Clinical trials: Inflammatory Bowel Disease (IBD)
Crohn Disease
Diet Intervention for Crohn's Disease Patient
The purpose of this study is to determine the effectiveness of a low-fat, high fiber diet (LFD) containing a minimal proportion of fat to improve gastrointestinal symptoms, quality of life and signs of inflammation in blood and…
- Trial name
- NCT04213729
- Testing
- Diet Counseling, CD LFD, Dyadic Psychological Support (DPS)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Miami
Ulcerative Colitis
Induction and Maintenance of Remission With Pentasa as Ulcerative Colitis Treatment
For both induction of remission and in maintenance of remission, different doses and treatment durations are used in practice. The aim of this study is to assess how mesalazine is used in clinical practice, at which doses and for…
- Trial name
- IMPACT (NCT02261636)
- Testing
- mesalazine
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- Ferring Pharmaceuticals
Inflammatory Bowel Diseases
Care Coordination and Proactive Care to Improve Utilization of Resources and Reduce Expenditure in High Risk Inflammatory Bowel Disease (IBD) Patients
The study team performed a randomized controlled trial to evaluate the efficacy of a care coordination intervention composed of proactive symptom monitoring and algorithm-based triggers to improve patient reported outcomes (PROs)…
- Trial name
- CAPTURE IBD (NCT04796571)
- Testing
- Proactive Symptom Monitoring and Care Coordination
- Where
- United States
- Volunteers
- 425 people
- Sponsor
- University of Michigan
Crohn's Disease
The MOTOR-CD Trial
Both single-balloon enteroscopy (SBE) and novel motorized spiral enteroscopy (NMSE) are effective techniques for small bowel endoscopy in suspected Crohn's disease (CD).
- Trial name
- NCT05363930
- Testing
- Novel motorized spiral enteroscopy, Single balloon enteroscopy
- Where
- India
- Volunteers
- 128 people
- Sponsor
- Asian Institute of Gastroenterology, India
Ulcerative Colitis
A Safety Study of Lactobacillus Reuteri BGP-014 in Patients With Ulcerative Colitis
The objectives of this study are to evaluate the safety, tolerability and preliminary efficacy of Lactobacillus reuteri BGP-014 in mild to moderate active Ulcerative Colitis (UC) patients as an oral administered local treatment…
- Trial name
- NCT05118919
- Testing
- BGP-014
- Where
- 4 sites in Sweden
- Volunteers
- 35 people
- Sponsor
- BioGaia Pharma AB
Colitis, Ulcerative
An Open Label Phase 4 Study to Evaluate Efficacy of Early Versus Late Use of Vedolizumab in Ulcerative Colitis
This multi-centre open label study will involve a minimum of 120 patients in 2 cohorts: 60 patients with 'early UC' defined as disease duration < 4 years and no other treatments than aminosalicylates and/or corticosteroids and 60…
- Trial name
- LOVE-UC (NCT02646657)
- Testing
- Vedolizumab 300 mg
- Where
- 20 sites in Belgium, Hungary and 1 more
- Volunteers
- 120 people
- Sponsor
- Geert D'Haens
Crohns Disease, Fistula
Study to Look at Benefit of Surgical Drainage Before Beginning Medical Therapy for Crohns Perianal Fistulas
This study is looking at the advantage of establishing surgical drainage for Crohn's fistulas and abscesses prior to starting medical therapy.
- Conditions
- Crohns Disease, Fistula, Abscess
- Trial name
- NCT01145365
- Testing
- Exam under anesthesia (EUA)
- Where
- 3 sites in United States
- Volunteers
- 21 people
- Sponsor
- Vanderbilt University Medical Center
Inflammatory Bowel Diseases
A First Time In Human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of GSK1399686
A First-Time-in-Human Study to Evaluate the Safety, Tolerability and Pharmacokinetics of GSK1399686 After Single and Repeated Oral Dosing in Healthy Volunteers
- Trial name
- NCT00721812
- Testing
- GSK1399686
- Where
- United Kingdom
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Inflammatory Bowel Diseases
Response To Medical Therapy in Inflammatory Bowel Disease Patients Carrying-out a Prescribed Exercise Programme
The investigators propose the use of a 20 week physician-derived exercise programme will lead to an improvement in physical fitness which will in turn lead to an increase in muscle mass, a reduction in visceral obesity resulting…
- Trial name
- NCT05174754
- Testing
- Physician-prescribed Exercise Programme, Best Medical Therapy
- Where
- Ireland
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons, Ireland
Inflammatory Bowel Diseases
Role of Multislice CT in Diagnosis of Inflammatory Bowel Disease
Aim of the work: To evaluate the role of CT in diagnosis of IBD
- Trial name
- NCT03436966
- Testing
- MULTI SLICE CT
- Volunteers
- 30 people
- Sponsor
- Assiut University
Rheumatoid Arthritis, Spondyloarthritis
The Norwegian Drug Monitoring Study
Infliximab and other TNF-inhibitors have revolutionised the treatment of several immunological inflammatory diseases. Still, more than half of the patients either do not respond sufficiently to infliximab therapy or loose…
- Conditions
- Rheumatoid Arthritis, Spondyloarthritis, Ankylosing Spondylitis, Crohn Disease
- Trial name
- NOR-DRUM (NCT03074656)
- Testing
- Therapeutic drug monitoring, Standard care
- Where
- 21 sites in Norway
- Volunteers
- 611 people
- Sponsor
- Diakonhjemmet Hospital
Ulcerative Colitis
Mind/Body Medicine and IBD Flare-Up
Ulcerative Colitis is an Inflammatory Bowel disease that is a life-long, relapsing disabling disorder. Current treatments for Ulcerative Colitis are not satisfactory.
