pouch, Ileal, Pouches, Ileoanal
Tirzepatide for Ileal Pouch-anal Anastomosis (IPAA) and Chronic High Bowel Frequency (I8F-NS-X008)
The goal of this clinical trial is to learn if Tirzepatide (Zepbound) can decrease bowel frequency in patients that have an ileal-pouch anal anastomosis (IPAA or pouch) better than standard of care anti-diarrheal therapy.
- Conditions
- Pouch, Ileal, Pouches, Ileoanal, Bowel Diseases, Inflammatory
- Trial name
- PROP-ZEP (NCT07756359)
- Testing
- Tirzepatide, Loperamide, Diphenoxylate/Atropine
- Where
- 5 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of North Carolina, Chapel Hill
Inflammatory Bowel Disease, Ulcerative Colitis Type, Functional Disorder of Gastrointestinal Tract
Evaluation of the Effects of Colipral on Microbiota Gut Composition in Patients Presenting With Ulcerative Colitis During Remission Phase and Functional Disorders
The study is a double-blind, placebo-controlled, crossover, randomised trial, in which enrolled subjects will be included for 18 months.
- Trial name
- COLIPRAL (NCT07751081)
- Testing
- Food Supplement Colipral in film-coated tablets containing Escherichia coli 5C LMG S-33222
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Padova
Ulcerative Colitis (Disorder), Inflammatory Bowel Disease (IBD)
Mediterranean Diet and Time-Restricted Feeding in Ulcerative Colitis Remission
This study will evaluate whether a 12-week dietary intervention can improve gut health, inflammation, and quality of life in adults with ulcerative colitis in remission.
- Trial name
- MEDITIME-UC (NCT07752446)
- Testing
- Mediterranean Diet, Mediterranean Diet + Time-Restricted Feeding, Standard Dietary Advice
- Where
- Chile
- Volunteers
- 45 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Ulcerative Colitis, Inflammatory Bowel Diseases
BOOM-IBD2 Pivotal Clinical Trial
Ulcerative colitis is a long-lasting condition that causes swelling and sores in the large intestine. This study tests whether a small device placed under the skin can help reduce bowel urgency in people with ulcerative colitis.
- Trial name
- NCT06571669
- Testing
- Neuromodulation
- Where
- 19 sites in United States
- Volunteers
- 137 people
- Sponsor
- Boomerang Medical
Crohn Disease (CD)
HB-adMSCs for the Treatment of Crohn's Disease
Methodology: Randomized, double-blind, efficacy and safety study of allogeneic HB-adMSCs vs placebo for the treatment of Crohn's Disease with a 16-week treatment period and a safety and efficacy follow up period for 52 weeks post…
- Trial name
- NCT07077746
- Testing
- HB-adMSCs - Hope Biosciences Adipose Derived Mesenchymal Stem Cells, 0.9% sodium chloride
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Hope Biosciences Research Foundation
ColoRectal Cancer and Inflammatory Bowel Disease
Impact of the Enhanced Recovery After Surgery System for Colorectal Surgery
This is an observational study to look at the impact of the Enhanced Recovery After Surgery system for colorectal surgery (Group 1) in shortening hospital length of stay, reducing postoperative narcotic consumption, lowering…
- Trial name
- NCT02997293
- Testing
- Enhanced Recovery protocol
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Inflammatory Bowel Diseases
Social Determinants of Health, Medication Use, and Quality of Life in Inflammatory Bowel Disease
Optimizing health related-quality of life (HRQoL) for patients with inflammatory bowel disease (IBD), who often experience a relapsing disease course, is an essential component of care.
- Trial name
- NCT06266663
- Testing
- Survey
- Where
- 2 sites in United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Ulcerative Colitis (UC), Crohn's Disease (CD)
Zymfentra (Infliximab-dyyb) REal World Cohort STudy
The goal of this observational study is to learn about how effective Zymfentra (IFX=dyyb) is when treating patients with Crohn's disease (CD) and ulcerative colitis (UC) Does Zymfentra lead to a reduction in symptoms at intervals…
- Conditions
- Ulcerative Colitis (UC), Crohn's Disease (CD), Indeterminate Colitis, Inflammatory Bowel Disease (IBD)
- Trial name
- ZEST (NCT07237516)
- Where
- 11 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of North Carolina, Chapel Hill