Clinical trials: Inflammatory Bowel Disease
Ulcerative Colitis
Chronotherapy of 5-Aminosalicylic Acid in Ulcerative Colitis
The hypothesis of this study is that appropriate time of day of administration of oral, once daily 5-ASA therapy in alignment with the host circadian rhythms will improve subclinical inflammation and microbial structure/function…
- Trial name
- NCT05213234
- Testing
- Chronotherapy
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Rush University Medical Center
Crohn's Disease
Volatiles in Exhaled Breath and Blood in Crohn's Disease: Validation Cohort
This study evaluates the use of exhaled air analysis as tool to monitor the disease activity in Crohn's Disease (CD). This study is a validation of the previous findings.
- Trial name
- NCT02641171
- Testing
- Specimen sampling
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Ulcerative Colitis
TP0501 - Pharmaco-Scintigraphic-Study
This is a Phase I, open-label, single-site trial to evaluate the drug release, using Scintigraphic images and mesalazine plasma levels (PK) in healthy subjects.
- Trial name
- NCT02306772
- Testing
- TP05 Coating A, TP05 Coating B
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Tillotts Pharma AG
Crohn Disease, Colitis, Ulcerative
Improving the Health Care in Inflammatory Bowel Disease.
Inflammatory Bowel Disease (IBD) refers to two chronic diseases (Crohn's disease and Ulcerative colitis) both complex disorders requiring a long-term management, with significant healthcare resource consumption.
- Trial name
- NCT02770599
- Testing
- IBD multidisciplinary team model including IBD nurse
- Where
- Norway
- Volunteers
- 304 people
- Sponsor
- University Hospital of North Norway
Inflammatory Bowel Disease
Genetic, Serological Fecal and Clinical Markers in Siblings of Children With Inflammatory Bowel Disease
Although the precise etiology of inflammatory bowel disease (IBD) is still unknown, over the last decade active research allowed to gain more precise insights in the pathophysiology of IBD indicating that the chronic inflammation…
- Trial name
- NCT02181153
- Testing
- sample blood and fecal collection
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University of Roma La Sapienza
Crohn's Disease, Fatigue
L-carnitine to Treat Fatigue Associated With Crohn's Disease
This is a randomized, double-blind, placebo-controlled study, comparing the effect of L-carnitine vs placebo on fatigue among Crohn's disease patients.
- Trial name
- NCT01523106
- Testing
- L-carnitine
- Where
- United States
- Sponsor
- University of California, San Francisco
Ulcerative Colitis (UC), Healthy Volunteer
Phase 1 Study Evaluating PALI-2108 in Healthy Volunteers and Ulcerative Colitis Patients.
PALI-2108 is a new oral medication designed to treat ulcerative colitis (UC) by targeting the intestines. It works as a phosphodiesterase-4 (PDE4) inhibitor prodrug, meaning it becomes active only after being processed by…
- Trial name
- NCT06663605
- Testing
- PALI-2108
- Where
- Canada
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Palisade Bio
Inflammatory Bowel Diseases
Mitochondrial DAMPs as Mechanistic Biomarkers of Mucosal Inflammation in Crohn's Disease and Ulcerative Colitis
The MUSIC study is a multi-centre, longitudinal study set in the real world IBD clinical setting to investigate and develop a new biomarker approach that aims to inform both patients and clinicians of the current state of the…
- Trial name
- MUSIC (NCT04760964)
- Where
- 3 sites in United Kingdom
- Volunteers
- 250 people
- Sponsor
- University of Edinburgh
Rectal Cancer, Ulcerative Colitis
Bioabsorbable Staple Line Reinforcement in Colorectal,Coloanal and Ileoanal Anastomoses
The primary purpose of this prospective, randomized multicenter center study is to evaluate and compare the outcomes of colorectal, coloanal and ileoanal anastomoses reinforced with a bioabsorbable staple line reinforcement…
- Conditions
- Rectal Cancer, Ulcerative Colitis, Familial Adenomatous Polyposis, Diverticulitis
- Trial name
- NCT00663819
- Testing
- GORE SEAMGUARD® Bioabsorbable Staple Line Reinforcement, Staple line without reinforcement
- Where
- 16 sites in United States
- Volunteers
- 258 people
- Sponsor
- W.L.Gore & Associates
Crohn Disease
A Clinical Trial of Antibody GSK1070806 in the Treatment of Patients With Moderate to Severe Crohn's Disease
This trial aims to investigate the safety, tolerability and clinical activity of humanised antibody GSK1070806 delivered via intravenous infusion in the treatment of patients with moderate-to-severe Crohn's disease.