- Trial name
- NCT00568256
- Testing
- Mind/Body Courses
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- Rush University Medical Center
Crohn's Disease (CD)
Clinical Study of the Efficacy, Safety, Pharmacokinetics, Pharmacodynamics, and Immunogenicity of BCD-261 in Subjects With Moderate to Severe Active Crohn's Disease
The aim of the study is to evaluate the efficacy, safety, pharmacokinetics, pharmacodynamics and immunogenicity of study drug (BCD-261) in comparison with placebo and to characterize the dose-response relationship in patients…
- Trial name
- COMANDOR (NCT07078994)
- Testing
- anti-TL1A monoclonal antibody, low dose, anti-TL1A monoclonal antibody, medium dose, anti-TL1A monoclonal antibody, high dose
- Where
- 20 sites in Russia
- Volunteers
- 204 people
- Sponsor
- Biocad
Rectal Neoplasms, Colitis, Ischemic
Anterior Perineal Plane for Ultra Low Anterior Resection of the Rectum
Anal sphincter preserving operations are now commonplace for both cancer and non-cancerous rectal diseases. However, this has not always been the case and this development has been facilitated by the invention of circular…
- Conditions
- Rectal Neoplasms, Colitis, Ischemic, Colitis, Ulcerative
- Trial name
- APPEAR (NCT00534131)
- Testing
- Standard abdominal approach for rectal excision, APPEAR Procedure, Proctectomy
- Where
- United Kingdom
- Volunteers
- 23 people
- Sponsor
- Queen Mary University of London
Inflammatory Bowel Diseases
Positron Emission Tomography (PET)-Computed Tomography (CT) in Inflammatory Bowel Disease (IBD)
The main hypothesis is that PET-CT will be a valuable diagnostic tool in diagnosing and evaluating treatment for IBD.
- Trial name
- NCT00205062
- Testing
- PET-CT
- Where
- United States
- Sponsor
- University of Wisconsin, Madison
Colitis, Ulcerative
Safety and Tolerability Study of GSK2586184 in Patients With Moderate to Severely Active Ulcerative Colitis.
This is an open label exploratory study to investigate the safety of 400 milligram (mg ) twice a day (b.i.d.) GSK2586184 in patients with moderate to severe, active ulcerative colitis (UC).
- Trial name
- NCT02000453
- Testing
- GSK2586184 400mg
- Where
- Netherlands
- Volunteers
- 2 people
- Sponsor
- GlaxoSmithKline
Granulomatous Colitis, Crohn's Disease
An Investigational Study of Experimental Medication BMS-986165 in Participants With Moderate to Severe Crohn's Disease
The purpose of this study is to assess the safety and effectiveness of BMS-986165 compared to placebo in participants with moderately to severely active Crohn's Disease.
- Conditions
- Granulomatous Colitis, Crohn's Disease, Crohn's Enteritis, Granulomatous Enteritis
- Trial name
- NCT03599622
- Testing
- BMS-986165
- Where
- 259 sites in United States, Australia and 24 more
- Volunteers
- 239 people
- Sponsor
- Bristol-Myers Squibb
Crohn, Ulcerative Colitis (UC)
Research and Follow-up of the Determinants of the Progression and Complications of Inflammatory Bowel Diseases Treated or Not With Immunosuppressants.
Inflammatory Bowel Diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic, disabling conditions affecting young adults, marked by flare-ups and remissions.
- Conditions
- Crohn, Ulcerative Colitis (UC), IBD (Inflammatory Bowel Disease)
- Trial name
- SUIVITHEQUE2 (NCT07172945)
- Testing
- Blood, fecal, saliva, intestinal content samples and biopsies
- Volunteers
- 4,500 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Inflammatory Bowel Diseases, Ulcerative Colitis
Global IBD Visualization of Epidemiology Studies (GIVES) in the 21st Century
Crohn's disease (CD) and Ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBD) of unknown etiology. The pathophysiology of IBD relates to the mucosal immune response to antigenic stimulation from the gut…
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- GIVES-21 (NCT04748627)
- Where
- Hong Kong
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Crohn's Disease
Placebo Controlled Study of 3 Doses of Rifaximin-EIR Tablet to Treat Moderate, Active Crohn's Disease
This study aims to determine which of 3 doses of a non-absorbable antibiotic Rifaximin is most effective in treating active moderate Crohn's disease.
- Trial name
- NCT00528073
- Testing
- Rifaximin-EIR
- Where
- 57 sites in France, Germany and 5 more
- Volunteers
- 410 people
- Sponsor
- Alfasigma S.p.A.
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