Clinical trials: Inflammatory Bowel Disease 1
Inflammatory Bowel Diseases, Ulcerative Colitis
Enhancing Ultrasound & Photoacoustic for Recognition of Intestinal Abnormalities
The clinical investigation aims to generate clinical data to support the use of Multispectral Optoacoustic Tomography (MSOT) in clinical practice, its inclusion in diagnostic guidelines and to support its reimbursement…
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- EUPHORIA (NCT04456400)
- Testing
- Multispectral Optoacoustic Tomography (MSOT)
- Where
- 6 sites in Germany, Italy
- Volunteers
- 200 people
- Sponsor
- iThera Medical GmbH
Crohn Disease, Ulcerative Colitis
Inflammatory Bowel Diseases Remission Registry
The inflammatory bowel diseases (IBDs), ulcerative colitis (UC) and Crohn's disease (CD), are characterized by lifelong relapsing-remitting gastrointestinal inflammation, with symptoms of abdominal pain, diarrhea, and rectal…
- Conditions
- Crohn Disease, Ulcerative Colitis, Pouchitis
- Trial name
- NCT04912999
- Where
- Israel
- Volunteers
- 1,000 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
IBD, Ulcerative Colitis
High Dose Interval Vitamin D Supplementation in Patients With IBD Receiving Remicade
The goal of this study will be to assess the safety and efficacy of high-dose interval Vitamin D3 therapy in children and young adults with Inflammatory Bowel Disease being treated with serial Remicade infusions.
- Conditions
- IBD, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT03162432
- Testing
- Vitamin D3
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston Children's Hospital
Inflammatory Bowel Diseases, Crohn Disease
Study Evaluating the Persistence, Efficacy and Tolerability of Methotrexate in Inflammatory Bowel Disease Patients
Methotrexate is one of the immunosuppressants used in chronic inflammatory bowel disease (IBD). It is indicated as monotherapy for induction and maintenance treatment of Crohn's disease (CD), or in combination with anti-tumor…
- Conditions
- Inflammatory Bowel Diseases, Crohn Disease, Ulcerative Colitis
- Trial name
- MICI-METHO (NCT05927064)
- Where
- France
- Volunteers
- 1,282 people
- Sponsor
- Central Hospital, Nancy, France
Crohn Disease in Remission
Stratifying Crohn's Using Biomarker Assessment
Crohn's disease (CD) is a relapsing-remitting condition that requires lifelong monitoring. Non-invasive tests such as faecal calprotectin (FC) are more acceptable to patients and cost-effective than invasive tests such as…
- Trial name
- SCUBA (NCT04321863)
- Testing
- Faecal calprotectin (FC), quantitative Faecal Immunochemical Testing (qFIT), Serum and faecal zinc
- Where
- United Kingdom
- Volunteers
- 315 people
- Sponsor
- NHS Greater Glasgow and Clyde
Inflammatory Bowel Diseases
Butyrate in Pediatric Inflammatory Bowel Disease
The first prospective randomised placebo-controlled study in the IBD pediatric population was conducted to evaluate the effectiveness of oral sodium butyrate as add-on therapy in IBD.
- Trial name
- NCT05456763
- Testing
- sodium butyrate
- Volunteers
- 100 people
- Sponsor
- Centre of Postgraduate Medical Education
Crohn's Disease
Contrast-Enhanced Ultrasound in Human Crohn's Disease
To determine if contrast enhanced ultrasound (CEUS) and shear wave elastography can accurately diagnose bowel wall inflammation and fibrosis in patients with known Crohn's disease.
- Trial name
- NCT02061163
- Testing
- Contrast Enhanced Ultrasound, Optison
- Where
- United States
- Sponsor
- University of Michigan
Crohn's Disease
Intermittent Caloric Restriction in Patients With Mild to Moderate Crohn's Disease
Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal (GI) tract. CD is a common inflammatory bowel disease (IBD), frequent (150,000 patients in France and 1.5 million in Europe), disabling and incurable.
- Trial name
- TONIC (NCT05683730)
- Testing
- Intermittent caloric restriction
- Where
- France
- Volunteers
- 174 people
- Sponsor
- Central Hospital, Nancy, France
Crohn's Disease
Use of Combined Measurements of Serum Infliximab and Anti-infliximab Antibodies in the Treatment of Patients With Crohns Disease Failing Infliximab Therapy
To compare treatment outcome in patients with Crohn's disease with secondary loss of response to infliximab (i.e. initial good response follow by loss of response) treated according to current standards based only on clinical…
- Trial name
- NCT00851565
- Testing
- Measurement of serum infliximab and anti-infliximab antibodies, Treatment according to current standards without knowledge of serum infliximab and anti-infliximab Ab status
- Where
- 8 sites in Denmark
- Volunteers
- 120 people
- Sponsor
- Copenhagen University Hospital at Herlev
Ulcerative Colitis (Disorder), Crohn Disease (CD)
Incremental Value of Traditional Chinese Medicine Features in Two-Stage Pre-Endoscopic Prediction
This observational study evaluates whether adding Traditional Chinese Medicine (TCM)-related clinical features improves the performance of machine-learning models that estimate disease risk before colonoscopy.
