Clinical trials: Inflammatory Bowel Disease 1
Ulcerative Colitis (UC)
A Study to Investigate the Safety, Tolerability, and Pharmacokinetics of ONO-6414 Administered Orally in Healthy Adult Participants and Patients With Active Ulcerative Colitis
A study to investigate the safety, tolerability, and pharmacokinetics (PK) of ONO-6414 orally in healthy adult participants and in patients with active ulcerative colitis (UC).
- Trial name
- NCT07749768
- Testing
- ONO-6414
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Ulcerative Colitis and Crohn's Disease
Entyvio (Vedolizumab) Long Term Safety Study
The purpose of this study is to assess the long-term safety of vedolizumab versus other biologic agents in participants with Ulcerative Colitis (UC) or Crohn's Disease (CD).
- Trial name
- Entyvio PASS (NCT02674308)
- Testing
- Vedolizumab, Other Biologic Agents
- Where
- 287 sites in United States, Austria and 19 more
- Volunteers
- 5,302 people
- Sponsor
- Takeda
Crohn's Disease
Transmural Healing and Disease-Modifying Effect of Guselkumab in Crohn's Disease Patients
The purpose of this study is to evaluate the efficacy of guselkumab in healing of all layers of the digestive tract (transmural healing) with the help of a score called Magnetic Resonance Index of Activity (MaRIA) based on a scan…
- Trial name
- REASON (NCT06408935)
- Testing
- Guselkumab
- Where
- 84 sites in United States, Australia and 12 more
- Volunteers
- 120 people
- Sponsor
- Janssen-Cilag Ltd.
Pediatric Penetrating Crohn's Disease
Pediatric Penetrating Crohn's Disease
The incidence of Crohn's disease (CD) increased the last few years, especially in children, with 20% percent of CD patients diagnosed during childhood.
- Trial name
- Pediatric B3 (NCT04119635)
- Where
- France
- Volunteers
- 500 people
- Sponsor
- University Hospital, Montpellier
Inflammatory Bowel Diseases (IBD), Remission of IBD
VIBRANT-IBD: Brain Effects of Non-Invasive Vagus Nerve Stimulation in IBD Remission
The VIBRANT-IBD study is a pilot, prospective, single-arm feasibility study investigating the effects of non-invasive vagus nerve stimulation (nVNS) in adults with inflammatory bowel disease (IBD) in clinical remission.
- Conditions
- Inflammatory Bowel Diseases (IBD), Remission of IBD, In Adults, Inflammatory Bowel Disease (Crohn's Disease; Ulcerative Colitis)
- Trial name
- VIBRANT-IBD (NCT07636304)
- Testing
- Non-invasive vagus nerve stimulation (nVNS)
- Where
- Poland
- Volunteers
- 15 people
- Sponsor
- University of Gdansk
Crohn Disease (CD)
Comparison Between Artificial Intelligence and Standard Reading to Investigate Suspected Crohn Disease: the SCAI STUDY
The diagnosis of Crohn's Disease (CD) is based on a combination of clinical, biochemical (serological and fecal), endoscopic, radiological, and histological investigations.
- Trial name
- SCAI (NCT07111715)
- Testing
- Small bowel Video Capsule Endoscopy (VCE) using an Capsule System equipped with a Deep Neural Network based system called SmartScan (SC),
- Where
- Italy
- Volunteers
- 180 people
- Sponsor
- Fondazione Poliambulanza Istituto Ospedaliero
Inflammatory Bowel Diseases, Yoga
Yoga for Youth With IBD: a Pilot Feasibility Study
An 8-week yoga intervention to determine the feasibility and acceptability of yoga as a supplemental therapy in the management of inflammatory bowel disease in the adolescent population.
- Conditions
- Inflammatory Bowel Diseases, Yoga, Adolescents, Crohn Disease
- Trial name
- NCT04757935
- Testing
- Yoga
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Stanford University
Crohn's Disease, Ulcerative Colitis
Dysmenorrhea in Women With Crohn's Disease and Ulcerative Colitis
This case-control study will screen for dysmenorrhea and assess severity of menstrual symptoms in menstruating women with CD and UC compared with healthy age-matched controls.
- Trial name
- NCT02274714
- Testing
- Questionnaire Only
- Where
- United States
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Inflammatory Bowel Disease, Crohn's Disease
Anti-TNF-alpha Trough Level Measurements in Inflammatory Bowel Disease
Drug serum concentrations will be measured at several time-points for inflammatory disease patients treated with anti-TNF agents.
- Conditions
- Inflammatory Bowel Disease, Crohn's Disease, Ulcerative Colitis
- Trial name
- NCT02073526
- Testing
- Infliximab, adalimumab, certolizumab pegol
- Where
- Norway
- Volunteers
- 1,230 people
- Sponsor
- Oslo University Hospital
Inflammatory Bowel Disease
The EDICT Trial - Therapy for Inflammatory Bowel Disease Flares
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are chronic inflammatory conditions of the gastrointestinal tract that affect millions of people in the United States of America.
