Clinical trials: Inflammatory Bowel Disease (IBD)
Ulcerative Colitis
Efficacy and Safety Study of SHP647 as Induction Therapy in Participants With Moderate to Severe Ulcerative Colitis
The purpose of this study is to evaluate the efficacy of SHP647 in inducing remission, based on composite score of participant-reported symptoms and centrally read endoscopy, in participants with moderate to severe ulcerative…
- Trial name
- FIGARO UC 301 (NCT03259334)
- Testing
- Ontamalimab
- Where
- 207 sites in United States, Australia and 16 more
- Volunteers
- 380 people
- Sponsor
- Shire
Rheumatoid Arthritis, Ankylosing Spondylitis
Post-marketing Observational Study to Evaluate the Incremental Impact of AbbVie's Patient Support Program on Patient Reported Outcomes and Health Resource Utilization in Inflammatory Arthritis, Psoriasis and Inflammatory Bowel Diseases in Hungary (VALUE)
The objective of this post-marketing observational study (PMOS) was to evaluate the effectiveness of adalimumab plus the AbbVie Care 2.0 patient support program in participants with rheumatoid arthritis (RA), ankylosing…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis, Psoriasis
- Trial name
- VALUE (NCT02750800)
- Testing
- Adalimumab, AbbVie Care 2.0
- Volunteers
- 427 people
- Sponsor
- AbbVie
Colitis, Ulcerative
A Study of Ustekinumab in Pediatric Participants With Moderately to Severely Active Ulcerative Colitis (UC)
The purpose of this study is to evaluate: a) the efficacy of ustekinumab dosing in inducing clinical remission, b) safety profile of ustekinumab, and c) ustekinumab exposure (pharmacokinetics [PK]) in pediatric participants with…
- Trial name
- UNIFI Jr (NCT04630028)
- Testing
- Ustekinumab Dose Based on BSA and Body Weight
- Where
- 58 sites in United States, Belgium and 7 more
- Volunteers
- 112 people
- Sponsor
- Janssen Research & Development, LLC
Inflammatory Bowel Diseases, Contraception
Hormonal Influences on Inflammatory Bowel Diseases
Of the 1.8 million females with inflammatory bowel diseases (IBD) in the US, over half of those who are premenopausal suffer from cyclical menstrual-related IBD symptoms, regardless of how well their disease is controlled.
- Conditions
- Inflammatory Bowel Diseases, Contraception, Menstrual Problem
- Trial name
- NCT05610527
- Testing
- Proposed study design and randomization scenarios, Repeated measures of validated Inflammatory Bowel Disease Patient Reported Outcome Instruments, Inflammatory marker collection and assessment for correlation with PRO responses and menstrual timing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Utah
Ulcerative Colitis
Investigation of the Effects of Curcumin and Resveratrol Supplements Added to the Mediterranean Diet on Disease Severity and Inflammatory Biomarkers in Patients With Ulcerative Colitis
The aim of the study was to examine and compare the effects of Mediterranean diet, curcumin supplementation with Mediterranean diet in individuals with ulcerative colitis, and resveratrol supplementation with Mediterranean diet…
- Trial name
- NCT05761327
- Testing
- Mediterranean Diet, Curcumin Supplementation, Resveratrol Supplementation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Ardahan University
Inflammatory Bowel Diseases
Nabilone Use For Acute Pain in Inflammatory Bowel Disease Patients
This is a clinical trial of nabilone for patients with Inflammatory Bowel Disease (IBD) who are undergoing IBD-related surgery (Any abdominal surgery lasting for more than one hour).
- Trial name
- NCT03422861
- Testing
- Nabilone
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
IBD, Crohn's Disease
Pregnancy and Inflammatory Bowel Disease
Inflammatory Bowel disease, including Crohn's disease and Ulcerative Colitis, are chronic diseases. Diagnosis is most often done in women of childbearing age.
- Conditions
- IBD, Crohn's Disease, Ulcerative Colitis, Pregnancy
- Trial name
- MICI-Birth (NCT07377188)
- Where
- France
- Volunteers
- 945 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Crohn Disease
Shear-Wave Elastography in Intestinal Fibrosis Evaluation in Crohn's Disease
The choice of the optimal timing for surgery in Crohn's disease is a challenging issue and diagnostic tools able to estimate the degree of fibrosis are of great interest in this context.
- Trial name
- EL-CHIR (NCT06056986)
- Testing
- multimodal ultrasound
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Vitamin D Deficiency, Inflammatory Bowel Diseases
Vitamin D Status in Inflammatory Bowel Disease
Inflammatory bowel disease (IBD), comprising crohn's disease (CD) and ulcerative colitis (UC), is a a chronic, relapsing-remitting systemic disease.
- Trial name
- vdsinibd (NCT03496246)
- Testing
- serum total 25 hydroxycholecalciferol 25(OH) vitamin D, complete blood count (CBC), serum calcium level
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Assiut University
Colitis, Ulcerative
An Efficacy and Safety Study of Vedolizumab Intravenous (IV) Compared to Adalimumab Subcutaneous (SC) in Participants With Ulcerative Colitis
The purpose of this study is to evaluate the efficacy and safety of vedolizumab intravenous (IV) treatment compared to adalimumab subcutaneous (SC) treatment over a 52-week treatment period.