- Conditions
- Ulcerative Colitis (Disorder), Crohn Disease (CD), Inflammatory Bowel Diseases, Colorectal Neoplasms
- Trial name
- NCT07784114
- Volunteers
- 1,500 people
- Sponsor
- Beijing University of Chinese Medicine
Crohn's Disease
Wireless Capsule Endoscopy in Small-Bowel Crohn's Disease
The purpose of this study is to determine the best role for capsule endoscopy in diagnosing Crohn's disease.
- Trial name
- NCT00178438
- Testing
- Capsule Endoscopy
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Rochester
Crohn Disease
Search for New Genetic Mutations Major Effect in Crohn's Disease
This study highlight genetics mutations with major effect in Crohn's Disease (CD) by WES in individuals affected and healthy individuals from EPIMAD Inserm InVS registry families.
- Trial name
- MC-WES (NCT02851134)
- Testing
- genetic analysis, blood and stools samples
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Lille
Crohn's Disease
A First Time in Human Study in Healthy Volunteers and Patients
A multi-part study to investigate the safety, tolerability and local and systemic pharmacokinetics of V565
- Trial name
- NCT03010787
- Testing
- V565
- Where
- United Kingdom
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- VHsquared Ltd.
Crohn's Disease
A Study To Monitor Long-Term Treatment With PF-00547659
This study provides open-label drug to eligible patients who have completed a prior study of PF-00547659. The primary endpoint for this study is long-term safety.
- Trial name
- OPERA II (NCT01298492)
- Testing
- PF-00547659
- Where
- 112 sites in United States, Austria and 13 more
- Volunteers
- 268 people
- Sponsor
- Shire
Insomnia, Crohn Disease
RISE: A Remote Study of Insomnia Treatment in Crohn's Disease
The purpose of this study is to assess whether the investigators can treat insomnia in people with Crohn's disease, and if insomnia treatment can make other things better, like pain or inflammation.
- Trial name
- RISE (NCT05956158)
- Testing
- Behavioral Treatment, Sleep Education Treatment
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Crohn Disease
Precise Infliximab Exposure and Pharmacodynamic Control
Approximately 3 million people in the United States are living with inflammatory bowel disease, which includes Crohn's Disease (CD).
- Trial name
- REMODEL-CD (NCT05660746)
- Testing
- RoadMAB, Infliximab
- Where
- 11 sites in United States
- Volunteers
- 180 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Crohn's Disease
Controlled Trial of 4-Aminosalicylic Acid in Patients With Small Bowel Crohn's Disease
OBJECTIVES: I. Assess the efficacy and safety of 4-aminosalicylic acid in patients with active Crohn's disease of the small bowel.
- Trial name
- NCT00004423
- Testing
- -aminosalicylic acid
- Volunteers
- 80 people
- Sponsor
- University of Vermont
Crohn Disease, Anal Fistula
Study on the Treatment of Anal Fistulas Using Alofisel Versus Fat Autologous Stem Cells
One of the newest and most innovative medicinal approaches is cell therapy. Several clinical trials and experimental investigations have looked into the feasibility of treating CD-related fistulas with stem cells.
- Trial name
- CHAZAM (NCT05974280)
- Testing
- Alofisel, Fat stem cell
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Nantes University Hospital
Perianal Fistula, Primary; Complex
Follow-up Study of Autologous Adipose-derived Stem Cells (ANTG-ASC) for the Complex Fistula (ANTG-ASC-211)
This is an open follow-up clinical trial to evaluate a sustained efficacy and safety of ANTG-ASC injection for 4 months (6 months after final dose injection) after Phase II clinical trial.
- Trial name
- ANTG (NCT01623453)
- Testing
- Autologous adipose derived stem cells(low dose group), Autologous adipose derived stem cells(high dose group)
- Where
- 2 sites in South Korea
- Volunteers
- 6 people
- Sponsor
- Anterogen Co., Ltd.
Inflammatory Bowel Diseases, Colitis, Ulcerative
A Study of Kynteles Injection (Vedolizumab) in Adults With Moderate to Severe Ulcerative Colitis or Crohn's Disease or Chronic Pouchitis
In this study, participants with ulcerative colitis or Crohn's disease or pouchitis will be treated with Kynteles injection (Vedolizumab) according to their clinic's standard practice.
- Conditions
- Inflammatory Bowel Diseases, Colitis, Ulcerative, Crohn Disease
- Trial name
- NCT04799496
- Where
- 43 sites in South Korea
- Volunteers
- 688 people
- Sponsor
- Takeda
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