- Trial name
- CDAID (NCT03681067)
- Testing
- GSK1070806
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- University of Birmingham
Ulcerative Colitis
Safety and Efficacy Study of PTG-100 in the Treatment of Moderate to Severe Ulcerative Colitis
The main objectives of this study are to evaluate the efficacy, safety, and tolerability of daily doses of PTG-100 in subjects with moderate to severe ulcerative colitis (UC).
- Trial name
- NCT02895100
- Testing
- PTG-100
- Where
- 98 sites in United States, Australia and 15 more
- Volunteers
- 98 people
- Sponsor
- Protagonist Therapeutics, Inc.
Inflammatory Bowel Diseases (IBD), Fatigue
Adapted Physical Activity for Persistent Fatigue in Patients With Inflammatory Bowel Disease in Remission
The cAPAble study aims to evaluate the impact of an adapted physical activity program on persistent fatigue in patients with inflammatory bowel disease in remission.
- Conditions
- Inflammatory Bowel Diseases (IBD), Fatigue, Crohn Disease (CD), Ulcerative Colitis (UC)
- Trial name
- cAPAble (NCT07804511)
- Testing
- Adapted Physical Activity, Usual Care
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Grenoble
Ulcerative Colitis
Retarded Phosphatidylcholine Versus Mesalazin in Remission of Ulcerative Colitis.
The purpose of this study is to evaluate if retarded phosphatidylcholine is as effective as mesalazin in preventing an acute episode in ulcerative colitis.
- Trial name
- NCT00259571
- Testing
- retarded release phosphatidylcholine
- Where
- Germany
- Sponsor
- Heidelberg University
Ulcerative Colitis
Phase 2 Study of CU104 in Moderate-Severe Ulcerative Colitis
The study is designed to investigate efficacy and safety of CU104 in patients with moderate to severe ulcerative colitis.
- Trial name
- UC (NCT05907330)
- Testing
- CU104
- Volunteers
- 45 people
- Sponsor
- Curacle Co., Ltd.
Inflammatory Bowel Disease (IBD)
Gut Microbial Transplantation in Pediatric Inflammatory Bowel Diseases
Inflammatory bowel disease (IBD) is a chronic, debilitating, relapsing inflammatory disorder affecting the gastrointestinal tract which does not have a medical cure.
- Trial name
- GMT (NCT01560819)
- Testing
- Gut Microbial Transplantation
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Corewell Health West
Pediatric Inflammatory Bowel Disease
Durability and Tolerability of Infliximab in Pediatric Inflammatory Bowel Disease Patients: A 10 Year Single Center Experience
There is little data published on the long term durability of infliximab in pediatric patients. In particular a focus on durable remission, frequency of dose/frequency change and switch within class.
- Trial name
- NCT01490528
- Volunteers
- 200 people
- Sponsor
- Cedars-Sinai Medical Center
Ulcerative Colitis
Bioequivalency Study of Balsalazide Capsules Under Fasting Conditions
The objective of this study was to assess bioequivalence of a potential generic 750 mg balsalazide disodium capsule formulation compared with Salix Pharmaceutical's 750 mg balsalazide disodium capsule, Colazal, following a single…
- Trial name
- NCT00618228
- Testing
- Balsalazide
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Inflammatory Bowel Diseases
Clinical Study to Evaluate the Possible Efficacy of Nifuroxazide in Patient With Ulcerative Colitis
Ulcerative colitis (UC) is one of the most common types of chronic and non-specific inflammatory bowel diseases (IBD). It is characterized by cytokine-induced continuous and diffuse inflammatory infiltrations into the rectum's…
- Trial name
- NCT05988528
- Testing
- Mesalamine, Nifuroxazide
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mostafa Bahaa
Colitis, Ulcerative
A First-time in Human (FTIH) Study to Evaluate Safety, Tolerability, Pharmacokinetics and Target Engagement of GSK4528287 in Healthy Participants
"GSK4528287 is a drug being developed to treat like inflammatory bowel diseases like Crohns disease and ulcerative colitis. This study is the first time that GSK4528287 will be given to humans.
- Trial name
- NCT06681181
- Testing
- GSK4528287
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Quality of Life
Biological Therapy in Patients With Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is characterised by chronic, relapsing inflammation of the intestinal mucosa and an inability to down regulate the inflammatory immune response once activated.
- Trial name
- NCT05599867
- Testing
- quality of life
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University