- Trial name
- NCT02497469
- Testing
- Vedolizumab, Adalimumab
- Where
- 330 sites in United States, Argentina and 32 more
- Volunteers
- 771 people
- Sponsor
- Takeda
Crohn Disease
Effect of Grapes in Inflammatory Bowel Disease
The overall objective of this pilot intervention study is to determine the impact of grape powder (46g/day freeze dried whole grape powder provided by the California Table Grape Commission) on the gut microbiotacomposition in…
- Trial name
- NCT05972694
- Testing
- Freeze dried grape powder
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Case Western Reserve University
Inflammatory Bowel Diseases, Primary Sclerosing Cholangitis
A Systems Biology Approach for Identification of Host and Microbial Mechanisms and Druggable Targets for the Treatment of PSC-IBD
Primary sclerosing cholangitis (PSC) is the classical hepatobiliary manifestation of inflammatory bowel disease (IBD). Although rare, PSC is associated with significant and disproportionate unmet needs; with heightened risks of…
- Trial name
- PSC-Vanc (NCT05376228)
- Testing
- Oral Vancomycin
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Crohn's Disease, Nephrotic Syndrome
Glucocorticoid-induced Osteopenia in Children
The purpose of this study is to characterize the skeletal deficits and risk factors for impaired skeletal development in children requiring glucocorticoid therapy.
- Trial name
- NCT00289328
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Ulcerative Colitis (UC), Crohn Disease (CD)
Exploring Multiple Self-Help Interventions to Promote Self-Efficacy and Overcome Disability
EMPOWER-IBD aims to identify behavioral interventions to strengthen patients' self-efficacy for self-management as a mechanism to reduce IBD-related disability.
- Trial name
- EMPOWER-IBD (NCT06646757)
- Testing
- APP, CBT, HELP
- Where
- United States
- Volunteers
- 803 people
- Sponsor
- University of Pennsylvania
Ulcerative Colitis
Phosphatidylcholine (LT-02) vs. Placebo vs. Mesalamine for Maintenance of Remission in Ulcerative Colitis (PROTECT-2)
The purpose of this study is to prove the superiority of a 48-weeks treatment with 3.2 g/day delayed-release phosphatidylcholine (LT-02) versus placebo for the maintenance of remission in patients with ulcerative colitis (UC)
- Trial name
- PROTECT-2 (NCT02280629)
- Testing
- LT-02, Mesalamine
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Dr. Falk Pharma GmbH
Inflammatory Bowel Diseases
Use of Autologous, Adult Adipose-Derived Stem/Stromal Cells in Inflammatory Bowel Disease
Inflammatory Bowel Disease (IBD) is a group of inflammatory conditions of the small bowel and colon. Main types include Ulcerative Colitis and Crohn's Disease.
- Trial name
- ADcSVF-IBD (NCT02952131)
- Testing
- Lipoaspiration, AD-cSVF, Normal Saline IV
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Healeon Medical Inc
Inflammatory Bowel Disease, Ulcerative Colitis
Safety of Anti-tumor Necrosis Factor (TNF) Monoclonal Antibodies in Inflammatory Bowel Disease
Anti-TNF (tumor necrosis factor) monoclonal antibodies have revolutionized management of Inflammatory bowel disease. Their common features include high efficacy but also immunogenicity and increased infection risk.
- Conditions
- Inflammatory Bowel Disease, Ulcerative Colitis, Crohn's Disease, Indeterminate Colitis
- Trial name
- SATIMOS (NCT02066272)
- Where
- 2 sites in Poland
- Volunteers
- 400 people
- Sponsor
- Maria Sklodowska-Curie National Research Institute of Oncology
Inflammatory Bowel Disease (IBD)
Clinical Investigation of MYIBDDiet App Developed for Inflammatory Bowel Disease (IBD) Patients to Self-manage Their Diet
The goal of this clinical trial is to learn if an app designed for diet education can help patients with inflammatory bowel disease (IBD) learn about healthy eating.
- Trial name
- NCT06683105
- Testing
- MyIBDDiet app
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Alberta
Inflammatory Bowel Diseases
Early Proactive Therapeutic Drug Monitoring of Infliximab in Children: EPIC Study
The purpose of the study is to assess whether a proactive therapeutic drug monitoring strategy, introduced early during treatment, improves Infliximab (IFX) durability, efficacy and safety in children and young adults with…
- Trial name
- EPIC (NCT05280405)
- Testing
- Infliximab
- Where
- Italy
- Volunteers
- 86 people
- Sponsor
- IRCCS Burlo Garofolo
Ulcerative Colitis
NBI With Magnification for Dysplasia Detection in Ulcerative Colitis
The purpose of the study is to determine whether a new colonoscopic viewing technique called narrow band imaging (NBI) helps doctors detect more patients with at leat one pre-cancerous area (dysplasia associated lession or mass…
- Trial name
- NCT00292175
- Testing
- Narrow Band Imaging, colonoscopy
- Where
- 2 sites in United Kingdom
- Volunteers
- 110 people
- Sponsor
- London North West Healthcare NHS Trust
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