- Trial name
- EDICT (NCT07143188)
- Testing
- elemental diet (ED)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Wake Forest University Health Sciences
Pediatric Crohn's Disease
Clinical Study of TA-650 in Pediatric Patients With Crohn's Disease
The purpose of this study is to evaluate the efficacy of TA-650 using Pediatric Crohn's Disease Activity Index (PCDAI) in pediatric patients with moderate to severe Crohn's disease after TA-650 administration at a dose of 5 mg/kg…
- Trial name
- NCT01580670
- Testing
- TA-650
- Where
- 7 sites in Japan
- Volunteers
- 14 people
- Sponsor
- Tanabe Pharma Corporation
Crohn's Disease
Diagnostic Accuracy of Capsule Endoscopy in Small Bowel Crohn's Disease
Prospective study to compare in a blinded fashion four different diagnostic modalities to detect active small bowel Crohn's disease: a) colonoscopy with ileoscopy; b) small bowel follow through; c) capsule endoscopy; and d)…
- Trial name
- NCT00588653
- Testing
- Capsule endoscopy, CT enterography, colonoscopy, small bowel follow-through
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Mayo Clinic
Ankylosing Spondylitis, Autoimmune Disease
Testing of an Educational Tool for Patients With Melanoma and Pre-Existing Autoimmune Disease Who Are Candidates for Immune Checkpoint Inhibitors
This study learn how easily patients can use an educational tool that will be created for patients with melanoma and pre-existing autoimmune diseases who receive or will receive immune checkpoint inhibitor drugs.
- Conditions
- Ankylosing Spondylitis, Autoimmune Disease, Crohn Disease, Enteropathic Arthritis
- Trial name
- NCT04751396
- Testing
- Best Practice, Educational Intervention, Interview
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- M.D. Anderson Cancer Center
Crohn Disease
TRansmural hEaliNg Definition in CroHn's Disease (TRENCH 1)
Multicenter prospective cross-sectional study of CD patients, its aim is the construction of an objective and reproducible system for evaluation of Transmural healing in Crohn's Disease (CD).
- Trial name
- TRENCH 1 (NCT05903066)
- Testing
- Magnetic Resonance Enterography (MRE)
- Where
- 13 sites in Belgium, France
- Volunteers
- 320 people
- Sponsor
- Groupe d'Etude Therapeutique des Affections Inflammatoires Digestives
Age-Related Macular Degeneration, Allergies
Tissue Repository Providing Annotated Biospecimens for Approved Investigator-directed Biomedical Research Initiatives
To collect, preserve, and/or distribute annotated biospecimens and associated medical data to institutionally approved, investigator-directed biomedical research to discover and develop new treatments, diagnostics, and…
- Conditions
- Age-Related Macular Degeneration, Allergies, Alpha-Gal Syndrome, Alzheimer Disease
- Trial name
- NCT05635266
- Testing
- Specimen sample
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Sanguine Biosciences
Inflammatory Bowel Disease (IBD), Ulcerative Colitis
Healthy Approach to Physical and Psychological Problems in Youngsters With IBD (HAPPY-IBD).
The presented study aims to reduce symptoms of depression and anxiety in adolescents with inflammatory bowel disease and increased symptoms of anxiety and depression by using the disease specific CBT program (PASCET-PI)in order…
- Conditions
- Inflammatory Bowel Disease (IBD), Ulcerative Colitis, Crohn's Disease, Anxiety
- Trial name
- HAPPY-IBD (NCT02265588)
- Testing
- Cognitive behavioral therapy
- Where
- Netherlands
- Volunteers
- 70 people
- Sponsor
- Erasmus Medical Center
Crohn Disease, Ulcerative Colitis
Autoimmune Protocol Diet and Inflammatory Bowel Disease
There is limited data to guide the use of dietary change in the management of IBD, and it can prove challenging to implement in the setting of altered anatomy, comorbid conditions, and patient compliance.
- Conditions
- Crohn Disease, Ulcerative Colitis, Inflammatory Bowel Diseases
- Trial name
- NCT03512327
- Testing
- Autoimmune protocol (AIP) diet
- Volunteers
- 15 people
- Sponsor
- Scripps Health
IBD, Inflammatory Bowel Diseases
The Assessment of Infrared Treatment for Crohn's Disease
The goal of this clinical trial is to test the safety and efficacy of far Infra-red (fIR) therapy in Crohn's disease patients. The main questions it aims to answer are: 1.
- Conditions
- IBD, Inflammatory Bowel Diseases, Crohn Disease
- Trial name
- NCT06146816
- Testing
- High level photobiomodulation treatment in the infrared (IR) range., Medium level photobiomodulation treatment in the far infrared (IR) range, Low level photobiomodulation treatment in the far infrared (IR) range
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Shmuel Kivity, MD
Crohn Disease
Mesenteric Sparing for the Prevention of Recurrent Crohn's Disease
The purpose of this study is to determine if taking an increased sampling of mesentery (fatty tissue next to the intestine) and lymph nodes at the time of the subject's ileocolic resection prevents a 4-6 month recurrence of…
- Trial name
- NCT03172143
- Testing
- Mesenteric Sparing Ileocolic Resection, High Ligation Ileocolic Resection
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Crohn's Disease (CD)
An Observational, Multicenter Study to Evaluate the Effectiveness of Guselkumab for the Treatment of Participants With Crohn's Disease After Surgical Resection
The goal of this single arm ,non-interventional, prospective, descriptive study is to evaluate the efficacy of guselkumab treatment in preventing endoscopic recurrence of Crohn's Disease in adult participants who have a…
- Trial name
- POST-CD (NCT07528040)
- Testing
- Guselkumab
- Where
- China
- Volunteers
- 88 people
- Sponsor
- Shanghai 10th People's Hospital
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